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SWIR FluorescenceImaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

Engineering 2024年第2期33卷 283-294页

作者： Mo chen Yuzhou chen Sijia Feng Shixian Dong Luyi Sun Huizhu Li Fuchun chen Nguyen Thi Kim Thanh Yunxia Li shiyi chen You Wang Jun chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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Antibody Levels and Infection Status of Pertussis in the Population under Pertussis Resurgence in Guangxi in 2018:A Cross-Sectional Survey

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Biomedical and Environmental Sciences 2024年第6期37卷 628-638页

作者： Liang Liang Qiuyun Deng Lili Deng Jinghang Wei shiyi chen Yizhi Wei Yuyan Ma Yue Qin Wei Liu Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina

Objective Pertussis cases have increased markedly since 2018 in *** aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident *** A total of 10,215 serum samples from residents were collected from August-November 2018 and tested for anti-pertussis IgG and toxin IgG using the enzyme-linked immunosorbent assay(ELISA).Results Of the collected samples,1,833(17.94%)tested positive for anti-pertussis IgG,with the median concentration of 16.06 IU/*** level<10 IU/mL accounted for more than 60%in children under 4 years of age,but declined with age,whereas the percentages of the other three levels(10-40,40-50,and≥50 IU/mL)increased almost with age(P<0.001).Moreover,7,924 samples were selected for anti-pertussis toxin IgG,of which 653(8.24%)tested positive(≥40 IU/mL)with the median concentration of 5.89 IU/mL,and 204 participants(2.56%)had recent pertussis infection(≥100 IU/mL).Among the different age groups,the highest rates of positivity and recent infection were observed at 11-20 years of age,the lowest positivity rate at 5 years of age,and the lowest recent infection rate at 4 years of age(P<0.001,P=0.005,respectively).Conclusion The survey results showed that all age groups in Guangxi lacked immunity against pertussis,which was one of the main factors contributing to the resurgence of pertussis in *** addition,the prevalence of pertussis is relatively high in Guangxi,and its incidence is seriously underestimated,especially in adolescents and adults.

关键词： Pertussis resurgence Anti-pertussis IgG Anti-pertussis toxin IgG Antibody level Infection status

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Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs

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Journal of Animal Science and Biotechnology 2024年第1期15卷 108-126页

作者： Tianqi Duo Xiaohong Liu Delin Mo Yu Bian Shufang Cai Min Wang Ruiqiang Li Qi Zhu Xian Tong Ziyun Liang Weilun Jiang shiyi chen Yaosheng chen Zuyong He State Key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhou 510275GuangdongChina Department of Pharmacology(the State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal College of Animal Science and TechnologyHunan Agricultural UniversityChangsha 410128China

Background Chinese indigenous pigs are popular with consumers for their juiciness,flavour and meat quality,but they have lower meat ***-like growth factor 2(IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation.A single nucleotide polymorphism(SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor,zinc finger BED-type containing 6(ZBED6),leading to up-regulation of IGF2 and causing major effects on muscle growth,heart size,and backfat *** favorable mutation is common in Western commercial pig populations,but absent in most Chinese indigenous pig *** improve meat production of Chinese indigenous pigs,we used cytosine base editor 3(CBE3)to introduce IGF2 intron3-C3071T mutation into porcine embryonic fibroblasts(PEFs) isolated from a male Liang Guang Small Spotted pig(LGSS),and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer(SCNT) to generate the founder line of IGF2^(T/T) *** We found the heterozygous progeny IGF2^(C/T) pigs exhibited enhanced expression of IGF2,increased lean meat by 18%-36%,enlarged loin muscle area by 3%-17%,improved intramuscular fat(IMF) content by 18%-39%,marbling score by 0.75-1,meat color score by 0.53-1.25,and reduced backfat thickness by 5%-16%.The enhanced accumulation of intramuscular fat in IGF2^(C/T) pigs was identified to be regulated by the PI3K-AKT/AMPK pathway,which activated SREBP1 to promote *** We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality,and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3KAKT/AMPK signaling *** study provides a further understanding of the biological functions of IGF2and an example for improving porcine economic traits through precise base editing.

关键词： CBE3 IGF2 Intramuscular fat Meat production PI3K-AKT/AMPK ZBED6

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou chen Mo chen chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang shiyi chen Yunxia Li Yuefeng Hao Sijia Feng Jun chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

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网络强国战略下党的数字领导力的功能定位与提升路径

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探索 2024年第4期 66-78页

作者：陈诗怡沈阳师范大学管理学院辽宁沈阳110034

习近平总书记关于网络强国的重要思想,为新时代党的网信工作指明了方向、提供了指引。作为网络信息时代运用数字手段治国理政的基础性能力,党的数字领导力是贯彻习近平总书记关于网络强国的重要思想、实现网络强国战略目标的重要抓手,... 详细信息

习近平总书记关于网络强国的重要思想,为新时代党的网信工作指明了方向、提供了指引。作为网络信息时代运用数字手段治国理政的基础性能力,党的数字领导力是贯彻习近平总书记关于网络强国的重要思想、实现网络强国战略目标的重要抓手,也是新时代全面加强党对网信工作领导的迫切课题。党的数字领导力是党的政治领导力、思想引领力、群众组织力、社会号召力在领导数字化治理实践过程中的具体体现,包括了数字应用力、数字变革力、数字沟通力、数字引导力。网络强国战略下党的数字领导力明确的功能定位,体现为全面领导国家“数智化”转型发展、丰富拓展数字时代思想理论体系、引领走好新时代网上群众路线、动员网络社会多元群体等。为完成新时代网络强国战略的新使命,全面提升党的数字领导力,需要提升党的数字应用力,赋能政治领导前瞻化;提升党的数字变革力,赋能思想引领前沿化;提升党的数字沟通力,赋能群众组织高效化;提升党的数字引导力,赋能社会号召权威化。党的数字领导力提升有助于丰富网络信息时代马克思主义中国化的新理论,也将为建设具有中国特色的网络文明贡献力量。

