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Ethnic Chinese Medicine,Borderless Civilization--On the Identity of Humane and Scientific Nature of Chinese and Western Medicines

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Chinese Journal of Integrative Medicine 2017年第8期23卷 563-565页

作者： chen ke-ji Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing 100091China

The identity of Eastern and Western cultures should include aspects such as its concepts of societal development and science and *** this is related to issues like history of the culture and regional cultural psycholo... 详细信息

关键词： Ethnic Chinese Medicine,Borderless Civilization On the Identity of Humane and Scientific Nature of Chinese and Western Medicines

Evidence-Based Clinical Chinese Medicine: Novel Exploration through Global Vision

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Chinese Journal of Integrative Medicine 2019年第11期25卷 879-880页

作者： chen ke-ji Center of Cardiovascular Diseases Xiyuan Hospital Academy of Chinese Medical Sciences

In 2008, the Royal Melbourne Institute of Tech no logy (RMIT University, Australia) and the Guangdong Provincial Hospital of Chinese Medicine (GPHCM, China) initiated an inter national cooperati on network for evidence-based clinical Chinese medicine (CM). Based on the exciting successful collaboration, the establishment of China-Australia International Research Centre for Chinese Medicine (the Centre) supported by both institutions was approved by the government in 2013.

关键词： RMIT GPHCM Guangdong

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中西药杂合体多靶点抗阿尔茨海默病研究进展

中国中西医结合杂志 2024年第3期44卷 373-378页

作者：胡胜全陈可冀吴正治深圳市转化医学研究院深圳大学第一附属医院/深圳市第二人民医院深圳518035 深圳市老年医学研究所深圳518035 中国中医科学院西苑医院心血管病中心国家中医心血管病临床医学研究中心北京100091

阿尔茨海默病(Alzheimer's disease,AD)是最为常见的中枢神经系统退行性疾病。目前临床AD治疗药物包括多奈哌齐(donepezil)、利斯的明(rivastigmine)、美金刚(memantine),以及源于天然药用植物石蒜科雪花莲的加兰他敏(galantamine)和千... 详细信息

阿尔茨海默病(Alzheimer's disease,AD)是最为常见的中枢神经系统退行性疾病。目前临床AD治疗药物包括多奈哌齐(donepezil)、利斯的明(rivastigmine)、美金刚(memantine),以及源于天然药用植物石蒜科雪花莲的加兰他敏(galantamine)和千层塔的石杉碱甲(huperzine A)。但这些药物大多作用于单一靶点,无法延缓AD进程。原因在于:随着AD病程进展,各种AD神经毒素相互影响,神经元损伤级联性放大。

关键词：杂合体加兰他敏阿尔茨海默病石蒜科石杉碱甲神经毒素利斯的明美金刚

Innovative Modernization and Industrialization of Traditional Chinese Medicine

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Chinese Journal of Integrative Medicine 2020年第8期26卷 563-564页

作者： chen ke-ji CAS National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

Since the founding of New China 70 years ago,remarkable achievements have been attained in the fields of traditional Chinese medicine(TCM)and integrated Chinese and Western medicine(ICWM).At the education front,generations of new Chinese medicine practitioners have been trained and cultivated,and in basic medical research and clinical services,great strides were made drawing worldwide attention.

关键词： medicine(TCM) Medicine clinical

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基于贝叶斯网络评价中医药疗效思路与方法

中国中西医结合杂志 2024年第4期44卷 486-491页

作者：甘叶娜李多多梁少伟陈可冀刘建平北京中医药大学东直门医院推拿疼痛科北京100700 深圳市人工智能与机器人研究院深圳518129 中国中医科学院西苑医院心血管病中心北京100091 北京中医药大学循证医学中心北京100029

中医药疗效评价研究是推动中医药现代化、国际化发展的重要内容,但通过现有疗效评价方法常难以表示和呈现真实世界研究证据间潜在的因果关联。贝叶斯网络可利用网络来解析场景中潜在的因果关联,并对其进行动态更新,若能运用此方法来表... 详细信息

中医药疗效评价研究是推动中医药现代化、国际化发展的重要内容,但通过现有疗效评价方法常难以表示和呈现真实世界研究证据间潜在的因果关联。贝叶斯网络可利用网络来解析场景中潜在的因果关联,并对其进行动态更新,若能运用此方法来表示和呈现中医药诊疗研究证据,将有望从因果关联视角更清晰地了解、说明和评价中医药临床疗效的研究证据。

关键词：中医药疗效评价贝叶斯网络临床研究方法真实世界研究证据

Comparison on Anticoagulation and Antiplatelet Aggregation Effects of Puerarin with Heparin Sodium and Tirofiban Hydrochloride: An In Vitro Study

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Chinese Journal of Integrative Medicine 2018年第2期24卷 103-108页

作者： LI Si-wei FENG Xue XU Hao chen ke-ji Cardiovascular Center Xiyuan HospitalChina Academy of Chinese Medical Sciences Xiyuan Hospital Postdoctoral Research Station of China Academy of Chinese Medical Sciences Cardiac Rehabilitation Center Fuwai HospitalChinese Academy of Medical Sciences

