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瑞马唑仑对鼻内镜手术老年患者术中脑氧饱和度及术后认知功能的影响

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中国新药与临床杂志 2024年第2期43卷 143-148页

作者：陈琴琴胡茜陈秋红刘博文杨文明张学康南昌大学附属口腔医院、江西省口腔生物医学重点实验室、江西省口腔疾病临床医学研究中心江西南昌330006 南昌大学第一附属医院江西南昌330006

目的探讨瑞马唑仑对鼻内镜手术老年患者术中脑氧饱和度及术后认知功能的影响。方法选择拟行鼻内镜手术的老年患者60例,随机均分为2组。对照组给予丙泊酚2.0mg·kg^(-1)诱导,丙泊酚4~6mg·kg^(-1)·h^(-1)维持,试验组给予瑞马唑仑0.3mg·... 详细信息

目的探讨瑞马唑仑对鼻内镜手术老年患者术中脑氧饱和度及术后认知功能的影响。方法选择拟行鼻内镜手术的老年患者60例,随机均分为2组。对照组给予丙泊酚2.0mg·kg^(-1)诱导,丙泊酚4~6mg·kg^(-1)·h^(-1)维持,试验组给予瑞马唑仑0.3mg·kg^(-1)诱导,瑞马唑仑0.2~0.3mg·kg^(-1)·h^(-1)维持,2组其他麻醉诱导和维持给药相同。采用硝酸甘油0.5~2.0g·kg^(-1)·min^(-1)静脉泵注,使平均动脉压(MAP)维持在50~65mmHg,手术结束后停止泵注。术中监测局部脑氧饱和度(rcSO_(2)),并在麻醉诱导前、拔管后和术后1h检测血清S100β和白细胞介素(IL)-6浓度。应用蒙特利尔认知评估量表(MoCA)评估患者认知功能,检测血流动力学指标,观察术后苏醒质量。结果术前1d、术后1d和7d,2组MoCA评分比较均无显著差异(P>0.05);且术后1d和7d,2组术后认知功能障碍(POCD)发生率比较无显著差异(P>0.05)。与对照组比较,试验组降压后的rcSO_(2)显著增高(P0.05),且均未发生明显不良反应。结论瑞马唑仑可减少老年鼻内镜手术患者术中S100β及IL-6的产生,并在一定程度上改善脑氧饱和度,但对POCD的发生无明显影响。

关键词：瑞马唑仑老年人认知功能障碍鼻内镜手术脑氧饱和度

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吸入用盐酸氨溴索溶液致呼吸困难1例

解放军药学学报 2024年第3期37卷 297-298页

作者：陈节兵黄惠丽陈秋红联勤保障部队第909医院/厦门大学附属东南医院福建漳州363000 联勤保障部队第903医院浙江杭州310013 联勤保障部队第900医院福建福州350001

1病例资料.患者,女,80岁。2023年5月6日因“反复咳嗽、咳痰、气喘5年余,加重1周”就诊于第909医院急诊室。入院体检:体质量52 kg,神志清楚,急性病容,无鼻翼煽动,呼吸稍促,节律齐,胸式呼吸,呼吸动度两侧对称,触诊语颤两侧减弱,双肺叩诊... 详细信息

1病例资料.患者,女,80岁。2023年5月6日因“反复咳嗽、咳痰、气喘5年余,加重1周”就诊于第909医院急诊室。入院体检:体质量52 kg,神志清楚,急性病容,无鼻翼煽动,呼吸稍促,节律齐,胸式呼吸,呼吸动度两侧对称,触诊语颤两侧减弱,双肺叩诊呈过清音,双肺呼吸音减弱,可闻及双肺弥漫性哮鸣音。既往“慢性阻塞性肺疾病、哮喘”病史10年,未规律用药。

关键词：氨溴索呼吸困难药品不良反应

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浅析轴系对中时百分表位置的选取和应用

内燃机与配件 2024年第5期 49-52页

作者：杨延涛陈秋红白金中国船舶集团有限公司第七一一研究所上海200090 不详

百分表对中法是设备轴系连接过程中最常用的对中方法,针对百分表对中不同的计算方法已有较多文章描述,但鲜有针对百分表安装位置进行的专业分析和指导。本文旨在针对轴系对中时,对百分表放置位置、百分表头预压位置进行介绍和分析,有利... 详细信息

百分表对中法是设备轴系连接过程中最常用的对中方法,针对百分表对中不同的计算方法已有较多文章描述,但鲜有针对百分表安装位置进行的专业分析和指导。本文旨在针对轴系对中时,对百分表放置位置、百分表头预压位置进行介绍和分析,有利于对中人员在对中过程中能在不同对中设备及空间条件下,快速的判断最佳的百分表放置位置,得出准确的对中读数,保证读数的有效性,从而保证轴系对中精度,保障设备运行安全。

关键词：轴系对中百分表位置转动轴选取

水稻DUF1771基因家族的全基因组鉴定与表达谱分析

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农业生物技术学报 2024年第3期32卷 493-504页

作者：肖秀文杜强王志龙高芙蓉杜文唐文帮陈秋红湖南农业大学农学院水稻油菜抗病育种湖南省重点实验室国家耐盐碱水稻技术创新中心/湖南杂交水稻研究中心

未知功能结构域1771 (domain of unknown function 1771, DUF1771)基因家族是植物中一个功能未被鉴定的家族。本研究通过生物信息学技术在水稻(Oryza sativa)中鉴定了5个DUF1771家族成员，与拟南芥(Arabidopsis thaliana)中鉴定到的4个D... 详细信息

未知功能结构域1771 (domain of unknown function 1771, DUF1771)基因家族是植物中一个功能未被鉴定的家族。本研究通过生物信息学技术在水稻(Oryza sativa)中鉴定了5个DUF1771家族成员，与拟南芥(Arabidopsis thaliana)中鉴定到的4个DUF1771家族成员进行系统进化树分析，9个DUF1771家族成员可分为2个亚族，保守基序分析发现motif 1和motif 2在所有的DUF1771家族成员中存在。5个OsDUF1771基因家族成员的启动子中与各类胁迫响应和激素响应相关的顺式作用元件整体相对较少，以OsDUF1771-1为最少。实时荧光定量PCR分析显示，OsDUF1771家族成员在各类激素处理前后水稻中的表达水平变化幅度整体上不大。在低温、干旱和稻瘟菌(Magnaporthe oryzae)处理水稻时，OsDUF1771-1, 2, 3, 5虽然有一些响应变化，但变化幅度亦不大，OsDUF1771-4对低温处理具有相对最大的响应，在处理12 h的表达水平是未处理样品的4.54倍。在4个OsDUF1771家族成员的启动子中均发现了种子储存蛋白代谢调控相关元件O2-site，仅OsDUF1771-1的启动子中未发现此元件，这与各成员的组织表达谱检测结果相吻合，OsDUF1771-2, 3, 4, 5均在穗中具有最高的表达水平，而OsDUF1771-1在叶中具有最高的表达水平，且OsDUF1771-1编码蛋白预测定位于叶绿体。此外OsDUF1771-3的启动子中还含有胚乳特异表达元件GCN4-motif，进一步说明OsDUF1771-3在水稻种子的胚乳储存蛋白代谢中发挥功能，本研究为深入解析OsDUF1771家族成员的生物学功能提供了重要线索。

关键词：水稻未知功能结构域1771(DUF1771)基因家族进化分析表达谱分析

Advances in metal-organic framework-derived single-atom catalysts for biomedicine

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Nano Materials Science 2024年第4期6卷 396-412页

作者： Li qiu Yingxi Lin Jun Song chen hong Luo Rui Wu Department of Ultrasound West China Second University Hospital Sichuan University Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education Sichuan University School of Materials and Energy University of Electronic Science and Technology of China Interdisciplinary Materials Research Center Institute for Advanced Study Chengdu University

As a alternative for natural enzymes, nanozymes has shown enzyme-like activity and selectivity in the field of various kinds of biomedical application, which has attracted considerable research interest. Recently, single-atom catalysts(SACs) have been extensively studied due to their similar active centers, coordination environment and better stability to natural enzymes. Metal-organic frameworks(MOFs) have been demonstrated as highly promising precursors for the synthesis of various types of SACs. MOF-derived SACs can not only significantly enhance the catalytic activity, but also improve the selectivity of nanozymes due to tunable coordination environment and structure, thereby receiving widespread attention in biomedicine. This review provided an overview of the preparation strategies for MOF-derived SACs, and then detailed the latest research progress of the SACs in the biomedical field for cancer, antibacterial, antioxidation and biosensors. Finally, the challenges and potential future opportunities of MOF-derived SACs in biomedical applications are proposed.

关键词： Biomedicine MOF-Derived SAC nanozymes Catalytic mechanisms

联合预测因子对利拉鲁肽致胃肠道不良反应风险的预测价值

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中国药物应用与监测 2024年第1期21卷 59-62页

作者：黄文辉侯幸赟陈建明陈秋红赖淑斌王芳芳薛鸿林第九○九医院(厦门大学附属东南医院)药剂科漳州363000 海军军医大学长征医院药材科上海200003 第九○九医院(厦门大学附属东南医院)内分泌风湿科漳州363000

目的探讨利拉鲁肽致胃肠道反应(GIAR)的危险因素并建立预测模型,同时验证该模型的准确率。方法回顾性分析2021年7月—2022年9月第九○九医院(厦门大学附属东南医院)使用利拉鲁肽治疗的149例2型糖尿病住院患者的信息,按照4∶1的比例随机... 详细信息

目的探讨利拉鲁肽致胃肠道反应(GIAR)的危险因素并建立预测模型,同时验证该模型的准确率。方法回顾性分析2021年7月—2022年9月第九○九医院(厦门大学附属东南医院)使用利拉鲁肽治疗的149例2型糖尿病住院患者的信息,按照4∶1的比例随机分为研究集119例和验证集30例。将119例研究集患者的临床指标进行统计分析,筛选出利拉鲁肽致GIAR的独立危险因素,对Logistic模型方程进行转换建立联合预测因子,采用ROC曲线确定联合预测因子的曲线下面积(AUC)及最佳临界值。结果119例患者中,共有28例患者(23.53%)发生了GIAR,多因素Logistic回归分析表明晕车史、联合α-葡萄糖苷酶抑制剂(AGI)和性别是利拉鲁肽致GIAR的独立危险因素。对Logistic模型方程转换得出联合预测因子(Y联合预测因子)的计算公式,Y联合预测因子=X晕车史+1.165X联合AGI+3.285X性别,联合预测因子的AUC最大为0.741,约登指数(Youden)最大时(0.376)对应的最佳临界值为3.785。利用30例验证集患者的临床指标验证该模型预测的准确率为76.67%。结论晕车史、联合AGI和性别是利拉鲁肽致GIAR的独立危险因素,联合上述3项临床指标构建联合预测因子对利拉鲁肽致GIAR风险具有良好的预测价值。

关键词：利拉鲁肽胃肠道不良反应危险因素预测模型

Clinical risk factors for preterm birth and evaluating maternal psychology in the postpartum period

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World Journal of Psychiatry 2024年第5期14卷 661-669页

作者： Jia-Jun chen Xue-Jin chen qiu-Min She Jie-Xi Li qiu-hong Luo Department of Clinical Laboratory Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina Department of Otolaryngology Head and Neck Surgery Outpatient Shenzhen Children’s HospitalShenzhen 518000Guangdong ProvinceChina Department of Prevention and Health Care Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina Department of Obstetrics Shenzhen Bao’an District Songgang People’s HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND Although the specific pathogenesis of preterm birth(PTB)has not been thoroughly clarified,it is known to be related to various factors,such as pregnancy complications,maternal socioeconomic factors,lifestyle habits,reproductive history,environmental and psychological factors,prenatal care,and nutritional *** has serious implications for newborns and families and is associated with high mortality and ***,the prediction of PTB risk can facilitate early intervention and reduce its resultant adverse *** To analyze the risk factors for PTB to establish a PTB risk prediction model and to assess postpartum anxiety and depression in *** A retrospective analysis of 648 consecutive parturients who delivered at Shenzhen Bao’an District Songgang People’s Hospital between January 2019 and January 2022 was *** to the diagnostic criteria for premature infants,the parturients were divided into a PTB group(n=60)and a full-term(FT)group(n=588).Puerperae were assessed by the Self-rating Anxiety Scale(SAS)and Self rating Depression Scale(SDS),based on which the mothers with anxiety and depression symptoms were screened for further *** factors affecting PTB were analyzed by univariate analysis,and the related risk factors were identified by logistic *** According to univariate analysis,the PTB group was older than the FT group,with a smaller weight change and greater proportions of women who underwent artificial insemination and had gestational diabetes mellitus(P<0.05).In addition,greater proportions of women with reproductive tract infections and greater white blood cell(WBC)counts(P<0.05),shorter cervical lengths in the second trimester and lower neutrophil percentages(P<0.001)were detected in the PTB group than in the FT *** PTB group exhibited higher postpartum SAS and SDS scores than did the FT group(P<0.0001),with a higher number of mothers experiencing anxiety and depress

关键词： Preterm birth Risk factors Postpartum psychological state Risk model Prediction

The First Five Years of a Phase Theory for Complex Systems and Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1728-1743页

作者： Dan Wang Wei chen Li qiu Division of Decision and Control Systems KTH Royal Institute of TechnologyStockholm 10044Sweden Department of Mechanics and Engineering Science&the State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing 100871China hong Kong University of Science and Technology Hong KongChinaand also with the Southern University of Science and TechnologyShenzhen 518055China

In this paper,we review the development of a phase theory for systems and networks in its first five years,represented by a trilogy:Matrix phases and their properties;The MIMO LTI system phase response,its physical interpretations,the small phase theorem,and the sectored real lemma;The synchronization of a multi-agent network using phase *** the end,we also summarize a list of ongoing research on the phase theory and speculate what will happen in the next five years.

关键词： Consensus and synchronization matrix phases multi-agent systems phase theory sectored real lemma small phase theorem.

Cross-sectional study of congenital heart disease among Tibetan children aged from 4 to 18 years at different altitudes in Qinghai Province

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Chinese Medical Journal 2008年第24期121卷 2469-2472页

作者： chen qiu-hong WANG Xiao-qin QI Sheng-gui Central Laboratory Qinghai Cardiovascular Diseases Vocational Hospital Xining Qinghai 810012 China

Background Congenital heart disease （CHD） is a common heart condition which does considerable harm to the health of children and adolescents. CHD epidemiological characteristics of Tibetan children whose ages ranged from 4 to 18 years were investigated in Qinghai Province. Methods A total of 32 578 Tibetan children, living at altitudes of 2535 m, 3600 m and 4200 m, were examined using a three-stage protocol： prescreening, rechecking and diagnosis using a color Doppler. The distribution of CHD at different altitudes was analyzed together with differences in occurrence according to age and gender. Results A total of 235 CHD cases were discovered. The total prevalence of CHD was 7.21‰. Prevalence of CHD has been shown to increase along with increase in altitude with 5.45‰ at an altitude of 2535 m, 6.80‰ at 3600 m and 9.79‰ at 4200 m. There were no statistically significant differences between the prevalence at 2535 m and 3600 m （Х^2=1.594, P 〉0.05）. However, there was a significant difference between the prevalence at 2535 m and 4200 m （Х^2=7.002, P 〈0.01）. Also, apparent differences existed between the prevalence at 3600 m and at 4200 m （Х^2=5.540, P 〈0.05）. There was no statistically significant difference in prevalence according to age at an altitude of 2535 m, but the rate of CHD increased significantly along with increasing age at 3600 m and 4200 m. The total prevalence ratio of children aged from 16 to 18 years was significantly higher than that of children from 4 to 7, and from 8 to 12 with Х^2 values of 10.79 （P 〈0.005）, and 5.60 （P 〈0.05） respectively. Within the constituent ratio of CHD, the prevalence of atrial septal defect （ASD） was the highest at 39.10%, followed by the prevalence of ventricular septal defect （VSD） at 32.8% and patent ductus arteriosus （PDA） at 24.7%. Furthermore the proportion of the four categories of CHD varied at different altitude levels： at 2535 m, of those diagnosed with CHD, the prevalence rate of VSD was the highest at 43.5%, at

关键词： congenital heart disease epidemiological monitoring prevalence Tibetan