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基于信息化建设的特种设备管理平台应用与展望

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乙烯工业 2024年第3期36卷 5-9页

作者：马彪马飞龙盛楠黄佰朋张道君赵万庆中国石油天然气股份有限公司独山子石化分公司新疆独山子 833699

论述了特种设备信息化管理的重要意义、核心任务.以独山子石化公司开发的特种设备信息化管理平台为例,介绍平台整体功能架构、模块功能明细、企业内部各设备管理系统信息互联、业务流程管理等功能的应用,讲述特种设备信息化管理的方法.... 详细信息

论述了特种设备信息化管理的重要意义、核心任务.以独山子石化公司开发的特种设备信息化管理平台为例,介绍平台整体功能架构、模块功能明细、企业内部各设备管理系统信息互联、业务流程管理等功能的应用,讲述特种设备信息化管理的方法.独山子石化公司将法律法规、标准规范及企业管理制度等全面映射至特种设备信息化管理平台.以数据平台化、平台信息化、信息智能化管理理念,对特种设备进行全过程监管.减少人为失误造成的设备超期、超允许参数运行等违规风险.将人工管理的精力和时间最小化,从而达到信息化、智能化提升工作效率的目标.最后,通过对特种设备信息化发展的展望,提出设特种备信息化发展的思路.

关键词：特种设备信息化建设智能化管理平台

A differential control method for the proportional directional valve

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 892-902页

作者： Bo JIN Ya-guang ZHU Wei LI De-sheng ZHANG Lu-lu ZHANG Fei-fei chen The State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Ningbo HOYEA Machinery Manufacture Co. Ltd.

For the proportional directional valve controlled by two proportional solenoids, the normal control method(NCM) energizes only one solenoid at a time. The performance of the valve is greatly influenced by the nonlinearity of the proportional solenoid, such as dead zone and low force gain with a small current, and this effect cannot be eliminated by a simple dead-zone current compensation. To avoid this disadvantage, we propose the differential control method(DCM). By employing DCM, the controller outputs differential signals to simultaneously energize both solenoids of the proportional valve, and the operating point is found by analyzing the force output of the two solenoids to make a minimum variation of the current force gain. The comparisons of the valve response characteristics are made between NCM and DCM by nonlinear dynamic simulation and experiments. Simulation and experimental results show that by using DCM, the frequency response of the valve is greatly enhanced, especially when the input is small, which means that the dynamic characteristics of the proportional valve are improved.

关键词： Differential control method Frequency response Proportional directional valve Spool displacement feedback

Optimization of Calcium Addition to High-strength Low-alloy Steels

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Journal of Iron and Steel Research International 2015年第7期22卷 590-597页

作者： Gu-jun chen sheng-ping HE Yin-tao GUO Bo-yi SHEN Shuo ZHAO Qian WANG College of Materials Science and Engineering Chongqing University

Nozzle blockage is a common problem during continuous casting of Al-killed steel, and calcium treatment is widely used to resolve it. In consideration of the production costs, the technology of nonmetallic inclusion control was studied to optimize the Ca consumption. The proposed process of slag washing was employed, and the refining slag composition, deoxidation conditions and alloying systems were optimized. Using these measures, the steel cleanliness before Ca addition was improved significantly, and the corresponding Ca consumption was reduced. More- over, the continuous casting could be conducted smoothly.

关键词： nozzle blockage high-strength low-alloy steel calcium treatment slag washing steel cleanliness

Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways

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Chinese Journal of Natural Medicines 2017年第11期15卷 825-833页

作者： XU Jing GAN sheng LI Jun WAND De-Bing chen Yu HU Xin YANG Guang-Zhong Laboratory for Natural Products Chemistry School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan 430074 China College of Chemistry and Material Sciences South Central University for Nationalities Wuhan 430074 China

The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2 O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit Et OAc fraction(fruit-EFr., 12.5–50 μmol·L^(-1)) of G. xanthochymus for 24 h prior to H_2O_2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes(superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases(MMP), and scavenged reactive oxygen species(ROS). Fruit-EFr. also reduced BAX and cytochrome C expression and improved BCL-2 expression, thereby decreasing the ratio of BAX to BCL-2. Fruit-EFr. activated the nuclear translocation of NRF2 to increase HO-1 and induced the phosphorylation of AKT. Its cytoprotective effect was abolished by LY294002, a specific inhibitor of PI3 K. Taken together, the above findings suggested that *** G. xanthochymus could enhance cellular antioxidant defense capacity, at least in part, through upregulating HO-1 expression and activating the PI3 K/AKT pathway and that it could suppress H_2O_2-induced oxidative damage via PI3 K/AKT and NRF2/HO-1 signaling pathways.

关键词： Garcinia xanthochymus Oxidative stress PC12 PI3K/Akt pathway Nrf2/HO-1 signaling pathways

Alkaloids from stems of Ervatamia yunnanensis

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Chinese Chemical Letters 2007年第6期18卷 697-699页

作者： Xin Gen Luo Hai sheng chen Shuang Liang Mao Huang Wei Dong Xuan Li Jin College of Pharmacy Second Military Medical University Shanghai 200433 China Department of Pharmacy Guangzhou Military General Hospital Guangzhou 510010 China Center of New Drug Evaluation Institute of Basic Medical Sciences Second Military Medical University Shanghai 200433 China

Six indole alkaloids were isolated from the stems of Ervatamia yunnanensis. Among them, yunnanensine (I) is new. The other five are known alkaloids, namely: 19,20-E-vallesamine (II), 19s-heyneanine (III), ibogaine (IV... 详细信息

关键词： Ervatamia yunnanensis Indole alkaloids

IGF2BP3基因表达水平在急性髓系白血病患者中的预后价值

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中国实验血液学杂志 2024年第2期32卷 355-364页

作者：乐凝杨晶晶刘宇辰张夏玮王昊温亚男焦一帆王莉莉窦立萍解放军医学院中国人民解放军总医院第五医学中心血液病医学部北京100853

目的:探寻IGF2BP3基因表达水平与急性髓系白血病(AML)患者预后的关系。方法:通过对本中心27例AML患者骨髓原代白血病细胞进行转录组高通量测序,分析IGF2BP3基因表达水平与患者临床特征之间的关系,并在初治AML患者及难治AML(Refractory A... 详细信息

目的:探寻IGF2BP3基因表达水平与急性髓系白血病(AML)患者预后的关系。方法:通过对本中心27例AML患者骨髓原代白血病细胞进行转录组高通量测序,分析IGF2BP3基因表达水平与患者临床特征之间的关系,并在初治AML患者及难治AML(Refractory AML)患者样本中验证。分析20例健康对照者和26例AML患者中IGF2BP3基因表达水平的差异。采用RT-qPCR、Western blot检测两种蒽环类耐药细胞系(HL60/ADR、K562/ADR)中IGF2BP3表达水平,比较其与敏感细胞(HL60、K562)的表达差异。通过3个数据集,分析IGF2BP3在AML患者中的表达水平及与预后的关系,进一步使用Cox生存分析IGF2BP3在AML中的预后价值。结果:在本中心27例AML患者骨髓原代白血病细胞中,难治性AML患者的IGF2BP3表达量明显高于化疗敏感的患者(P=0.0343),白血病细胞髓外浸润(extramedullary infiltration,EMI)患者的IGF2BP3表达量明显高于无髓外浸润的AML患者(P=0.0049)。与健康人比较,IGF2BP3在AML患者中表达增加(P=0.0009)。蒽环类耐药细胞系(HL60/ADR、K562/ADR)中IGF2BP3 mRNA的表达显著高于敏感细胞系(K562/ADR vs K562,P=0.0430;HL60/ADR vs HL60,P=0.7369)。Western blot结果显示,耐药细胞中IGF2BP3蛋白表达显著高于敏感细胞(P<0.001)。qPCR结果显示,难治AML患者中IGF2BP3的mRNA表达水平明显高于化疗敏感患者(P=0.002)。在3个大样本AML患者队列中IGF2BP3高表达预示AML预后不良(P<0.05)。单因素和多因素预后分析证实IGF2BP3高表达与患者较短的无事件生存(HR=1.887,P=0.024)和总体生存(HR=1.619,P=0.016)显著相关。结论:IGF2BP3基因高表达可能是AML预后不良的重要因素,提示IGF2BP3基因有望成为AML的临床预后评估和提供治疗策略的新的分子标志物。

关键词：急性髓系白血病 IGF2BP3 预后

Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis

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Cellular & Molecular Immunology 2019年第3期16卷 288-301页

作者： Wen-Yu chen sheng-Yang Wu Ta-Chun Lin Shuei-Liong Lin Betty A.Wu-Hsieh Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Graduate Institute of Physiology College of MedicineNational Taiwan UniversityTaipeiTaiwanChina

