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LVIS单支架辅助栓塞颅内多发动脉瘤的临床体会

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中华神经外科杂志 2017年第3期33卷 285-288页

作者：彭汤明陈义天董劲虎万伟峰江涌杨晓波王中陈礼刚黄昌仁西南医科大学附属医院神经外科四川泸州646000 苏州大学医学部苏州大学附属第一医院神经外科

目的探讨LVIS单支架辅助栓塞颅内多发动脉瘤的安全性及有效性。方法回顾性分析西南医科大学附属医院神经外科2014年10月至2016年4月收治的19例颅内多发动脉瘤经LVIS单支架一站式辅助栓塞2个动脉瘤的临床资料及影像学资料。结果本组19例... 详细信息

目的探讨LVIS单支架辅助栓塞颅内多发动脉瘤的安全性及有效性。方法回顾性分析西南医科大学附属医院神经外科2014年10月至2016年4月收治的19例颅内多发动脉瘤经LVIS单支架一站式辅助栓塞2个动脉瘤的临床资料及影像学资料。结果本组19例患者共38个多发动脉瘤行LVIS单支架辅助栓塞。平均11个月的临床随访发现，临床预后良好率为79％（15／19）[改良Rankin量表（mRS）评分为0～1分]，轻残率为21％（4／19）（mRS评分为2～3分），无重残及死亡发生。6个月后的数字减影血管造影（DSA）随访结果显示完全栓塞率为87％（33／38），近全栓塞率为13％（5／38）。共4个动脉瘤在随访中发生动脉瘤内进一步血栓化形成，其瘤内进一步血栓化形成率占非完全栓塞患者的57％（4／7）。术中发生并发症3例，分别为术中动脉瘤破裂1例、脑血管严重痉挛1例及术中支架内血栓形成1例。结论LVIS单支架辅助栓塞颅内多发动脉瘤具有良好的安全性和有效性，但仍然不可忽视其症状性支架内血栓事件的发生。

关键词：颅内动脉瘤支架栓塞治疗性治疗结果

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医疗机构受赠药品分析及管理工作探讨

中国药事 2021年第1期35卷 99-108页

作者：余恒毅陈逸天宗凯陈莉孙明辉贡雪芃刘东华中科技大学同济医学院附属同济医院武汉430030

目的:分析新冠疫情期间华中科技大学同济医院(光谷院区)接受与使用捐赠药品情况,为医疗机构受赠药品管理工作提供参考,以期加快我国药品捐赠管理规范化进程。方法:收集2020年2月9日至2020年3月30日期间接受捐赠药品的相关数据并进行统... 详细信息

目的:分析新冠疫情期间华中科技大学同济医院(光谷院区)接受与使用捐赠药品情况,为医疗机构受赠药品管理工作提供参考,以期加快我国药品捐赠管理规范化进程。方法:收集2020年2月9日至2020年3月30日期间接受捐赠药品的相关数据并进行统计分析,包括来源、通用名、失效日期、数量和使用情况;通过查询世界卫生组织系统解剖学治疗学及化学分类系统、《新编简明中成药手册》、国家药品监督管理局数据系统、《国家基本药物目录》、中国医保药品目录查询系统及《新型冠状病毒肺炎诊疗手册》等数据库或文献资料识别药品属性。结果:疫情期间,共接受85种品规的捐赠药品,其中68种(80%)为企业捐赠,是受赠药品的主要来源。受赠药品品种适宜性方面,55种(64.7%)被视为适宜捐赠,30种(35.3%)不适宜捐赠。剩余效期方面,77种(90.6%)的剩余效期≥12个月,6种(7.0%)介于6至11个月之间,但有2种(2.4%)中药免煎颗粒未注明失效日期。使用率方面,8种(9.4%)的总使用率达100%,25种(29.4%)介于50%至100%之间,16种(18.8%)介于10%至50%之间,17种(20%)介于0%至10%之间,19种(22.4%)的总使用率为0%;受赠药品在患者中的使用率较低。结论:本次受赠药品在品种适宜性、剩余效期、受赠数量和使用率方面均存在一定问题。我国应尽快制定药品捐赠指南以规范捐赠行为。医疗机构也应建立相应的管理制度,科学合理地选择与使用受赠药品。

