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Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus

Stroke & Vascular Neurology 2024年第1期9卷 1-7页

作者： Jin-An Huang Ching-Heng Lin Ming-Ju Wu Yi-Hsing chen Kuo-cheng Chang Chung-Wei hou Division of Neurology Neurological InstituteTaichung Veterans General HospitalTaichungTaiwan Department of Health Business Administration Hungkuang UniversityTaichungTaiwan Department of Medical Research Taichung Veterans General HospitalTaichungTaiwan Division of Nephrology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine Chung Shan Medical UniversityTaichungTaiwan College of Medicine National Chung Hsing UniversityTaichungTaiwan Division of Allergy Immunology and RheumatologyDepartment of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaichungTaiwan

Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance Research Database.Patients with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December 2013.Adjusted HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival analysis.Results In total,8310 patients with SLE and 16620 patients without SLE were included.In general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in controls.In multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with SLE.Patients with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,phould be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

关键词： erythematosus diagnosis likely

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Corrosion Behavior of Graphene Nanosheets Reinforced Magnesium Matrix Composites in Simulated Body Fluids

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 525-536页

作者： Liwen chen Jianhui Jing Lulu Zhang Jing Li Weipeng chen Limin Li Yuan Zhao Hua hou Yuhong Zhao School of Materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-Performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051China Shanxi Key Laboratory of Advanced Manufacturing Technology School of Mechanical EngineeringNorth University of ChinaTaiyuan 030051China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Magnesium(Mg)alloy is considered as a promising biodegradable implant material but restricted to rapid degradation.Here,the new strategies based on thixomolding process had been explored to utilize the outstanding anti-permeability of graphene nanosheets(GNPs)while inhibit its galvanic corrosion with the matrix,so as to improve the corrosion resistance of composites.The agglomerate of GNPs with 0.9 wt%content is the main reason for the deterioration of corrosion performance due to the formation of micro-galvanic corrosion.The grain refinement of composites with 0.6 wt%content had positive effects on the better corrosion resistance.After process adjusting,the unique distributions of GNPs along grain boundaries play a vital role in improving the corrosion resistance.It can be ascribed to the following mechanisms:(I)The barriers can be established between the Mg matrix and corrosive medium,hence blocking the charge transfer at the interface;(II)The GNPs can effectively promote apatite deposition on the Mg matrix,leading to form dense apatite layers and prevent the further invasion of SBF;(III)The GNPs acting as reinforcements exists in the corrosion layer and apatite layer,impede the apatite layer falling off from the Mg matrix.These findings broaden the horizon for biomedical applications in Mg matrix composites to realize desired performances.

关键词： Magnesium matrix composite Graphene nanosheets Corrosion resistance

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Remote sensing of air pollution incorporating integrated-path differential-absorption and coherent-Doppler lidar

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Defence Technology（防务技术） 2024年第1期31卷 594-601页

作者： Ze-hou Yang Yong chen Chun-li chen Yong-ke Zhang Ji-hui Dong Tao Peng Xiao-feng Li Ding-fu Zhou School of Physics Beijing Institute of TechnologyBeijing 100081China Southwest Institute of Technical Physics Chengdu 610041SichuanChina School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

An innovative complex lidar system deployed on an airborne rotorcraft platform for remote sensing of atmospheric pollution is proposed and demonstrated.The system incorporates integrated-path differential absorption lidar(DIAL) and coherent-doppler lidar(CDL) techniques using a dual tunable TEA CO_(2)laser in the 9—11 μm band and a 1.55 μm fiber laser.By combining the principles of differential absorption detection and pulsed coherent detection,the system enables agile and remote sensing of atmospheric pollution.Extensive static tests validate the system’s real-time detection capabilities,including the measurement of concentration-path-length product(CL),front distance,and path wind speed of air pollution plumes over long distances exceeding 4 km.Flight experiments is conducted with the helicopter.Scanning of the pollutant concentration and the wind field is carried out in an approximately 1 km slant range over scanning angle ranges from 45°to 65°,with a radial resolution of 30 m and10 s.The test results demonstrate the system’s ability to spatially map atmospheric pollution plumes and predict their motion and dispersion patterns,thereby ensuring the protection of public safety.

关键词： Differential absorption LIDAR Coherent Doppler lidar Remoting sensing Atmospheric pollution

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Epitaxial growth of borophene on graphene surface towards efficient and broadband photodetector

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Nano Research 2024年第4期17卷 3053-3060页

作者： Zenghui Wu chen Shifan Zitong Wu Yi Liu Wei Shao Xinchao Liang Chuang hou Guoan Tai The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory of Intelligent Nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

In-situ integration of multiple materials with well-defined interfaces as heterostructures is of great interest due to their unique properties and potential for new device functionality.Because of its polymorphism and diverse bonding geometries,borophene is a promising candidate for two-dimensional heterostructures,but suitable synthesis conditions have limited its potential applications.Toward this end,we demonstrate the vertical borophene and graphene heterostructures which form by epitaxial growth of borophene onto multilayer graphene on Cu substrates via chemical vapor deposition,where hydrogen and NaBH_(4) are respectively used as the carrier gas and the boron source.The lattice structure of the as-synthesized borophene well coincides with the predictedα′-boron sheet.The borophene-based photodetector shows an excellent broadband photoresponse from the ultraviolet(255 nm)to the infrared(940 nm)wavelengths,with enhanced responsivity compared to pristine borophene or graphene photodetectors.This work informs emerging efforts to integrate borophene into nanoelectronic applications for both fundamental investigations and technological applications.

关键词： borophene graphene heterostructure photodetector two-dimensional materials

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Research on Anti-collision Capability and Safety Supervision Measures of the Nanjing Yangtze River Bridge

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Journal of Shipping and Ocean Engineering 2022年第1期12卷 12-18页

作者： HAN Diao chen hou-zhong School of Navigation Wuhan University of TechnologyWuhan 430063China Hubei Key Laboratory of Inland Shipping Technology Wuhan 430063China

With the vigorous development of inland river shipping economy,the trend of large ships passing Nanjing Yangtze River Bridge is obvious.The standard formula of ship collision force is selected by comparing the empirical calculation formulas.Four representative ship types are selected for calculation and analyzing of collision force.It is concluded that the anti-collision ability of the Nanjing Yangtze River Bridge does not meet the requirement of large ship collision force when the speed is more than 8-knots.From the perspective of active collision avoidance,this paper puts forward the navigation safety supervision countermeasures.A conceptual model of guided pulley anti-collision device is designed from the perspective of passive anti-collision.The research results provide references for safety supervision and anti-collision measures for the bridge.

关键词： Anti-collision ability formula anti-collision device navigation safety supervision

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Recovery of Li, Ni, Co and Mn from spent lithium-ion batteries assisted by organic acids: Process optimization and leaching mechanism

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 518-530页

作者： Liuyi Ren Bo Liu Shenxu Bao Wei Ding Yimin Zhang Xiaochuan hou Chao Lin Bo chen School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China State Environmental Protection Key Laboratory of Mineral Metallurgical Resources Utilization and Pollution Control Wuhan University of Science and TechnologyWuhan 430081China Zhejiang New Era Zhongneng Recycling Technology Co. LtdShaoxing 312000China Shenzhen Water Planning&Design Institute Co. LtdShenzhen 518000China

The proper recycling of spent lithium-ion batteries(LIBs)can promote the recovery and utilization of valuable resources,while also negative environmental effects resulting from the presence of toxic and hazardous substances.In this study,a new environmentally friendly hydro-metallurgical process was proposed for leaching lithium(Li),nickel(Ni),cobalt(Co),and manganese(Mn)from spent LIBs using sulfuric acid with citric acid as a reductant.The effects of the concentration of sulfuric acid,the leaching temperature,the leaching time,the solid-liquid ratio,and the reducing agent dosage on the leaching behavior of the above elements were investigated.Key parameters were optimized using response surface methodology(RSM)to maximize the recovery of metals from spent LIBs.The maxim-um recovery efficiencies of Li,Ni,Co,and Mn can reach 99.08%,98.76%,98.33%,and 97.63%.under the optimized conditions(the sulfuric acid concentration was 1.16 mol/L,the citric acid dosage was 15wt%,the solid-liquid ratio was 40 g/L,and the temperature was 83℃ for 120 min),respectively.It was found that in the collaborative leaching process of sulfuric acid and citric acid,the citric acid initially provided strong reducing CO_(2)^(-),and the transition metal ions in the high state underwent a reduction reaction to produce transition metal ions in the low state.Additionally,citric acid can also act as a proton donor and chelate with lower-priced transition metal ions,thus speeding up the dissolution process.

关键词： spent lithium-ion batteries leaching response surface methodology sulfuric acid citric acid

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A 26.5–29.5-GHz Doherty PA with enhanced linearity and efficiency based on adaptive bias circuit for 5G MIMO arrays

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Science China(Information Sciences) 2024年第7期67卷 341-342页

作者： Long WANG Jixin chen Debin hou Xiaojie XU Wei HONG State Key Laboratory of Millimeter Waves Southeast University Misic Microelectronics Co. Ltd.

Power amplifiers (PAs) play a crucial role in achieving key performance metrics such as efficiency, power, and linearity.However, in the millimeter-wave frequency range, the performance of active devices rapidly deteriorates with increasing frequency. The typical Doherty architecture, through load modulation techniques, can achieve high back-off efficiency [1]. To enhance the linearity of the PA, adaptive bias circuits (ADBs) have been widely adopted [2, 3].

关键词： POWER-AMPLIFIER

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Early Triassic Volcanic Rocks in the Western Yarlung Zangbo Suture Zone:Implications for the Opening of the Neo-Tethys Ocean

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 324-336页

作者： HE Juan LI Yalin hou Yunling Zhou Aorigele WEI Yushuai chen Xi DAI Jingen School of Civil Engineering and Architecture West Yunnan University of Applied SciencesDaliYunnan 671006China School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100080China West Yunnan University of Applied Sciences DaliYunnan 671006China MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100080China

In this study,zircon U-Pb dating of volcanic rocks from the Zhongba ophiolite of the Yarlung Zangbo Suture Zone(YZSZ)in southern Xizang(Tibet)yielded an age of 247±3 Ma.According to whole rock geochemical and Sr-NdPb isotopic data,the Early Triassic samples could be divided into two groups:Group 1 with P-MORB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70253–0.70602,ε_(Nd)(t)values of 4.2–5.3,(^(206)Pb/^(204)Pb)_(t)ratios of 16.353–18.222,(^(207)Pb/^(204)Pb)_(t)ratios of 15.454–15.564,and(^(208)Pb/^(204)Pb)_(t)ratios of 35.665–38.136;Group 2 with OIB affinity,showing initial^(87)Sr/^(86)Sr ratios of 0.70249–0.70513,ε_(Nd)(t)values of 4.4–4.9,(^(206)Pb/^(204)Pb)_(t)ratios of 17.140–18.328,(^(207)Pb/^(204)Pb)_(t)ratios of 15.491–15.575,and(^(208)Pb/^(204)Pb)_(t)ratios of 36.051–38.247.Group 2 rocks formed by partial melting of the mantle source enriched by a former plume,and assimilated continental crustal material during melt ascension.The formation of Group 1 rocks corresponds to the mixing of OIB melts,with the same components as Group 2 and N-MORBs.The Zhongba Early Triassic rocks belong to the continental margin type ophiolite and formed in the continental–oceanic transition zone during the initial opening of the Neo-Tethys in southern Xizang(Tibet).

关键词： rift Early Triassic magmatism Yarlung Zangbo Suture Zone Neo-Tethys Southern Xizang Tibet

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Chronological Study of Coal-seam Water and its Implication on Gas Production in the South Qinshui Basin

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 207-219页

作者： chen Biying FANG Lujia LANG Yunchao XU Sheng LIU Congqiang ZHANG Luyuan hou Xiaolin Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China Institute of Earth Environments Chinese Academy of SciencesXi’an 710061China

The knowledge of the residence time of formation water is fundamental to understanding the subsurface flow and hydrological setting.To better identify the origin and evolution of coal seam water and its impact on gas storage and production,this study collected coalbed methane co-produced water in the southeast Qinshui Basin and detected chemical and isotopic compositions,especially 36Cl and 129I concentrations.The calculated tracer ages of 129I(5.2–50.6 Ma)and 36Cl(0.13–0.76 Ma)are significantly younger than the age of coal-bearing formation(Pennsylvanian-Cisuralian),indicating freshwater recharge after coal deposition.The model that utilises 129I/I and 36Cl/Cl ratios to constrain the timing of recharge and the proportion of recharge water reveals that over 60%of pre-anthropogenic meteoric water entered coal seams since 10 Ma and mixed with residue initial deposition water,corresponding to the basin inversion in Cenozoic.The spatial distribution of major ion concentrations reveals the primary recharge pathway for meteoric water from coal outcrops at the eastern margin to the basin center.This study demonstrates the occurrence of higher gas production rates from wells that accept water recharge in recent times and suggests the possible potential of the non-stagnant zones for high gas production.

关键词： CBM co-produced water iodine-129 chlorine-36 water chemistry Qinshui Basin

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Characterization,expression dynamics,and potential function of OPA1 for regulation of mitochondrial morphology during spermiogenesis in Phascolosoma esculenta

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Journal of Oceanology and Limnology 2024年第1期42卷 187-200页

作者： Xinming GAO Binbin FENG chen DU Congcong hou Shan JIN Daojun TANG Junquan ZHU Key Laboratory of Applied Marine Biotechnology by the Ministry of Education and Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China College of Ecology Lishui UniversityLishui 323000China

Mitochondria undergo morphological changes during spermatogenesis in some animals.The mechanism and role of mitochondrial morphology regulation,however,remain somewhat unclear.In this study,we analyzed the molecular characteristics,expression dynamics and subcellular localization of optic atrophy protein 1(OPA1),a mitochondrial fusion and cristae maintenance-related protein,to reveal the possible regulatory mechanisms underlying mitochondrial morphology in Phascolosoma esculenta spermiogenesis.The full-length cDNA of the P.esculenta opa1 gene(Pe-opa1)is 3743 bp in length and encodes 975 amino acids.The Pe-OPA1 protein is highly conservative and includes a transmembrane domain,a GTPase domain,two helical bundle domains,and a lipid-interacting stalk.Gene and protein expression was higher in the coelomic fluid(a site of spermatid development)of male P.esculenta and increased first and then decreased from March to December.Moreover,their expression during the breeding stage was significantly higher than during the non-breeding stage,suggesting that Pe-OPA1 is involved in P.esculenta reproduction.The Pe-OPA1 protein was more abundant in components consisting of many spermatids than in components without,indicating that Pe-OPA1 mainly plays a role in the spermatid in coelomic fluid.Moreover,Pe-OPA1 was mainly detected in the spermatid mitochondria.Immunofluorescence experiments showed that the Pe-OPA1 are constitutively expressed and co-localized with mitochondria during spermiogenesis,suggesting its involvement in P.esculenta spermiogenesis.These results provide evidence for Pe-OPA1's involvement in the regulation of mitochondrial morphology during spermiogenesis.

关键词： optic atrophy protein 1(OPA1) spermiogenesis Phascolosoma esculenta mitochondrial dynamics spermatid

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