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müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao chen Aerospace Clinical m.d.cal Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Aviation m.d.cine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Emergency m.d.cine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal m.d.l of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to müller cell activation,were significantly *** addition,müller cell regeneration and müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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Glutamatergic CYLd deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi chen Erwen Wu Xiaoxi dai danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of major Obstetric diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational m.d.cal Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLd)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLd in the rem.d.ling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLd in glutamatergic neurons is largely ***,we first proposed involvement of CYLd in cued fear *** next constructed transgenic m.d.l mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLd deficiency exaggerated the expression of cued fear in only male ***,loss of CYLd in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLd in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-d-aspartate receptor 1 neuronal activation synaptic transmission

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Utility of semivariogram for spatial variation of soil nutrients and the robust analysis of semivariogram

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Journal of Environmental Sciences 2001年第4期13卷 453-458页

作者： Guo, X.-d. Fu, B.-j. ma, K.-m. chen, L.-d. department of Systems Ecology Res. Cntr. Eco-Environmental Sci. Chinese Academy of Sciences Beijing 100085 China

The spatial variation of soil nutrients in topsoil (0-20cm) was analyzed using semivariogram in the Zunhua County of Hebei Province, China. The effect on semivariogram with randomly deleted data and kriged estimates using various reduced sample sizes was also analyzed. The semivariograms of available N, total N, available P, organic matter were best described by a spherical m.d.l, except for available K, which best fitted a complex structure of exponential m.d.l and linear with sill m.d.l. The ratio of nugget to total sample variance ranged from 34.4% to 68.4%, indicating the spatial correlation of tested soil nutrients on a large scale was m.d.rately dependent. Among five soil nutrients, available nitrogen and available phosphorus had the shortest spatial correlation range (5 km and 5.5 km), available K had the longest range (25.5 km), whereas total nitrogen and organic matter had interm.d.ate spatial correlation range (14.5 km and 8.5 km). The semivariograms of available N, total N, available P, and organic matter were insensitive to a 50%-60% reduction in original sampling density, while for available K, it is up to 70%. The estimated spatial distributions of total N by kriging, under various reduced sample sizes, all correlated significantly (P = 0.001) with those obtained from original data. The results showed that the semivariogram was a relatively robust tool when used in a large region and sufficient spatial variation information could be relained regardless of a higher deletion proportion of the original data. The original sample data could be reduced by kriging and the estimates showed no loss of spatial information, however, the results may be unreliable unless a clearly identified semivariogram m.d.l could be obtained. The results may provide useful information for determining the appropriate sampling densities for these scales of soil survey.

关键词： Correlation methods data reduction Nitrogen Phosphorus Sampling Soils Surveying

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Structure,extraction,processing,and applications of collagen as an ideal component for biomaterials-a review

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Collagen and Leather 2023年第2期5卷 21-47页

作者： Qijue chen Ying Pei Keyong Tang m.d.lina Georgiana Albu-Kaya School of materials Science and Engineering Zhengzhou UniversityHenan 450001 ZhengzhouPeople's Republic of China Collagen department INCDTP-Leather and Footwear Research Institute93 Ion MinulescuBucha-rest 031215Romania

Collagen with a multi-hierarchical architecture exhibits powerful biological performance,thus being developed in biom.d.cal applications as a processing building *** isolated collagen after extraction from biological tissues can be processed into various forms such as fibrils,scaffolds,membranes,microspheres,hydrogels,and sponges for further use in specific *** review briefly discusses the multi-hierarchical structure,powerful biological performances,extraction,and processing approaches of collagen as a natural *** processing of collagen including dissolution,self-assembly,cross-linking,and electrospinning,is discussed to show more feasibility for specific applications of collagen composite *** emphasis is directed towards the biom.d.cal applications of drug and gene delivery,as well as tissue repair involving bone,cartilage,vascular,and corneal,along with wound ***,there is a focus on the development of flexible sensors and electronic skins(e-skins).Furthermore,the potential challenges and perspectives for the development of collagen-based biomaterials are *** short,collagen-based biomaterials are expected to facilitate sustainable development and the next generation of advanced biomaterial applications.

