检索结果-南通市图书馆

Nutritional and lipid profile status of children with spinal muscular atrophy in China: A retrospective case-control study

引用

中华医学杂志(英文版) 2024年第10期137卷 1243-1245页

作者： Feng Yijie Wei Jia Yao Mei Jin Jianing Cui Yiqin Long Qi chen Fei Hong Yi Zhou Dongming Hu Jingjing chen xiao Gao Feng Yuan Changzheng Mao Shanshan Department of Neurology Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China Department of Infection Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China Department of Nutrition Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China Children’s Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China School of Public Health Zhejiang University School of Medicine Hangzhou Zhejiang China Children’s Hospital School of Public Health Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China

5q spinal muscular atrophy (5qSMA) is an autosomal recessive neuromuscular disorder caused by the lack of the survival motor neuron (SMN) protein encoded by the SMN1 gene, located at 5q11.2-q13.3.[1] The incidence is 1/10,000-1/6000 live births, and the mutation carrier rate in China is 1/42.[1] Spinal muscular atrophy (SMA) is mainly divided into four subtypes: SMA type I, II, III, and IV, based on the motor milestones ever achieved. Types I-III occur in children,[1] which often result in progressive muscular atrophy and weakness as well as multi-system dysfunction, including nutritional and metabolic issues.[2] Children with SMA may have hidden nutritional and lipid imbalances, despite normal body appearance and anthropometric measurements, making it difficult to detect early and intervene. Fewer studies have elucidated both the nutritional status and lipid metabolism in SMA patients,[2] especially in Asia, which may have some of the highest numbers of SMA patients in the world. To inform the development of targeted nutritional management strategies, this study aimed to investigate the nutritional status and serum lipid profile characteristics in children with SMA, based on a hospital-based case-control study in China. This study was approved by the Ethics Committee of Children's Hospital of Zhejiang University School of Medicine (No. 2019-IRB-171). Written informed consent was obtained from all the patients and their legal guardians.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Insights for Africa’s Industrialisation

引用

ChinAfrica 2024年第1期16卷 14-15页

作者： ZHANG JIN chen xiao Centre for International Knowledge on Development Beijing

The First Industrial Revolution in the 18th century started the modernisation process marked by profound economic,social,and cultural transformations in the world.Research shows that the process of industrialisation is closely associated with improvements in people’s living standards and their quality of life.Industrialisation,with economic and technological change at its core,is central to modernisation.

关键词： Africa profound economic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis

引用

Asian Journal of Andrology 2024年第2期26卷 212-219页

作者： Gao-Qing Qian xiao-chen Wang Xi Zhang Bin Shen Qiang Liu State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical UniversityNanjing 211166China Shanghai Key Laboratory of Reproductive Medicine Department of HistoembryologyGenetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Male germ cells employ specific metabolic pathways throughout their developmental stages.In a previous study,we discovered heightened expression of pyruvate kinase M(PKM),a pivotal glycolytic enzyme,in spermatogonia and spermatids.To gain deeper insights into PKM's roles in spermatogenesis,sperm function,and male fertility,we engineered a conditional-knockout mouse model(Pkm-vkO mice)to selectively disrupt the Pkm gene within germ cells.Despite maintaining regular testicular histology and sperm morphology,the male Pkm-vko mice were infertility,characterized by significant impairments in sperm motility and adenosine triphosphate(ATP)generation.In addition,Pkm-null spermatozoa exhibited similar deficits in protein tyrosine phosphorylation linked to capacitation,as well as compromised performance in in vitro fertilization experiments.To conclude,PKM's presence is not obligatory for the entirety of spermatogenesis in male germ cells;however,it emerges as a critical factor influencing sperm motility and overall male fertility.

关键词： glycolysis male fertility pyruvate kinase M sperm motility spermatogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Field-assisted machining of difficult-to-machine materials

引用

International Journal of Extreme Manufacturing 2024年第3期6卷 39-89页

作者： Jianguo Zhang Zhengding Zheng Kai Huang Chuangting Lin Weiqi Huang xiao chen Junfeng xiao Jianfeng Xu State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Mechanical Engineering Hubei University of TechnologyWuhan 430068People’s Republic of China

Difficult-to-machine materials (DMMs) are extensively applied in critical fields such as aviation,semiconductor,biomedicine,and other key fields due to their excellent material properties.However,traditional machining technologies often struggle to achieve ultra-precision with DMMs resulting from poor surface quality and low processing efficiency.In recent years,field-assisted machining (FAM) technology has emerged as a new generation of machining technology based on innovative principles such as laser heating,tool vibration,magnetic magnetization,and plasma modification,providing a new solution for improving the machinability of DMMs.This technology not only addresses these limitations of traditional machining methods,but also has become a hot topic of research in the domain of ultra-precision machining of DMMs.Many new methods and principles have been introduced and investigated one after another,yet few studies have presented a comprehensive analysis and summarization.To fill this gap and understand the development trend of FAM,this study provides an important overview of FAM,covering different assisted machining methods,application effects,mechanism analysis,and equipment design.The current deficiencies and future challenges of FAM are summarized to lay the foundation for the further development of multi-field hybrid assisted and intelligent FAM technologies.

关键词： field-assisted machining difficult-to-machine materials materials removal mechanism surface integrity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

引用

World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-Fei Qu xiao Ma Lu-Yao Ma xiao-xiao chen Yu-Qin Wang xiao-Bing Qin Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human health.Owing to challenges in early diagnosis,most patients lose the opportunity for radical treatment when diagnosed.Nonetheless,recent advancements in cancer immunotherapy provide new directions for the treatment of HCC.For instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with HCC.However,tumor cells can evade the immune system through various mechanisms.With the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer vaccines.This review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genesis and Accumulation of Paleo-Oil Reservoir in Dabei Area,Kuqa Depression,Northwest China:Implications for Tight-Gas Accumulation

引用

Journal of Earth Science 2024年第2期35卷 655-665页

作者： Fujie Jiang xiao chen Pengwei Wang Xinghe Shao Haijun Yang State Energy Center for Shale Oil Research and Development Beijing102206China National Key Laboratory of Oil and Gas Resources and Engineering Beijing102249China College of Geosciences China University of PetroleumBeijing102249China CNOOC International Ltd. Beijing100027China Research Institute of Petroleum Exploration&Production SINOPECBeijing100083China Research Institute of Petroleum Exploration and Development Tarim OilfieldPetroChinaKorla841000China

Paleo-oil reservoir is of great importance to understand hydrocarbon enrichment mechanism and hydrocarbon exploration potential,but is yet poorly investigated in Kuqa Depression.The occurrence of the paleo-oil reservoir in Dabei area was proved by quantitative grain fluorescence(QGF)and fluid inclusion petrography.Development history of the paleo-oil reservoir was reconstructed through:(1)oil-source correlation;(2)time coupling of source rock maturation,porosity evolution and migration pathways.The impact of paleo-oil reservoir on tight-gas accumulation was consequently discussed.Results suggest that considerable oil was accumulated in the K_(1)bs reservoir with paleo oil-water contact in Dabei 2 Well and Dabei 201 Well at 5800 and 6040 m,respectively.Crude oil was primarily sourced from Triassic source rocks with Jurassic source rocks of secondary importance,which was at oil generation window(0.7%–1.1%Ro)during 9–6 and 7.5–5 Ma,respectively.The occurrence of K_(1)bs tight reservoir(porosity<12%)was about 25 Ma,while faults and associated fractures at Kelasue structural belt were developed approximately from 8 to 3.5 Ma.Therefore,the tight oil accumulation was formed during 8–5 Ma.The paleo-oil reservoir in Dabei 1 gas field was destroyed by the evaporation fractionation in later stage.

关键词： Paleo-oil reservoir Dabei area Kuqa Depression Northwest China petroleum geology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Scattered Co-anchored MoS2 synergistically boosting photothermal capture and storage of phase change materials

引用

Journal of Energy Chemistry 2024年第8期95卷 208-215页

作者： Yang Li Panpan Liu Yan Gao Yuhao Feng Peicheng Li xiao chen Institute of Advanced Materials Beijing Normal University School of Materials Science and Engineering University of Science and Technology Beijing School of Environment Beijing Normal University

Pristine phase change materials（PCMs） suffer from inherent deficiencies of poor solar absorption and photothermal conversion.Herein,we proposed a strategy of co-incorporation of zero-dimensional（OD）metal nanoparticles and two-dimensional（2D） photothermal materials in PCMs for efficient capture and conversion of solar energy into thermal energy.Highly scattered Co-anchored MoS2nanoflower cluster serving as photon and phonon triggers was prepared by in-situ hydrothermal growth of ZIF67 polyhedron on 2D MoS2and subsequent high-temperature carbonization.After encapsulating thermal storage unit（paraffin wax）,the obtained composite PCMs integrated high-performance photothermal conversion and thermal energy storage capability.Benefiting from the synergistic enhancement of OD Co nanoparticles with localized surface plasmon resonance effect,carbon layer with the conjugation effect and 2D MoS2with strong solar absorption,composite PCMs exhibited a high photothermal conversion efficiency of 95.19%,Additionally,the resulting composite PCMs also demonstrated long-term thermal sto rage stability and durable structu ral stability after 300 thermal cycles.The proposed collabo rative co-incorporation strategy provides some innovative references for developing next-generation photothermal PCMs in solar energy utilization.

