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Journal of Iron and Steel Research(International) 2024年第3期31卷 660-669页

作者： Shuang Liu chen du Cong Zhang Zhen-hua Bai Key Lab of Industrial Computer Control Engineering of Hebei Province Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina

An anti-saturation fault-tolerant adaptive torsional vibration control method with fixed-time prescribed performance for the rolling mill main drive system(RMMDS)was investigated,which is affected by control input saturation,actuator faults,sensor measurement errors,and parameter ***,we gave a continuously differentiable saturation function to approximate the control input saturation characteristic of the RMMDS,translating the saturation characteristic into the matched uncertainty and unknown time-varying gain in the ***,an RMMDS mathematical model with unmatched uncertainty and unknown time-varying gain was developed,taking into account the presence of control input saturation,actuator faults,sensor measurement errors,and parameter *** on the established mathematical model,an error transformation model of the roll speed tracking was constructed by the equivalent error transformation *** to the error transformation model,a barrier Lyapunov function and a novel adaptive controller were studied to ensure that the roll speed tracking error always evolves inside a fixed-time asymmetric ***,numerical simulations were performed in Matlab/Simulink to verify the effectiveness and superiority of the proposed control method in suppressing the RMMDS torsional vibration.

关键词： Fixed-time prescribed performance Control input saturation Actuator fault Unknown time-varying gain Adaptive control Asymmetric constraint

Characterization,expression dynamics,and potential function of OPA1 for regulation of mitochondrial morphology during spermiogenesis in Phascolosoma esculenta

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Journal of Oceanology and Limnology 2024年第1期42卷 187-200页

作者： Xinming GAO Binbin FENG chen du Congcong HOU Shan JIN Daojun TANG Junquan ZHU Key Laboratory of Applied Marine Biotechnology by the Ministry of Education and Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China College of Ecology Lishui UniversityLishui 323000China

Mitochondria undergo morphological changes during spermatogenesis in some *** mechanism and role of mitochondrial morphology regulation,however,remain somewhat *** this study,we analyzed the molecular characteristics,expression dynamics and subcellular localization of optic atrophy protein 1(OPA1),a mitochondrial fusion and cristae maintenance-related protein,to reveal the possible regulatory mechanisms underlying mitochondrial morphology in Phascolosoma esculenta *** full-length cDNA of the *** opa1 gene(Pe-opa1)is 3743 bp in length and encodes 975 amino *** Pe-OPA1 protein is highly conservative and includes a transmembrane domain,a GTPase domain,two helical bundle domains,and a lipid-interacting *** and protein expression was higher in the coelomic fluid(a site of spermatid development)of male *** and increased first and then decreased from March to ***,their expression during the breeding stage was significantly higher than during the non-breeding stage,suggesting that Pe-OPA1 is involved in *** *** Pe-OPA1 protein was more abundant in components consisting of many spermatids than in components without,indicating that Pe-OPA1 mainly plays a role in the spermatid in coelomic ***,Pe-OPA1 was mainly detected in the spermatid *** experiments showed that the Pe-OPA1 are constitutively expressed and co-localized with mitochondria during spermiogenesis,suggesting its involvement in *** *** results provide evidence for Pe-OPA1's involvement in the regulation of mitochondrial morphology during spermiogenesis.

关键词： optic atrophy protein 1(OPA1) spermiogenesis Phascolosoma esculenta mitochondrial dynamics spermatid

Micro defects formation and dynamic response analysis of steel plate of quasi-cracking area subjected to explosive load

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Defence Technology（防务技术） 2024年第1期31卷 580-593页

作者： Zheng-qing Zhou Ze-chen du Xiao Wang Hui-ling Jiang Qiang Zhou Yu-long Zhang Yu-zhe Liu Pei-ze Zhang Research Institute of Macro-Safety Science University of Science and TechnologyBeijing100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China School of Mechanical Engineering Nantong UniversityNantong226019China China North Industry Advanced Technology Generalization Institute Beijing100089China China Academy of Ordnance Science China

As the protective component,steel plate had attracted extensive attention because of frequently threats of explosive *** this paper,the evolution of microstructure and the mechanism of damage in the quasi-cracking area of steel plate subjected to explosive load were discussed and the relationships between micro defects and dynamic mechanical response were *** the explosion experiment,five observation points were selected equidistant from the quasi-cracking area of the section of the steel plate along the thickness direction,and the characteristics of micro defects at the observation points were analyzed by optical microscope(OM),scanning electron microscope(SEM) and electron backscattered diffraction(EBSD).The observation result shows that many slip bands(SBs) appeared,and the grain orientation changed obviously in the steel plate,the two were the main damage types of micro *** addition,cracks,peeling pits,grooves and other lager micro defects were appeared in the lower area of the *** stress parameters of the observation points were obtained through an effective numerical *** mechanism of damage generation and crack propagation in the quasicracking area were clarified by comparing the specific impulse of each observation point with the corresponding micro *** result shows that the generation and expansion of micro defects are related to the stress area(*** upper compression area,the neutral plane area,and the lower tension area).The micro defects gather and expand at the grain boundary,and will become macroscopic damage under the continuous action of tensile ***,the micro defects at the midpoint of the section of the steel plate in the direction away from the explosion center(*** horizontal direction) were also *** was found that the specific impulse at these positions were much smaller than that in the thickness direction,the micro defects were only SBs and a few micro cracks,and the those decrea

关键词： Explosive load Quasi-cracking area Micro defects Steel plate Dynamic response Numerical simulation

Efficacy and safety of targeted therapy plus immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX) for unresectable hepatocarcinoma

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World Journal of Gastroenterology 2024年第17期30卷 2321-2331页

作者： Zhi-Peng Lin Xiao-Long Hu du chen Da-Bei Huang Xu-Gong Zou Hai Zhong Sheng-Xiang Xu Yuan chen Xiao-Qun Li Jian Zhang Department of Interventional Medicine Zhongshan People’s HospitalZhongshan 528400Guangdong ProvinceChina

BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more efficacious than ***,the mechanisms underlying this innovative treatment modality have not been *** To evaluate the clinical efficacy of targeted therapy plus immunotherapy combined with hepatic arterial infusion chemotherapy(HAIC)of FOLFOX in patients with unresectable *** We enrolled 53 patients with unresectable HCC who received a combination of targeted therapy,immunotherapy,and HAIC of FOLFOX between December 2020 and June 2021 and assessed the efficacy and safety of the treatment *** The objective response rate was 60.4%(32/53),complete response was 24.5%(13/53),partial response was 35.9%(19/53),and stable disease was 39.6%(21/53).The median duration of response and median progression-free survival were 9.1 and 13.9 months,*** surgical conversion rate was 34.0%(18/53),and 1-year overall survival was 83.0%without critical complicating diseases or adverse events(AEs).CONCLUSION The regimen of HAIC of FOLFOX,targeted therapy,and immunotherapy was curative for patients with unresectable HCC,with no serious AEs and a high rate of surgical conversion.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Targeted therapy Immunotherapy Adverse events

基于t检验和逐步网络搜索的有向基因调控网络推断算法

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计算机应用 2024年第1期44卷 199-205页

作者：陈都李圆媛陈彧武汉理工大学理学院武汉430070 武汉工程大学数理学院武汉430205

为了克服基于条件互信息的路径一致算法(PCA-CMI)无法识别调控方向的缺陷,并进一步提高网络推断准确率,提出了一种基于t检验和逐步网络搜索的有向网络推断算法(DNI-T-SRS)。首先,对不同实验条件下的表达数据进行t检验以辨别基因调控的... 详细信息

为了克服基于条件互信息的路径一致算法(PCA-CMI)无法识别调控方向的缺陷,并进一步提高网络推断准确率,提出了一种基于t检验和逐步网络搜索的有向网络推断算法(DNI-T-SRS)。首先,对不同实验条件下的表达数据进行t检验以辨别基因调控的上下游关系,指导路径一致(Path Consensus)算法中条件基因的选取,根据CMI2(Conditional Mutual Inclusive Information)剔除网络中的冗余边,得到了基于t检验的有向调控关系推断算法CMI2NI-T(CMI2-based Network Inference guided by t-Test);然后,建立有向调控关系对应的米氏微分方程模型对数据进行拟合,根据贝叶斯信息准则进行逐步网络搜索以修正网络推断结果。利用CMI2NI-T推断DREAM6挑战中的两个测试网络,所得到的曲线下面积(AUC)分别为0.7679和0.9796,相较于PCA-CMI分别提高了16.23%和11.62%;通过进一步的数据拟合后DNI-T-SRS的推断准确率分别达到了86.67%和100.00%,相较于PCA-CMI分别提高了18.19%和10.52%。实验结果表明,所提DNI-T-SRS算法能够有效剔除间接调控关系并保留直接调控连接,得到精确的基因调控网络推断结果。

关键词：基因调控网络条件互信息 t检验逐步网络搜索米氏微分方程模型贝叶斯信息准则

混合式购买与回应性治理:中国政府购买服务的实践逻辑

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吉林大学社会科学学报 2024年第1期64卷 93-105,237页

作者：杨宝杜晨阳重庆大学公共管理学院重庆400044

在国家治理能力现代化背景下,中国各级政府逐步推行政府购买服务制度这一源起于西方的政策工具,但仍有问题亟待阐释:中西之间政府购买服务的实践逻辑有何差异,政府购买服务如何提升国家治理能力?基于政策文本和典型案例的混合分析,探究... 详细信息

在国家治理能力现代化背景下,中国各级政府逐步推行政府购买服务制度这一源起于西方的政策工具,但仍有问题亟待阐释:中西之间政府购买服务的实践逻辑有何差异,政府购买服务如何提升国家治理能力?基于政策文本和典型案例的混合分析,探究中国政府购买服务“目标-程序”的逻辑关系,可以发现:1)中西政府购买服务的共性在于强调以“市场竞争”形式外包公共服务,但中国政府购买服务并未局限于西式的效率型导向,而是表现为兼具效率型、发展型、放权型等多重逻辑并存的“混合式”图景,中西政府购买服务之间属于“形似神异”。2)中国政府购买服务之所以表现为混合式购买,本质上是政府回应不同公共服务需求时采取的多元化策略,其终极目标则是迈向“回应性治理”。3)政府在购买服务过程中以“规制性动员”策略消解社会组织发育不足和公共服务模糊性的潜在挑战,以获取建制性权力的方式增强国家治理的回应能力。对中国政府购买服务“目标-程序”逻辑关系的研究本质上是基于“本土实践”讲述中国故事。

关键词：回应性治理混合式购买政府购买服务实践逻辑

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炼油企业原油金融衍生品工具应用研究

当代石油石化 2024年第2期32卷 26-31页

作者：陈都中国石油化工股份有限公司炼油事业部北京100728

原油贸易具有全球性特点,其交易金额巨大,影响因素较多,复杂性和不确定性显著。原油期纸货流通性强,期纸货交易量远大于原油实际贸易量,应用原油金融衍生品对冲炼油企业生产经营风险具备可行性。炼油企业可通过使用原油金融衍生品工具,... 详细信息

原油贸易具有全球性特点,其交易金额巨大,影响因素较多,复杂性和不确定性显著。原油期纸货流通性强,期纸货交易量远大于原油实际贸易量,应用原油金融衍生品对冲炼油企业生产经营风险具备可行性。炼油企业可通过使用原油金融衍生品工具,从炼油全产业链的角度,充分降低原油采购、运输、库存运作和产品销售及出口等环节的经营风险,理论上可锁定炼油利润,有助于炼油企业生产经营优化及稳定创效。

关键词：炼油企业金融衍生品原油采购和运输库存运作成品油出口

山西多地主产区酸枣叶醇提物抗氧化活性与抑菌作用比较研究

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饲料研究 2024年第7期47卷 82-87页

作者：张琰杜晨晖山西药科职业学院山西太原030031 山西中医药大学山西太原030619

试验比较山西多地主产区酸枣叶醇提物的抗氧化活性与抑菌作用。收集晋北、晋中、晋东南、晋南等主产区的酸枣叶样品,通过醇提物有机溶剂萃取法对酸枣叶抗氧化活性部位进行筛选,并对不同主产区酸枣叶的不同极性部位的抗氧化活性进行比较... 详细信息

试验比较山西多地主产区酸枣叶醇提物的抗氧化活性与抑菌作用。收集晋北、晋中、晋东南、晋南等主产区的酸枣叶样品,通过醇提物有机溶剂萃取法对酸枣叶抗氧化活性部位进行筛选,并对不同主产区酸枣叶的不同极性部位的抗氧化活性进行比较,对酸枣叶醇提物水溶液的抑菌作用进行试验。结果显示,酸枣叶醇提物乙酸乙酯相的总黄酮含量最高;乙酸乙酯相提取物对2, 2-联氮-双-3-乙基苯并噻唑啉-6-磺酸(ABTS)自由基、1, 1-二苯基-2-苦肼基(DPPH)自由基的清除能力最强。在不同产区中,晋中地区酸枣叶不同极性部位的抗氧化活性最强,晋南地区最弱。太谷区和平遥县酸枣叶醇提物水溶液的抑菌作用最强。研究表明,山西晋中地区酸枣叶醇提物的抗氧化活性较高,且乙酸乙酯相的抗氧化活性比其他极性部位高,山西晋中地区的酸枣叶醇提物水溶液抑菌和杀菌作用最强。

关键词：酸枣叶抗氧化活性抑菌作用 DPPH ABTS

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飞机铝合金材料的腐蚀与防腐蚀探讨

山西冶金 2024年第3期47卷 137-138,206页

作者：陈都厦门太古飞机工程有限公司福建厦门361015

铝合金在航空领域应用广泛,其防腐蚀是飞机维修维护的重要工作。飞机铝合金部件的腐蚀多数是由原电池效应引起的电化学腐蚀。对铝合金材料腐蚀进行分类阐述,了解腐蚀本质、成因及表征,并对飞机维修维护中的防腐蚀处理进行分析。

关键词：飞机铝合金腐蚀防腐蚀

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想象与国家:论霍布斯的国家观

政治思想史 2024年第2期15卷 91-106,198页

作者：杜陈中山大学哲学系〈珠海〉

一直以来,研究者对于霍布斯政治哲学中不受制约的主权者和公民个体之间的关系争论不休。然而,这些讨论大多忽略了想象在霍布斯国家观中的关键地位。通过对想象在人与世界关系、人与人关系中的阐发和利用,霍布斯揭示了国家作为人造人格... 详细信息

一直以来,研究者对于霍布斯政治哲学中不受制约的主权者和公民个体之间的关系争论不休。然而,这些讨论大多忽略了想象在霍布斯国家观中的关键地位。通过对想象在人与世界关系、人与人关系中的阐发和利用,霍布斯揭示了国家作为人造人格的想象性和合作性。面对共和主义者的诘难,霍布斯以想象的思维运动取代了共和主义式的积极行动,最终指向君主和臣民围绕想象进行的合作。霍布斯的国家人格思想内涵丰富,揭示了政治观念与政治事实的复杂关联。

关键词：霍布斯国家观想象