关键词： Collagen Structure Extraction Self-assembly Biomaterials

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Towards standardizing retinal optical coherence tomography angiography:a review

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Light(Science & Applications) 2022年第4期11卷 520-541页

作者： danuta m.Sampson Adam m.d.bis Fred K.chen Robert J.Zawadzki david d.Sampson Surrey Biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biom.d.cal Research Centre at moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and Visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. department of Ophthalmology&Vision Science University of California DavisSacramentoCA 95817USA. Surrey Biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from.d.fferent studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent

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ON mAXWELL EQUATIONS WITH THE TRANSPARENT BOUNdARY CONdITION

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Journal of Computational mathematics 2008年第3期26卷 284-296页

作者： Zhiming chen Jean-Claude Nédélec LSEC ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China Centre de mathématiques Appliquées Ecole Polytechnique 91228 Palaiseau Cedex France

In this paper we show the well-posedness and stability of the maxwell scattering problem with the transparent boundary condition. The proof depends on the well-posedness of the time-harmonic maxwell scattering problem... 详细信息

关键词： Electromagnetic scattering Well-posedness Stability

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A verification framework for spatio-temporal consistency language with CCSL as a specification language

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Frontiers of Computer Science 2020年第1期14卷 105-129页

作者： Yuanrui ZHANG Frédéric mALLET Yixiang chen moE Engineering Research Center for Software/Hardware Co-design Technology and Application East China Normal UniversityShanghai 200062China University Nice Sophia Antipolis I3SUMR 7271 CNRSINRIA06900 Sophia AntipolisFrance

The Spatio-Temporal Consistency Language(STeC)is a high-level m.d.ling language that deals natively with spatio-temporal behaviour,i.e.,behaviour relating to certain locations and *** restriction by both locations and time is of first importance for some types of real-time *** is a formal specification language based on logical *** is used to describe some crucial safety properties for real-time systems,due to its powerful expressiveness of logical and chronometric time *** consider a novel verification framework combining STeC and CCSL,with the advantages of addressing spatio-temporal consistency of system behaviour and easily expressing some crucial time *** propose a theory combining these two languages and a method verifying CCSL properties in STeC *** adopt UPPAAL as the m.d.l checking tool and give a simple example to illustrate how to carry out verification in our framework.

关键词： spatio-temporal consistency real-time systems spatio-temporal systems high-level m.d.lling language clock constraint specification m.d.l checking verification framework

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different diffusion Behavior of Cu and Ni Undergoing Liquidesolid Electromigration

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Journal of materials Science & Technology 2014年第12期30卷 1235-1242页

作者： m.L.Huang Z.J.Zhang H.T.ma L.d.chen Electronic Packaging materials Laboratory School of Materials Science & Engineering Dalian University of Technology IC Packaging department Xi'an Institute of Microelectronic Technology

The diffusion behavior of Cu and Ni atoms undergoing liquidesolid electromigration（L-S Em） was investigated using Cu/Sn/Ni interconnects under a current density of 5.0 103A/cm2 at 250℃. The flowing direction of electrons significantly influences the cross-solder interaction of Cu and Ni atoms, i.e., under downwind diffusion, both Cu and Ni atoms can diffuse to the opposite interfaces; while under upwind diffusion,Cu atoms but not Ni atoms can diffuse to the opposite interface. When electrons flow from the Cu to the Ni, only Cu atoms diffuse to the opposite anode Ni interface, resulting in the transformation of interfacial intermetallic compound（ImC） from Ni3Sn4into（Cu,Ni）6Sn5and further into [（Cu,Ni）6Sn5t Cu6Sn5], while no Ni atoms diffuse to the opposite cathode Cu interface and thus the interfacial Cu6Sn5 *** electrons flow from the Ni to the Cu, both Cu and Ni atoms diffuse to the opposite interfaces,resulting in the interfacial ImC transformation from initial Cu6Sn5into（Cu,Ni）6Sn5and further into[（Cu,Ni）6Sn5t（Ni,Cu）3Sn4] at the anode Cu interface while that from initial Ni3Sn4into（Cu,Ni）6Sn5and further into（Ni,Cu）3Sn4at the cathode Ni interface. It is more damaging with electrons flowing from the Cu to the Ni than the other way.

关键词： Cu/Sn/Ni Electromigration Cross-solder interaction Interfacial reaction diffusion

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differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng chen Shengli Clinical m.d.cal College of Fujian m.d.cal University Fujian Medical UniversityFuzhouFujian ProvinceChina department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency m.d.cine FuzhouFujian ProvinceChina The Second department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture m.d.l of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the mAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat m.d.l induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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