Objective： To detect the anticoagulation and antiplatelet effects of different concentrations of puerarin, heparin sodium and tirofiban hydrochloride on the blood samples of healthy volunteers by Sonoclot coagulation and platelet function analyzer. Methods： Peripheral blood samples were extracted from 20 healthy volunteers, followed by adding different concentrations of puerarin, heparin sodium and tirofiban hydrochloride. Samples were detected for activated clotting time（ACT）, clot rate（CR） and platelet function（PF） by Sonoclot coagulation and platelet function analyzer instrument. Results： For puerarin and heparin sodium, the values of ACT gradually increased, and the values of CR and PF gradually decreased with increasing in drug concentration. There was a linear（or log linear） relationship between ACT, CR, PF value and drug concentration（P〈0.01）. Corresponding to each value, a regression equation was obtained. For tirofiban hydrochloride, the values of ACT and CR had no significant changes, while PF values gradually decreased with concentration increasing. There was also a linear relationship between PF values and concentrations of tirofiban hydrochloride（P〈0.01）. Under the same ACT values, the puerarin corresponding CR values（CR = e^（-0.0062） ACT＋4.31, P〈2.2 e^（-16）） were always higher than the corresponding values（CR = e-^（0.0028） ACT＋2.79, P-value〈2.2 e^（-16）） of heparin sodium. For high concentrations of puerarin（e.g. 3.8 mg/600 μL） and tirofiban hydrochloride（e.g. 0.8 μg/600 μL）, PF values had no significant difference. However, PF values for high puerarin concentration had a larger variance. Conclusions： Puerarin has similar anticoagulant and antiplatelet effects with the heparin sodium, and may have a lower hemorrhage risk than heparin sodium when obtained the same anticoagulation effect in the concentration range of this experiment. In addition, for high concentration, puerarin had the same antiplatelet function as tirofiban hydrochloride but with a larg

关键词： puerarin heparin tirofiban hydrochloride in vitro Sonoclot coagulation analyzer anticoagulation antiplatelet aggregation

基于病证结合探讨心房颤动中西医诊疗康复思路

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中国中西医结合杂志 2024年第9期44卷 1114-1118页

作者：闫龙美陈可冀陈斌邢雅璇高慧容陈益多李慧张京春北京中医药大学研究生院北京100029 中国中医科学院西苑医院心血管科国家中医心血管病临床医学研究中心北京100091 北京市健宫医院心血管内科北京100054

心房颤动(房颤)患病率较高,临床特点复杂多变,单一模式在防治房颤研究中存在不足,基于病证结合的中西医临床诊疗康复实践较为适合患者临床需求。本文探讨中西医结合治疗房颤的病证结合模式,从房颤的病证特点、诊疗思路和综合康复等方面... 详细信息

心房颤动(房颤)患病率较高,临床特点复杂多变,单一模式在防治房颤研究中存在不足,基于病证结合的中西医临床诊疗康复实践较为适合患者临床需求。本文探讨中西医结合治疗房颤的病证结合模式,从房颤的病证特点、诊疗思路和综合康复等方面进行了阐述,强调了“中西互参,优势互补;病证结合,精准辨治;形神合一,双心同调”的诊疗原则。

关键词：心房颤动病证结合中西医结合临床诊疗中医康复

Clinical Practice Guideline of Integrative Chinese and Western Medicine for Acute Myocardial Infarction

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Chinese Journal of Integrative Medicine 2020年第7期26卷 539-551页

作者： LIAO Peng-da chen ke-ji GE Jun-bo ZHANG Min-zhou Guangdong Provincial Hospital of Chinese Medicine Guangzhou(510120)China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou(510120)China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing(100091)China Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan UniversityShanghai(200032)China

With increasing morbidity and mortality,acute myocardial infarction(AMI)has become one of the major causes of human death,leading to heavy burdens to individuals,families and *** researches have found that though large amount of resources and great effort were devoted,no significant improvements were achieved in reducing the in-hospital mortality of AMI ***,extensive studies about Chinese medicine(CM)have found that CM has special advantages in treating AMI ***,there is no standardized and unified clinical practice guideline(CPG)of CM for ***,a CPG with strict standard and generally acknowledgement is urgent to be *** guideline was developed following the methodological process established by the World Health Organization Handbook for Guideline *** search on clinical evidences including systematic review(SR),randomized controlled trial(RCT),observational study and case reports was launched,covering evidence of CM for AMI on several aspects,such as diagnosis,CM patterns,CM interventions on AMI and complications,cardiac rehabilitation and clinical pathway ***,the application of Grading of Recommendations Assessment,Development and Evaluation(GRADE)approach enabled the evaluation of evidence and formulation of grade of recommendation(GOR)and level of evidence(LOE).With the help of GOR and LOE,this CPG recommends the integrative CM and WM treatment method in AMI patients and provides useful information on medical decision for clinical physicians.

关键词： acute myocardial infarction integrative Chinese and Western medicine clinical practice guideline

Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics:Two Examples of Rheumatoid Arthritis

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Chinese Journal of Integrative Medicine 2021年第6期27卷 465-469页

作者： ZHANG Chi LI Li ZHANG Ge chen ke-ji LU Ai-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Institute for Advancing Translational Medicine in Bone and Joint Diseases Hong Kong Baptist UniversityHong Kong SARChina Cardiovascular Disease Centre Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China

Biological complexity and the need for personalized medicine means that biomarker development has become increasingly ***,new paradigms for research need to be created that bring together a different classifier of *** potential solution is collaboration between biomarker development and Chinese medicine pattern *** this article,two examples of rheumatoid arthritis are discussed,including a new biomarker candidate casein kinase 2 interacting protein 1(CKIP-1)and a micro RNA *** authors obtained a"snapshot"of pattern classification with disease in biomarker *** analyses revealed underlying biological functions of two biomarker candidates,in varying degrees,are correlated with Chinese medicine pattern of rheumatoid *** authors'initial attempt can provide a new window for studying the win-win potential correlation between the biomarkers and pattern classification in Chinese medicine.

关键词： Chinese medicine pattern classification biomarker rheumatoid arthritis