关键词：受赠药品适宜性系统评价新型冠状病毒肺炎

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Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zhang Hanyu Wu Qi chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

Inexact proximal gradient algorithm with random reshuffling for nonsmooth optimization

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Science China(Information Sciences) 2025年第1期68卷 219-237页

作者： Xia JIANG Yanyan FANG Xianlin ZENG Jian SUN Jie chen National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of Technology Beijing Institute of Technology Chongqing Innovation Center School of Electronic and Information Engineering Tongji University

Proximal gradient algorithms are popularly implemented to achieve convex optimization with nonsmooth regularization. Obtaining the exact solution of the proximal operator for nonsmooth regularization is challenging because errors exist in the computation of the gradient; consequently, the design and application of inexact proximal gradient algorithms have attracted considerable attention from researchers. This paper proposes computationally efficient basic and inexact proximal gradient descent algorithms with random reshuffling. The proposed stochastic algorithms take randomly reshuffled data to perform successive gradient descents and implement only one proximal operator after all data pass through. We prove the convergence results of the proposed proximal gradient algorithms under the sampling-without-replacement reshuffling *** computational errors exist in gradients and proximal operations, the proposed inexact proximal gradient algorithms can converge to an optimal solution neighborhood. Finally, we apply the proposed algorithms to compressed sensing and compare their efficiency with some popular algorithms.

关键词： proximal operator random reshuffling inexact computation compressed sensing nonsmooth optimization

Experimental Study on Geometry Characteristics of Turbulent Premixed Flames for Natural Gas/Air Mixtures

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Journal of Thermal Science 2025年第1期34卷 268-282页

作者： ZHENG Weilin WANG Qijiao XIAO Huahua chen Xiaoxiao XIE Fan ZENG Wen Liaoning Key Lab of Advanced Test Technology for Aerospace Propulsion System Shenyang Aerospace University State Key Laboratory of Fire Science University of science and Technology of China AVIC Shenyang Aircraft Design and Research Institute

In this study,focusing on the geometry characteristics of spherical expanding flame,the turbulent premixed flames of natural gas/air mixtures were investigated in a fan-stirred turbulent *** effects of initial temperature（T=300-400 K）,initial pressure（P=0.1-0.3 MPa）,turbulence intensity（u'=1.0-2.7 m/s）,oxygen volumetric percentage(φ（O2）=15%-21%) and carbon dioxide volumetric percentage(φ（CO2）=0-20%)were delved *** flame profile under the Cartesian coordinate system was derived from the schlieren images taken by the high-speed ***,from both macroscopic and microscopic perspectives,the influence of experimental conditions on the flame geometry characteristics was explored through flame front extraction,wavelet decomposition and network *** results demonstrate that for significant flame wrinkling,changes in species concentrations and turbulence intensity have more pronounced effects on the flame wrinkling *** wrinkling of the flame front maintains a certain degree of similarity,as evidenced by the locally concentrated distribution of the angles of the maximum fluctuation *** disturbance energy under large-scale（D6-D8） disturbances exhibits relatively high values with a similar trend,exerting a significant impact on the geometry characteristics of the flame *** peaks of correlation degree are scattered either with the decomposition scale or the development of flame radius,indicating no linear correlation between different detail ***,the probability distribution of node degrees in key wrinkled regions exhibits different trends with that of large-scale wrinkling and disturbance energy,especially with changes in initial *** occurs because the number of key wrinkles varies based on the perturbation's strength or the region's ***,an increase in the fluctuation frequency of the flame's local radius may not necessarily lead to an increase in the number of key folded regions.