We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin(DC-SIGN)transgenic mouse in which renal tubular epithelial cells expressed *** transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic *** discovered that,while *** infection induced renal fibrosis in both transgenic and littermate control mice,the transgenic mice had significantly lower levels of Acta2,Col1a2,Col3a1,and Col4a1 mRNA transcripts compared to the ***-1,an emerging biomarker for kidney injury,along with Tnf,Il6,and Tgfb1 transcripts,were lower in infected transgenic mice,and yet,the levels of Il10 remained comparable to the *** renal CD45+infiltrating cells were the source of Tnf,Il6,and Il10,LTL+renal proximal tubular epithelial cells were TGF-β1 producers in both infected transgenic and littermate ***-SIGN-expressing tubular epithelial cells produced less TGF-β1 in response to *** *** vivo experiments demonstrated that renal proximal tubular epithelial cell production of TGF-β1 was key to ***-induced renal fibrosis and *** of transgenic mice induced a marked increase of phosphorylated Raf-1 and p38 in the ***,ERK1/2 and JNK phosphorylation was more pronounced in the infected-littermate ***,treating the infected transgenic mice with a Raf-1 inhibitor increased the levels of the Tgfb1,Kim1,and Acta2 *** results indicate that DC-SIGN signaling,through activation of Raf-1 and p38 and suppression of JNK and ERK1/2 phosphorylation,reduces TGF-β1 production and ***-induced renal *** study reveals for the first time the effect of DC-SIGN expression on ***-induced renal fibrosis.

关键词： DC-SIGN Candida albicans Renal fibrosis TGF-β1 Raf-1

Discovery of novel KRAS-PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models

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Acta Pharmaceutica Sinica B 2022年第1期12卷 274-290页

作者： Long chen Jing Zhang Xinjing Wang Yu Li Lu Zhou Xiongxiong Lu Guoqiang Dong Chunquan sheng School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Pathology Changzheng HospitalSecond Military Medical UniversityShanghai 200003China Department of General Surgery Pancreatic Disease CenterRuijin HospitalShanghai Jiao Tong UniversityShanghai 200025China Research Institute of Pancreatic Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

KRAS-PDEδ interaction is revealed as a promising target for suppressing the function of mutant KRAS. The bottleneck in clinical development of PDEδ inhibitors is the poor antitumor activity of known chemotypes. Here, we identified novel spiro-cyclic PDEδ inhibitors with potent antitumor activity both in vitro and in vivo. In particular, compound 36 l(KD= 127 ± 16 nmol/L) effectively bound to PDEδ and interfered with KRAS-PDEδ interaction. It influenced the distribution of KRAS in Mia PaCa-2 cells, downregulated the phosphorylation of t-ERK and t-AKT and promoted apoptosis of the cells. The novel inhibitor 36 l exhibited significant in vivo antitumor potency in pancreatic cancer patient-derived xenograft(PDX) models. It represents a promising lead compound for investigating the druggability of KRAS-PDEδ interaction.

关键词： KRAS-PDEδinteraction PDX Spiro-cyclic inhibitors Lead optimization SBDD Anti-pancreatic cancer activity

电极/碱性聚电解质界面的微分电容曲线和零电荷电位测定

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电化学（中英文） 2024年第3期30卷 24-33页

作者：刘晨希邹泽萍胡梅雪丁宇谷宇刘帅南文静马溢昌陈招斌詹东平张秋根庄林颜佳伟毛秉伟厦门大学化学化工学院福建厦门361005 武汉大学化学与分子科学学院湖北武汉430072

碱性聚合物电解质作为现代碱性氢氧燃料电池的核心组成部分,其单离子导体的特性使得“电极/碱性聚电解质”界面的性质与“电极/溶液”界面有所不同。本文使用微电极,运用循环伏安、电化学交流阻抗以及浸入法等方法,测定了电极/碱性聚电... 详细信息

碱性聚合物电解质作为现代碱性氢氧燃料电池的核心组成部分,其单离子导体的特性使得“电极/碱性聚电解质”界面的性质与“电极/溶液”界面有所不同。本文使用微电极,运用循环伏安、电化学交流阻抗以及浸入法等方法,测定了电极/碱性聚电解质界面的微分电容曲线和零电荷电位。该界面的微分电容曲线呈“U”状,且存在局域极小值,该极小值所对应的电位与浸入法测得的零电荷电位数值一致。单离子导体的特性使得“电极/碱性聚电解质”界面在零电荷电位两侧表现出不同的电化学极化行为。

关键词：碱性物电解质双电层微电极微分电容曲线零电荷电位