检索结果-南通市图书馆

Full-parameter constrained parsimonious subspace identification with steady-state information for DC–DC converters

在线全文

学校读者我要写书评

暂无评论

Control Theory and Technology 2024年第2期22卷 173-183页

作者： Jie hou Zhen Yang Taifu Li Huiming Wang Jincheng Jiang Xiaolei chen College of Automation Chongqing University of Posts and TelecommunicationsChongqing400065China School of Electrical and Information Engineering Chongqing University of Science and TechnologyChongqing401331China

A full-parameter constrained parsimonious subspace identification method that incorporates the steady-state a priori infor-mation of the system is proposed to model the DC-DC converters.A parsimonious model with fewer parameters is used to represent the system,and then an optimal weighted methods is used to estimate the system parameters matrices by taking into account both dynamical data and steady-state data.Compared with traditional data-driven methods for DC-DC convert-ers,the subspace-based method can simultaneously estimate model structure and parameter with appropriate computational complexity.Moreover,compared with the traditional full-parameter constrained subspace approach,the proposed algorithm can accurately estimate the system parameters with a smaller variance.The experimental results on a DC-DC synchronous buck converter verify the effectiveness and superiority of the proposed method.

关键词： System identification Constrained identification DC-DC converters Subspace identification

A causal convolutional neural network for multi-subject motion modeling and generation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Visual Media 2024年第1期10卷 45-59页

作者： Shuaiying hou Congyi Wang Wenlin Zhuang Yu chen Yangang Wang Hujun Bao Jinxiang Chai Weiwei Xu State Key Lab of CAD&CG Zhejiang UniversityHangzhou310058China Xmov Shanghai200030China School of Automation Southeast UniversityNanjing210096China

Inspired by the success of WaveNet in multi-subject speech synthesis,we propose a novel neural network based on causal convolutions for multi-subject motion modeling and generation.The network can capture the intrinsic characteristics of the motion of different subjects,such as the influence of skeleton scale variation on motion style.Moreover,after fine-tuning the network using a small motion dataset for a novel skeleton that is not included in the training dataset,it is able to synthesize high-quality motions with a personalized style for the novel skeleton.The experimental results demonstrate that our network can model the intrinsic characteristics of motions well and can be applied to various motion modeling and synthesis tasks.

关键词： deep learning optimization motion generation motion denoising motion control

Influence of self-similar stresses on scenario earthquake construction:An example along the Tanlu Fault

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第5期67卷 1687-1697页

作者： Feng HU Huajian YAO houyun YU Zeyu LU Jieyi hou Song LUO Zhigang SHAO Xiaofei chen School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Mengcheng Geophysical National Field Scientific Observatory Hefei 230026China Department of Earth and Space Science Southern University of Science and TechnologyShenzhen 518055China Institute of Earthquake Prediction China Earthquake AdministrationBeijing 100036China

As a famous deep and large fault in eastern China,the Tanlu Fault passes through Anhui,Jiangsu,and Shandong and into northeastern China.It is important to improve the understanding of seismic hazard assessments in areas near faults.We start a scenario earthquake simulation in the M7.5 earthquake potential area of the Xinyi-Sihong segment of the Tanlu Fault.The fault rupture length and width are constrained according to the scaling law of large intraplate earthquakes,the background normal stress is depth dependent,and the initial shear stresses are determined using trial and error by matching the earthquake magnitude.Considering the 120 km rupture length of the M7.5 earthquake,we compare the horizontal uniform stress model and self-similar stress perturbation model.Our findings reveal that the seismic source time function of the horizontal uniform stress model is similar to that of the Haskell model and that of the self-similar stress perturbation model is more similar to that of a real earthquake case.We compare the dynamic rupture simulation and ground motion results under four different stress conditions and find that the shorter the characteristic length of the self-similar function is,the rougher the initial stress.For the M7.5earthquake with an epicenter in the vicinity of Suqian,the Xinyi-Tancheng segment,which is located in the IX-intensity zone north of the epicenter,vibrates more strongly on the northern side than on the southern side due to the influence of the lowvelocity zone and the peak slip rate.The response spectra analysis at stations in the study area is useful for improving the earthquake resistance capability.

关键词： Scenario earthquakes Self-similar stress Tanlu Fault Dynamic rupture Ground motion

Mechanism of high Li-ion conductivity in poly(vinylene carbonate)-poly(ethylene oxide)cross-linked network based electrolyte revealed by solid-state NMR

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第6期93卷 377-383,I0010页

作者： Fan Li Tiantian Dong Yi Ji Lixin Liang Kuizhi chen Huanrui Zhang Guanglei Cui Guangjin hou State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyCollaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101ShandongChina

Solid polymer electrolytes(SPEs)have become increasingly important in advanced lithium-ion batteries(LIBs)due to their improved safety and mechanical properties compared to organic liquid electrolytes.Cross-linked polymers have the potential to further improve the mechanical property without trading off Li-ion conductivity.In this study,focusing on a recently developed cross-linked SPE,i.e.,the one based on poly(vinylene carbonate)-poly(ethylene oxide)cross-linked network(PVCN),we used solid-state nuclear magnetic resonance(NMR)techniques to investigate the fundamental interaction between the chain segments and Li ions,as well as the lithium-ion motion.By utilizing homonuclear/heteronuclear correlation,CP(cross-polarization)kinetics,and spin-lattice relaxation experiments,etc.,we revealed the structural characteristics and their relations to lithium-ion mobilities.It is found that the network formation prevents poly(ethylene oxide)chains from crystallization,which could create sufficient space for segmental tumbling and Li-ion co nductio n.As such,the mechanical property is greatly improved with even higher Li-ion mobilities compared to the poly(vinylene carbonate)or poly(ethylene oxide)based SPE analogues.

关键词： ssNMR Lithium-ion mobility Cross-link Solid polymer electrolyte

Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第3期11卷 215-226页

作者： Jian-Hong Xiao Zhen-Bang Zhang JiaHao Li Si-Ming chen Huai-Ling Gao YinXiu Liao Lu chen ZiShuo Wang YiFan Lu YuanZhen hou HengAn Wu DuoHong Zou Shu-Hong Yu Department of Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials&Chemistry Anhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Department of Dental Implant Center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Department of Oral Surgery College of Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Institute of Innovative Materials(I2M) Department of Chemistry Department of Materials Science and Engineering Southern University of Science and Technology

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration（HCH） of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties. The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected. As one demonstration, a membrane assembled by bacterial cellulose nanofiber-network and Ca2+-crosslinked and hydrated sodium alginate molecule-network is designed. Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge. Overall, the molecule-network makes the membrane hydrated and flexible; the nanofiber-network as stress-bearing component provides strength and toughness.The HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

关键词： bioinspiration heterogeneous crosslink-and-hydration dual-scale network nanocomposite membrane wet mechanical properties guided bone regeneration

Punicalagin,ellagic acid and gallic acid promotes Cholesterol Efflux from raw264.7 Macrophages

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Punicalagin,ellagic acid and gallic acid promotes Cholestero...

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

陕西省毒理学会新时代环境与健康学术会议暨第四届会员代表...

作者： Shengjuan Zhao chen hou Jianke Li College of Food Engineering and Nutritional Science Shaanxi Normal University College of Food ＆ Bioengineering Henan University of Science and Technology University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization Xi’an

Pomegranate peel polyphenols have been shown to inhibit foam cell formation by preventing cholesterol accumulation and promoting cholesterol efflux.However,it remains to be clarified whether punicalagin,ellagic acid and gallic acid,as the main component,play a role.In this work,we investigated the effects of Punicalagin,ellagic acid and gallic acid on the foam cell formation and cholesterol efflux in raw264.7 macrophages.The results showed that punicalagin and ellagic acid inhibited the enhanced cholesterol accumulation caused by ox-LDL in raw264.7 macrophages,perhaps by restraining the CD36 expression.Punicalagin and ellagic acid raised the cholesterol efflux probably via the LXRa-ABCA1/ABCG1,and gallic acid promoted the cholesterol efflux maybe by PPARγ-LXRα-ABCA1/ABCG1.

