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Expression of Skin Barrier Protein Filaggrin in Skin Diseases without Atopic Dermatitis

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Journal of Biosciences and Medicines 2018年第1期6卷 101-112页

作者： Yang Zhang chen tu Shuang Wang Shengxiang Xiao Department of Dermatology The Second Affiliated Hospital School of Medicine Xi’an Jiaotong University Xi’an China

The epidermis represents an essential barrier versus a broad range of exogenous stimuli. To form a functional epidermis, keratinocytes express filaggrin which plays a vital role in atopic dermatitis. However the relationship between filaggrin and other skin diseases remains unknown. In our study we chose 5 different common skin diseases and analyzed the expression of filaggrin in the skin using immunohistochemistry. Imiquimod (IMQ)-induced mouse model was used for detecting the filaggrin level and barrier function. The results indicated that the expression of filaggrin is reduced in psoriasis compared to the other skin diseases. Furthermore in vivo study showed that the skin barrier is defected with a decreased expression of filaggrin in IMQ-induced psoriasis mouse model, which is accompanied with an increased level of IL-17/IL-23. In conclusion, the defective skin barrier is involved in the development of psoriasis in human and mice with a reduced expression of filaggrin which may be regulated by the increased level of IL-17/IL-23 in the skin.

关键词： Skin Barrier Psoriasis Filaggrin Atopic Dermatits

A systematic review of the impacts of exposure to micro-and nano-plastics on human tissue accumulation and health

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Eco-Environment & Health 2023年第4期2卷 195-207页

作者： Yudong Feng chen tu Ruijie Li Di Wu Jie Yang Yankai Xia Willie J.G.M.Peijnenburg Yongming Luo CAS Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166China National Institute of Public Health and the Environment Center for Safety of Substances and ProductsBilthoventhe Netherlands Institute of Environmental Sciences(CML) Leiden UniversityLeidenthe Netherlands

Micro-and nano-plastics(MNPs)pollution has become a pressing global environmental issue,with growing concerns regarding its impact on human ***,evidence on the effects of MNPs on human health remains *** paper reviews the three routes of human exposure to MNPs,which include ingestion,inhalation,and dermal *** further discusses the potential routes of translocation of MNPs in human lungs,intestines,and skin,analyses the potential impact of MNPs on the homeostasis of human organ systems,and provides an outlook on future research priorities for MNPs in human *** is growing evidence that MNPs are present in human tissues or *** studies,including in vivo animal models and in vitro human-derived cell cultures,revealed that MNPs exposure could negatively affect human *** exposure could cause oxidative stress,cytotoxicity,disruption of internal barriers like the intestinal,the air–blood and the placental barrier,tissue damage,as well as immune homeostasis imbalance,endocrine disruption,and reproductive and developmental *** available epidemiological studies suggest that disorders like lung nodules,asthma,and blood thrombus might be caused or exacerbated by MNPs ***,direct evidence for the effects of MNPs on human health is still scarce,and future research in this area is needed to provide quantitative support for assessing the risk of MNPs to human health.

关键词： Microplastics Nanoplastics Environmental exposure Human system homeostasis Health effects Risk assessment

加强土壤微/纳塑料研究支持新污染物治理行动

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生态与农村环境学报 2023年第5期39卷 565-567页

作者：涂晨骆永明中国科学院土壤环境与污染修复重点实验室(南京土壤研究所) 江苏南京210008 中国科学院大学北京100049

自20世纪50年代以来,全球塑料年生产量从1950年的1.70×10^(6) t激增到2020年的3.67×10^(8) t[1]。塑料的大量广泛使用、不完善的废物回收体系和不健全的废物管理制度,导致大量塑料垃圾被丢弃而进入环境和生态系统,造成日益严重的塑料... 详细信息

