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Improved creep aging response in Al-Cu alloy by applying pre-aging before pre-straining

Chinese Journal of Aeronautics 2023年第7期36卷 518-530页

作者： Fangpu LYU Chunhui LIU Peipei MA Jianshi YANG longhui chen Lihua ZHAN Minghui HUANG State Key Laboratory of Precision Manufacturing for Extreme Service Performance School of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Light Alloy Research Institute Central South UniversityChangsha 410083China Advanced Research Center Central South UniversityChangsha 410083China

The improvement of post-form properties without compromising creep formability has been a critical issue in creep age forming of aluminum alloy component. A pretreatment process incorporating artificial pre-aging at 165 °C for 6 h/12 h/24 h followed by pre-strain(3%–9%)has been developed. This method not only evidently improves the strength but also accelerates the creep deformation during creep aging of an Al-Cu alloy. A strength increase of 50 MPa with a slight decrease of ductility relative to the 9% pre-strained alloy is acquired in the alloy artificially pre-aged for 24 h regardless of the pre-strain level(3%–9%). Artificial aging for 24 h prior to 3%pre-strain enables an increase of creep strain by 30%. The creep strain in the alloy artificially preaged for 24 h and pre-strained by 6% is comparable to that in the alloy pre-strained by 9%. The strength and ductility in the alloy artificially pre-aged for 6 h/12 h and pre-strained by 3% are even slightly higher than those in the alloy purely pre-strained by 9%. The characterizations by transmission electron microscopy reveal that pre-aging at 165 °C could promote the accumulation of dislocations during pre-straining due to the pinning effect of pre-existing Guinier-Preston zones(GP zones)/θ’’phases and thus expedite the creep deformation in respect to the pure pre-straining treatment. The enhanced precipitation of θ’phases at these pinned dislocations contributes to the improved strength after creep aging. The results demonstrate applying artificial pre-aging before pre-straining is an efficient strategy to elevate the creep aging response in Al alloys.

关键词： Al-Cu alloy Creep aging Pre-aging Precipitation Pre-strain

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Weipixiao ameliorates gastric precancerous lesions in a rat's model by regulating GSK3β and C-myc

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Journal of Traditional Chinese Medicine 2018年第5期38卷 705-713页

作者： Zeng Jinhao Pan Huafeng Guo Jing Gong Daoyin Cai Tiantian chen Xiaodong Zhang Yi You Fengming chen longhui Zhao Ziming Liang Chao Clinical Medical College Chengdu University of Traditional Chinese MedicineChengdu 610075China Guangzhou University of Chinese Medicine Guangzhou 510405China Guangdong Provincial Institute of Chinese Medicine Guangzhou 510095China

OBJECTIVE: To investigate the mechanism underlying the action of Weipixiao(WPX) in a rat's model with ameliorating gastric precancerous lesions(GPL).METHODS: HPLC analysis was performed to identify the chemical constituents of WPX ***-Dawley rats were randomly assigned into control group, model group, vitacoenzyme group,high-dose WPX group(H-WPX), medium-dose WPX group(M-WPX) and low-dose WPX group(L-WPX).After modeling, the treated rats were administrated WPX or vitacoenzyme intragastrically for consecutive 10 weeks. Gene and protein expressions ofGSK3β, C-myc, Cylin E were evaluated by quantitative real-time reverse transcription-polymerase chain reaction(RT-qPCR) and immunohistochemistry, ***: WPX could efficiently attenuate the pathological alterations of "non-progressive GPL" in *** expected, mRNA and protein levels of C-myc and Cylin E were up-regulated in model rats, while GSK3β expression down-regulated(P < 0.01). WPX treatment, especially at low dose, could significantly down-regulate the m RNA as well as protein levels of C-myc, and could lead to remarkable up-regulation of mRNA and protein levels of GSK3β in GPL rats(P < 0.05). However, no significant changes were observed in WPX-treated ***: Our findings suggested that WPX-mediated attenuation of GPL pathological alterations might be due to its regulatory effect on the expressions of GSK3β and C-myc, and on the dysregulation of Wnt/GSK3β pathway.

关键词： Gastric precancerous lesions GSK3β C-myc Cylin E Weipixiao

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Influences of AMY1 gene copy number and protein expression on salivary alpha-amylase activity before and after citric acid stimulation in splenic asthenia children

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Journal of Traditional Chinese Medicine 2015年第3期35卷 266-272页

作者： Yang Zemin Lin Jing chen longhui Zhang Min Yang Xiaorong chen Weiwen Department of Biochemistry and Molecular Biology School of Basic CoursesGuangdong Pharmaceutical University Pi-Wei Institute Guangzhou University of Chinese Medicine Pediatrics of Traditional Chinese Medicine Haizhu Maternal and Child health Hospital Clinical Laboratory the First Affiliated Hospital of Guangdong Pharmaceutical University

