检索结果-南通市图书馆

Gastroenterology Report 2022年第1期10卷 341-348页

作者： Shiguang chen Wenchang Yu Kongzhi Zhang Weifu Liu Xiaolong Wang chuanben chen Department of Interventional Oncology Fujian Medical University Cancer HospitalFuzhouChina Department of Radiotherapy Oncology Fujian Medical University Cancer HospitalFuzhouChina

Background Unresectable hepatocellular carcinoma(HCC)has a poor *** to the HCC management guidelines in China,the standard treatment of Barcelona Clinic Liver Cancer(BCLC)stage B or C HCC with portal vein tumour thrombosis(PVTT)is ***,some patients with BCLC stage B or C HCC with PVTT respond poorly to *** aimed to compare tumour responses and survival benefits between patients with unresectable HCC with or without *** We reviewed 119 consecutive patients with unresectable HCC with PVTT(n=67)and without PVTT(n=52)who underwent hepatic arterial infusion of oxaliplatin plus raltitrexed between January 2018 and April *** survival,progression-free survival,tumour responses,and adverse events were compared between the *** There were no significant between-group differences in the objective response rates and median progression-free *** median overall survival was significantly longer in the group without PVTT than in that with PVTT(17.0 vs 10.4 months,respectively;P=0.024).Conclusion Hepatic arterial infusion of oxaliplatin plus raltitrexed may be efficacious in patients with unresectable HCC with or without PVTT.

关键词： hepatic arterial infusion hepatocellular carcinoma oxaliplatin portal vein tumour thrombosis raltitrexed

Comparison of Volumetric and Dosimetric Variations in Nasopharyngeal Carcinoma during Intensity-modulated Radiation Therapy with and without Neoadjuvant Chemotherapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Biomedical Engineering(English Edition) 2020年第3期29卷 24-32页

作者： Zhaodong Fei Yi Li Xiufang Qiu Yingying Huang Li Li chuanben chen Department of Radiotherapy Fujian Medical University Cancer HospitalFujian Provincial Cancer HospitalFuzhou Fujian Province 350014China Department of Radiation Oncology Fujian Medical University Cancer HospitalFujian Provincial Cancer HospitalFuzhou Fujian Province 350014China

Objective Patients with nasopharyngeal carcinoma(NPC)undergoing intensity-modulated radiation therapy(IMRT)may experience significant volumetric and dosimetric variations throughout the treatment ***,neoadjuvant chemotherapy may reduce the extent of these *** study was carried out to evaluate volumetric and dosimetric changes in target volumes and organs at risk(OARs)during IMRT in patients with locally advanced NPC who received concurrent chemoradiotherapy(CCRT)alone or in combination with neoadjuvant chemotherapy(NACT).Methods 35 NPC patients were recruited for this study and divided into the NACT(n=15)and CCRT(n=20)*** tomography(CT)scans were performed before neoadjuvant chemotherapy,before IMRT,before the 24 th fraction of IMRT,and after *** original plan(plan 0)was based on CT images collected before *** plan 1(plan 1)and hybrid plan 2(plan 2)were generated by applying the beam configurations of plan0 to the CT scans collected before the 24 th fraction of IMRT and after *** and dosimetric variations were assessed by comparing the results of plan 0 with those of plan 1 and plan *** In the NACT group,compared with that in plan 0,the primary gross tumor volume(GTVnx)decreased by 33.2%±18.4%and 50.5%±12.6%in plan1 and plan 2,*** the CCRT group,the corresponding reduction rates in plan 1 and plan 2 were 49.4%±8.0%and 77.8%±28.1%,*** volume decrease rates in the NACT group were less than those in the CCRT group(P<0.001).In the NACT group,compared with that of plan0,the dose to 95%of the volume(D95)for the planning target volume of the primary tumor(PTVnx)decreased by 1.0%±0.7%and 0.6%±0.6%in plan 1 and plan 2,*** the CCRT group,the corresponding decrease rates in plan 1 and plan 2 were 4.2%±3.8%and 6.1%±6.3%,*** decrease rate of D95 for PTVnx in the NACT group was less than that in the CCRT group(P<0.001).Similar results among the plans were

关键词： Nasopharyngeal carcinoma Intensity-modulated radiation therapy Adaptive radiation therapy Neoadjuvant chemotherapy Concurrent chemoradiotherapy

在线全文

学校读者我要写书评

暂无评论

肿瘤放射治疗质量安全评价标准指南

中华放射肿瘤学杂志 2024年第4期33卷 281-295页

作者：国家癌症中心/国家肿瘤质控中心陈传本不详福建医科大学肿瘤临床医学院福建省肿瘤医院/福建省肿瘤质控中心福州350014

目前各地区不同级别的放疗单位中,临床治疗流程、人员资质和结构、设备的配置和状态、质控水平尚不统一,多数省级质控中心尚无可量化、客观化的质量安全评价标准进行放疗质量安全和质控水平的评价。这影响了省级质控中心对本省放疗单位... 详细信息

目前各地区不同级别的放疗单位中,临床治疗流程、人员资质和结构、设备的配置和状态、质控水平尚不统一,多数省级质控中心尚无可量化、客观化的质量安全评价标准进行放疗质量安全和质控水平的评价。这影响了省级质控中心对本省放疗单位的质控管理、质量安全和质控水平进行检查、监督和评价,也影响国家肿瘤质控中心对全国放疗单位质控水平进行同质化评估。鉴于此,本指南系统介绍肿瘤放射治疗质量安全的评价项目、评价要点、检查要素和评价对象等内容,以期建立适用各级放疗单位的放疗质量安全评价标准体系,搭建同质化平台,以解决当前不同省份、不同级别的医院质量保证难以监控的实际问题,为各级放疗质控中心的质控评价和质量安全管理提供统一的、有效的评价标准。

关键词：放射疗法质量安全评价项目评价要点检查要素评价对象

Prognostic value of serum uric acid and tumor response to induction chemotherapy in locally advanced nasopharyngeal carcinoma

在线全文

学校读者我要写书评

暂无评论

Prognostic value of serum uric acid and tumor response to in...

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Xinyi Huang Qinyan chen Lin chen Yuanji Xu Zijie Wu Penggang Bai chuanben chen Department of Radiation Oncology Fujian Medical University Cancer Hospital Fujian Cancer Hospital

Background: To explore the combined predictive value of serum uric acid(SUA) and tumor response to induction chemotherapy(IC) in locally advanced nasopharyngeal carcinoma(LANPC) patients receiving IC followed by concurrent chemoradiation therapy(CCRT).Methods: A total of 341 LANPC patients treated with IC + CCRT were enrolled in this retrospective *** survival(OS), progression-free survival(PFS), locoregional relapse-free survival(LRFS), and distant metastasis-free survival(DMFS) were compared by the Kaplan-Meier analysis and the logrank test, and multivariable survival analysis was carried out to investigate the independent prognostic ***: Univariate analysis showed that a low SUA level and unsatisfactory tumor response to two cycles of IC both were negative predictors for OS, PFS, and DMFS in patients with LANPC. multivariable analysis demonstrated that the SUA level after two cycles of IC was an independent prognostic factor for OS(P=0.012) but of borderline significance for PFS and DMFS(P=0.055 and P=0.067,respectively). Furthermore, tumor response to IC was of independent significance for predicting OS,PFS, and DMFS, respectively. Finally, LANPC patients with satisfactory tumor response and a high SUA level after two cycles of IC had a better OS, PFS, and DMFS than those with unsatisfactory tumor response and a low SUA ***: The SUA level and the tumor response to two cycles of IC had predictive value for LANPC patients treated with IC plus CCRT. However, more aggressive therapeutic strategies are recommended for those with a low SUA level and unsatisfactory tumor response to two cycles of IC.

关键词： Nasopharyngeal carcinoma Serum uric acid Tumor response Prognosis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

对网格中间区域矫正更优的图像矫正算法

计算机辅助设计与图形学学报 2012年第8期24卷 1076-1081页

作者：闵小平黄绍辉陈传本柏朋刚厦门大学计算机科学系厦门361005 福建省肿瘤医院放疗科福州350014

常规放疗中模拟定位机影像增强器采集的图像常存在失真,为了保证放疗的精度,必须进行矫正,为此提出一种以点到直线距离为目标函数的图像矫正算法.在综合考虑矫正的速度、精度、平滑性的前提下,先采用基于一次线性基的移动最小二乘法对... 详细信息

常规放疗中模拟定位机影像增强器采集的图像常存在失真,为了保证放疗的精度,必须进行矫正,为此提出一种以点到直线距离为目标函数的图像矫正算法.在综合考虑矫正的速度、精度、平滑性的前提下,先采用基于一次线性基的移动最小二乘法对图像进行了矫正,取得了比较理想的结果;进一步,利用矫正后各线条应该为直线这一特征增加了参考点的数量,使交叉点中间区域也有了参考点.矫正结果显示,矫正之后各网格线呈现更理想的直线,交叉点之间的区域矫正比只考虑交叉点的矫正算法理想.当参考点增加到2 000多个点时,算法运行时间仍然较短.

关键词：模拟机图像处理图像矫正移动最小二乘法

Identification of potential plasma biomarkers in early-stage nasopharyngeal carcinoma-derived exosomes based on RNA sequencing

在线全文

学校读者我要写书评

暂无评论

Identification of potential plasma biomarkers in early-stage...

Effects of oral maintenance chemotherapy and predictive value of circulating EBV DNA in metastatic nasopharyngeal carcinoma

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Xinyi Huang Qinyan chen Lin chen Wangzhong Ye Wei Zheng Zijie Wu Yuanji Xu Penggang Bai chuanben chen Department of Radiation Oncology Fujian Medical University Cancer Hospital Fujian Cancer Hospital

Background: Early diagnosis of nasopharyngeal carcinoma(NPC) is vital to improve the prognosis of these patients. However, early diagnosis of NPC is typically challenging. Therefore, we explored the pathogenetic roles and associated mechanisms of exosomes in plasma of patients with early-stage ***: Exosomes in plasma were extracted by ultra-high-speed centrifugation. Western blot and transmission electron microscopy(TEM) were used to verify the purity of exosomes. The sequencing data(6 plasma samples from healthy volunteers vs. 6 NPC plasma samples) were analyzed by principal component analysis(PCA), DESeq2, gene ontology(GO), Kyoto encyclopedia of genes and genomes(KEGG), and TargetScan. The diferentially expressed miRNAs(DEmiRNAs) were obtained from the dataset(GSE118720) downloaded from the Gene Expression Omnibus(GEO) ***, the datasets downloaded from the GEO database(GSE12452, GSE13597, GSE53819,GSE64634) were used to predict the target genes and functions of hsa-miR-1301-3 p. Quantitative reverse-transcription polymerase chain reaction(qRT-PCR) was applied to verify the diferences in the expressions of hsa-miR-1301-3 p between 10 normal plasma and 10 NPC plasma ***: Western blot, TEM, and Nanoparticle Tracking Analysis showed adequate purity of the extracted exosomes. RNA-sequencing(RNA-seq) analysis revealed 21 upregulated miRNAs, and 10 downregulated miRNAs in plasma exosomes of early-stage NPC patients. GO analysis showed that the target genes of DEmiRNAs were mainly enriched in DNA synthesis and transcription *** analysis revealed that DEmiRNAs were mainly enriched in phosphatidylinositol-3 kinase/protein kinase B(PI3 K-Akt) and mitogen-activated protein kinase(MAPK) signaling ***, the expression of hsa-mir-1301-3 p was verifed to be signifcantly upregulated in enlarged samples of plasma ***: We identifed several DEmiRNAs extracted from tumor-derived exosomes between normal

关键词： Nasopharyngeal carcinoma(NPC) Exosomes Gene Expression Omnibus(GEO) Bioinformatics analysis Kyoto encyclopedia of genes and genomes(KEGG)

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Effects of oral maintenance chemotherapy and predictive valu...

综合施策强预防科学抗癌惠民生——福建省肿瘤防控工作30余年发展历程

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Zhou,Han Lu,Tianzhu Guo,Qiaojuan chen,Yan chen,Mengwei chen,Yansong Lin,Yingying chen,chuanben Ma,Liqin Xu,Yun Lin,Shaojun Pan,Jianji Department of Radiation Oncology Fujian Cancer Hospital & Fujian Medical University Cancer Hospital Department of Clinical Laboratory Fujian Cancer Hospital and Fujian Medical University Cancer Hospital

Oral maintenance chemotherapy can effectively prolong overall survival(OS) in many types of metastatic cancer,but its role in metastatic nasopharyngeal carcinoma(mNPC) is *** this study,the efficacy of oral maintenance chemotherapy in mNPC and the effectiveness of circulating tumor EBV-DNA for screening patients were *** June 2016 and December 2017,141 patients with mNPC who received platinum-based systemic chemotherapy were included(median follow-up time,21 months).Patients were classified into two groups according to the administration of oral maintenance *** samples were collected before,during,and after treatment for the measurement of circulating EBV *** 2-year OS was higher for patients who received maintenance chemotherapy than for patients without maintenance chemotherapy(78.9% vs.62.7%,p = 0.016).Patients with undetectable post-treatment EBV-DNA after 4–6 cycles of systemic chemotherapy(n = 73) had a higher 2-year OS than that of patients with detectable EBV-DNA(n = 68)(82.16% vs.51.45%,p = 0.001).For patients with undetectable post-treatment EBV-DNA,OS was better for those with maintenance chemotherapy than for those without(86.7% vs.73%,p = 0.027).For patients with detectable post-treatment EBV-DNA,maintenance chemotherapy did not improve outcomes(49.5% vs.55.4%,p = 0.824).The most common acute events were hematological toxicity,and all were tolerable and *** maintenance chemotherapy with S1 or capecitabine can improve OS in ***-treatment EBV-DNA was an independent prognostic factor for m *** patients with detectable EBV-DNA after systematic chemotherapy,maintenance chemotherapy was not sufficient.

关键词： metastatic nasopharyngeal carcinoma oral maintenance chemotherapy EBV-DNA prognosis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国肿瘤 2024年第11期33卷 879-885页

作者：周衍吴琳榕陈传本陈建顺陈上清福建医科大学肿瘤临床医学院福建省肿瘤医院福建福州350014 福州市长乐区疾病预防控制中心福建福州350200 厦门市同安区疾病预防控制中心福建厦门361100

福建省是消化系统肿瘤相对高发的省份之一,肿瘤防治工作始于20世纪80年代后期的高发现场研究。30余年来,福建省在肿瘤病因研究、防癌科普宣传、筛查与早诊早治等方面做了大量的工作,肿瘤防控取得一定成效。全文就福建省癌症防治机构概... 详细信息

福建省是消化系统肿瘤相对高发的省份之一,肿瘤防治工作始于20世纪80年代后期的高发现场研究。30余年来,福建省在肿瘤病因研究、防癌科普宣传、筛查与早诊早治等方面做了大量的工作,肿瘤防控取得一定成效。全文就福建省癌症防治机构概况、肿瘤登记体系完善、重点肿瘤筛查工作进展、肿瘤高发现场防控情况进行了总结,并对未来福建省癌症防控工作进行展望。

关键词：肿瘤防控肿瘤登记癌症筛查福建

鼻咽癌XRCC4基因第8外显子突变与临床分期及预后的关系

在线全文

学校读者我要写书评

暂无评论

中国肿瘤临床 2012年第24期29卷 2009-2012页

作者：宗井凤潘建基贾静苏颖陈增邹长棪陈传本福建医科大学教学医院福建省肿瘤医院放疗科福州市350014 放射生物研究室

目的：探讨XRCC4基因突变与鼻咽癌分期及放疗疗效的关系。方法：选取68例病理确诊为鼻咽癌的鼻咽肿瘤活检新鲜组织标本，变性高效液相色法检测XRCC4基因突变情况，收集患者的性别、年龄、病理类型、肿瘤分期、生存等临床资料，分析XRCC... 详细信息

目的：探讨XRCC4基因突变与鼻咽癌分期及放疗疗效的关系。方法：选取68例病理确诊为鼻咽癌的鼻咽肿瘤活检新鲜组织标本，变性高效液相色法检测XRCC4基因突变情况，收集患者的性别、年龄、病理类型、肿瘤分期、生存等临床资料，分析XRCC4基因突变与临床分期、肿瘤局部复发、远处转移以及疾病相关死亡等关系。结果：27例标本检出XRCC4基因存在第8外显子突变，突变率39．7％（27／68）。全组中位随访98（6～106）个月，XRCC4基因第8外显子突变与T分期有关，局部晚期患者（T3～T4）的突变率高于早期（T1～T2）（x2=4．686，P=0．03），突变与N分期、临床分期、局部复发、远处转移、疾病相关死亡均无相关性。T分期、N分期、临床分期分别是影响局部复发、远处转移和疾病相关死亡的独立预后因素，而XRCC4基因突变对生存无影响。结论：鼻咽癌组织中存在XRCC4基因第8外显子突变，这种突变与鼻咽癌的放疗疗效无关，但与T分期有关，考虑XRCC4基因突变可能参与了肿瘤发展的某个阶段。

关键词：鼻咽肿瘤 XRCC4基因突变预后分析肿瘤分期

HER2阳性乳腺癌患者选择靶向治疗的影响因素分析

在线全文

学校读者我要写书评

暂无评论

中国循证医学杂志 2023年第1期23卷 7-13页

作者：王鑫吴其佑连至炜孙静吴凡张弓刘健陈传本中国医学科学院北京协和医学院/卫生健康管理政策学院北京100005 福建医科大学肿瘤临床医学院/福建省肿瘤医院福州350014

目的分析人类表皮生长因子受体2(HER2)阳性乳腺癌患者选择靶向治疗的影响因素,为完善创新抗癌药物纳入公共保障政策提供参考。方法研究对象为2014—2020年在福建省肿瘤医院确诊为HER2阳性乳腺癌且符合靶向治疗适应证,并接受治疗的女性... 详细信息

目的分析人类表皮生长因子受体2(HER2)阳性乳腺癌患者选择靶向治疗的影响因素,为完善创新抗癌药物纳入公共保障政策提供参考。方法研究对象为2014—2020年在福建省肿瘤医院确诊为HER2阳性乳腺癌且符合靶向治疗适应证,并接受治疗的女性患者。基于医院信息系统收集患者的人口社会学信息和临床资料。采用二分类logistic多元回归模型分析HER2阳性乳腺癌患者选择靶向治疗的影响因素,并进一步根据肿瘤分期进行亚组回归分析。结果共纳入1041例患者,其中803例接受过靶向治疗。2017年9月,HER2阳性乳腺癌靶向治疗药物开始纳入当地基本医疗保险。此时间点前接受靶向治疗的患者只有282例(35.1%),此后增加至521例(64.9%)。2014—2020年接受靶向治疗的患者中,正规就业人员(45.8%)和职工医保参保人员(66.0%)最多。未接受靶向治疗的患者,无业人员(42.4%)和居民医保参保人(50.0%)最多。多元回归分析结果发现,患者职业、雌激素受体表达、肿瘤分期、是否手术、是否放疗和接受主要治疗的时间(2017年9月首个HER2阳性乳腺癌靶向治疗药物纳入医保前后)均是患者选择靶向治疗的影响因素(P<0.05)。结论HER2阳性乳腺癌靶向治疗药物纳入医保的政策实施后,患者选择靶向药物治疗的意愿大幅提高。个人经济负担是符合靶向治疗适应证的患者决定是否采用靶向治疗的决定因素。应进一步加强对支付能力相对较弱患者的公共保障力度,使创新抗癌药物治疗惠及更多患者。

关键词：乳腺癌人类表皮生长因子受体2 靶向治疗影响因素 logistic回归