关键词： punicalagin ellagic acid gallic acid raw264.7 macrophage cholesterol efflux

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu chengpeng Tao Weiming chen Wen hou Kui cheng Huichang Bi Wanyi Pan Jianjun chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

Micro femoral head prosthesis in applications to collapsed femoral head necrosis in the weight-bearing dome(ARCO III):A case series with short-term follow-up

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第6期137卷 737-739页

作者： Zhongzheng Wang Yuchuan Wang Tianyu Wang Yining Lu Xiaodong Lian Yanbin Zhu Wei chen Zhiyong hou Yingze Zhang Department of Orthopaedic Surgery Hebei Medical University Third HospitalShijiazhuangHebei 050051China Key Laboratory of Biomechanics of Hebei Province ShijiazhuangHebei 050051China NHC Key Laboratory of Intelligent Orthopaedic Equipment ShijiazhuangHebei 050051China Chinese Academy of Engineering Beijing 100088China

Osteonecrosis of the femoral head(ONFH)is mainly caused by a decrease in the vascular supply to the subchondral bone of the femoral head,leading to the death of bone cells,degeneration and necrosis of the subchondral bone,and eventually collapse of the femoral head.^([1])Early and accurate diagnosis is the key to successful hip-preserving therapy,and the size/location of necrosis is the main determinant for ONFH treatment.Previous studies have shown that many hip-preserving therapies achieved satisfactory results in ONFH patients with Association Research Circulation Osseous(ARCO)I–II.When ONFH progresses to ARCO IV with clinical manifestations of osteoarthrosis,total hip arthroplasty(THA)may be the only option.

关键词： ARCO diagnosis death head

在线全文

学校读者我要写书评

暂无评论

阴香龙脑含量对叶际细菌多样性的影响

林业与环境科学 2024年第3期40卷 16-25页

作者：张宏博李兵钟泳林张谦何波祥汪迎利侯晨殷祚云仲恺农业工程学院广东广州510225 广东省森林培育与保护利用重点实验室/广东省林业科学研究院广东广州510520

为了解龙脑含量的高低对阴香Cinnamomum burmanni叶不同发育阶段叶际细菌群多样性的影响,文章以2个阴香品系(高龙脑含量—H和低含量—L)的2个发育时期叶片(嫩叶和成熟叶)为研究材料,利用气相-质谱联用仪检测4组样本的龙脑含量,利用16S... 详细信息

为了解龙脑含量的高低对阴香Cinnamomum burmanni叶不同发育阶段叶际细菌群多样性的影响,文章以2个阴香品系(高龙脑含量—H和低含量—L)的2个发育时期叶片(嫩叶和成熟叶)为研究材料,利用气相-质谱联用仪检测4组样本的龙脑含量,利用16S测序结果比较分析叶际细菌结构和相对丰度的变化。结果表明:(1)相较于嫩叶,2个品系的成熟叶中龙脑含量均显著增加。(2)4组样本共检测出259个操作分类单元,其中H特有操作分类单元的数量最多。(3)基于这些H成熟叶的菌群α多样性指数在4组样本中最高,高龙脑含量品系的叶片中叶际细菌群落多样性随着叶片成熟而提升,低龙脑含量品系的叶际细菌群落多样性随着叶片成熟变化并不显著。4组样本之间菌群丰度的差异主要集中在鞘氨醇单胞菌属菌Sphingomonas sp.、短小杆菌属菌Curtobacterium sp.、假单胞菌属菌Pseudomonas sp.、肠杆菌科菌Enterobacteriaceae sp.、类芽孢杆菌属菌Paenibacillus sp.和芽孢杆菌属菌Bacillus sp.。研究结果表明阴香叶中龙脑含量的变化影响了叶际细菌菌群结构和丰度,阴香叶片中的龙脑含量越高则叶际细菌菌群多样性随着叶片成熟后越容易发生变化。

关键词：阴香龙脑叶际细菌生物多样性