自20世纪50年代以来,全球塑料年生产量从1950年的1.70×10^(6) t激增到2020年的3.67×10^(8) t[1]。塑料的大量广泛使用、不完善的废物回收体系和不健全的废物管理制度,导致大量塑料垃圾被丢弃而进入环境和生态系统,造成日益严重的塑料污染[2]。进入环境中的塑料垃圾在物理、化学和生物学作用下不断发生风化、破碎和降解,形成微塑料(<5 mm)和纳塑料(<1μm)[3]。当前,环境中的微/纳塑料污染已成为全球广泛关注的热点环境问题。

关键词：塑料垃圾废物回收微塑料污染物治理生态系统生物学作用

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EFFECTS OF B^+ IMPLANTATION ON MECHANICAL PROPERTIES AND MICROSTRUCtuRE OF POLYCRYSTALLINE Ni

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Acta Metallurgica Sinica(English Letters) 1993年第2期6卷 86-91页

作者： chen Lifan BA tu SHI Changxu State Key Laboratory for Fatigue and Fracture of Materials,Institute of Metal Research,Academia Sinica,Shenyang,China Doctorate Student.Institute of Physics.Academia Sinica,Beijing 100080,China Inst of Metal Research Acad Sinica Sheyang China

50 keV B^+ ions was implanted to polycrvstalline with 50 keV B^+ to a dose o/ 3x 10~17 ions/cm^2 at room *** specimens with and without B^+implantation were tested in micro-hardness and load or unload tensile fatigue under stress-controlled eondition. The surface layer structure was observed with IMA,SEM and TEM before and after implantation and/or *** B^+ implanted surface region consists of amorphous Ni-B phase,Ni_3B and Ni_4B_3 second phases,and damage *** corresponding measurements indicate that both surface micro-hardness and endurance limit of the specimens have increased after *** with unimplanted specimens under the same fa- tigue condition,all implanted specimens show the smallest overall fatigue *** cyclic loading at room temperature can lead to migration of implanted B^+ out surface layer and reerystallization of amorphous Ni-B phase,Possible strengthening *** these ex- perimental results were discussed.

关键词： ion implantation fatigue polycrystalline Ni implanted layer

Discussion on Chinese Chess Decision-making System with Emotion

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Discussion on Chinese Chess Decision-making System with Emot...

2011 Chinese Control and Decision Conference（CCDC）

作者： Xiao-chuan Zhang,Lian-chang chen,Fei-tu,Zu-shuLi

This paper analyzes the existing decision-making system of Chinese Chess computer game,and points out some of ***,a new three-level decision-making system of Chinese Chess computer game is *** this decision-making system,affection computing is *** the system achieves the high-speed searching and decision-making top-down though affection *** with the existing decision-making system,the three-level decision-making system is proved workable.

关键词： Chinese Chess computer game emotion decision-making

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点衍射波前位相的测评

光学精密工程 2010年第11期18卷 2390-2397页

作者：马冬梅陈土泉中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院研究生院北京100039

提出一种检测点衍射干涉仪关键部件针孔所产生的衍射光学波前的方法。介绍了点衍射波前的产生原理,分析了小孔质量状态、照明光路调整状态与波前各个像差分量之间的关系。基于信息光学基础理论,采用傅里叶变换和迭代算法,采集针孔衍射... 详细信息

提出一种检测点衍射干涉仪关键部件针孔所产生的衍射光学波前的方法。介绍了点衍射波前的产生原理,分析了小孔质量状态、照明光路调整状态与波前各个像差分量之间的关系。基于信息光学基础理论,采用傅里叶变换和迭代算法,采集针孔衍射图像并进行计算分析,实现对衍射波前的位相复原以获得波前信息。阐述了测试方法的理论依据和计算公式,应用研制的位相复原分析计算软件测试并分析了实际采集的点衍射图像,通过15次的迭代,输出的位相值逐渐收敛,图像误差因子下降到0.12。目前,该方法已用于对针孔的筛选和针孔照明系统的装调中,实验结果证明了该测试方法的可行性。

