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Synthesis of ribonucleoside analogues containing thio-substituted 1,3,4-triazole as heterocyclic base

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Chinese Journal of Chemistry 1997年第4期15卷 379-384页

作者： Ding, Y Zhang, J chen, yq Laboratory of Bio-Organic & Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China [?]Department of Chemistry University of Iowa Iowa City IA 52242 USA

New ribonucleoside analogues containing thio-substituted 1,3,4-triazole as heterocyclic base have been synthesized via condensation of the central intermediate 1 with various acids, esters, amides, and anhydrides in a... 详细信息

关键词： ribonucleoside analogues thio-substituted 1,3,4-triazoles heterocyclic base

Effects of antigen presentation of eosinophils on lung Th1/Th2 imbalance

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中华医学杂志(英文版) 2005年第1期000卷 7-12页

作者： XIE Zheng fu, SHI Huan zhong, QIN Xue jun, KANG Lan fu, HUANG Chun ping and chen Yi qiangDepartments of Respiratory and Critical Care Medicine, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China (Xie ZF, Shi HZ, Qin XJ, Kang LF, Huang CP and chen yq) Departments of Respiratory and Critical Care Medicine First Affiliated Hospital Guangxi Medical University Nanning 530021 China

Background Antigen loaded eosinophils (EOSs) instilled intratracheally into mice were capable of inducing Th2 type cytokine production in the draining lymph nodes The aim of the present study was to evaluate whether EOSs within the tracheobronchial lumen can stimulate Th2 cell expansion in the lung tissues Methods Airway EOSs were recovered from ovalbumin sensitized and challenged BALB/c mice, these EOSs were then cocultured with CD4 + cells isolated from sensitized mice in the absence or presence of anti CD80 or/and CD86 monoclonal antibodies Airway EOSs were instilled into the trachea of sensitized mice. At the day 3 thereafter, the lung tissues were removed and prepared into cell suspensions for culture Cell free culture supernatants were collected for detection of cytokines Results Airway EOSs functioned as CD80 and CD86 dependent antigen presenting cells to stimulate lung CD4 + lymphocytes to produce interleukin 4, interleukin 5 and interleukin 13, but not interferon γ in in vitro assay When instilled intratracheally in sensitized recipient mice, airway EOSs primed lung Th2 cells in vivo for interleukin 4, interleukin 5 and interleukin 13, but not interferon γ, production during the in vitro culture that was also CD80 and CD86 dependent Conclusion EOSs within the lumina of airways could process inhaled antigen and function in vitro and in vivo as antigen presenting cells to promote expansion of Th2 cells in the lungs

关键词： Eosinophil · Th1/Th2 cell · antigen presenting cell · lung

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严重创伤的免疫学研究进展

军医进修学院学报 2011年第7期32卷 771-774页

作者：陈云强孙天胜北京军区总医院北京100070 军医进修学院北京100853

机体在严重损伤或多发伤后的免疫反应是重症治疗中的重要课题。创伤后体内产生过多的炎性调节介质(如细胞因子、趋化因子),同时出现细胞介导的固有免疫严重失衡,导致威胁生命的创伤后并发症。本文旨在从免疫学角度概述创伤的免疫调节。

关键词：创伤炎性反应免疫抑制

同种异体胚胎神经干细胞移植修复脊髓损伤的时效性观察

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中国组织工程研究与临床康复 2007年第11期11卷 2091-2093,2097页

作者：宋飞邢琪魏明海陈一曲刘天庆马学虎大连医科大学附属第二医院神经外科辽宁省大连市116027 大连医科大学附属第一医院麻醉科辽宁省大连市116021 大连理工大学环境与生命学院辽宁省大连市116023

目的:观察同种异体胚胎神经干细胞移植对脊髓损伤大鼠双后肢运动功能的修复作用,并分析其移植时效性。方法:实验于2003-07/08在大连医科大学分子生物学实验室和大连理工大学环境与生命学院生物医学实验室完成。①取孕14￣16d的大白鼠1只... 详细信息

目的:观察同种异体胚胎神经干细胞移植对脊髓损伤大鼠双后肢运动功能的修复作用,并分析其移植时效性。方法:实验于2003-07/08在大连医科大学分子生物学实验室和大连理工大学环境与生命学院生物医学实验室完成。①取孕14￣16d的大白鼠1只,引颈处死,剖腹,取出胎鼠,钳取大脑皮质及皮质下脑室旁的脑组织,体外培养大鼠胚胎神经干细胞。②将30只成年SD大鼠按随机数字表法分为3组,即损伤对照组、早期移植组和延期移植组,每组10只。3组大鼠均制作脊髓横断损伤模型,造成大鼠下肢瘫痪,早期移植组、延期移植组大鼠分别在伤后3d及3周移植胎鼠脑组织神经干细胞。观察移植后大鼠双后肢的运动功能恢复情况,通过胶质原纤维酸性蛋白及神经元特异性烯醇化酶免疫组化染色法观察各组大鼠的脊髓组织形态学变化,胶质原纤维酸性蛋白是星形胶质细胞特异性标志蛋白,神经元特异性烯醇化酶是神经元特异性蛋白。结果:脊髓损伤建模实验纳入大鼠30只,全部进入结果分析,无脱失。①各组大鼠神经干细胞移植后双后肢的功能恢复情况:早期移植组和延期移植组大鼠双后肢的运动功能均有明显改善,但早期移植组表现尤为显著。早期移植组和延期移植组细胞移植后五六天即可见瘫痪大鼠的后肢肌力开始恢复,二三周后可出现爬行,4周后后肢活动活跃;损伤对照组大鼠的瘫痪肢体无任何恢复。②移植4周后早期移植组大鼠移植区脊髓组织的形态学变化:脊髓移植区肉眼可见有增生的组织充填,镜下有大量新生的细胞,表现为神经元和神经胶质细胞阳性染色(胶质原纤维酸性蛋白(+),神经元特异性烯醇化酶(+))。结论:神经干细胞移植对脊髓横断大鼠运动功能恢复有促进作用,早期移植疗效更好。

关键词：胚胎神经干细胞脊髓损伤移植修复同种异体神经元特异性烯醇化酶时效性胶质原纤维酸性蛋白成年SD大鼠

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： Yang Liu Huopo chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao Xu Xuan Wu Jiarui Li Shiling chen Danyang chen Gaigai Li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Magneto-rheological elastomer (MRE) based composite structures for micro-vibration control

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 345-356页

作者： yq Ni ZG Ying ZH chen Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hung Horn Kowloon Hong Kong China Department of Mechanics Zhejiang University Hangzhou 310027 China

Magneto-rheological elastomers （MILEs） are used to construct composite structures for micro-vibration control of equipment under stochastic support-motion excitations. The dynamic behavior of MREs as a smart viscoelastic material is characterized by a complex modulus dependent on vibration frequency and controllable by external magnetic fields. Frequency-domain solution methods for stochastic micro-vibration response analysis of the MRE-based structural systems are developed to derive the system frequency-response function matrices and the expressions of the velocity response spectrum. With these equations, the root-mean-square （RMS） velocity responses in terms of the one-third octave frequency band spectrum can be calculated. Further, the optimization problem of the complex moduli of the MRE cores is defined by minimizing the velocity response spectra and the RMS velocity responses through altering the applied magnetic fields. Simulation results illustrate the influences of MRE parameters on the RMS velocity responses and the high response reduction capacities of the MRE-based structures. In addition, the developed frequency-domain analysis methods are applicable to sandwich beam structures with arbitrary cores characterized by complex shear moduli under stochastic excitations described by power spectral density functions, and are valid for a wide frequency range.

关键词： magneto-rheological elastomer (MRE) micro-vibration control equipment composite structure sandwich beam stochastic excitation

肺移植受者痰标本细菌培养和药敏试验结果:12例特点分析

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中国组织工程研究与临床康复 2007年第21期11卷 4066-4069页

作者：肖华龙强新晨张晓峰周丽珍孙剑陈云清江南大学附属无锡市第五人民医院检验科江苏省无锡市214073

目的:了解肺移植受者感染病原菌的分布及其对抗菌药物的耐药情况,为临床合理使用抗生素提供依据。方法:选择2003-06/2005-05在江南大学附属无锡市第五人民医院进行肺移植的受者12例,术前均知情并签署手术同意书。其中双肺移植3例(男1例,... 详细信息

目的:了解肺移植受者感染病原菌的分布及其对抗菌药物的耐药情况,为临床合理使用抗生素提供依据。方法:选择2003-06/2005-05在江南大学附属无锡市第五人民医院进行肺移植的受者12例,术前均知情并签署手术同意书。其中双肺移植3例(男1例,女2例),单肺移植9例(均为男性)。在肺移植前后分别对受者深部脓性痰标本镜检筛选合格标本,将合格标本接种于平板培养基培养,对可疑菌落进行分离,采用法国梅里埃公司VITEK-32全自动微生物分析系统各种细菌鉴定卡和药敏试验卡进行细菌鉴定和药敏试验。结果:①12例肺移植受者移植前后痰标本中分离出各种细菌14种,肺移植前培养出阳性标本8例,其中2例为1种细菌,6例为2种以上的细菌混合感染。移植术前,对培养出阳性的肺移植受者抗感染治疗至痰培养阴性。在移植后3d内,每天连续培养均未检出阳性标本,第4天起开始有阳性标本出现。肺移植后培养出阳性标本10例,其中4例为1种细菌,6例为2种以上的细菌混合感染。②肺移植前后共分离出菌株48株,G+菌28株,占58.3%(28/48);G-菌9株,占18.8%(9/48);真菌11株占22.9%(11/48)。感染的主要病原菌除对磷霉素、万古霉素较为敏感外,其他均有多药耐药性。结论:在肺移植前后受者痰内均可培养分离出多种致病菌,肺部感染是普遍存在的问题。药敏试验结果表明,多数菌株具有多药耐药性。因此,分析肺移植受者痰液标本的细菌种类及耐药性情况对临床合理选择抗菌药物,避免盲目经验用药,及时控制感染有重要意义。

关键词：肺移植痰/微生物学细菌学技术药物耐受性器官移植

Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis coupled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li Shuang Pan Yihuang chen Qiong Liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Atomic economy Radical pathway regulation Rubidium atom coordination Biomass valorization