关键词：网络强国数字领导力党的领导数字赋能

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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu shiyi chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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政府引导基金研究综述

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商业观察 2024年第23期10卷 109-111,115页

作者：陈诗怡广西大学工商管理学院广西南宁530004

政府引导基金作为将政策性和市场化合为一体的财政工具,在撬动社会资本和公司治理中均起到重要作用。现有研究对于政府引导基金的经济后果结论存在不一致的情况。基于信号传递理论、认证效应、资源基础观,从政府引导基金的引导效果、对... 详细信息

政府引导基金作为将政策性和市场化合为一体的财政工具,在撬动社会资本和公司治理中均起到重要作用。现有研究对于政府引导基金的经济后果结论存在不一致的情况。基于信号传递理论、认证效应、资源基础观,从政府引导基金的引导效果、对企业融资和创新的影响以及政府引导基金与风险投资的协同与冲突3个角度进行文献综述。最后根据现有文献的空白进行了未来展望。

关键词：政府引导基金企业融资企业创新产品市场竞争

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基层治理的地域领域化与阶级生命政治的变迁——以珠海市A镇产业园区为例

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热带地理 2024年第3期44卷 520-531页

作者：李辉霞陈世熠胡珏滢林锦标佛山科学技术学院环境与化学工程学院广东佛山528000 中山大学政治与公共事务管理学院广州510006 云南师范大学教育学部昆明650000

在城市化高速发展的背景下,如何形成空间存量的治理模式是构建现代化治理体系的棘手难题。空间存量中的领域化过程,在市场化的进程中不断地影响着不同群体的生命政治。文章在领域理论的基础上引入福柯生命政治的视角,构建了“社会资本... 详细信息

在城市化高速发展的背景下,如何形成空间存量的治理模式是构建现代化治理体系的棘手难题。空间存量中的领域化过程,在市场化的进程中不断地影响着不同群体的生命政治。文章在领域理论的基础上引入福柯生命政治的视角,构建了“社会资本—空间关系—生命政治”三方耦合互动的领域政治框架。通过对普通工人、中层管理者和高层董事的半结构访谈及问卷调查,探究基层治理领域化过程中工人的生命政治变迁规律。结果表明:产业园区的经济属性塑造了工人、中层干部、高层董事三方不同的生活、生产的空间关系,导致不同阶层的社会资本积累产生差异。同时,工人经历了自我主导到经济依附再到全面依附的生命政治过程。政府一方面需要完善薄弱地区的公共服务建设,另一方面需要逐步减少国家对社会的控制,培养社会组织能力,实现工人自我推进社会服务。文章对理解工人生计演变提供了地学理论视角,描述了不同阶层在空间分布上如何形成生命政治的差异。

关键词：领域理论生命政治基层治理产业园区珠海市

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债务违约风险的影响因素分析

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商业观察 2024年第9期10卷 57-61页

作者：陈诗怡广西大学工商管理学院广西南宁530004

选取2019—2020年沪深A股上市公司为研究样本,并根据以往文献选取可能影响债务违约风险的变量进行研究。主要的研究结果表明基本财务指标、股权结构、产品市场竞争、股价同步性均对债务违约风险有显著的影响。研究发现在非国有企业样本... 详细信息

选取2019—2020年沪深A股上市公司为研究样本,并根据以往文献选取可能影响债务违约风险的变量进行研究。主要的研究结果表明基本财务指标、股权结构、产品市场竞争、股价同步性均对债务违约风险有显著的影响。研究发现在非国有企业样本中,股权质押、第一大股东持股比例和利息保障倍数对债务违约风险的影响更为显著。进一步运用主成分分析将因子重新归为4类,并基于行业对影响因素进行K-均值聚类。所用的分析方法包括描述性检验、独立样本均值t检验、线性回归分析、因子分析、K-均值聚类分析。

关键词：债务违约风险股权质押产品市场竞争股价同步性

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商业建筑中的空间人流分析与路径优化策略

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中国厨卫 2024年第7期23卷 171-173页

作者：陈世毅遵义市建筑规划设计院有限责任公司贵州遵义563000

优化商店路径布局不仅可以激发人们的购物乐趣,还能减少拥挤现象,提升商业空间的管理效率。因此,深入理解人流分布,积极寻找的路经优化策略,对提高商业建筑设计与规划水平具有重要价值。基于此,文章分析了人员流动情况,从店铺可见性、... 详细信息

优化商店路径布局不仅可以激发人们的购物乐趣,还能减少拥挤现象,提升商业空间的管理效率。因此,深入理解人流分布,积极寻找的路经优化策略,对提高商业建筑设计与规划水平具有重要价值。基于此,文章分析了人员流动情况,从店铺可见性、可达性以及安全疏散等方面入手,优化了商业流动路径布局,旨在提升顾客购物体验感的同时,提高商业的空间价值。

关键词：商业建筑空间人流分析路径规划可见性购物体验

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