OBjECTIVE:To compare the correlations between salivary alpha-amylase(sAA) activity and amylase,alpha 1(salivary) gene(AMY1) copy number or its gene expression between splenic asthenia and healthy children,and investigate the reasons of attenuated sAA activity ratio before and after citric acid stimulation in splenic asthenia ***:Saliva samples from 20 splenic asthenia children and 29 healthy children were collected before and after citric acid ***1 copy number,sAA activity,and total sAA and glycosylated sAA contents were determined,and their correlations were ***:Although splenic asthenia and healthy children had no differences in AMY1 copy number,splenic asthenia children had positive correlations between AMY1 copy number and sAA activity before or after citric acid *** asthenia children had a higher sAA glycosylated proportion ratio and glycosylated sAA content ratio,while their total sAA content ratio and sAA activity ratio were lower compared with healthy *** glycosylated sAA content ratio was higher than the total sAA content ratio in both *** asthenia and healthy children had positive correlations between total sAA or glycosylated sAA content and sAA ***,the role played by glycosylated sAA content in sAA activity in healthy children increased after citric acid stimulation,while it decreased in splenic asthenia ***:Genetic factors like AMY1 copy number variations,and more importantly,sAA glycosylation abnormalities leading to attenuated sAA activity after citric acid stimulation,which were the main reasons of the attenuated sAA activity ratio in splenic asthenia children compared with healthy children.

关键词： Spleen deficiency Salivary alpha-amylase AMY1A protein,human Glycosylation Citric acid stimulation

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Differential expression of immune-related genes between healthy volunteers and type 2 diabetic patients with spleen-deficiency pattern

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Journal of Traditional Chinese Medicine 2015年第6期35卷 646-652页

作者： chen longhui Yang Zemin chen Weiwen Li Ruliu Lin Chuanquan Guan Lihua Zhu Zhangzhi chen Ruifang Li Saimei Zhao Lingbo Zeng Jinhao Wang Jianhua Pi-wei Institute Guangzhou University of Chinese Medicine School of Basic Courses Guangdong Pharmaceutical University the First Affiliated Hospital of Guangzhou University of Chinese Medicine Clinical Medical College of Acupuncture Moxibustion and RehabilitationGuangzhou University of Chinese Medicine

OBJECTIVE: To investigate the clinical differentiation of spleen-deficiency pattern(SDP), a group of symptoms and signs defined in terms of Traditional Chinese Medicine for its clinical ***: Peripheral venous blood(> 3 m L) was collected from each of six type 2 diabetes mellitus(T2DM)-SDP patients and six healthy volunteers. After the isolation of peripheral white blood cells(PWBCs), total RNA was extracted, and quality control was performed on all RNA samples. Microarray experiments were conducted using the Agilent human whole genome gene chip, and genes demonstrating differential expression were screened. Bioinformatics analysis was conducted on these genes using several online ***: We screened a total of 175 differentially expressed genes(DEGs), of which 111(63%) were down-regulated and 64(37%) were up-regulated in T2DM-SDP patients compared with healthy controls. Among the 175 genes, 158 had biological function annotations: 46(29%) were directly related to an individual's immune regulation or response, 25(16%) were associated with substance and energy metabolism of PWBCs which could also indirectly influence immunity, and the remaining87(55%) were involved in a variety of PWBC biological processes that might eventually influence the immune function. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that the DEGs were predominantly enriched in seven immune-related pathways. Hierarchical cluster analysis identified gene expression patterns that were distinguishable between the two study ***: Our results suggest that T2DM-SDP patients experience significant hypoimmunity and/or immune dysfunctions, and possess a specific gene expression profile. These findings offer new insights into SDP and the clinical pattern differentiation of T2DM-SDP.

关键词： Diabetes mellitus, Type 2 Immunity Metabolism Leukocytes Oligonucleotide array se-quence analysis Spleen-deficiency pattern

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不同化学改性方法提高玉米芯骨料混凝土的性能

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农业工程学报 2024年第11期40卷 220-226页

作者：范炜刘国超陈龙辉王德辉福建江夏学院新型高性能混凝土材料与结构福建省高校工程研究中心福州350108 福州大学土木工程学院福州350108 福建筑兆建设有限公司厦门361000

玉米芯具有较低的导热系数,可以作为天然的保温材料,用于混凝土砌块中。然而,由于玉米芯的多孔结构,导致玉米芯骨料混凝土的抗压强度偏低,亟需进行改性。为了推广玉米芯的规模化利用,该研究以玉米芯为原料改善混凝土砌块的性能,通过红... 详细信息

