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Lycium barbarum glycopeptide(wolfberry extract)slows N-methyl-N-nitrosourea-induced degradation of photoreceptors

Neural Regeneration Research 2024年第10期19卷 2290-2298页

作者： Qihang kong Xiu Han Haiyang cheng Jiayu Liu Huijun Zhang Tangrong Dong Jiansu chen Kwok-Fai So Xuesong Mi Ying Xu Shibo Tang Department of Ophthalmology Aier Eye HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong kong-Macao Institute of CNS Regeneration Key Laboratory of CNS Regeneration(Ministry of Education)Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology Guangzhou Panyu Central HospitalGuangzhouGuangdong ProvinceChina School of Stomatology Jinan UniversityGuangzhouGuangdong ProvinceChina Aier Academician Station ChangshaHunan ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina State Key Laboratory of Brain and Cognitive Sciences Hong Kong Special Administrative RegionChina

Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photoreceptors in rd1, a transgenic mouse model of retinitis pigmentosa. L. barbarum glycopeptide(Lb GP) is an immunoreactive glycoprotein extracted from LBP. In this study, we investigated the potential protective effect of Lb GP on a chemically induced photoreceptor-degenerative mouse model. Wild-type mice received the following: oral administration of Lb GP as a protective pre-treatment on days 1–7;intraperitoneal administration of 40 mg/kg N-methylN-nitrosourea to induce photoreceptor injury on day 7;and continuation of orally administered Lb GP on days 8–14. Treatment with Lb GP increased photoreceptor survival and improved the structure of photoreceptors, retinal photoresponse, and visual behaviors of mice with photoreceptor degeneration. Lb GP was also found to partially inhibit the activation of microglia in N-methyl-N-nitrosourea-injured retinas and significantly decreased the expression of two pro-inflammatory cytokines. In conclusion, Lb GP effectively slowed the rate of photoreceptor degeneration in N-methyl-N-nitrosourea-injured mice, possibly through an anti-inflammatory mechanism, and has potential as a candidate drug for the clinical treatment of photoreceptor degeneration.

关键词： anti-inflammation inherited retinal diseases Lycium barbarum glycopeptide N-methyl-N-nitrosourea opsin photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa rhodopsin

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Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

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Nano-Micro Letters 2024年第12期16卷 59-80页

作者： Qing chen Miao Yan Annan Hu Bing Liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia Dihan Su Biao kong Wei Hong Libo Jiang Jian Dong Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai 200032People’s Republic of China Department of Chemistry Fudan UniversityShanghai 200438People’s Republic of China Department of Surgery Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore Department of Geriatrics and Gerontology Huadong HospitalFudan UniversityShanghai 200438People’s Republic of China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438People’s Republic of China Department of Orthopaedic Surgery Zhongshan Hospital Wusong Branch Fudan UniversityShanghai 200940People’s Republic of China

Surgery remains the standard treatment for spinal ***,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical *** this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril *** superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse *** near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled ***-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal *** minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

关键词： Silk fibroin Nanofibril hydrogels Nanorobots Thrombin Spinal metastasis

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CNT array-induced nanobubble assembly,nanodisk fabrication and enhanced spectral detection of CNT bundle density

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Nano Research 2024年第8期17卷 7737-7745页

作者： Zhiyuan Xia Ziming Ye Bo Zhao Tingsong Zhang Qi Wang Kun chen Meng Li Xiaobing kong Yu-Qing Zheng Enzheng Shi Yuanyuan Shang Anyuan Cao School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Integrated Circuits Peking UniversityBeijing 100871China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Engineering Westlake UniversityHangzhou 310024China

Alignment,functionalization and detection of carbon nanotube(CNT)bundles are vital processes for utilizing this onedimensional nanomaterial in ***,we report a polymer-assisted wet shearing method to acquire super-aligned craterpatterned CNT arrays by nanobubble(NB)self-assembly with a"migrate and aggregation"mechanism and use craters to controllably mold even-sized nanodisks periodically along CNT bundles with tunable *** green,low-cost method can be extended to diverse substrates and fabricate different *** an example,the Ag-nanodisk-patterned CNT arrays are utilized as substrates of surface-enhanced Raman scattering(SERS)for rhodamine 6G(R6G)and methylene blue(MB)in which a linear correlation is found between the SERS intensity and the CNT bundle density due to the periodic distribution of hot spots,enabling a spectral detection of CNT bundles and their densities by conventional dye *** from routine morphological characterization,this spectral method possesses an enhanced accuracy and a detection range of 0.1–2μm^(–1),showing its uniqueness in the detection of CNT bundle density since the intensity of traditional spectral merely relates to the quantity of CNTs,exhibiting its potential in future CNT-bundle-based electronics.

关键词： CNT arrays nanobubbles self-assembly nanodisks surface-enhanced Raman scattering(SERS)

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阿散酸及其降解产物对鱼和蚯蚓的遗传毒性

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环境科学与技术 2007年第4期30卷 11-13页

作者：孔志明孔琛污染控制与资源化研究国家重点实验室南京大学环境学院南京210093 南京大学图书馆南京210093

为了全面评价有机胂制剂阿散酸对水生生物和土壤生物的遗传毒性效应,文章分别以红鲤鱼和赤子爱胜蚓为生物材料,采用单细胞凝胶电泳技术从细胞水平上研究了阿散酸降解前后对鲤鱼肾细胞和蚯蚓体腔细胞DNA的损伤。鲤鱼肾细胞单细胞凝胶电... 详细信息

为了全面评价有机胂制剂阿散酸对水生生物和土壤生物的遗传毒性效应,文章分别以红鲤鱼和赤子爱胜蚓为生物材料,采用单细胞凝胶电泳技术从细胞水平上研究了阿散酸降解前后对鲤鱼肾细胞和蚯蚓体腔细胞DNA的损伤。鲤鱼肾细胞单细胞凝胶电泳试验结果表明,阿散酸降解之前和降解的第4周阿散酸对鲤鱼肾细胞DNA有显著损伤,表现出明显的遗传毒性作用,但第二周却不引起鲤鱼肾细胞DNA的任何损伤。蚯蚓体腔细胞单细胞凝胶电泳试验结果表明,阿散酸降解之前不能诱导蚯蚓体腔细胞DNA的明显损伤,不表现遗传毒性效应,与对照组相比没有显著性差异(P>0.05);但阿散酸降解开始后,各浓度的降解混合物体系都能引起蚯蚓体腔细胞DNA的明显损伤,表现出较强的遗传毒性作用。

关键词：阿散酸鱼类蚯蚓降解产物单细胞凝胶电泳遗传毒性

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Residue behaviors and dietary risk assessment of dinotefuran and its metabolites in Lycium barbarum from farm to fork

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Food Science and Human Wellness 2024年

作者： Ouli Xiao Minmin Li Jieyin chen Ran Wang Xiaofeng Dai Zhiqiang kong State Key Laboratory for Biology of Plant Diseases and Insect Pests， Institute of Plant Protection， Chinese Academy of Agricultural Sciences Western Agricultural Research Center， Chinese Academy of Agricultural Sciences Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process， Ministry of Agriculture and Rural Affairs/Institute of Food Science and Technology， Chinese Academy of Agricultural Sciences Institute of Plant Protection， Beijing Academy of Agriculture and Forestry Sciences

Lycium barbarum， known as wolfberry or goji berry， is consumed by humans as a medicine and a food homology product. Conventionally grown wolfberry is often treated extensively with pesticides， which could pose a hazard to humans. Here， the degradation dynamics of dinotefuran and its two metabolites (UF and DN)， during wolfberry cultivation and processing was investigated. The half-life (T1/2) of dinotefuran was 11.36 d and 9.12 d， respectively， under the recommended dosage and double the recommended dosage. During the oven and sun drying processes， processing factors (PFs) of dinotefuran were 1.07 - 1.34， implying the enrichment of pesticide residues. Decoction process made the removal rate of dinotefuran reach 87.48%， which is higher than that of the brewing process (14.7%)， while dinotefuran remained in the wine with high ethanol content in the alcohol soaking process. The hazard quotient (HQ) of dinotefuran， as determined via dietary risk assessment combined with PFs， was gastric (5.45% - 86.72%) > oral (23.18%) via in vitro simulated digestive system. These findings provide scientific evidence for reasonable application and risk assessment of dinotefuran residues in wolfberry.

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基于大偏差理论的随机动力学研究

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力学进展 2020年第1期50卷 358-405页

作者：朱金杰陈朕孔琛刘先斌南京理工大学机械工程学院南京210094 南京航空航天大学机械结构力学及控制国家重点实验室南京210016 罗切斯特大学大脑与认知科学系美国罗切斯特146274 远景能源(江苏)有限公司数字化产品开发与应用部上海200051

本文介绍了大偏差理论的基本思想、基本概念以及大偏差理论在离出问题研究中的应用.本文评述了有关离出问题的三个重要指标:平均首次离出时间、离出位置分布和最优离出路径相关研究的思路和方法,而其中对最优离出路径的刻化是结构性的难... 详细信息

本文介绍了大偏差理论的基本思想、基本概念以及大偏差理论在离出问题研究中的应用.本文评述了有关离出问题的三个重要指标:平均首次离出时间、离出位置分布和最优离出路径相关研究的思路和方法,而其中对最优离出路径的刻化是结构性的难题.针对平均首次离出时间,本文介绍了它与拟势的关系,并应用平均首次离出时间的结论分析了随机共振以及自诱导随机共振中的时间匹配机制.对于离出位置分布,本文介绍了提高蒙特卡罗模拟速度的相关算法,并重点评述了其中的概率演化算法和相关的算例.最后,对于最优离出路径的研究,本文讨论了几类计算方法,分析了最优路径满足的辅助哈密尔顿系统轨线由于非线性多值性形成的拉格朗日流形拓扑结构的奇异性及其动力学含义,并进一步给出了有限噪声强度激励条件下的作用量修正方法.最后,给出了大偏差理论应用发展的一些开放性问题的展望.

关键词：大偏差理论离出问题最优离出路径平均首次离出时间离出位置分布

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Defatted Hickory Meal Hydrolysate's Impact on Memory Impairment Induced by D-Galactose in Mice

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Food Science and Human Wellness 2024年

作者： Fanping Qin Ruiling Liu Qi kong Hangjun chen Xiangjun Fang Huizhi chen Weijie Wu Haiyan Gao State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Post-Harvest Vegetable Preservation and Processing (Co-construction by Ministry and Province)， Ministry of Agriculture and Rural Affairs，Key Laboratory of Light Industry Fruit and Vegetable Preservation and Processing， Institute of Food Science， Zhejiang Academy of Agricultural Sciences

Defatted hickory meal (DHM)， a by-product of hickory oil production， is a protein source rich in essential amino acids. In this study， the functional properties of DHM hydrolysate (DHMH) were assessed using in vitro and in vivo assays in context to its antioxidant and memory-enhancing effects. To induce memory impairment， D-galactose (D-gal) was administered to mice at a dose of 120 mg/kg body weight per day， and DHMH was orally administered at doses of 300， 600， and 1000 mg/kg body weight per day for 8 weeks. DHMH treatment led to improved memory performance in D-gal-induced memory-impaired mice， as observed in the Morris water maze test. Furthermore， DHMH mitigated the accumulation of amyloid beta 1-42 triggered by D-gal exposure. Notably， high-dose DHMH significantly reduced the elevation of pro-inflammatory markers， including tumor necrosis factor alpha， interleukin 1β， and interleukin 6. Additionally， DHMH prevented the decline in total superoxide dismutase activity， glutathione peroxidase activity， and glutathione levels， while reducing malondialdehyde content in D-gal-induced mice， indicative of its antioxidant properties. Moreover， DHMH treatment effectively prevented histological alterations in neurons within the hippocampal CA1 area induced by D-gal. Collectively， our findings suggest that DHMH may counteract memory dysfunctions resulting from oxidative stress injury in the brain， positioning it as a potential candidate for use as a functional food.

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系列C3α-位芳基取代的四氢吡咯并吲哚骨架衍生物的合成

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高等学校化学学报 2013年第4期34卷 846-852页

作者：孔晨王雨王霞王琼宋颢四川大学华西药学院靶向药物与释药系统教育部重点实验室成都610041 四川大学华西第二医院西部妇幼研究院分子与转化医学实验室成都610041

通过银促进的傅-克反应可以合成系列C3α-位为不同类型芳基取代的四氢吡咯并吲哚骨架的类天然产物.在该合成方法的基础上,发现C3α-位分别为对乙酰氨基苯基取代和甲基吲哚取代的四氢吡咯并吲哚类衍生物3a和3b对多种肿瘤细胞均表现出微... 详细信息

通过银促进的傅-克反应可以合成系列C3α-位为不同类型芳基取代的四氢吡咯并吲哚骨架的类天然产物.在该合成方法的基础上,发现C3α-位分别为对乙酰氨基苯基取代和甲基吲哚取代的四氢吡咯并吲哚类衍生物3a和3b对多种肿瘤细胞均表现出微摩尔级的活性,是具有重要临床应用前景的药物候选化合物.为了进一步研究该类化合物的成药性及其构效关系,以化合物3a为前体化合物合成了一系列类天然产物(化合物4～17),对其抗肿瘤活性进行了研究,并初步探讨了其构效关系.所合成化合物的结构经1H NMR、13C NMR和HRMS分析确证.本研究为该类化合物的临床前研究奠定了基础.

关键词：四氢吡咯并吲哚生物碱衍生物抗肿瘤构效关系

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二二八事件中的本省人与外省人

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台湾研究集刊 2006年第3期 52-59,66页

作者：陈孔立厦门大学台湾研究中心福建厦门361005

台湾“二二八事件”已经得到“平反”,本省人的受难者得到赔偿,但外省人中的受害者却尚未得到公正的待遇,其中涉及一些历史真相问题。本文就当时本省人与外省人的关系做全面的考察,试图说明其复杂性,并澄清一些被某些人出于政治目的加... 详细信息

台湾“二二八事件”已经得到“平反”,本省人的受难者得到赔偿,但外省人中的受害者却尚未得到公正的待遇,其中涉及一些历史真相问题。本文就当时本省人与外省人的关系做全面的考察,试图说明其复杂性,并澄清一些被某些人出于政治目的加以掩盖或歪曲的事实。着重指出,作为当年本省人与外省人关系的主导面,一般老百姓是和平相处,互相帮助的;外省人的受害者是国民党政府的替罪羊,理应由现在的国民党做出正确的处理。

关键词：二二八事件本省人外省人受难者

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组织认同与亲组织财务报告舞弊决策——多重中介效应分析

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经济管理 2020年第9期42卷 176-192页

作者：陈邑早张莹孔晨东北财经大学会计学院辽宁大连116025 青岛农业大学管理学院山东青岛266109

本文采用情景模拟的调查研究方法,从亲组织动机视角切入,考察了行为人亲组织财务报告舞弊决策的影响因素。实证结果证实,组织认同对亲组织财务报告舞弊具有显著的正向影响。进一步,考察了上述影响的作用机理,结果表明,道德辩护、负性情... 详细信息

本文采用情景模拟的调查研究方法,从亲组织动机视角切入,考察了行为人亲组织财务报告舞弊决策的影响因素。实证结果证实,组织认同对亲组织财务报告舞弊具有显著的正向影响。进一步,考察了上述影响的作用机理,结果表明,道德辩护、负性情绪在组织认同和亲组织财务报告舞弊之间发挥着同步和链式中介效应。此外,通过对比中介效应发现,道德辩护所揭示的认知作用路径影响最大,负性情绪所揭示的情绪作用路径次之,而两者的链式作用路径影响最低。

关键词：组织认同亲组织财务报告舞弊道德辩护负性情绪

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