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Clinical efficacy and safety of Gandouling plus low-dose D-penicillamine for treatment of Wilson's disease with neurological symptoms

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Journal of Traditional Chinese Medicine 2018年第1期38卷 89-94页

作者： Zhang Jing Li Liangyong chen huaizhen Yang Wenming Department of Neurology The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

OBJECTIVE： To investigate the effect and safety of Gandouling plus low-dose D-penicillamine for treating patients with Wilson＇s disease （WD） who have neurological symptoms. METHODS： WD patients with neurological symptoms were divided into two groups： a treatment group （n = 53） and a control group （n = 50）. The treatment group received anti-copper therapy with a combination of Gandouling and low-dose D-peni- cillamine （10 mglkg）, whereas the control group was with conventional dose D-penicillamine （20 rag/ kg） monotherapy. The clinical efficacies, adverse re- actions, and results of the various hematological and biochemical investigations were recorded and analyzed statistically. RESULTS： Overall, 98.11% of the WD patients treated with the combined therapy experienced alleviation of their neurological condition （paralleled by a significantly improved Global Assessment Scale score or remained stable）. Their white blood cell and platelet counts stabilized, and their liver function was improved or remained stable. The combined therapy also obviously promoted improved 24-h urinary copper excretion. Only 15.09% of the WD patients with the combined therapy experienced adverse reactions, including neurological deterioration in one case （1.89%） and hepatic worsening in one case （1.89%）, which was less frequent than that in the control group given conventional-dose D-penicillamine monotherapy. CONCLUSION： Treating WD patients with neurological symptoms using Gandouling plus low-close D-penicillamine is effective and safe.

关键词： Hepatolenticular degeneration Penicillaminate Neurologic manifestations Gandouling

Evaluation of efficacy and safety of gandouling plus sodium dimercaptosulphonate in treatment of patients with neurological Wilson's disease from China

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Journal of Traditional Chinese Medicine 2018年第5期38卷 781-786页

作者： Zhang Jing Xie Daojun Guo Yanbing Li Yajun Li Liangyong Han Hui Zhang Juan chen huaizhen Wang Meixia Department of Neurology the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine Department of Pediatrics the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

OBJECTIVE: To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate(DMPS) on neurological Wilson's disease(WD) in ***: We retrospectively evaluated the clinical records of 125 WD patients with neurological syndromes who were treated with gandouling plus sodium DMPS or DMPS used alone. All patients had a history of neurological deterioration during their diseases courses. The clinical efficacies, adverse reactions, and results of the various hematological and biochemical investigations were recorded for statistical ***: 92.30%(60 patients) of the WD patients treated with the combined therapy experienced an improved or stable neurological condition paral-leled by a significantly improved GAS score. Meanwhile, the WBC and PLT counts stabilized, liver function and renal function were improved or remained stable. The combined therapy also obviously promoted the 24-h urinary copper excretion. In particular, only 30.76% of the WD patients experienced mild adverse reactions, including neurological deterioration in 5 patients(7.69%), hepatic worsening in 1 subject(1.89%), which was less frequently than those in the control group treated with DMPS ***: Our findings indicate that the safety and efficacy of gandou-ling plus DMPS is superior to those of DMPS used alone in the WD patients with neurological symptoms.

关键词： Wilson's disease Gandouling,Sodium dimercaptosulphonate Neurological deterioration

陈怀珍治疗顽固性带状疱疹后遗神经痛的临床经验

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中医药临床杂志 2019年第6期31卷 1053-1057页

作者：王玉陈怀珍王苏悦安徽中医药大学安徽合肥230038 安徽中医药大学第一附属医院安徽合肥230031

目的:介绍陈怀珍教授治疗顽固性带状疱疹后遗神经痛临床经验。方法:通过长期随诊及验案的收集与整理,学习和总结出陈怀珍教授治疗顽固性带状疱疹后遗神经痛的学术观点和临证经验。结果:陈怀珍教授认为,顽固性带状疱疹后遗神经痛的病机... 详细信息