玉米芯具有较低的导热系数,可以作为天然的保温材料,用于混凝土砌块中。然而,由于玉米芯的多孔结构,导致玉米芯骨料混凝土的抗压强度偏低,亟需进行改性。为了推广玉米芯的规模化利用,该研究以玉米芯为原料改善混凝土砌块的性能,通过红外光谱、拉曼光谱和扫描电镜等测试手段,探讨了3种不同改性技术对玉米芯骨料混凝土水化产物化学键、分子结构、界面过渡区微观结构、抗压强度和导热系数的影响。结果表明:与环氧树脂改性相比,陶粒法改性和裹浆法改性不仅增加了玉米芯骨料混凝土界面过渡区的水化硅酸钙凝胶含量,同时也降低了界面过渡区的厚度,优化了混凝土砌块的微观结构、提高了混凝土砌块的抗压强度、降低了混凝土砌块的导热系数。其中,陶粒法改性技术的效果尤为明显。界面过渡区厚度水化硅酸钙特征峰由大到小顺序分别为陶粒法改性、裹浆法改性、环氧树脂改性。经过陶粒法改性、裹浆法改性和环氧树脂改性后,玉米芯骨料混凝土的界面过渡区分别为无明显界面过渡区、55~66 μm和93~101 μm之间。和未改性玉米芯骨料混凝土相比,掺30%陶粒法改性玉米芯骨料混凝土的抗压强度的导热系数分别降低了51.5%和32.2%。当掺入不超过15%的改性玉米芯骨料时,混凝土砌块满足国家标准GB/T8239-2014中对抗压强度的要求。为了改善玉米芯骨料混凝土砌块的综合性能,建议掺入不超过15%的陶粒法改性玉米芯骨料。研究结果为玉米芯在混凝土砌块中的大规模利用提供了依据,同时也为进一步改善混凝土砌块的相关性能提供了参考。

关键词：抗压强度导热系数玉米芯改性技术水化产物界面过渡区

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灼烙法治疗慢性扁桃体炎68例

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陕西中医 2006年第3期27卷 342-344页

作者：胡文健陈隆晖四川泸州医学院附属中医(第二)医院 646000

目的:观察分析中医灼烙方法治疗慢性扁桃体炎的临床效果。方法:对68例进行中医灼烙方法治疗,对照组54例采用超短波治疗;结果:治疗组总有效率为91.17%,对照组为61.11%;结论:中医灼烙方法简便、安全、可靠、价廉,适应年龄广(3～70岁),疗... 详细信息

目的:观察分析中医灼烙方法治疗慢性扁桃体炎的临床效果。方法:对68例进行中医灼烙方法治疗,对照组54例采用超短波治疗;结果:治疗组总有效率为91.17%,对照组为61.11%;结论:中医灼烙方法简便、安全、可靠、价廉,适应年龄广(3～70岁),疗效显著。

关键词：扁桃体炎中医药疗法灼烙法临床效果

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大型公共建筑中处理地基方案的选择及应用--以某图书信息楼为例

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工程质量 2021年第11期39卷 54-57页

作者：陈龙辉广东工贸职业技术学院广东广州510510

工程建设中地基处理越来越普遍,处理地基的方法也非常丰富,很多大型公共建筑的地基需要处理后才能满足安全性要求。以某图书信息楼为例,通过分析比较处理地基方案,选择水泥土搅拌桩复合地基对该工程进行地基处理,最后经施工质量检测证... 详细信息

工程建设中地基处理越来越普遍,处理地基的方法也非常丰富,很多大型公共建筑的地基需要处理后才能满足安全性要求。以某图书信息楼为例,通过分析比较处理地基方案,选择水泥土搅拌桩复合地基对该工程进行地基处理,最后经施工质量检测证明此处理方法在该工程应用中效果良好,值得在类似工程中进行应用。

关键词：大型公共建筑处理地基水泥土搅拌桩复合地基

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公路桥梁工程中预应力施工技术的应用

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上海建材 2024年第3期 87-90页

作者：陈龙辉漳州市公路事业发展中心应急保障分中心福建漳州363100

为降低公路桥梁工程大跨度施工建设难度,本文介绍了预应力施工技术的应用局限,并以实际工程项目为例,分析了预应力施工技术的优化应用策略,即技术流程规范与工艺控制要点。结果表明:公路桥梁工程建设者需结合图纸要求与场地条件来落实... 详细信息

为降低公路桥梁工程大跨度施工建设难度,本文介绍了预应力施工技术的应用局限,并以实际工程项目为例,分析了预应力施工技术的优化应用策略,即技术流程规范与工艺控制要点。结果表明:公路桥梁工程建设者需结合图纸要求与场地条件来落实支架、模板与钢筋、混凝土以及张拉等施工操作控制,进而使预应力结构稳定性作用效果充分发挥出来;在工艺方面,同样需要按照既定要求,对下料、压浆、穿索以及碳纤维加固进行有效控制,规避不合理施工操作因素的影响。

关键词：公路桥梁预应力张拉钢绞线

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