关键词： fan-stirred turbulent combustor geometry characteristics large-scale wrinkling network topology wavelet decomposition

Aerodynamic Optimization and Flow Mechanism for a Compressor Cascade at Low Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 92-109页

作者： LI Lin ZHANG Jianshe chen Caiyan TAN Wei ZHANG Yanfeng Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of Sciences University of Chinese Academy of Sciences National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine

Low-Reynolds-number effect is an important factor affecting the performance of compressors and other main components of high-altitude long-endurance unmanned aerial *** improve the flow condition and reduce flow loss under the condition of high altitude and low Reynolds number(Re),this paper proposes an optimization process based on a surrogate model,which combines the class-shape transformation method(CST),the Latin hypercube sampling(LHS) method,the light gradient-boosting machine algorithm(LightGBM),and a genetic algorithm(GA) to optimize a high-subsonic compressor *** surrogate model is verified to be accurate and can be used in the optimization *** accuracy of the GA is higher than the other algorithms under common test *** optimization results are verified by numerical simulation,and the flow differences before and after optimization are compared,especially the flow within the boundary *** changing the blade shape,the optimization process adjusts the loading distribution to delay the transition of the optimized blade on the suction surface,which changes the turbulent reattachment in the laminar separation bubble(LSB) into laminar ***,the mixing loss induced by the turbulent reattachment of the LSB and the wake loss of turbulent separation at the trailing edge are significantly reduced,and the performance of the compressor profile is finally *** addition,turbulent separation of the optimized profile is delayed reducing the range of the wake region on the suction *** this optimization process,the reduction of total pressure loss coefficient at Re of 2.5×10～5,3.5×10～5,and 4.5×10～5 are 16.32%,20.76%,and 22.16%,respectively.

关键词： Reynolds number

Post-tunable salt gel electrolytes toward flexible supercapacitor switches

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Journal of Energy Chemistry 2025年第1期100卷 114-124页

作者： Hui Wang Shuang chen Xuming Liu Qin Zhang Xin Liu Polymeric and Soft Materials Laboratory School of Chemistry and Life Science and Advanced Institute of Materials Science Changchun University of Technology Polymeric and Soft Materials Laboratory School of Chemical Engineering and Advanced Institute of Materials Science Changchun University of Technology

Convertible hydrogel supercapacitors have emerged as promising energy storage devices in switches,diodes, and transistors. However, inherent weaknesses in ionic conductivity, mechanical properties,and water retention of hydrogel electrolytes seriously hinder their development. Inspired by the hardness conversion of sea cucumber skin, a conductivity and mechanics dual-tunable salt gel electrolyte is successfully designed. The salt gel presents a reversible switching of conductors-insulators and a mechanical regulation between softness and hardness via the dissolution-crystallization transition of sodium acetate trihydrate（SAT）. Meanwhile, the salt gels spontaneously grow a layer of “armor” through saturated phase-change salt crystals effectively reducing water evaporation of hydrogel ***, this phase-change soft-rigid conversion strategy will expand the capabilities of gel-based flexible supercapacitors(area capacitance: 258.6 mF cm-2), and the capacitance retention rate could still reach 86.9% after 3000 cycles at high temperatures. Moreover, the salt gel supercapacitor is potentially used in over-heat alarm systems. It is anticipated that the strategy of conductivity and mechanics of dual-tunable salt gel would provide a new perspective on the development of energy storage devices,wearable electronics, and flexible robots.

关键词： Capacitance

A Review on Thermal Management of Li-ion Battery:from Small-Scale Battery Module to Large-Scale Electrochemical Energy Storage Power Station

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Journal of Thermal Science 2025年第1期34卷 1-23页

作者： chen Zhifeng JIA Li YIN Liaofei DANG Chao REN Honglei ZHANG Zhiqiang Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong University

Li-ion battery is an essential component and energy storage unit for the evolution of electric vehicles and energy storage technology in the ***,in order to cope with the temperature sensitivity of Li-ion battery and maintain Li-ion battery safe operation,it is of great necessary to adopt an appropriate battery thermal management system(BTMS).In this paper,the current main BTM strategies and research hotspots were discussed from two aspects:small-scale battery module and large-scale electrochemical energy storage power station(EESPS).The practical application situation,advantages and disadvantages,and the future development trend of each heat dissipation method(air,liquid,PCM,heat pipe,hybrid cooling) were described in *** them,the air cooling and liquid cooling were reviewed in-depth based on the engineering *** PCM,heat pipe and hybrid cooling were reviewed extensively based on the latest *** research provides a comprehensive understanding for the BTMS in all scales.

关键词： battery thermal management cooling methods large-scale electrochemical energy storage power station small-scale battery module

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing chen Jiafu Ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution