检索结果-南通市图书馆

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第20期9卷 5442-5452页

作者： Jian-xia Xiong Tao Cai Li Hu xiao-Li chen Kun Huang Ai-Jun chen Ping wang Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Dermatofibrosarcoma protuberans(DFSP)is a rare low-grade malignant soft tissue tumor characterized by rosette-like infiltrative *** recurrence of this tumor is very *** To evaluate the risk factors related to recurrence after wide local excision(WLE)of DFSP and to guide clinical diagnosis and *** The medical records of 44 DFSP patients confirmed by pathology at our hospital from 2012 to 2019 were retrospectively *** relationship between clinical features,tumor characteristics,treatment,and recurrence risk were analyzed,and the possible risk factors for postoperative tumor recurrence were *** There were 44 patients in total,including 21 males and 23 *** median progression free survival was 36 mo(range,1-240 mo).Twenty patients were treated for the first time,while 24 had previous treatment ***-two cases were followed for 25.76±22.0 mo,among whom four(9.52%)experienced recurrence after WLE(rate was 9.52%).The recurrence rate in the recurrent group was higher than that in the patients with primary tumor(19.05%vs 0%,P=0.028).Eighteen cases had a history of misdiagnosis(rate was 40.91%).The recurrence rate among patients with previous experience of misdiagnosis was significantly higher than in patients without(68%vs 36.84%,P=0.04).The tumor diameter in patients with a history of treatment was larger than in patients treated for the first time(4.75±0.70 cm vs 2.25±0.36 cm,P=0.004).CONCLUSION To sum up,the clinical manifestations of DFSP are not specific and are easily misdiagnosed,thus commonly causing the recurrence of *** incomplete resection,the tumor may rapidly *** recurrence history may be a risk factor for postoperative recurrence,and tumor location may have an indirect effect on postoperative recurrence;however,we found no significant correlation between sex,age,course of the disease,or tumor size and postoperative recurrence.

关键词： Dermatofibrosarcoma protuberans Recurrence Clinical features Wide local excision Surgery Retrospective research

Intracellular alpha-fetoprotein mitigates hepatocyte apoptosis and necroptosis by inhibiting endoplasmic reticulum stress

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第26期28卷 3201-3217页

作者： Yun-Fen chen Si-ying Liu Qi-Jiao cheng Yu-Jiao wang Shuang chen Yi-Yang Zhou xia Liu Zhi-Gang Jiang Wei-Wei Zhong Yi-Huai He Department of Infectious Diseases The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of General Medicine The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina School of Public Health Zunyi Medical UniversityZunyi 563099Guizhou ProvinceChina Department of Endoscopy Jingmen No.1 People’s HospitalJingmen 448000Hubei ProvinceChina

BACKGROUND Endoplasmic reticulum(ER)stress contributes to the pathogenesis of chronic liver diseases,but how hepatocytes respond to ER stress has not been ***(AFP)is secreted by hepatoma cells and elevated levels of serum AFP are associated with development of liver *** To investigate whether and how AFP could regulate ER stress and hepatocyte *** The distribution of AFP and the degrees of ER stress in liver tissues and liver injury were characterized by histology,immunohistochemistry,and Western blot in biopsied human liver specimens,two mouse models of liver injury and a cellular *** levels of AFP in sera and the supernatants of cultured cells were quantified by *** High levels of intracellular AFP were detected in liver tissues,particularly in the necrotic areas,from patients with chronic liver diseases and mice after carbon tetrachloride(CCl4)administration or induction of ER stress,but not from the *** induced intracellular AFP was accompanied by elevated activating transcription factor-6(ATF6)expression and protein kinase R-like ER kinase(PERK)phosphorylation in mouse *** stress induced AFP expression in LO2 cells and decreased their ***6,but not PERK,silencing mitigated the ER-stress-induced AFP expression in LO2 ***,AFP silencing deteriorated the ER stress-mediated LO2 cell injury and CCl4 administration-induced liver damages by increasing levels of cleaved caspase-3,the C/enhancer binding protein homologous protein expression,mixed lineage kinase domain-like pseudokinase and PERK phosphorylation,but decreasing ATF6 *** ER stress upregulated intra-hepatocyte AFP expression by activating ATF6 during the process of liver injury and intracellular AFP attenuated hepatocyte apoptosis and necroptosis by alleviating ER stress.

关键词： Alpha-fetoprotein Endoplasmic reticulum stress Necroptosis Apoptosis Liver injury

含重组人碱性成纤维细胞生长因子和重组人骨形态发生蛋白-2骨水泥在骨质疏松性腰椎压缩性骨折治疗的应用价值

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国骨伤 2024年第1期37卷 15-20页

作者：夏钰东张荣刘琼陈佳汝重庆市长寿区人民医院脊柱创伤外科重庆401220 重庆市长寿区人民医院急诊科重庆401220

目的:探讨含重组人碱性成纤维细胞生长因子(recombinant human basic fibroblast growth factor,rhbFGF)和重组人骨形态发生蛋白-2(recombinant human bone morphogenetic protein-2,rhBMP-2)骨水泥在骨质疏松性腰椎压缩性骨折(osteoporotic vertebral compression fracture,OVCF)患者经皮椎体后凸成形术(percutaneous kyphoplasty,PKP)治疗的应用价值。方法:回顾性分析2018年1月至2021年1月收治的103例行PKP手术治疗的OVCF患者,男40例,女63例;年龄61~78(65.72±3.29)岁。受伤原因:滑倒33例,跌倒42例,提重物受伤28例。根据填充骨水泥不同分为3组:磷酸钙组34例,男14例,女20例,年龄(65.1±3.3)岁,填充磷酸钙骨水泥;rhBMP-2组34例,男12例,女22例,年龄(64.8±3.2)岁,填充含rhBMP-2的骨水泥;rhbFGF+rhBMP-2组35例,男14例,女21例,年龄(65.1±3.6)岁,填充含rhbFGF和rhBMP-2的骨水泥。比较3组Oswestry功能障碍指数(Oswestry dysfunction index,ODI)、骨密度、椎体前缘丢失高度、伤椎前缘压缩率、疼痛视觉模拟评分(visual simulation score,VAS)及再骨折发生率。结果:所有患者获得12个月随访。3组术后ODI、VAS呈下降(P0.05)。结论:含rhbFGF和rhBMP-2骨水泥可更有效地增加OVCF患者骨密度,获得术后满意的临床和放射学效果,显著改善临床症状。

关键词：经皮椎体后凸成形术骨水泥骨质疏松腰椎压缩性骨折重组人碱性成纤维细胞生长因子重组人类骨形态发生蛋白-2

在线全文

学校读者我要写书评

暂无评论

超滤工艺运行参数优化研究

给水排水 2024年第5期50卷 53-60页

作者：廖先涛王为民张涛段冬刘彦伶夏圣骥同济大学环境科学与工程学院上海200092 北京赛诺水务科技有限公司北京100083 上海市政工程设计研究总院(集团)有限公司上海200092

针对超滤工艺处理中运河水的运行参数开展中试,优化过滤周期、膜通量、化学增强反洗加药量及清洗周期4个运行参数,考察不同运行条件对出水水质的影响及膜污染控制效果,从而确定超滤工艺稳定运行的参数。结果表明,超滤系统在60~80 LMH的... 详细信息

针对超滤工艺处理中运河水的运行参数开展中试,优化过滤周期、膜通量、化学增强反洗加药量及清洗周期4个运行参数,考察不同运行条件对出水水质的影响及膜污染控制效果,从而确定超滤工艺稳定运行的参数。结果表明,超滤系统在60~80 LMH的膜通量、30~60 min的过滤周期能稳定运行;250~500 ppm的反洗加药量能保证不同进水条件下的清洗效果;清洗周期为7 d时超滤系统仍能稳定运行;运行参数调整对产水水质无显著影响。

关键词：超滤膜污染跨膜压差运行参数

艾司氯胺酮对儿童内镜下腺样体切除术后苏醒的影响

在线全文

学校读者我要写书评

暂无评论

复旦学报（医学版） 2024年第1期51卷 76-80页

作者：陈恺铮谢亚明薛期能沈霞复旦大学附属眼耳鼻喉科医院麻醉科上海200031 上海交通大学附属上海市第六人民医院麻醉科上海200233

目的观察艾司氯胺酮对儿童内镜下腺样体切除术后苏醒的影响。方法选取于2022年1月至2023年1月在复旦大学附属眼耳鼻喉科医院全身麻醉下行内镜下腺样体切除术的患儿60名。随机将患儿分为氢吗啡酮组(n=30)和艾司氯胺酮组(n=30)。麻醉诱导... 详细信息

目的观察艾司氯胺酮对儿童内镜下腺样体切除术后苏醒的影响。方法选取于2022年1月至2023年1月在复旦大学附属眼耳鼻喉科医院全身麻醉下行内镜下腺样体切除术的患儿60名。随机将患儿分为氢吗啡酮组(n=30)和艾司氯胺酮组(n=30)。麻醉诱导:经静脉注射利多卡因1.5 mg/kg、丙泊酚2.5 mg/kg和瑞芬太尼4μg/kg后行气管插管。麻醉维持:持续输注瑞芬太尼0.2~0.5μg·kg^(-1)·min^(-1),维持呼气末七氟醚浓度0.7~1.0最小肺泡浓度(minimum alveolar concentration,MAC)。手术结束后分别予以氢吗啡酮0.01 mg/kg或艾司氯胺酮0.5 mg/kg进行镇痛治疗。记录两组患儿术后自主呼吸恢复时间、呼吸频率、苏醒时间、血流动力学变化以及去氧合及躁动等不良反应。结果和氢吗啡酮组患儿相比,艾司氯胺酮组患儿恢复自主呼吸的时间短(P=0.048);自主呼吸恢复时的呼吸频率高(P=0.001);呼气末CO_(2)水平低(P=0.005),提示艾司氯胺酮不损害患儿的呼吸功能。艾司氯胺酮组患儿苏醒时间短于氢吗啡酮组,差异有统计学意义(P=0.020)。艾司氯胺酮不影响患儿的心率和血压,相关的不良反应少。结论与0.01 mg/kg氢吗啡酮相比,0.5 mg/kg艾司氯胺酮不影响呼吸功能,利于儿童全身麻醉下经内镜腺样体切除术后的快速苏醒。

关键词：腺样体切除内镜氯胺酮术后苏醒儿童

维普期刊数据库博看期刊

顺层深路堑边坡滑带土强度特性和基底预留厚度预警分析

在线全文

学校读者我要写书评

暂无评论

地质科技通报 2024年第3期43卷 279-288页

作者：高峰陈爱云许方党杨亮汪洋中国地质大学(武汉)地质调查研究院武汉430074 中国地质大学(武汉)工程学院武汉430074 中铁第四勘察设计院集团有限公司武汉430063 浙江省地矿科技有限公司杭州310007

含软弱夹层的顺层深路堑边坡在边坡工程中普遍存在,滑带土强度和基底预留厚度(开挖边坡基底到软弱夹层的距离)是影响其稳定性的2个关键性因素。以杨宣(杨柳-宣城)高速K42路堑边坡为例,分析了边坡变形演化过程和基底隆起变形特征,通过适... 详细信息

含软弱夹层的顺层深路堑边坡在边坡工程中普遍存在,滑带土强度和基底预留厚度(开挖边坡基底到软弱夹层的距离)是影响其稳定性的2个关键性因素。以杨宣(杨柳-宣城)高速K42路堑边坡为例,分析了边坡变形演化过程和基底隆起变形特征,通过适合研究大剪切位移下土体抗剪强度的环剪试验揭示了边坡深部滑带土的特性,应用滑带土的饱和残余强度参数进行了边坡开挖基底预留厚度分析。结果表明:K42滑带土有明显的应变软化特性,且法向应力越小滑带土应变软化特性表现越明显;由峰值抗剪强度到残余抗剪强度,黏聚力和内摩擦角均表现出衰减效应,且黏聚力衰减程度大于内摩擦角;滑带土残余抗剪强度参数中的残余黏聚力随剪切速率的变化很小,而残余内摩擦角和剪切速率呈对数函数φ=0.1303ln v+7.3197关系变化,当剪切速率min时,滑带土残余抗剪强度参数对剪切速率较为敏感,反之敏感性较差;最后,依据边坡不同临界状态的回归方程h_(1)、h_(2)、h_(3)将不同坡率下的基底预留厚度分成A(失稳)、B(欠稳定)、C(基本稳定)以及D(稳定)4个区,并且在此基础上建立了基底预留厚度判据和边坡开挖基底预留厚度预警模型。

关键词：软弱夹层深路堑边坡滑带土残余强度基底预留厚度预警模型

维普期刊数据库博看期刊

An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1947-1954页

作者： Jun-Hui chen Ting Wu Wen-Yuan xia Zhong-Hua Shi Chun-Lei Zhang Lei chen Qian-Xue chen Yu-Hai wang Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurosurgery Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina Department of Cardiology Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina Department of Science and Education Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina

Atorvastatin has been shown to reduce early brain edema and neuronal death after subarachnoid hemorrhage,but its mechanism is not *** this study,rat models of subarachnoid hemorrhage were established by autologous blood injection in the cisterna *** models were intragastrically administered 20 mg/kg atorvastatin 24 hours before subarachnoid hemorrhage,12 and 36 hours after subarachnoid *** with the controls,atorvastatin treatment demonstrated that at 72 hours after subarachnoid hemorrhage,neurological function had clearly improved;brain edema was remarkably relieved;cell apoptosis was markedly reduced in the cerebral cortex of rats;the number of autophagy-related protein Beclin-1-positive cells and the expression levels of Beclin-1 and LC3 were increased compared with subarachnoid hemorrhage *** ultrastructural damage of neurons in the temporal lobe was also noticeably *** similarities between the effects of atorvastatin and rapamycin were seen in all the measured outcomes of subarachnoid ***,these were contrary to the results of 3-methyladenine injection,which inhibits the signaling pathway of *** findings indicate that atorvastatin plays an early neuroprotective role in subarachnoid hemorrhage by activating *** experimental protocol was approved by the Animal Ethics Committee of Anhui Medical University,China(904 Hospital of Joint Logistic Support Force of PLA;approval ***-2017-09)on February 22,2017.

关键词： 3-methyladenine apoptosis atorvastatin autophagy early brain injury LC3 neuroprotection rapamycin subarachnoid hemorrhage

高脂饲喂对肉鸡腹脂和肝脏组织RNA可变剪接的影响

在线全文

学校读者我要写书评

暂无评论

广东农业科学 2024年第2期51卷 112-123页

作者：敖广宇陈庚华夏燚琳罗文华南农业大学动物科学学院/广东省农业动物基因组学与分子育种重点实验室/农业农村部鸡遗传育种与繁殖重点实验室广东广州510642

【目的】腹脂过度沉积会降低肉鸡抗病力和屠宰率。RNA可变剪接是影响基因功能的重要调控方式,对肉鸡腹脂沉积过程的RNA可变剪接事件进行系统分析,有助于进一步了解肉鸡腹脂沉积的分子调控机理。【方法】利用高脂饲喂肉鸡和普通饲喂肉鸡... 详细信息

【目的】腹脂过度沉积会降低肉鸡抗病力和屠宰率。RNA可变剪接是影响基因功能的重要调控方式,对肉鸡腹脂沉积过程的RNA可变剪接事件进行系统分析,有助于进一步了解肉鸡腹脂沉积的分子调控机理。【方法】利用高脂饲喂肉鸡和普通饲喂肉鸡肝脏组织和腹脂组织的转录组测序结果,鉴定高脂饲喂过程中肉鸡腹脂和肝脏组织的差异表达和差异剪接基因。采用GO功能注释、KEGG通路富集分析和Metascape富集分析对显著差异剪接基因进行分析,并对显著差异剪接事件进行可视化处理,以及分析调控这些差异剪接事件的剪接因子。【结果】对高脂饲喂肉鸡与普通饲喂肉鸡的腹脂和肝脏组织进行转录组测序,在腹脂组织中发现233个显著差异表达基因和349个显著差异剪接基因,对显著差异剪接基因进行富集分析,发现显著差异剪接基因主要富集于细胞分裂、细胞生长等细胞增殖相关生物学进程,还富集于甘油磷脂代谢和胰岛素信号通路等脂肪生成相关通路。在肝脏组织中发现276个显著差异表达基因和224个显著差异剪接基因,对显著差异剪接基因进行富集分析,发现显著差异剪接基因主要富集于蛋白质乙酰化、蛋白质内部氨基酸乙酰化和mRNA加工等细胞代谢相关生物进程,还富集于胰岛素信号通路、胰高血糖素信号通路、AMPK信号通路等脂肪生成相关通路。在腹脂和肝脏的显著差异剪接基因中,共筛选到影响肉鸡腹脂沉积性状的相关候选基因4个,包括GPAT4、RELCH、CYP39A1和PPARA。【结论】研究结果初步揭示高脂饲喂下肉鸡腹脂和肝脏组织的RNA可变剪接调控规律。推断高脂饲喂可能通过影响基因可变剪接过程,进而激活前脂肪细胞的增殖和脂肪生成相关细胞代谢,从而导致肉鸡的腹脂沉积现象;剪接因子对靶基因的调控显著参与影响肉鸡的腹脂沉积过程。

关键词：杏花鸡高脂饲料腹脂沉积转录组可变剪接差异表达基因

维普期刊数据库博看期刊

Dauricine can inhibit the activity of proliferation of urinary tract tumor cells

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 973-976页

作者： Jun wang Yuan Li Xiong-Bing Zu min-Feng chen Lin Qi Department of Urology Xiangya HospitalCentral South University

Objective:To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain,prostate cancer PC-3Mcell strain and primary cell culture ***:The main effective component-phenolic alkaloids of Menispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical *** method was used to detect dauricine anti-tumor ***:Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary *** minimum drug sensitivity concentration was between ***μg/mL,and the inhibition ratio increased with the increase of ***:Dauricine,the main effective component extracted from asiatic moonseed rhizome,had a good inhibition effect on tumor cells in urinary *** the same time,Dauricine has certain inhibition effects on the primary cultured tumor cell.

关键词： PAMD Dauricine Urinary system EJ cell strain PC-3Mcell strain