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Stress Distribution in GaN Films grown on Patterned Si (111) Substrates and Its Effect on LED Performance

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Chinese Physics Letters 2013年第9期30卷 165-168页

作者： chen dan-yang WANG Li XIONG Chuan-Bing ZHENG Chang-Da MO Chun-Lan JIANG Feng-Yi National Engineering Research Center for LED on Si Substrate Nanchang UniversityNanchang 330047

Crack free GaN films were grown on 1200×1200𝜈m^(2) patterned Si(111)substrates and 36 light emitting diodes(LEDs)were fabricated in each pattern *** distribution of the tensile stress in the pattern units and its influence on the LED performance are studied by micro-Raman and electroluminescence(EL).The Raman shift of the GaN𝐹E_(2) mode shows that the tensile stress is the maximum at the center,partially relaxed at the edge,and further relaxed at the *** the stress relaxation,the EL wavelength has a significant blue shift and the luminous intensity shows a great enhancement.

关键词： Si(111) GaN pattern

Nitration of TRPM2 as A Molecular Switch Induces Autophagy During Brain Pericyte Injury

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神经药理学报 2019年第Z1期 96-97页

作者： chen dan-yang JIANG Quan GAO Yin-ping HAN Feng Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang University Key Laboratory of Cardiovascular & Cerebrovascular Medicine School of PharmacyNanjing Medical University

Aims:Dysfunction of neurovascular pericytes underlies breakdown of the bloodbrain barrier,but the molecular mechanisms are largely unknown. In this study,we evaluated the role of the transient receptor potential melastatin-related 2(TRPM2) channel and autophagy during brain pericyte injury both in vitro and in vivo. Results:A rapid induction in autophagy in human brain vascular pericytes,in the zinc oxide nanoparticles(ZnONP)-induced cell stress model,was paralleled with an increase in the expression of the TRPM2-S truncated isoform,which was abolished by treatment with a nitric oxide synthase inhibitor and a peroxynitrite scavenger. Furthermore,Y1485 in the C-terminus of the TRPM2 protein was identified as the tyrosine nitration substrate by mass spectrometry. Overexpression of the Y1485 S TRPM2 mutant reduced LC3-Ⅱ accumulation and pericyte injury induced by ZnO-NP. Consistently,LC3-Ⅱ accumulation was reduced and pericytes were better preserved in intact brain microvessels of the TRPM2 knockout mice after ZnO-NP-induced vascular injury. Innovation and Conclusions:Our present study has revealed a novel mechanism of autophagy disturbance secondary to nitrosative stress-induced tyrosine nitration of TRPM2 during pericyte injury.

关键词： autophagy TRPM2 nitrosative stress protein nitration pericyte brain

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精准纳米气体治疗研究进展

无机材料学报 2018年第8期33卷 811-824页

作者：何前军陈丹阳范明俭深圳大学医学部生物医学工程学院深圳518060

精准纳米气体治疗具有低毒高效等特性,作为一种新兴的疾病治疗手段受到越来越多的关注。研究表明,纳米气体治疗不仅能在特定疾病部位选择性杀死癌细胞,还能保护正常细胞。本文总结了国际最新研究成果,对精准纳米气体治疗的最新研究进展... 详细信息

精准纳米气体治疗具有低毒高效等特性,作为一种新兴的疾病治疗手段受到越来越多的关注。研究表明,纳米气体治疗不仅能在特定疾病部位选择性杀死癌细胞,还能保护正常细胞。本文总结了国际最新研究成果,对精准纳米气体治疗的最新研究进展进行了总结归纳和展望。首先,阐述了纳米气体治疗的治疗作用和特点;然后,总结了实现精准纳米气体治疗的主要途径,包括靶向气体传输、可控气体释放、医学成像引导和监控气体治疗、基于治疗性气体的多模式联合治疗等;最后,对纳米气体治疗存在的问题和发展前景做出了总结和展望。

关键词：气体治疗纳米药物可控释放药物传输介孔二氧化硅石墨烯综述

Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan Shuai chen dan Liu Qian Xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee dan Cao Younghye Moon chen chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng dan yang Lingxi Qing Yifei chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

若尔盖不同退化高寒草甸土壤磷形态及其影响因素

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草业学报 2023年第12期32卷 36-46页

作者：杨志强刘丹廖小琴陈丹阳宋小艳柳杨王长庭西南民族大学青藏高原研究院四川成都610041

为了明确不同退化高寒草甸土壤磷含量的变化特征,以若尔盖未退化(UD)、轻度退化(LD)、中度退化(MD)、重度退化(SD)和极度退化(ED)高寒草甸为研究对象,采用Hedley磷分级法,测定并比较不同退化程度下高寒草甸土壤磷形态含量差异,探讨影响... 详细信息

为了明确不同退化高寒草甸土壤磷含量的变化特征,以若尔盖未退化(UD)、轻度退化(LD)、中度退化(MD)、重度退化(SD)和极度退化(ED)高寒草甸为研究对象,采用Hedley磷分级法,测定并比较不同退化程度下高寒草甸土壤磷形态含量差异,探讨影响退化高寒草甸土壤磷形态的环境因素。结果显示:1)整体上高寒草甸土壤磷形态以盐酸磷为主,稀盐酸无机磷(DHCl-P_(i))、浓盐酸无机磷(CHCl-P_(i))和浓盐酸有机磷(CHCl-P_(o))含量之和占总磷(TP)的50%以上。2)高寒草甸土壤各形态磷随退化程度加剧整体呈下降趋势。与未退化草甸相比,极度退化草甸0~10 cm土壤水溶性磷(H2O-P)、碳酸氢钠无机磷(NaHCO_(3)-P_(i))和碳酸氢钠有机磷(NaHCO_(3)-P_(o))显著降低了92.51%、89.57%和85.10%,10~20 cm土壤仅NaHCO_(3)-P_(o)显著降低了80.32%;0~20 cm土壤氢氧化钠无机磷(NaOH-P_(i))、氢氧化钠有机磷(NaOH-P_(o))、浓盐酸有机磷(CHCl-P_(o))和残余磷(residual-P)整体表现为随退化加剧而降低,最小值均在极度退化草甸且分别为12.15、7.09、21.14和26.48 mg·kg^(-1)。3)H2O-P与土壤容重(BD)显著负相关;NaHCO_(3)-P_(i)、NaHCO_(3)-P_(o)、NaOH-P_(i)、NaOH-P_(o)、CHCl-P_(o)和residual-P与土壤总碳(TC)和总氮(TN)显著正相关而与土壤pH和BD显著负相关;CHCl-P_(i)与所有环境因子相关性不显著;土壤BD、pH、含水量(SMC)、TC和TN共同解释土壤磷形态变异的78.79%,其中土壤pH的贡献率最高(52.29%)。综上,土壤各磷形态均随高寒草甸退化加剧而呈现出不同程度的降低,其中土壤有机磷的下降幅度最为明显。研究结果有望为未来若尔盖退化高寒草甸土壤养分保持及草甸恢复管理提供科学依据。

关键词：若尔盖退化草甸土壤磷形态 Hedley磷分级法

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Y型喷嘴反压环境粒径的图像捕捉测量技术

航空动力学报 2018年第1期33卷 174-181页

作者：王丹陈鹏飞杨岸龙李龙飞中国航天科技集团公司西安航天动力研究所液体火箭发动机技术重点实验室西安710100

鉴于Y型喷嘴反压条件下的粒径难以采用传统光学测量手段获得有效数据,提出一种基于图像捕捉的粒径处理程序,通过微距镜头拍摄雾场图像,通过图像识别和数据统计获取有效索太尔平均直径(SMD)。该处理方法在大气下与相位多普勒粒子分析仪(P... 详细信息

鉴于Y型喷嘴反压条件下的粒径难以采用传统光学测量手段获得有效数据,提出一种基于图像捕捉的粒径处理程序,通过微距镜头拍摄雾场图像,通过图像识别和数据统计获取有效索太尔平均直径(SMD)。该处理方法在大气下与相位多普勒粒子分析仪(PDPA)测量结果误差不超过12%。实验结果表明:在反压条件下,当气流量为0g/s时,雾化粒径较大,随着环境压力升高和液流量增大,雾化粒径呈减小趋势;当加入气流量为5.5g/s时,雾化粒径显著降低,并且粒径随着环境压力升高而增大(该结果与不加气时恰恰相反),而在同一反压、不同液流量工况下,雾化粒径基本保持不变。在燃烧室变工况条件下,加入少量的气体即可使雾化粒径显著减小且在变工况条件下基本保持一致。

关键词： Y型喷嘴图像识别索太尔平均粒径(SMD) 反压条件雾化实验