目的:介绍陈怀珍教授治疗顽固性带状疱疹后遗神经痛临床经验。方法:通过长期随诊及验案的收集与整理,学习和总结出陈怀珍教授治疗顽固性带状疱疹后遗神经痛的学术观点和临证经验。结果:陈怀珍教授认为,顽固性带状疱疹后遗神经痛的病机多属本虚标实,辨证着眼于“虚”“痰”“瘀”“郁”4字,并结合辨病位遣方用药,治疗上扶正与祛邪并举。结论:陈怀珍教授治疗顽固性带状疱疹后遗神经痛临床疗效显著,其临证经验值得学习和推广使用。

关键词：带状疱疹后遗神经痛蛇串疮名医经验

Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma

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Journal of Pharmaceutical Analysis 2024年第2期14卷 211-224页

作者： Jingjing Wang Qi Su Kun chen Qing Wu Jiayan Ren Wenjuan Tang Yu Hu Zeren Zhu cheng cheng Kaihui Tu huaizhen He Yanmin Zhang School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an710061China

Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. However, few mitophagy inhibitors have been approved for clinical use in humans. Pyrimethamine (Pyr) is used to treat infections caused by protozoan parasites. Recent studies have reported that Pyr may be beneficial in the treatment of various tumors. However, its mechanism of action is still not clearly defined. Here, we found that blocking mitophagy sensitized cells to Pyr-induced apoptosis. Mechanistically, Pyr potently induced the accumulation of autophagosomes by inhibiting autophagosome-lysosome fusion in human HCC cells. In vitro and in vivo studies revealed that Pyr blocked autophagosome-lysosome fusion by upregulating BNIP3 to inhibit synaptosomal-associated protein 29 (SNAP29)-vesicle-associated membrane protein 8 (VAMP8) interaction. Moreover, Pyr acted synergistically with sorafenib (Sora) to induce apoptosis and inhibit HCC proliferation in vitro and in vivo. Pyr enhances the sensitivity of HCC cells to Sora, a common chemotherapeutic, by inhibiting mitophagy. Thus, these results provide new insights into the mechanism of action of Pyr and imply that Pyr could potentially be further developed as a novel mitophagy inhibitor. Notably, Pyr and Sora combination therapy could be a promising treatment for malignant HCC.

关键词： Pyrimethamine BNIP3 SNARE Autophagosome-lysosome fusion Hepatocellular carcinoma Sorafenib

Application Prospects of Shenhua Industrial Boilers

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Application Prospects of Shenhua Industrial Boilers

中美工业锅炉先进技术研讨会

作者： chen huaizhen Gu Xiaoyu Cui Fenghai Shenhua Coal Trading Co.

The paper introduces both the application of industrial boilers and the relevant requirements to industrial boilers in China and sets forth the advantage of Shenhua coal in terms of resources, product

关键词： Shenhua Coal Industrial Boilers Application Prospects

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EI二阶导数的储层参数和流体模量反演方法

地球物理学报 2023年第9期66卷 3854-3868页

作者：蒋志恒陈怀震刘垒蔡纪琰中海石油(中国)有限公司天津分公司渤海石油研究院天津300452 同济大学海洋地质国家重点实验室海洋与地球科学学院上海200092

储层孔隙度、泥质含量及流体类型估测是地球物理勘探的重点及难点问题.基于岩石物理理论及等效模型,可以构建油气储层反射特征与储层孔隙度、泥质含量及流体的映射关系.本文从流体替换模型出发,结合矿物平均模型,首先推导了以孔隙度、... 详细信息

储层孔隙度、泥质含量及流体类型估测是地球物理勘探的重点及难点问题.基于岩石物理理论及等效模型,可以构建油气储层反射特征与储层孔隙度、泥质含量及流体的映射关系.本文从流体替换模型出发,结合矿物平均模型,首先推导了以孔隙度、泥质含量、流体模量和密度表征的非线性反射系数及弹性阻抗公式;然后根据推导的反射系数和弹性阻抗公式,建立了一套两步法反演策略:利用部分角度叠加数据进行线性反演预测弹性阻抗体;利用预测的弹性阻抗体开展泥质含量、孔隙度、流体模量和密度等变量的非线性反演,引入弹性阻抗对于反演变量的一阶和二阶导数以提高反演的精度.最后,利用层状模型验证了新推导的反射系数方程的精度,并分别利用测井数据模型生成的含噪声合成地震记录及实际工区地震数据验证了所提出的反演方法的可靠性.

关键词：岩石物理孔隙度泥质含量流体模量叠前地震反演

中国公共行政文化研究——基于2000-2013年的文献数据

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辽宁工程技术大学学报（社会科学版） 2014年第4期16卷 374-376页

作者：陈怀珍福建师范大学公共管理学院福建福州350007

针对公共行政文化研究问题,采用文献分析法,以"公共行政文化"为"主题"在"中国期刊网"上对1980年至2013年期间的全部文献进行模糊搜索,发现对于公共行政文化的研究主要集中在公共行政文化的内涵特征及构建、公共行政文化的变革和走向趋... 详细信息

针对公共行政文化研究问题,采用文献分析法,以"公共行政文化"为"主题"在"中国期刊网"上对1980年至2013年期间的全部文献进行模糊搜索,发现对于公共行政文化的研究主要集中在公共行政文化的内涵特征及构建、公共行政文化的变革和走向趋势、公共行政文化的创新意义以及公共行政文化的影响作用这四个方面,分析关于公共行政文化的研究特点,以期为其他理论研究者和政策制定者提供借鉴与参考。

关键词：创新服务型政府公共行政文化行政管理行政文化

公务员招考中的性别差异分析——以福建省2010年～2013年公务员招考数据为例

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中北大学学报（社会科学版） 2014年第3期30卷 32-35页

作者：陈怀珍福建师范大学公共管理学院福建福州350007

福建省2010年～2013年公务员的招考数据显示,招考条件中关于＂性别＂要求这一栏在总体设置、不同地域和岗位职责上存在差异的现象。究其原因,主要来自女性自身特征、社会观念和岗位特征三方面。具体对策为女性改变自身观念、从法律制度... 详细信息

福建省2010年～2013年公务员的招考数据显示,招考条件中关于＂性别＂要求这一栏在总体设置、不同地域和岗位职责上存在差异的现象。究其原因,主要来自女性自身特征、社会观念和岗位特征三方面。具体对策为女性改变自身观念、从法律制度上落实男女平等意识、完善招考岗位设计,以有益于公务员招考制度的完善,进一步保证女性在公务员招考中的合法权益。

关键词：公务员招考性别差异职位选择

基于岩石物理模版的碳酸盐岩含气储层定量解释

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吉林大学学报（地球科学版） 2015年第2期45卷 630-638页

作者：张广智陈娇娇陈怀震张金强印兴耀中国石油大学(华东)地球科学与技术学院山东青岛266580 中国石化石油勘探开发研究院北京100083

笔者针对碳酸盐岩储层勘探开发面临的储层预测与流体识别难度大的问题,基于岩石物理理论,提出了一种对碳酸盐岩含气储层进行定量解释的方法:首先,综合碳酸盐岩地质和测井信息,以岩石物理理论为依据,实现了适用的碳酸盐岩岩石物理模型的... 详细信息

笔者针对碳酸盐岩储层勘探开发面临的储层预测与流体识别难度大的问题,基于岩石物理理论,提出了一种对碳酸盐岩含气储层进行定量解释的方法:首先,综合碳酸盐岩地质和测井信息,以岩石物理理论为依据,实现了适用的碳酸盐岩岩石物理模型的构建;然后基于岩石物理模型优选出对孔隙度、含气饱和度较为敏感的参数λρ和μρ,构建能够反映储层孔隙度与含气饱和度的碳酸盐岩岩石物理模版;最后,将岩石物理模版与工区反演提取的参数相结合,确定储层分布范围,并对储层范围内孔隙度和含气饱和度数值进行了定量解释。实例分析表明,基于该模版定量解释得到的孔隙度和含气饱和度与实际地层孔隙度及产气结果基本一致,经验证碳酸盐岩岩石物理模版的可靠性和适用性较好。

关键词：碳酸盐岩岩石物理模版储层参数定量解释