检索结果-南通市图书馆

Inheritance of resistance to race 7 of Cercospora sojina in soybeans and RAPD tagging of the resistance gene

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1999年第5期44卷 452-456页

作者： Zou, JJ Dong, W Yang, QK Cao, YP chen, sy Chinese Acad Sci Inst Genet Plant Biotechnol Lab Beijing 100101 Peoples R China NE Agr Univ Soybean Res Inst Harbin 150030 Peoples R China

Frog-eye leaf spot of soybean caused by Cercospora sojina Hara is a kind of worldwide disease. Resistance to race 7 of C. sojina was found to be due to a single dominant gene through analyzing resistant behavior of the cross NEAU91212 （susceptible to race 7）× NEAU9674 （resistant to all races）. 3 RAPD markers linked to the resistant gene Rcsc 7 were identified using the BSA method. 2 fragments of OPS03620 and OPS03580 amplified with primer OPS03 co-dominantly segregated in the F2 individuals. The genetic distance between OPS03620 and the resistant gene is 8.7 cM. According to the co-dominant marker, the accuracy of predicting the homozygous and heterozygous resistant F2 individuals were 100% and 97.6%, respectively.

关键词： Cercospora sojina Hara resistant gene molecular markers co-dominance.

The association between reproductive factors and systemic sclerosis in Chinese women:A case-control study and meta-analysis

在线全文

学校读者我要写书评

暂无评论

The association between reproductive factors and systemic sc...

安徽省2019年度流行病与卫生统计学学术年会

作者：李娟 chen sy Yin XD Cao LT Huang XL Xu JH Ye DQ Wang J 安徽医科大学公共卫生学院

AIM:To examine the associations between female menstrual or reproductive factors and the development of systemic sclerosis(SSc) in ***:In this hospital-based case-control study,for each subject,data on reproductive and menstrual factors such as number of births,abortions,and age at menarche were obtained by structured *** estimates,measured by the odds ratio(OR) and 95% confidence interval(CI),were obtained by unconditional logistics ***,meta-analysis was performed and pooled OR with 95% CI for the number of pregnancies and abortions were ***:There were 166 SSc and 392 female controls seen during the study *** results showed women with late menarche age(≥17 years) were less likely than those with earlier age at menarche to develop SSc(OR 0.347,95% CI 0.174-0.693) and compared with women without abortion,women with abortion(1 time) were at reduced risk of developing SSc(P =.036).After adjusting for potential confounders such as occupation and body mass index(BMI),late age at menarche(≥17 years) was associated with a decreased risk of SSc(OR 0.187,95% CI 0.068-0.513),but abortions were not significantly related to *** meta-analysis revealed there was no association between SSc and abortions or number of *** significant publication bias was observed(P >.05).CONCLUSION:Late age at menarche was associated with a reduced risk of SSc but abortion may not be an independent risk factor for *** investigations are required to verify our findings.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

在相对论自导沟道中用激光尾流场对电子加速

强激光技术进展 1998年第2期8卷 41-45页

作者： Wagne.,D chen.,sy

三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

临床肝胆病杂志 2021年第6期37卷 1403-1403页

作者： chen sy ZHANG HP LI J 陈三洋不详郑州大学第一附属医院急诊外科

【据Hepatology 2021年2月报道】题:三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤(作者chen sy等)肝缺血再灌注(IR)损伤是肝移植术后器官功能障碍的主要原因,其主要涉及炎症反应和细胞凋亡等过程。作... 详细信息

【据Hepatology 2021年2月报道】题:三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤(作者chen sy等)肝缺血再灌注(IR)损伤是肝移植术后器官功能障碍的主要原因,其主要涉及炎症反应和细胞凋亡等过程。作为调控多种细胞炎症和凋亡的关键介质,三结构域蛋白27(TRIM27)在肝IR损伤中的作用值得研究。

关键词：器官功能障碍肝缺血再灌注损伤肝移植术后结合蛋白细胞炎症细胞凋亡炎症反应降解转化

Molecular characterisation and phylogenetic analysis of Spirometra erinaceieuropaei from snakes in Hunan Province

在线全文

学校读者我要写书评

暂无评论

Molecular characterisation and phylogenetic analysis of Spir...