关键词：点衍射波相差傅里叶变换位相复原迭代算法

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论大学生网上集群行为的心理成因及其引导

中国青年政治学院学报 2011年第1期30卷 47-50页

作者：陈均土绍兴文理学院法学院浙江绍兴312000

大学生网上集群行为是在网络快速发展以及大学生利益诉求多样化的背景下涌现出的一种新的集群行为模式,它具有动机单纯、行为较少暴力性、情绪非理性和可控性等特点,具有从众、模仿、感染、情绪化等心理特征。引导和控制大学生网上集群... 详细信息

大学生网上集群行为是在网络快速发展以及大学生利益诉求多样化的背景下涌现出的一种新的集群行为模式,它具有动机单纯、行为较少暴力性、情绪非理性和可控性等特点,具有从众、模仿、感染、情绪化等心理特征。引导和控制大学生网上集群行为可通过文化引领、情绪转化、道德感化和榜样示范等来完成。

关键词：大学生网上集群行为榜样示范

Risk factors analysis for surgical site infection following elective colorectal resection:a retrospective regression analysis

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Chinese Medical Journal 2020年第5期133卷 571-576页

作者： Pu-Run Lei Jing-Wen Liao Ying Ruan Xiao-Feng Yang Kun-Peng Hu Jian-Pei Liu tu-Feng chen Department of Gastrointestinal Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510000China Department of Bone Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510000China Department of Thyroid and Breast Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510000China Department of General Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510000China

Background:A surgical site infection(SSI)is a major post-operative complication from elective colorectal surgery;however,few studies have focused on evaluating the risk factors for *** study aimed to analyze the relative correlation of medical and environmental factors as well as patient-related factors that contribute to the incidence of all types of ***:A retrospective search for eligible patients was conducted using the patient database of the Gastrointestinal Surgery Center of the Third Affiliated Hospital of Sun Yat-sen University from January 2011 to August ***-operative demographic and surgical data were extracted and recoded according to the study *** and multivariate analyses were performed to clarify factors affecting the incidence of *** analysis was conducted to minimize bias in the demographic characteristics to explore the prophylactic effect of pre-operative administration of oral ***:Univariate analysis of the baseline characteristics revealed that younger age(odds ratio[OR]:0.378;95%confidence interval[CI]:0.218–0.657)and pre-operative oral antibiotic use(OR:0.465;95%CI:0.255–0.850)were protective factors,while pre-operative anemia(OR:4.591;95%CI:2.567–8.211),neoadjuvant chemotherapy history(OR:2.398;95%CI:1.094–5.256),and longer surgical duration(OR:2.393;95%CI:1.349–4.246;P=0.002)were identified as risk factors for *** analysis indicated that age(P=0.003),surgical duration(P=0.001),and pre-operative oral antibiotic use(Ptudy

关键词： Surgical site infection Colorectal cancer Antibiotic

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高校优秀运动员培养的演化博弈分析

广州体育学院学报 2024年第2期44卷 94-100页

作者：陈土发东莞城市学院通识教育学院广东东莞523419

高校作为运动员培养的重要基地之一,对优秀运动员的培养与发掘有着重要作用。本研究根据双方的行为逻辑构建演化博弈模型,模拟不同时间序列下的情景,真实动态地分析探究高校运动员与高校教育体系投入(认真)行为的关联影响程度,深入研究... 详细信息

高校作为运动员培养的重要基地之一,对优秀运动员的培养与发掘有着重要作用。本研究根据双方的行为逻辑构建演化博弈模型,模拟不同时间序列下的情景,真实动态地分析探究高校运动员与高校教育体系投入(认真)行为的关联影响程度,深入研究寻找双方行为概率的关键性因素。研究表明:高校优秀运动员培养与高校方投入成本、运动员训练投入程度、社会声誉支持等参数有直接关系。结合Matlab仿真分析,高校竞技体育产业化道路、竞赛体制改革等方式有助于优化高校优秀运动员培养机制。

关键词：优秀运动员体制改革模式优化演化博弈