关键词： Phase change materials Photothermal conversion Thermal energy storage

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

引用

World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： chen-xiao Huang xiao-Dong Zhou Calvin Q Pan Ming-Hua Zheng Metabolic Dysfunction-Associated Fatty Liver Disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition worldwide.Current liver enzyme-based screening methods have limitations that may missed diagnoses and treatment delays.Regarding chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal range.Therefore,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early intervention.This paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on the clogging mechanism of punching screen in sand control by the punching structure parameters

引用

Petroleum Science 2024年第1期21卷 609-620页

作者： Fu-cheng Deng Fu-Lin Gui Bai-Tao Fan Lei Wen Sheng-Hong chen Ning Gong Yun-chen xiao Zhi-Hui Xu Yangtze University Jingzhou434023HubeiChina CNOOC Research Institute Ltd. Beijing100028China CNOOC Ener Tech-Drilling&Production Co. Tianjin300457China Tianjin Branch of CNOOC Ltd. Tianjin300459China

As an independent sand control unit or a common protective shell of a high-quality screen,the punching screen is the outermost sand retaining unit of the sand control pipe which is used in geothermal well or oil and gas well.However,most screens only consider the influence of the internal sand retaining medium parameters in the sand control performance design while ignoring the influence of the plugging of the punching screen on the overall sand retaining performance of the screen.To explore the clogging mechanism of the punching screen,this paper established the clogging mechanism calculation model of a single punching screen sand control unit by using the computational fluid mechanics-discrete element method(CFD-DEM)combined method.According to the combined motion of particles and fluids,the influence of the internal flow state on particle motion and accumulation was analyzed.The results showed that(1)the clogging process of the punching sand control unit is divided into three stages:initial clogging,aggravation of clogging and stability of clogging.In the initial stage of blockage,coarse particles form a loose bridge structure,and blockage often occurs preferentially at the streamline gathering place below chamfering inside the sand control unit.In the stage of blockage intensification,the particle mass develops into a relatively complete sand bridge,which develops from both ends of the opening to the center of the opening.In the stable plugging stage,the sand deposits show a“fan shape”and form a“V-shaped”gully inside the punching slot element.(2)Under a certain reservoir particle-size distribution,The slit length and opening height have a large influence on the permeability and blockage rate,while the slit width size has little influence on the permeability and blockage rate.The microscopic clogging mechanism and its law of the punching screen prevention unit are proposed in this study,which has some field guidance significance for the design of punching screen and sand prevention selection.

关键词： Punching screen Plugging CFD-DEM Size parameter Sand control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strong metal-support interactions between highly dispersed Cu^(+) species and ceria via mix-MOF pyrolysis toward promoted water-gas shift reaction

引用

Journal of Energy Chemistry 2024年第4期91卷 475-483页

作者： xiao-chen Sun Xing-Chi Li Ze-Wei Xie chen-Yue Yuan De-Jiu Wang Qian Zhang xiao-Yu Guo Hao Dong Hai-Chao Liu Ya-Wen Zhang Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The modulation of metal-support interfacial interaction is significant but challenging in the design of high-efficiency and high-stability supported catalysts.Here,we report a synthetic strategy to upgrade Cu-CeO_(2)interfacial interaction by the pyrolysis of mixed metal-organic framework(MOF)structure.The obtained highly dispersed Cu/CeO_(2)-MOF catalyst via this strategy was used to catalyze water-gas shift reaction(WGSR),which exhibited high activity of 40.5μmolCOgcat^(-1).s^(-1)at 300℃and high stability of about 120 h.Based on comprehensive studies of electronic structure,pyrolysis strategy has significant effect on enhancing metal-support interaction and then stabilizing interfacial Cu^(+)species under reaction conditions.Abundant Cu^(+)species and generated oxygen vacancies over Cu/CeO_(2)-MOF catalyst played a key role in CO molecule activation and H2O molecule dissociation,respectively.Both collaborated closely and then promoted WGSR catalytic performance in comparison with traditio nal supported catalysts.This study shall offer a robust approach to harvest highly dispersed catalysts with finely-tuned metal-support interactions for stabilizing the most interfacial active metal species in diverse heterogeneous catalytic reactions.

关键词： Cu-based catalyst MOF derivative Water-gas shift reaction Metal-support interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：