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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu Yi-sheng chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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SPECTRAL APPROXIMATION ORDERS OF MULTIDIMENSIONAL NONSTATIONARY BIORTHOGONAL SEMI-MULTIRESOLUTION ANALYSIS IN SOBOLEV SPACE

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Journal of Computational Mathematics 2006年第1期24卷 81-90页

作者： Wen-sheng chen chen Xu Wei Lin Department of Mathematics Shenzhen University Shenzhen 518060 China Key Laboratory of Mathematics Mechanization CAS Beijing 100080 China Department of Mathematics Sun Yat-Sen University Guangzhou 510275 China

Subdivision algorithm （Stationary or Non-stationary） is one of the most active and exciting research topics in wavelet analysis and applied mathematical theory. In multidimensional non-stationary situation, its limit functions are both compactly supported and infinitely differentiable. Also, these limit functions can serve as the scaling functions to generate the multidimensional non-stationary orthogonal or biorthogonal semi-multiresolution analysis （Semi-MRAs）. The spectral approximation property of multidimensional non-stationary biorthogonal Semi-MRAs is considered in this paper. Based on nonstationary subdivision scheme and its limit scaling functions, it is shown that the multidimensional nonstationary biorthogonal Semi-MRAs have spectral approximation order r in Sobolev space H^s（R^d）, for all r ≥ s ≥ 0.

关键词： Nonstationary subdivision algorithm Biorthogonal Semi-MRAs Wavelets,Spectral approximation Sobolev space

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Simulation of thermoacoustic waves by a pressure-based algorithm for compressible flows

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Acta Mechanica Sinica 2012年第3期28卷 819-824页

作者： Wei Li Qi-sheng chen Key laboratory of Microgravity Institute of MechanicsChinese Academy of Sciences15 Beisihuan West Road100190 BeijingChina

A modified SIMPLEC method which can solve compressible flows at low Mach number is introduced and used to study thermoacoustic waves induced by a rapid change of temperature at a solid wall and alternating- direction flows generated by thermoacoustic effects in a ta- pered resonator. The results indicate that the algorithm adopted in this paper can be used for calculating com- pressible flows and thermoacoustic waves. It is found that the pressure and velocity in the resonator behave as stand- ing waves, and the tapered resonator can suppress high- frequency harmonic waves as observed in a cylindrical res- onator.

关键词： Compressible flow Thermoacoustic wave Resonator. SIMPLEC

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Adjustable polarization-independent wide-incident-angle broadband far-infrared absorber

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Chinese Physics B 2020年第7期29卷 141-146页

作者： Jiu-sheng Li Xu-sheng chen Centre for THz Research China Jiliang UniversityHangzhou 310018China

To promote the application of far-infrared technology,functional far-infrared devices with high performance are ***,we propose a design scheme to develop a wide-incident-angle far-infrared absorber,which consists of a periodically semicircle-patterned graphene sheet,a lossless inter-dielectric spacer and a gold reflecting *** normal incidence for both TE-and TM-polarization modes,the bandwidth of 90%absorption of the proposed far-infrared absorber is ranging from 6.76 THz to 11.05 *** absorption remains more than 90%over a 4.29-THz broadband range when the incident angle is up to 50◦for both TE-and TM-polarization *** peak absorbance of the absorber can be flexibly tuned from 10%to 100%by changing the chemical potential from 0 eV to 0.6 *** tunable broadband far-infrared absorber has promising applications in sensing,detection,and stealth objects.

关键词： far-infrared absorber semicircle-patterned graphene wide incident angle

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Radiation-driven implosion in the Cepheus B molecular cloud

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Research in Astronomy and Astrophysics 2010年第8期10卷 777-784页

作者： sheng chen Maohai Huang National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

We analyze large scale mapping observations of the molecular lines in the ^12CO（J= 2-1）,^12CO（J=3-2）,^13CO（J=2-1）,and ^13CO（J=3-2） transition emissions toward the Cepheus B molecular cloud with the KOSMA 3mtelescope. The integrated intensity map of the ^12CO （J = 2 - 1） transition has shown a structure with a compact core and a compact ridge extended to the north-west of the core. The cloud is surrounded by an optically bright rim, where the radiation-driven implosion （RDI） may greatly change the gas properties. The intensities of the CO （J = 3 - 2） transition are higher than those of the CO （J = 2 - 1） transition along the rim area. We find characteristic RDI structure in position-velocity diagrams. Non-LTE large velocity gradient （LVG） model analysis shows that the density and temperature at the edge are higher than that in the center. Our results provide evidences that an RDI is taking place in the Cepheus B molecular cloud.