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： TF Gong LX Xie JL He F Li sy chen WC Li XR Xie YS Liu YF Zhou W Liu Research Center for Parasites & Vectors College of Veterinary MedicineHunan Agricultural University Orient Science & Technology College of Hunan Agriculture University

Sparganosis is a neglected zoonotic parasitic disease found *** play an important role in sparganosis transmission because they are the most common second intermediate hosts for Spirometra ***,the population genetics of Spirometra isolates from snakes is currently not well *** study obtained 49 Spirometra tapeworms from 15 geographical areas in Hunan Province,Central ***,18 S and 28 S ribosomal DNA(rDNA) fragments were amplified from the isolated parasites,and their sequences were analysed to assess their genetic *** analyses were performed using the maximum likelihood *** results showed that sequence variations amongst these isolates were 0%-2.3% and 0%-0.1% for 18 S and 28 S rDNA,*** analysis showed that all Spirometra isolates from Hunan Province were clustered into the same branch with *** isolated from different regions/hosts ***,phylogenetic trees revealed that Spirometra is closely related to Adenocephalus,Pyramicocephalus,Ligula,Dibothriocephalus,Schistocephalus and *** results provide reference values for the future taxonomic status of ***,and the exact phylogenetic position of Spirometra species should be further analysed with more sampling and more useful molecular markers.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

肝移植术围术期麻醉管理若干问题与对策

第四军医大学学报 2006年第2期27卷 97-100页

作者：陈绍洋熊利泽朱萧玲王强第四军医大学西京医院麻醉科陕西西安710033

肝移植围术期可发生多系统复杂的病理生理变化,而麻醉质量的高低将直接影响肝移植术的效果和成败.肝移植术麻醉管理的重点应予充分的术前准备,熟悉各项监测的临床意义,正确处理术中多系统功能紊乱,维持各重要脏器功能接近生理状态,并预... 详细信息

肝移植围术期可发生多系统复杂的病理生理变化,而麻醉质量的高低将直接影响肝移植术的效果和成败.肝移植术麻醉管理的重点应予充分的术前准备,熟悉各项监测的临床意义,正确处理术中多系统功能紊乱,维持各重要脏器功能接近生理状态,并预防和治疗各种可能的并发症.

关键词：肝移植麻醉围术期管理

Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing chen Wei-qing chen Fei-hua GONG Mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(sy)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(Psy(Psy(Psy on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(Psy inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

Ten ring-B aromatized ergosterols from Aspergillus spectabilis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第7期22卷 654-662页

作者： WEI Mengsha SUN Weiguang LIU Linlin LI Yongqi LI Lanqin LI Qin chen Yu GUO Jieru GU Lianghu ZHU Hucheng chen Chunmei ZHANG Yonghui Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Spectasterols F−O(1−10),ten interesting ergosterols with an aromatized B ring,were obtained from Aspergillus *** structures and absolute configurations were determined using a combination of high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),nuclear magnetic resonance(NMR)spectroscopy,single-crystal X-ray diffraction analyses,and electronic circular dichroism(ECD)***,these aromatic ergosterols feature versatile side ***,compound aromatic ergosterols featured versatile side chains,and compound 4 is an unusual C23 ergosterol characterized by a shorter side chain due to oxidative cleavage between C-23 and *** compounds were evaluated for their neuroprotective activities,with compound 8 showing a dose-dependent ability to reduce apoptosis and protect mitochondrial function in glutamate-induced SH-sy5Y cells.

关键词： Steroids Aspergillus spectabilis Aromatic ergosterols Neuroprotective activities Structure elucidation

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine