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Effect of Jianpi Bushen formula on aromatase-inhibitor-associated bone loss after menopause

Journal of Traditional Chinese Medicine 2018年第6期38卷 879-889页

作者： Dai Yan chen Qingqing Guan Ruodan Xu Rui Qiu Chang Song Xue Guo Qianqian Wang Zhiyu chen qianjun Department of Mammary Disease Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510000China The Research Centre for Integrative Medicine Guangzhou University of Chinese MedicineGuangzhou 510000China

OBJECTIVE: To investigate the effect of Jianpi Bushen(JPBS) formula on aromatase inhibitor(AI)-associated bone loss after menopause.METHODS: Six-month-old female rats were randomly divided into 6 groups: a sham group, an ovariectomized(OVX) group, an OVX treated with exemestane and 3 OVX groups each treated with a different dose of JPBS formula. Bone mineral density(BMD) at the lumbar vertebrae, histology, bone markers and serum levels of estrogen were assessed. Furthermore, a cohort study was conducted in 130 postmenopausal women with breast cancer that had undergone treatment with AIs. The subjects were given JPBS + caltrate D or caltrate D only, administered orally. BMD at the lumbar vertebrae and femoral neck and bone markers were evaluated in both control and herbal treatment groups at baseline and 12 months.RESULTS: Experimental results indicated that a high dose of JPBS significantly increased the trabecular bone area percentage(Tb.Ar %) and broadened the trabecular thickness(Tb.Th). The JPBS formula enriched the carboxyterrninal propeptide of type ipmcollagen and increased serum estrogen level significantly. The clinical investigation revealed that bone loss was decreased in the group treated with JPBS vs control(BMD T score at lumbar vertebrae, 3.9% increased vs 14.58% decreased, respectively, P = 0.004 and BMD T score on femoral neck, 1.8% decreased vs 22.45% decreased, respectively, P = 0.008). Besides, JPBS formula elevated Nmiddle osteocalcin and decreased type Ⅰ collagen cross-linked C-terminal telopeptide.CONCLUSION: JPBS formula prevented aromatase-inhibitor-associated bone loss after menopause by inhibiting bone resorption and promoting bone formation.

关键词： Aromatase inhibitors Menopause Bone resorption Osteogenesis Jianpi Bushen formula

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深部地热能系统主要挑战与耦合储能的增强型创新开发模式

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煤田地质与勘探 2024年第1期52卷 1-13页

作者：侯正猛吴旭宁罗佳顺张烈辉李早元曹成吴林陈前均克劳斯塔尔工业大学地下能源系统研究所德国克劳斯塔尔–采勒费尔德38678 西南石油大学油气藏地质及开发工程全国重点实验室四川成都610500

中国在中低温地热能直接利用方面早已领先全球,但在深部地热能发电方面却发展缓慢。深部高温高压环境下岩石渗透性降低,深部地热能开采需要建立工程型地热系统(Engineered Geothermal System,EGS),通过水力压裂对储层进行改造,以获得具... 详细信息

中国在中低温地热能直接利用方面早已领先全球,但在深部地热能发电方面却发展缓慢。深部高温高压环境下岩石渗透性降低,深部地热能开采需要建立工程型地热系统(Engineered Geothermal System,EGS),通过水力压裂对储层进行改造,以获得具有较高渗透性的人工地热储层。由于目前常用的深部地热能储层改造技术主要借鉴油气增产领域的水力压裂工艺,在热储改造效果、地震风险控制、高效取热等方面受到限制。首先总结深部地热能水力压裂的特点为:裂缝破坏主要以剪切机理为主;冷水回灌引起的温差效应产生拉应力会促使裂缝向更远处扩展;持续的注水使注入井井筒压力高于地层压力,有助于保持裂缝处于张开状态。因此,EGS水力压裂不需要使用支撑剂,与依靠支撑剂的油气井增产压裂完全不同。同时,系统剖析EGS面临的发电产能低、注采连通差、诱发破坏性地震以及无补贴难盈利4大难题与挑战。从创新压裂和循环利用层面提出耦合储能的增强型创新开发模式(Regenerative Engineered Geothermal System,REGS),通过数值模拟研究REGS的优点。结果表明,采用水平井非等距、非等面积、非等注水量分段压裂,可以提高注水井与生产井的连通能力。通过优化压裂工艺,采用多段压裂模式,每次压裂初始期间快速提高注水速率,而后期缓慢降低注水速率,避免井筒压力的突然波动,可以达到控制诱发地震震级的目的,避免产生实质性伤害地震。结合可再生能源大规模地下存储,既能实现多能互补,又能提高REGS项目生产寿命和盈利能力。研究成果有助于为我国深部地热能热电联产和储能一体化技术的试点和标准化推广奠定基础。

关键词：工程型地热系统热储改造支撑剂诱发地震耦合储能

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内隐联想测验中叠音姓名对人际知觉的影响

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心理学探新 2024年第1期44卷 60-65页

作者：陈建新方紫梦陈倩郡韩玥张晓晨杨伟平魏柳青湖北大学师范学院心理学系武汉430062

已有研究大多是从外显的角度探讨叠音姓名特征对人际知觉的影响,而内隐层面的研究还比较缺乏。研究采用内隐联想测验(IAT)任务,考察了叠音姓名对大学生人际知觉(温暖知觉、能力知觉)的影响。结果发现:与非叠音姓名相比,被试更多地将叠... 详细信息

已有研究大多是从外显的角度探讨叠音姓名特征对人际知觉的影响,而内隐层面的研究还比较缺乏。研究采用内隐联想测验(IAT)任务,考察了叠音姓名对大学生人际知觉(温暖知觉、能力知觉)的影响。结果发现:与非叠音姓名相比,被试更多地将叠音姓名与高温暖属性和高能力属性相联系。这说明在内隐认知层面上,个体对叠音姓名存在高温暖属性维度与高能力属性维度的偏好。

关键词：叠音姓名温暖知觉能力知觉内隐联想测验

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Numerical simulations of supercritical carbon dioxide fracturing:A review

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1895-1910页

作者： Lin Wu Zhengmeng Hou Zhifeng Luo Ying Xiong Nanlin Zhang Jiashun Luo Yanli Fang qianjun chen Xuning Wu Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal-Zellerfeld38678Germany b State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China

As an emerging waterless fracturing technology,supercritical carbon dioxide(SC-CO_(2))fracturing can reduce reservoir damage and dependence on water resources,and can also promote the reservoir stimulation and geological storage of carbon dioxide(CO_(2)).It is vital to figure out the laws in SC-CO_(2)fracturing for the large-scale field implementation of this technology.This paper reviews the numerical simulations of wellbore flow and heat transfer,fracture initiation and propagation,and proppant transport in SC-CO_(2)fracturing,including the numerical approaches and the obtained findings.It shows that the variations of wellbore temperature and pressure are complex and strongly transient.The wellhead pressure can be reduced by tubing and annulus co-injection or adding drag reducers into the fracturing fluid.Increasing the temperature of CO_(2)with wellhead heating can promote CO_(2)to reach the well bottom in the supercritical state.Compared with hydraulic fracturing,SC-CO_(2)fracturing has a lower fracture initiation pressure and can form a more complex fracture network,but the fracture width is narrower.The technology of SC-CO_(2)fracturing followed by thickened SC-CO_(2)fracturing,which combines with high injection rates and ultra-light proppants,can improve the placement effect of proppants while improving the complexity and width of fractures.The follow-up research is required to get a deeper insight into the SC-CO_(2)fracturing mechanisms and develop cost-effective drag reducers,thickeners,and ultra-light proppants.This paper can guide further research and promote the field application of SC-CO_(2)fracturing technology.

关键词： Wellbore Fracturing Proppant transport Supercritical carbon dioxide Fracture initiation and propagation

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Hydrothermal synthesis of polyimide-linked covalent organic frameworks towards ultrafast and stable cathodic sodium storage

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Science China Chemistry 2024年第4期67卷 1300-1310页

作者： Xiya Yang Lei Gong Zhixin Liu qianjun Zhi Baoqiu Yu Xin chen Kang Wang Xiaofeng Li Dongdong Qi Jianzhuang Jiang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline MaterialsDepartment of Chemistry and Chemical EngineeringSchool of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083China State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Redox-active organic materials are capturing growing attention as cathode materials for sustainable alkaline metal ion batteries.However,the storage of Na+in most organic materials-based cathodes is plagued by low capacity and unsatisfying rate performance due to their low active site densities and limited exposed active sites.Herein,two polyimide-linked covalent organic frameworks(COFs),namely HATN-PD-COF and HATN-TAB-COF,were fabricated from hydrothermal synthesis with redoxactive triphenylene-2,3,6,7,10,11-hexacarboxylic acid and aromatic amines as starting materials.Powder X-ray diffraction and electron microscopy analysis indicate the high crystalline nature of these COFs with AA stacking configuration and orderly mesoporous tunnel.N_(2) sorption measurement discloses the permanent porosity of these two COFs with a Brunauer-EmmettTeller surface area of 1,065-1,200 m^(2)g^(-1)and a large pore size of 2.0-3.1 nm.Galvanostatic intermittent titration technique and density functional theory calculations reveal the facile Na+ion diffusion along the mesoporous tunnel of these COFs with a small energy barrier of 0.13-0.40 e V.In particular,the as-prepared COFs based-cathodes show ultrafast and stable Na+storage associated with their conjugated electronic structure,highly ordered mesoporous tunnel,robust structure,and redox-active C=N/C=O-rich framework as exemplified by the high reversible capacity of 210 m A h g^(-1)at 200 m A g^(-1),record-high rate performance(195 m A h g^(-1)at a high current density of 10,000 m A g^(-1))among organic electrodes and the capacity retention of nearly 91%at 10,000 m A g^(-1)after 7,000 cycles for HATN-PD-COF.

关键词： covalent organic framework sodium ion battery cathode high rate organic electrode

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Preparation and Electromechanical Properties of PVDF Matrix Piezoelectric Composites Containing Highly Oriented BaTiO_3 Whiskers

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Journal of Materials Science & Technology 2004年第4期20卷 441-444页

作者： Xuetao LUO, Lifu chen, Xiaojun chen and qianjun HUANGDepartment of Materials Science and Engineering, Xiamen University, Xiamen 361005, China Dept. of Mat. Sci. and Eng. Xiamen Univ. Xiamen 361005 China

The piezoelectric composites containing highly oriented BaTiO3 whiskers as active phase and PVDF as matrix have been prepared by micro-hole extrusion and orientation in carried fibers. The morphology of oriented BaTiO3 whiskers and microstructure of the composites were observed by SEM. As for its electromechanical properties, it is found that the dielectric constant, piezoelectric constant and remnant of polarization in the BaTiO3 whisker-PVDF composite are considerably higher than that in the BaTiO3 powders-PVDF composite, while the loss factors follow the opposite trend. For the BaTiO3 whisker-PVDF composite, the values of ε, d33 and Pr parallel to the whisker orientation (normal specimen) are much higher than that perpendicular to the whisker orientation (parallel specimen). The significant effects of the connective passages of active phase on electromechanical properties of the piezoelectric composites has also been investigated.

关键词： Piezoelectric composite BaTiO3 whiskers Electromechanical properties Polarization Connective passages

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Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2250-2258页

作者： Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng qianjun chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang Department of Medical Oncology and State Key Laboratory of Molecular Oncology National Cancer Cener/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150000China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200000China Department of Galactophore Liaoning Cancer Hospital&InstituteShenyang 110801China Department of Oncology the First Hospital of Jilin UniversityChangchun 130061China Department of Galactophore Hunan Cancer HospitalChangsha 410000China Department of Galactophore Linyi Cancer HospitalLinyi 276000China Department of Breast Medical Oncology Tianjin Medical University Cancer Institute&HospitalTianjin 300000China Department of Breast Disease Henan Breast Cancer Centerthe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008China Department of Breast Oncology Beijing Cancer HospitalBeijing 100000China Breast Cancer Center Chongqing University Cancer HospitalChongqing 400000China Department of Breast and Thyroid Oncology Affiliated Hospital of Jining Medical UniversityChangchun 130021China Department of Medical Oncology Run Run Shaw HospitalAffiliated Hospital of Zhejiang UniversityHangzhou 310003China Department of Head and Heck Oncology West China HospitalSichuan UniversityChengdu 610000China Department of Thyroid&Breast Surgery the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210000China Department of Galactophore Guangdong Hospital of Traditional Chinese MedicineGuangzhou 510000China Department of Oncological Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China Taizhou EOC Pharma Co. Ltd.Taizhou 318000China

Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171).

关键词： Advanced breast cancer Hormone receptor-positive Histone deacetylase inhibitors Phase 3 clinical trial

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具有Gilpin-Ayala增长的随机捕食-食饵模型的动力学行为

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应用数学和力学 2022年第4期43卷 453-468页

作者：陈乾君蒋媛刘子建谭远顺重庆交通大学数学与统计学院重庆400074

该文研究了一类具有Gilpin-Ayala增长的随机捕食-食饵模型的动力学行为,证明了系统全局正解的存在性和唯一性,得到了灭绝性和持久性的充分条件.在此基础上,给出了控制捕食-食饵系统随机持久和灭绝的阈值,并且讨论了系统解的一些渐近性态... 详细信息

该文研究了一类具有Gilpin-Ayala增长的随机捕食-食饵模型的动力学行为,证明了系统全局正解的存在性和唯一性,得到了灭绝性和持久性的充分条件.在此基础上,给出了控制捕食-食饵系统随机持久和灭绝的阈值,并且讨论了系统解的一些渐近性态.最后通过数值模拟,验证了结果的有效性.

关键词： Gilpin-Ayala增长捕食-食饵模型 Markov状态切换脉冲扰动持久性

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先进表征技术在工业催化中的应用（英文）

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Chinese Journal of Catalysis 2019年第11期40卷 1637-1654页

作者： Shelly Kelly Wharton Sinkler Lijun Xu Sergio Sanchez Cem Akatay Haiyan Wang John qianjun chen 霍尼伟尔环球油品公司

分析表征与工业应用技术之间的相互影响对开发石油加工的催化材料一直起着至关重要的作用.本文着重介绍石油化工中两类最重要的催化材料:(1)催化重整工艺中广泛使用的负载于氧化铝上的铂纳米颗粒;(2)加氢处理工艺中用于加氢和去除杂原... 详细信息

分析表征与工业应用技术之间的相互影响对开发石油加工的催化材料一直起着至关重要的作用.本文着重介绍石油化工中两类最重要的催化材料:(1)催化重整工艺中广泛使用的负载于氧化铝上的铂纳米颗粒;(2)加氢处理工艺中用于加氢和去除杂原子的含钼和钨的层状硫化物.首先,我们综述了用扩展X射线吸收精细结构(EXAFS)和扫描透射电子显微镜研究铂团簇生长和结构的最新研究动态.详细讨论了氧化预处理条件以及氢气环境中的还原温度对铂纳米粒子形态的影响,并结合最近的实验结果进一步延伸对铂纳米颗粒结构演变的理解.随后,本文总结了一系列分析表征技术对层状硫化物纳米颗粒研究的贡献,综述了硫化物纳米粒子活性中心结构的研究进展,重点介绍了边缘活性中心与硫和氢之间的互动在化学吸附、物理吸附及溢流效应中的关键作用.本文也对负载及非负载型的硫化物纳米粒子最新程序升温还原实验结果进行了探讨.氧化铝负载的硫化钼颗粒在程序升温还原过程中的结构变化可以通过EXAFS实验和密度泛函理论模拟来解释.研究表明,可识别的硫化物边缘活性中心上硫原子的去除是导致这一类结构变化的主要原因.

关键词：催化基础研究铂金属硫化物催化重整加氢处理

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一种应用于氢能产业一体化的新型多功能盐穴储氢库

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工程科学与技术 2022年第1期54卷 128-135页

作者：方琰藜侯正猛岳也任利陈前均刘建锋德国克劳斯塔尔工业大学地下能源系统研究所克劳斯塔尔–采勒菲尔德38678 四川大学中德能源研究中心四川成都610065

为实现“双碳”目标,解决氢能大规模储存难题,结合中国氢能发展趋势,提出了包含盐穴储氢库的3种发展情景下的氢能“制–储–用”一体化方案:情景1,盐穴储存绿氢,用以燃料电池及炼钢炼铁领域;情景2,盐穴储存绿氢及CO_(2)–O_(2)混合气体... 详细信息

为实现“双碳”目标,解决氢能大规模储存难题,结合中国氢能发展趋势,提出了包含盐穴储氢库的3种发展情景下的氢能“制–储–用”一体化方案:情景1,盐穴储存绿氢,用以燃料电池及炼钢炼铁领域;情景2,盐穴储存绿氢及CO_(2)–O_(2)混合气体,用于地面合成甲烷及甲烷富氧燃烧发电;情景3,盐穴储存合成甲烷,用以除发电以外的其他用途。从盐穴储氢库全生命周期的角度,分析了储氢库在3种发展情景下的作用,提出了多功能储氢库的概念:可起到废电利用、电力平衡、氢能安全高效储存、CO_(2)减排等多项作用。以昆明市安宁盐矿及云南省为例,结合云南省水电为主的电力结构,分析了多功能盐穴储氢库在情景1、2中的建设需求:情景1,采用绿氢直接炼钢工艺,需电解绿氢约6.0×10^(5)t,配套多功能盐穴储氢库总气量1.3×10^(8) m^(3),可实现昆钢减排722 t;情景2,针对云南未来电力季节性缺额问题,假设甲烷富氧发电厂提供半年枯期电力,装机200 MW,仅需建设多功能盐穴储氢库总库容4.78×10^(6)m^(3),可消纳水电5.34×10^(8)kW·h,提供枯期发电量2.88×10^(8)kW·h。

关键词：碳中和氢能盐穴储氢氢能产业一体化

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