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HPLc测定防晒类化妆品中西诺沙酯等31种防晒剂的含量

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中国现代应用药学 2024年第12期41卷 1699-1708页

作者：卢端萍郭珊珊程佳华张丽蓉韩康印陈硕福建省食品药品质量检验研究院福州350012

目的建立防晒类化妆品中西诺沙酯等31种防晒剂的HPLc检测方法。方法样品以甲醇-四氢呋喃(1∶1)混合溶液超声提取21种脂溶性防晒剂(1^(#)~21^(#)),以甲醇-四氢呋喃-水(2∶3∶5)混合溶液超声提取10种水溶性防晒剂(22^(#)~31^(#)),采用Ag... 详细信息

目的建立防晒类化妆品中西诺沙酯等31种防晒剂的HPLc检测方法。方法样品以甲醇-四氢呋喃(1∶1)混合溶液超声提取21种脂溶性防晒剂(1^(#)~21^(#)),以甲醇-四氢呋喃-水(2∶3∶5)混合溶液超声提取10种水溶性防晒剂(22^(#)~31^(#)),采用Agilent ZORBAX SB c18(4.6 mm×250 mm,5μm)色谱柱分离西诺沙酯等20种脂溶性防晒剂(1^(#)~20^(#))、Agilent ZORBAX SB c18(2.1 mm×100 mm,3.5μm)色谱柱分离聚硅氧烷-15(21^(#))、Waters Symmetry c18(4.6 mm×250 mm,5μm)色谱柱分离10种水溶性防晒剂,分别以甲醇-异丙醇-水、异丙醇-四氢呋喃-水、甲醇-乙腈-0.02 mol·L^(-1)乙酸铵溶液(加磷酸调pH值至5.0)为流动相进行梯度洗脱,流速分别为1.2、0.5、1.0 mL·min^(-1),检测波长为358 nm(7^(#)、11^(#))、295 nm(23^(#)~25^(#)、27^(#)~31^(#))、311 nm(其余成分),进样量5μL(聚硅氧烷-15)、10μL(其余成分),柱温30℃。结果 31种防晒剂在考察的质量浓度范围内呈良好的线性关系(r>0.999 9),各成分的检测限范围为0.002%~0.02%,2个基质在3个不同添加水平的加样回收率为92.4%~110.3%,RSD范围为0.02%~4.5%。应用该方法对40批国产及进口防晒类化妆品进行检测,结果检出17种准用防晒剂,其中有10批检出聚硅氧烷-15。与《化妆品安全技术规范》(2015版)现行方法相比,该方法改善了部分脂溶性的防晒剂的提取效率,提高了甲酚曲唑三硅氧烷的稳定性,同时增加了西诺沙酯、聚硅氧烷-15等9种防晒剂的检测。结论本方法准确、灵敏、可靠,可用于防晒类化妆品中防晒剂的检测分析。

关键词：高效液相色谱法化妆品防晒剂西诺沙酯聚硅氧烷-15 含量测定

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氟溴唑仑的奖赏效应及其神经环路机制研究

中国药科大学学报 2024年第3期55卷 390-396页

作者：黄为国江炜楷邵雨微陈志刚唐苏苏洪浩中国药科大学药学院南京210009

氟溴唑仑(Flub)是一种新型苯二氮䓬类精神活性物质,其成瘾性及其机制尚不清楚。本研究采用小鼠条件位置偏爱(cPP)模型,研究Flub的奖赏效应,以c-Fos表达评定神经元活性,采用病毒示踪技术追踪神经环路,通过化学遗传技术研究神经环路对奖赏... 详细信息

氟溴唑仑(Flub)是一种新型苯二氮䓬类精神活性物质,其成瘾性及其机制尚不清楚。本研究采用小鼠条件位置偏爱(cPP)模型,研究Flub的奖赏效应,以c-Fos表达评定神经元活性,采用病毒示踪技术追踪神经环路,通过化学遗传技术研究神经环路对奖赏效应的调控作用。结果显示,Flub(ip 3 mg/kg)显著增加小鼠cPP评分,增加腹侧被盖区(VTA)多巴胺(DA)能神经元c-Fos表达。抑制VTA多巴胺能神经元活性,Flub小鼠cPP评分显著降低。病毒示踪显示,VTA多巴胺能神经元接受喙内侧被盖核(RMTg)γ氨基丁酸(GABA)能神经元投射。激活RMTgGABA→VTADA环路或阻断RMTg脑区苯二氮䓬受体,Flub小鼠的cPP评分显著降低。这些结果表明,Flub通过激活RMTg脑区GABA神经元中的苯二氮䓬受体,抑制RMTgGABA→VTADA环路,产生奖赏效应。

关键词：氟溴唑仑奖赏效应条件性位置偏好腹侧被盖区喙内侧被盖核苯二氮䓬受体

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Enhancing electromagnetic absorption performance of Molybdate@carbon by metal ion substitution

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Journal of Materials Science & Technology 2023年第32期163卷 92-100页

作者： Aming Xie Daohu Sheng Wenli Liu Youjian chen Siyao cheng School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of chemistry and chemical Engineering Nanjing University of Science and TechnologyNanjing

Transition metal molybdate(RMoO4)has been extensively studied in optics,electricity and catalysis due to its low cost and multivalent Mo atoms,while its poor electrical conductivity limits its application in electromagnetic wave absorption(EMA).compounding molybdate with conductive materials is an effective way to improve its electrical *** this work,a homogeneous coating on the molybdate surface was achieved by utilizing a pyrrole oxidation polymerization mechanism,and then stabilized composites of Molybdate@carbon(RMoO4@c)were obtained by high-temperature *** EMA properties of the nanocomposites were tuned by substituting the species of transition metal elements(RMoO_(4)@c,R=Fe,co,cu).Among them,Fe_(2)(MoO_(4))_(3)@c has a minimum reflection loss of−60.62 dB at an ultra-low thickness of 1.7 mm,and the effective absorption bandwidth(EAB)can reach 4.75 GHz at 3.00 *** work expands the range of applications for molybdate and provides a new material basis for building high-performance EMA materials.

关键词： Transition metal molybdate Electrical conductivity Molybdate@carbon Electromagnetic wave absorption

西伯利亚龟象取食对荞麦不同抗感品种生化物质的影响

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植物保护 2024年第3期50卷 181-187,265页

作者：陈磊常静王振李清宇周洪友李海平内蒙古农业大学园艺与植物保护学院呼和浩特010019 山西省植物保护植物检疫中心太原030002 内蒙古根河市农牧水利科技局根河022350

为探讨抗虫和感虫荞麦品种对西伯利亚龟象Rhinoncus sibiricus取食的反应,选择抗虫品种‘蒙0207’‘晋苦6’和感虫品种‘蒙0208’‘晋苦2’,研究害虫不同程度(轻度、中度和重度)取食情况下,荞麦叶片中营养物质(可溶性蛋白和可溶性糖)和... 详细信息

为探讨抗虫和感虫荞麦品种对西伯利亚龟象Rhinoncus sibiricus取食的反应,选择抗虫品种‘蒙0207’‘晋苦6’和感虫品种‘蒙0208’‘晋苦2’,研究害虫不同程度(轻度、中度和重度)取食情况下,荞麦叶片中营养物质(可溶性蛋白和可溶性糖)和次生代谢物质(单宁、总酚和类黄酮)含量,防御酶[过氧化氢酶(cAT)、苯丙氨酸解氨酶(PAL)]以及蛋白酶抑制剂[胰蛋白酶抑制剂(TI)、胰凝乳蛋白酶抑制剂(cI)]活性的变化,以及西伯利亚龟象体内主要解毒酶活性的变化。结果表明,西伯利亚龟象取食48 h后,各处理组荞麦叶片中可溶性性蛋白、可溶性糖、单宁、总酚和类黄酮的含量以及PAL、cAT、TI、cI活性均有增加。在供试的4个荞麦品种中,抗虫品种被取食后可溶性蛋白和可溶性糖含量上升幅度较感虫品种更大,感虫品种被取食后单宁含量,PAL、TI、cI活性上升幅度较抗虫品种更大。在不同取食程度下,抗虫品种中的TI和cI活性均显著高于感虫品种。西伯利亚龟象成虫取食抗虫荞麦品种后体内羧酸酯酶(carE)和谷胱甘肽S-转移酶(GSTs)活性均显著高于取食感虫品种的个体。研究结果表明,西伯利亚龟象取食能诱导荞麦抗虫性物质含量的变化,但对荞麦抗性品种与感虫品种的影响不同。

关键词：荞麦西伯利亚龟象取食抗虫性抗性物质防御酶

基于色味指标光谱特性的贺兰山东麓干红葡萄酒产地细分

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农业工程学报 2024年第15期40卷 253-261页

作者：白雪冰陈鑫龙刘乾鑫葛颖张旭董树萌杨佳宁陶永胜西北农林科技大学葡萄酒学院杨凌712100 西北农林科技大学宁夏贺兰山东麓葡萄酒试验示范站永宁750104 西北农林科技大学经济管理学院杨凌712100

贺兰山东麓被认为是全球最适宜种植葡萄和生产优质葡萄酒的区域之一。贺兰山东麓葡萄酒产区自北向南已形成石嘴山、银川、永宁、青铜峡和红寺堡等5个产地的区划格局,但因产地风土各异,尚未建立科学规范的葡萄酒产地细分管理方法。为了... 详细信息

贺兰山东麓被认为是全球最适宜种植葡萄和生产优质葡萄酒的区域之一。贺兰山东麓葡萄酒产区自北向南已形成石嘴山、银川、永宁、青铜峡和红寺堡等5个产地的区划格局,但因产地风土各异,尚未建立科学规范的葡萄酒产地细分管理方法。为了协助宁夏贺兰山东麓产区强化干红葡萄酒产品区划管理,该研究以贺兰山东麓干红葡萄酒为研究对象,分析葡萄酒色味理化指标的相关性和产地差异性,并依据随机森林的节点权值确定了可反映产地信息的关键色味理化指标。然后,基于近红外光谱和化学计量学方法构建了各项指标的定量分析模型,并以光谱预测结果为输入量,训练了以ReLU为最佳激活函数的人工神经网络产地判别模型,实现了贺兰山东麓干红葡萄酒的产地细分。结果表明,酒石酸酯和pH值的产地差异性最为显著,多项色味理化指标之间存在较强的相关性,通过去低权值指标分析确定了酒石酸酯、多聚体花色苷、pH值、红/绿通道a^(*)、黄/蓝通道b^(*)、总单宁、单体花色苷、明度L^(*)、黄酮醇、滴定酸、离子化指数、乙醇指数、色度c_(ab)^(*)、总花色苷等14项关键色味理化指标。每项指标的光谱定量模型决定系数(r^(2))均高于0.90,相对分析误差(RPD)高于2.5,具有准确的定量分析能力;人工神经网络模型对石嘴山酒样判别的灵敏度(sensitivity,SEN)为100%,准确率(accuracy,ccR)为100%;对银川酒样判别的SEN为100%,ccR为90%;对永宁酒样判别的SEN为87.5%,ccR为93.33%;对青铜峡酒样判别的SEN为94.74%,ccR为100%;对红寺堡酒样判别的SEN为92.31%,ccR为92.31%,具有可靠的产地判别能力。该方法可为贺兰山东麓干红葡萄酒的产品区划管理提供技术支撑,有助于中国葡萄酒原产地保护制度的建立与发展。

关键词：干红葡萄酒近红外光谱机器学习色味指标贺兰山东麓产地细分

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Interface Engineering and Anion Engineering of Mo-Based Heterogeneous Electrocatalysts for Hydrogen Evolution Reaction

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Energy & Environmental Materials 2023年第1期6卷 87-104页

作者： Zehao Yin Xuan Liu Siru chen Tingli Ma Yanqiang Li State Key Laboratory of Fine chemicals School of Chemical EngineeringDalian University of TechnologyPanjin CampusPanjin 124221China School of Material and chemical Engineering Centre for Advanced Materials ResearchZhongyuan University of TechnologyZhengzhou 450007China Department of Materials Science and Engineering China Jiliang UniversityHangzhou 310018China Graduate School of Life Science and Systems Engineering Kyushu Institute of TechnologyKitakyushu Fukuoka 808-0196Japan

Development and utilization of hydrogen energy is an effective way to achieve carbon neutrality,only hydrogen production through electrolytic water splitting meets the goal of zero carbon *** facilitate the large-scale commercialization of water splitting devices,the development of highly efficient and low-cost catalysts to reduce the energy consumption is ***_(2)has been regarded as a promising electrocatalyst to replace platinum in hydrogen evolution reaction due to its low price and unique 2D layered ***,the poor conductivity and inert basal planes of MoS_(2)limited its wide-spread ***,researches have demonstrated that the conductivity and active sites of MoS_(2)can be improved by heteroatoms doping or constructing of heterogeneous *** this review,the recent progress of Mo-based catalysts are summarized centered on MoS_(2)based on interface engineering and anion engineering,including MoS_(2)–MoO_(2),MoS_(2)–Mo_(2)c,MoS_(2)–MoN_(x),MoS_(2)–MoP,and MoS_(2)–MoSe_(2).The preparation method,structure,and performance of the catalysts are introduced and the possible mechanism behind the improved catalytic activity are revealed to give readers an overall comprehension on the progress of the Mo-based electrocatalysts for hydrogen evolution *** addition,an outlook on future opportunities and development directions of Mo-based catalysts are proposed to facilitate the development of Mo-based catalysts for hydrogen production.

关键词： electrocatalysis heterostructure hydrogen evolution reaction Mo-based catalysts

Fine particulate matter and cardiorespiratory health in china:A systematic review and meta-analysis of epidemiological studies

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Journal of Environmental Sciences 2023年第1期123卷 306-316页

作者： Huihuan Luo Qingli Zhang Yue Niu Haidong Kan Renjie chen School of Public Health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China

This review aimed to systematically summarize the epidemiological literature on the cardiorespiratory effects of PM_(2.5)published during the 13^(th) Five-Year Plan period(2016-2020)in *** articles published between January 1,2016 and June 30,2021 were searched in PubMed,Web of Science,the china National Knowledge Internet Database and Wanfang ***-or fixed-effects models were used to pool effect estimates where *** 8558 records identified,145 met the full eligibility criteria.A 10μg/m^(3) increase in short-term PM_(2.5)exposure was significantly associated with increases of 0.70%,0.86%,0.38%and 0.96%in cardiovascular mortality,respiratory mortality,cardiovascular morbidity,and respiratory morbidity,*** specific diseases with significant associations included stroke,ischemic heart disease,heart failure,arrhythmia,chronic obstructive pulmonary disease,pneumonia and allergic *** pooled estimates per 10μg/m^(3) increase in long-term PM_(2.5)exposure were 15.1%,11.9%and 21.0%increases in cardiovascular,stroke and lung cancer mortality,and 17.4%,11.0%and 4.88%increases in cardiovascular,hypertension and lung cancer incidence *** changes in blood pressure,heart rate variability,systemic infiammation,blood lipids,lung function and airway infiammation were observed for either short-term or long-term PM_(2.5)exposure,or ***,we summarized representative exposure-response relationships between short-and long-term PM_(2.5)exposure and a wide range of cardiorespiratory outcomes applicable to *** magnitudes of estimates were generally smaller in short-term associations and comparable in long-term associations compared with those in developed *** are helpful for future standard revisions and policy *** are still some notable gaps that merit further investigation in china.

关键词： Fine particulate matter Air pollution cardiovascular system Respiratory system Mortality Morbidity Epidemiological studies

Organic ligand mediated evolution from superalkalis to superatomic molecules and nanowires

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Nano Research 2022年第2期15卷 1162-1170页

作者： Jun Li Haicai Huang Jing chen Yuxiang Bu Shibo cheng Key Laboratory for colloid and Interface chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China Suzhou Institute of Shandong University Suzhou 215123China

Superatoms are considered as promising building blocks for customizing superatomic molecules and cluster-assembly nanomaterials due to their tunable electronic structures and *** counting rules,which mainly adjust the shell-filling of clusters,are classical strategies in designing ***,by employing the density functional theory(DFT)calculations,we proved that the 1,4-phenylene diisocyanide(cNc_(6)H_(4)Nc)ligand could dramatically reduce the adiabatic ionization potentials(AlPs)of the aluminum-based clusters,which have 39,40,and 41 valence electrons,respectively,to give rise to superalkali species without changing their ***,the rigid structure of the ligand can be used as a bridge firmly linking the same or different aluminum-based clusters to form superatomic molecules and *** particular,the bridging process was observed to enhance their nonlinear optical(NLO)responses,which can be further promoted by the oriented external electric field(OEEF).Also,the stable cluster-assembly XAl_(12)(cNc_(6)H_(4)Nc)(X=Al,c,and P)nanowires were constructed,which exhibit strong absorption in the visible light *** findings not only suggest an effective ligand-field strategy in superatom design but also unveil the geometrical and electronic evolution from the cNc_(6)H_(4)Nc-based superatoms to superatomic molecules and nanomaterials.

关键词： superatom-assembly nanomaterial density functional theory(DFT)calculation superatom networks superatomic molecule ligand-field strategy oriented external electric field

N^(6)-methyladenosine modification of cENPK mRNA by Zc3H13 promotes cervical cancer stemness and chemoresistance

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Military Medical Research 2022年第5期9卷 576-591页

作者： Xian Lin Feng Wang Jian chen Jing Liu Yi-Bin Lin Li Li chuan-Ben chen Qin Xu Departments of Gynecology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Department of Radiation Oncology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Shenzhen Key Laboratory of Immunity and Inflammatory Diseases Peking University Shenzhen HospitalShenzhen Peking University?the Hong Kong University of Science and Technology Medical CenterShenzhen 518036GuangdongChina Outpatient Department Fujian Hospital of People's Armed PoliceFujian Medical UniversityFuzhou 350014China

Background:Stemness and chemoresistance contribute to cervical cancer recurrence and *** the current study,we determined the relevant players and role of N^(6)-methyladenine(m^(6)A)RNA methylation in cervical cancer ***:The roles of m^(6)A RNA methylation and centromere protein K(cENPK)in cervical cancer were analyzed using bioinformatics *** RNA immunoprecipitation was adopted to detect m^(6)A modification of cENPK *** cervical cancer clinical samples,cell lines,and xenografts were used for analyzing gene expression and *** staining and the tumorsphere formation,clonogenic,MTT,and EdU assays were performed to determine cell stemness,chemoresistance,migration,invasion,and proliferation in HeLa and SiHa cells,*** blot analysis,co-immunoprecipitation,chromatin immunoprecipitation,and luciferase reporter,cycloheximide chase,and cell fractionation assays were performed to elucidate the underlying ***:Bioinformatics analysis of public cancer datasets revealed firm links between m^(6)A modification patterns and cervical cancer prognosis,especially through Zc3H13-mediated m^(6)A modification of cENPK *** expression was elevated in cervical cancer,associated with cancer recurrence,and independently predicts poor patient prognosis[hazard ratio=1.413,95%confidence interval=1.078−1.853,P=0.012].Silencing of cENPK prolonged the overall survival time of cervical cancer-bearing mice and improved the response of cervical cancer tumors to chemotherapy in vivo(PcENPK was directly bound to SOX6 and disrupted the interactions of cENPK withβ-catenin,which promotedβ-catenin expression and nuclear translocation,facilitated p53 ubiquitination,and led to activation of Wnt/β-catenin signaling,but suppression of the p53 *** dysregulation ultimately enhanced the tumorigenic pathways required for cell stemness,DNA damage repair pathways necessary f

关键词： N^(6)-methyladenosine centromere protein K cervical cancer Stemness chemoresistance