关键词： submillimeter -- ISM clouds -- ISM globules -- stars formation

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Recursive Least Squares Semi-blind Beamforming for MIMO Using Decision Directed Adaptation and Constant Modulus Criterion

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International Journal of Automation and computing 2017年第4期14卷 442-449页

作者： Xia Hong sheng chen Department of Computer Science School of Mathematical Physical and Computational Sciences University of Reading Reading RG6 6AY UK School of Electronics and Computer Science University of Southampton Southampton SO17 1B J UK King Abdulaziz University Jeddah 21589 Saudi Arabia

A new semi-blind adaptive beamforming scheme is proposed for multi-input multi-output （MIMO） induced and spacedivision multiple-access based wireless systems that employ high order phase shift keying signaling. A minimum number of training symbols, very close to the number of receiver antenna elements, are used to provide a rough initial least squares estimate of the beamformer＇s weight vector. A novel cost function combining the constant modulus criterion with decision-directed adaptation is adopted to adapt the beamformer weight vector. This cost function can be approximated as a quadratic form with a closed-form solution, based on which we then derive the recursive least squares （RLS） semi-blind adaptive beamforming algorithm. This semi-blind adaptive beamforming scheme is capable of converging fast to the minimum mean-square-error beamforming solution, as demonstrated in our simulation study. Our proposed semi-blind RLS beamforming algorithm therefore provides an efficient detection scheme for the future generation of MIMO aided mobile communication systems.

关键词： Multi-input multi-output (MIMO) space-division multiple-access beamforming semi-blind adaptive algorithm constant modulus criterion decision-directed adaption.

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New electrocatalysts and mechanisms pave the way to urea oxidation with superior activities and stability

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Science China Chemistry 2022年第2期65卷 199-201页

作者： Yuntong Sun sheng chen Key Laboratory for Soft Chemistry and Functional Materials(Ministry of Education) School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China

Urea(CO(NH_(2))_(2))is a globally abundant waste product in accompany with industrial activities and naturally breaks down into ammonia(NH_(3))and ***,over 80%of these pollutants are discharged directly into rivers and oceans,causing significant health and environmental problems[1].As a consequence,there are enormous interests in urea oxidation reaction(UOR).UOR is a central half-reaction in urea electrolysis and urea-based fuel cells that can treat urea-rich wastewater simultaneously[1].

关键词： wastewater globally consequence

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Porous Cube-like In_2O_3 Nanoparticles and Their Sensing Characteristics toward Ethanol

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Journal of Materials Science & Technology 2008年第4期24卷 667-674页

作者： Chih-Chia HUANG chen-sheng YEH Natl cheng Kung Univ Dept Chem Tainan 70101 Taiwan

Porous cube-like crystalline In2O3 nanoparticles with an average diagonal length of 34.8 nm were fabricated by a laser ablation-reflux process to form In（OH）3, followed by a calcination treatment to yield porous In2O3. HRTEM （high-resolution transmission electronic microscopy）, XRD （X-ray diffraction）, BET （Brunauer-Emmett-Teller）, and XPS （X-ray photoelectron spectroscopy） analysis were used to characterize their crystalline structures, grain sizes, surface areas, and surface compositions. The as-prepared porous in-dium oxides were tested for their sensing properties toward ethanol. Non-porous In2O3 nanopowder （about 40 nm） was also examined in order to compare the results with the as-prepared porous In2O3 nanomaterials. The porous In2O3 exhibited much better performance than that of non-porosus In2O3, and showed enhanced sensitivity with a lower detection limit than other reported In2O3-based materials when exposed to ethanol. Good gas sensitivity and linear behavior as a function of ethanol concentration were observed in the porous In2O3 nanoparticles.

关键词： In2O3 Porosity Nanoparticles Gas sensor

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Mechanical behavior of segment rebar of shield tunnel in construction stage

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 888-899页

作者： Jun-sheng chen Hai-hong MO Department of Civil Engineering South China University of Technology Guang＇zhou 510640 China State Key Laboratory of Subtropical Building Science South China University of Technology Guang＇zhou 510640 China

In this paper, a 3D finite element （FE） program ADINA was applied to analyzing a tunnel with 9 segment tings. The loads acting on these segment tings included the squeezing action of tail brush of shield machine under attitude deflection, the jacking forces, the grouting pressure and the soil pressure. The analyses focused on the rebar stress in two statuses：（1） normal construction status without shield machine squeezing; （2） squeezing action induced by shield machine under attitude deflection. The analyses indicated that the rebar stress was evidently affected by the construction loads. In different construction status, the rebar stress ranges from -80 MPa to 50 MPa, and the rebar is in elastic status. Even some cracks appear on segments, the stress of segment rebar is still at a low level. It is helpful to incorporate a certain quantity of steel fiber to improve the anti-crack and shock resistance performance.

关键词： Shield tunnel Construction Segment Rebar Finite element (FE) analysis

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Novel Adaptive Learning Control of Linear Systems with Completely Unknown Time Delays

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International Journal of Automation and computing 2009年第2期6卷 177-185页

作者： Wei-sheng chen Department of Applied Mathematics Xidian University Xi＇an 710071 PRC

A novel output-feedback adaptive learning control approach is developed for a class of linear time-delay systems. Three kinds of uncertainties： time delays, number of time delays, and system parameters are all assumed to be completely unknown, which is dfferent from the previous work. The design procedure includes two steps. First, according to the given periodic desired reference output and the allowed bound of tracking error, a suitable finite Fourier series expansion （FSE） is chosen as a practical reference output to be tracked. Second, by expressing the delayed practical reference output as a known time-varying vector multiplied by an unknown constant vector, we combine three kinds of uncertainties into an unknown constant vector and then estimate the vector by designing an adaptive law. By constructing a Lyapunov-Krasovskii functional, it is proved that the system output can asymptotically track the practical reference signal. An example is provided to illustrate the effectiveness of the control scheme developed in this paper.

关键词： Linear system unknown time delay output-feedback learning control Fourier series expansion (FSE).

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