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Fibromodulin reduces scar formation in adult cutaneouswounds by eliciting a fetal-like phenotype

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Signal Transduction and Targeted Therapy 2017年第1期2卷 73-84页

作者： Zhong Zheng Aaron W James chenshuang Li Wenlu Jiang Joyce Z Wang Grace X Chang Kevin S Lee Feng chen Emily A Berthiaume Yao chen Hsin Chuan Pan Eric C chen Weiming Li Zhihe Zhao Xinli Zhang Kang Ting Chia soo Division of Growth and Development School of DentistryUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA UCLA Division of Plastic and Reconstructive Surgery Department of Orthopaedic SurgeryThe Orthopaedic Hospital Research CenterUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21287USA State Key Laboratory of Oral Diseases Department of OrthodonticsWest China School of StomatologySichuan UniversityChengduSichuan 610041China Department of Emergency Medicine Highland General HospitalOaklandCA 94602USA David Geffen School of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095USA Central Laboratory School of StomatologyPeking UniversityBeijing 100081China Department of Orthopaedics the First Clinical Hospital of Harbin Medical UniversityHarbinHeilongjiang 150081China

Blocking transforming growth factor(TGF)β1 signal transduction has been a central strategy for scar reduction;however,this approach appears to be minimally ***,we show that fibromodulin(FMOD),a 59-kD small leucine-rich proteoglycan critical for normal collagen fibrillogenesis,significantly reduces scar formation while simultaneously increasing scar strength in both adult rodent models and porcine wounds,which simulate human cutaneous scar ***,FMOD uncouples promigration/contraction cellular signals from pro-fibrotic signaling by selectively enhancing SMAD3-mediated signal transduction,while reducing AP-1-mediated TGFβ1 auto-induction and fibrotic extracellular matrix ***,FMOD accelerates TGFβ1-responsive adult fibroblast migration,myofibroblast conversion,and ***,our findings strongly indicate that,by delicately orchestrating TGFβ1 activities rather than indiscriminately blocking TGFβ1,FMOD elicits fetal-like cellular and molecular phenotypes in adult dermal fibroblasts in vitro and adult cutaneous wounds in vivo,which is a unique response of living system undescribed *** together,this study illuminates the signal modulating activities of FMOD beyond its structural support functions,and highlights the potential for FMOD-based therapies to be used in cutaneous wound repair.

关键词： fetal scar cutaneous

Old stellar population synthesis:new age and mass estimates for Mayall II = G1

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Research in Astronomy and Astrophysics 2009年第6期9卷 641-652页

作者： Jun Ma Richard de Grijs Zhou Fan soo-Chang Rey Zhen-Yu Wu Xu Zhou Jiang-Hua Wu Zhao-Ji Jiang Jian-Sheng chen Kyungsook Lee Sangmo Tony Sohn National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Physics ＆ Astronomy The University of Sheffield Hicks Building Hounsfield Road Sheffield S3 7RH UK Graduate University Chinese Academy of Sciences Beijing 100049 China Department of Astronomy and Space Science Chungnam National University Daejeon 305-764 Korea Center for Space Astrophysics Yonsei University Seoul 120-749 Korea California Institute of Technology MC 405-47 1200 E. California Boulevard Pasadena CA 91125

Mayall Ⅱ = G1 is one of the most luminous globular clusters （GCs） in M31. Here, we determine its age and mass by comparing multicolor photometry with theoretical stellar population synthesis models. Based on far- and near-ultraviolet GALEX photometry, broad-band UBVRI, and infrared JHKs 2MASS data, we construct the most extensive spectral energy distribution of G 1 to date, spanning the wavelength range from 1538 to 20 000A. A quantitative comparison with a variety of simple stellar population （SSP） models yields a mean age which is consistent with G1 being among the oldest building blocks of M31 and having formed within ～1.7 Gyr after the Big Bang. Irrespective of the SSP model or stellar initial mass function adopted, the resulting mass estimates （of order 10^7M⊙） indicate that GI is one of the most massive GCs in the Local Group. However, we speculate that the cluster＇s exceptionally high mass suggests that it may not be a genuine GC. Our results also suggest that G1 may contain, on average, （1.65±0.63） × 10^2L⊙ far-ultraviolet-bright, hot, extreme horizontal-branch stars, depending on the adopted SSP model. In addition, we demonstrate that extensive multi-passband photometry coupled with SSP analysis enables one to obtain age estimates for old SSPs that have similar accuracies as those from integrated spectroscopy or resolved stellar photometry, provided that some of the free parameters can be constrained independently.

关键词： galaxies individual (M31) -- galaxies star clusters -- galaxies stellar content

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应用卡尔曼滤波的有源头靠噪声控制策略

西北工业大学学报 2021年第5期39卷 937-944页

作者：王磊陈克安胥健齐旺西北工业大学航海学院陕西西安710072

针对有源头靠中虚拟误差点噪声信号的自适应控制问题,提出了一种应用卡尔曼滤波(KF)的控制策略。与基于梯度的算法相比,KF具有更快的收敛速度和更好的收敛性能。在虚拟误差传感的基础上建立了系统的状态方程,在状态变量中仅考虑控制滤... 详细信息

针对有源头靠中虚拟误差点噪声信号的自适应控制问题,提出了一种应用卡尔曼滤波(KF)的控制策略。与基于梯度的算法相比,KF具有更快的收敛速度和更好的收敛性能。在虚拟误差传感的基础上建立了系统的状态方程,在状态变量中仅考虑控制滤波器权系数。为了保证算法收敛,给出了KF参数的在线更新策略,同时在算法中引入快速阵列方法从而降低运算量。仿真结果表明,文中提出的策略能够有效提升系统的收敛速度,降低虚拟误差点处的噪声信号。

关键词：有源噪声控制卡尔曼滤波有源头靠

Analysis and implementation of theFMLMS algorithm in AANC

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Chinese Journal of Acoustics 1997年第4期16卷 364-371页

作者： LI Haiying chen kean and SUN Jincai(College of Marine Engineerting, Northwestern Polytechnical University Xi’an 710072)

Although the Filtered-X LMS (FLMS) algorithm is widely used in the Adaptive Active Noise Control (AANC) system due to its simplicity, its applications to an AANC are limited because it is intensively sensitive to the dispersion of the eigenvalues of the autocorrelation matrix of the input signal vector. The Filtered-X Momentum LMS (FMLMS) algorithm proposed in this paper includes a momentum term to weight update equation of the FLMS algorithm. From the theoretical analysis, the computer simulations and the experimental resultsin a half-anechoic room, it is shown that the FMLMS algorithm has more advantages than the FLMS algorithm for a single-path AANC system.

关键词： Analysis and implementation of theFMLMS algorithm in AANC

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基于平面波分解的封闭空间次级声源布局优化

西北工业大学学报 2021年第4期39卷 794-800页

作者：胥健陈克安王磊张亚洲西北工业大学航海学院陕西西安710072 西安艾科特声学科技有限公司陕西西安710068

封闭空间有源噪声控制系统的次级声源布局优化一般只关注离散点的降噪需求,导致空间区域降噪效果不理想,而且需要预先知道误差传感器布局信息。为解决该问题,提出一种面向空间降噪的代价函数。利用声场的平面波分解,获取初级声场平面波... 详细信息

封闭空间有源噪声控制系统的次级声源布局优化一般只关注离散点的降噪需求,导致空间区域降噪效果不理想,而且需要预先知道误差传感器布局信息。为解决该问题,提出一种面向空间降噪的代价函数。利用声场的平面波分解,获取初级声场平面波和各备选次级声源的单位次级声场平面波作为布局优化先验信息,以此构造波域有源控制代价函数,优化方法采用模拟退火搜索。以刚性壁矩形腔为对象,利用波域先验信息解析值与2种空间域布局优化方法结果做比较,表明所提方法在不依赖于误差点位置信息的情况下,能获得更优的空间声势能降噪效果;利用随机分布的传声器测量估计波域先验信息做布局优化,结果说明实际中所选布局能够达到比空间域方法更优的空间声势能降噪效果,但测量传声器位置对结果影响较大。

关键词：有源噪声控制次级声源布局平面波分解声场重构

Acupuncture and moxibustion treating lower urinary tract symptoms due to benign prostatic hyperplasia:a systematic review and network meta-analysis

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Acupuncture and Herbal Medicine 2022年第2期2卷 84-90页

作者： Zhe chen Tao Jiang Yingying Peng Xiaoyu Qiang Fengwen Yang Haiyin Hu Chunxiang Liu Myeong soo Lee Evidence-based Medicine Center Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina Department of Pediatrics First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjinChina KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Korea

Objective: Lower urinary tract symptoms(LUTS) caused by benign prostatic hyperplasia(BPH) affect the quality of life of elderly individuals. Acupuncture and moxibustion are used in the clinic in China for improving LUTS symptoms due to BPH. However,there is no evidence to suggest which is the best option. We compared the efficacy of acupuncture and moxibustion to provide evidence for clinical ***: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wan Fang Data, and VIP databases were searched from inception to July 2020 to identify the randomized controlled trials(RCTs) of acupuncture and moxibustion for LUTS due to BPH. Two researchers filtered studies and extracted the information independently. This study conducted a network meta-analysis using the Bayesian random method. The interventions ranking was evaluated using the surface under the cumulative ranking curve(SUCRA).Results: We finally included 40 studies comprising 10 treating therapies and 3,655 patients with LUTS caused by BPH. In terms of the International Prostate Symptom Score, maximum urinary flow rate, and quality of life, electroacupuncture(EA) [MD =-3.6,95% credible interval(CrI)(-5.5,-1.8), very low certainty of evidence;MD = 2.2, 95% CrI(1.1, 3.3), low certainty of evidence;MD =-1.3, 95% CrI(-2.2,-0.43), very low certainty of the evidence] may be consistently the optimal treatment compared with other interventions, with SUCRA values of 84%, 81%, and 89%, ***: Of all treatments, EA may have the best efficacy with fewer adverse events for LUTS due to BPH. The quality of evidence supporting this result is low to very low certainty of the evidence due to the limitations of primary studies;thus, more highquality RCTs are needed for further evidence.

关键词： Acupuncture and moxibustion Benign prostatic hyperplasia Lower urinary tract symptoms Network meta-analysis Randomized controlled trial

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刚性球上均匀圆阵声源方位角估计算法仿真

计算机仿真 2009年第12期26卷 320-324页

作者：张成陈克安西北工业大学航海学院陕西西安710072

为了研究环绕在刚性球上均匀圆阵声源方位角估计问题。以环绕在刚性球上的均匀圆阵为阵列模型,分析了刚性球体对圆阵响应的影响,在球坐标系下对声场分解所得到的特征波束空间,利用EB-ESPRIT算法和EB-Unitary-ESPRIT算法实现了声源方位... 详细信息

为了研究环绕在刚性球上均匀圆阵声源方位角估计问题。以环绕在刚性球上的均匀圆阵为阵列模型,分析了刚性球体对圆阵响应的影响,在球坐标系下对声场分解所得到的特征波束空间,利用EB-ESPRIT算法和EB-Unitary-ESPRIT算法实现了声源方位角估计。计算机仿真表明,在独立声源条件下,两种算法均能较好地估计出空间多个声源的方位角,并且EB-Unitary-ESPRIT算法计算量小,估计精度高。另外具有解相关声源的能力。

关键词：均匀圆阵声场分解特征波束波达方向

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应用于多通道有源控制的自适应组合逆算法

信号处理 2006年第3期22卷 366-369页

作者：陈克安尹雪飞西北工业大学航海学院环境工程系西安710072

本文在分析单通道伴随LMS算法的基础上,对组合逆算法进行推导和分析,获得了一种有效多通道自适应的快速逆算法,分析了算法的性能,给出了算法的实现步骤。与同样参数条件下的FxLMS算法的运算量进行的比较结果表明: 该算法大大减少了计算量。

关键词：有源噪声控制自适应滤波快速实现

2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI

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Science Bulletin 2019年第3期64卷 166-179页

作者： Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan chen Guosheng Fu Yundai chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge Department of Cardiology Peking University First Hospital Department of Internal Medicine Gyeongsang National University School of Medicine and Cardiovascular Center Gyeongsang National University Changwon Hospital Division of Cardiology Internal Medicine Department Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Cardiology Shanghai Chest Hospital affiliated to Shanghai Jiaotong University Department of Cardiology Guangdong General Hospital Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine Department of Cardiology Chinese PLAG General Hospital Department of Cardiology General Hospital of Northern Theater Command Department of Medicine (Cardiology) Tokai University School of Medicine Inova Center for Thrombosis Research and Drug Development Inova Heart and Vascular Institute Cardiovascular Center Department of Internal Medicine Seoul National University Hospital The Heart Research Center Nominated by Korea Ministry of Health and Welfare Chonnam National University Hospital Division of Cardiology University of North Carolina Department of Cardiology Fudan University Zhongshan Hospital

East Asians are the most populous race in the world and their health status is an important global *** with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed.

关键词： East Asian Coronary artery disease Antiplatelet Bleeding