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Topology Optimization of Two Fluid Heat Transfer Problems for Heat Exchanger Design

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1949-1974页

作者： Kun yan Yunyu Wang jun yan School of Chemical Engineering Dalian University of TechnologyDalian116024China Jianghuai Advanced Technology Center Hefei230000China State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsInternational Research Center for Computational MechanicsDalian University of TechnologyDalian116024China

Topology optimization of thermal-fluid coupling problems has received widespread *** article proposes a novel topology optimization method for laminar two-fluid heat exchanger *** proposed method utilizes an artificial density field to create two permeability interpolation functions that exhibit opposing trends,ensuring separation between the two fluid ***,a Gaussian function is employed to construct an interpolation function for the thermal conductivity ***,a computational program has been developed on the OpenFOAM platform for the topology optimization of two-fluid heat *** program leverages parallel computing,significantly reducing the time required for the topology optimization *** enhance computational speed and reduce the number of constraint conditions,we replaced the conventional pressure drop constraint condition in the optimization problem with a pressure inlet/outlet boundary *** 3D optimization results demonstrate the characteristic features of a surface structure,providing valuable guidance for designing heat exchangers that achieve high heat exchange efficiency while minimizing excessive pressure *** the same time,a new structure appears in large-scale topology optimization,which proves the effectiveness and stability of the topology optimization program written in this paper in large-scale calculation.

关键词： Topology optimization two fluid heat exchanger OpenFOAM large scale

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超高层建筑中转换钢结构焊接施工技术研究

工程建设与设计 2024年第19期 181-183页

作者：姚伟豪袁和银丁德成陈俊言林贵鹏中建二局第一建筑工程有限公司广东深圳518001 中国建筑第二工程局有限公司广东深圳518001

为提高钢结构焊接质量,以某超高层建筑工程项目为例,开展转换钢结构焊接施工技术的研究。通过超高层建筑中转换钢结构焊接施工参数设计、焊前预热与层间温度控制、接头焊接与焊后保温缓冷,完成施工方案的设计。在此基础上,设计实例应用... 详细信息

为提高钢结构焊接质量,以某超高层建筑工程项目为例,开展转换钢结构焊接施工技术的研究。通过超高层建筑中转换钢结构焊接施工参数设计、焊前预热与层间温度控制、接头焊接与焊后保温缓冷,完成施工方案的设计。在此基础上,设计实例应用实验,通过实验证明,提出的施工技术应用效果良好,按照规范进行施工可以使工程中各项指标通过质量验收。

关键词：超高层建筑层间温度控制焊接参数施工技术焊接转换钢结构

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Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy:A case report

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1436-1442页

作者： Guo-Feng chen jun Wang Yu yan Song Xu Jian chen Department of Gastroenterology Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Pulmonary lymphoepithelioma-like carcinoma(PLELC)is a rare type of nonsmall-cell lung *** lymphoepithelioma-like carcinoma(LELC)metastasis secondary to PLELC has not been reported *** SUMMARY A 64-year-old female was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left *** emission tomography/computed tomography suggested high accumulation of 18F-fludeoxyglucose in the gastric cardia *** gastrointestinal endoscopy confirmed a large mass at the stomach ***(IHC)of the biopsy suggested metastatic stomach *** gastrectomy showed that this 6.5 cm×5.0 cm mass was located in the stomach fundus near the *** examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic *** demonstrated that the tumor was positive for CK(AE1/AE3),p63,p40,p53,Ki-67(70%),and EGFR(3+)and negative for CK7,CK20,Her2,and *** situ hybridization analysis showed positive staining Epstein-Barr virus-encoded *** programmed cell death ligand 1(PD-L1)expression score was 98%,and the combined positive score was 100,with no evidence of microsatellite ***,the patient was unequivocally diagnosed with metastatic stomach LELC secondary to pulmonary *** discharge,this patient underwent PD-1 inhibitor treatment(toripalimab,240 mg)every 3 wk for ten cycles,and she has had no tumor *** For gastric LELC metastasis,PD-1 inhibitor therapy could become a new therapeutic approach,though there is still no evidence from large data sets to support this.

关键词： Stomach neoplasm Pulmonary lymphoepithelioma-like carcinoma Metastasis Immune checkpoint inhibitor Case report

Pillar effect induced by ultrahigh phosphorous/nitrogen doping enables graphene/MXene film with excellent cycling stability for alkali metal ion storage

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Journal of Energy Chemistry 2024年第6期93卷 146-156,I0004页

作者： Meng Qin Yiwei Yao junjie Mao Chi chen Kai Zhu Guiling Wang Dianxue Cao jun yan Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001HeilongjiangChina Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials and Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021FujianChina

Graphene's large theoretical surface area and high conductivity make it an attractive anode material for potassium-ion batteries(PIBs).However,its practical application is hindered by small interlayer distance and long ion transfer ***,this paper aims to address the issue by introducing MXene through a simple and scalable method for assembling graphene and realizing ultrahigh P doping *** findings reveal that MXene and P-C bonds have a "pillar effect" on the structure of graphene,and the P-C bond plays a primary *** addition,N/P co-doping introduces abundant defects,providing more active sites for K^(+) storage and facilitating K^(+) *** expected,the developed ultrahigh phosphorous/nitrogen co-doped flexible reduced graphene oxide/MXene(NPrGM) electrode exhibits remarkable reversible discharge capacity(554 mA hg^(-1) at 0.05 A g^(-1)),impressive rate capability(178 mA h g^(-1) at 2 A g^(-1)),and robust cyclic stability(0.0005% decay per cycle after 10,000 cycles at 2 A g^(-1)).Furthermore,the assembled activated carbon‖NPrGM potassium-ion hybrid capacitor(PIHC) can deliver an impressive energy density of 131 W h kg^(-1) and stable cycling performance with 98.1% capacitance retention after5000 cycles at 1 A g^(-1).Such a new strategy will effectively promote the practical application of graphene materials in PIBs/PIHCs and open new avenues for the scalable development of flexible films based on two-dimensional materials for potential applications in energy storage,thermal interface,and electromagnetic shielding.

关键词： Graphene MXene Phosphorous doping Pillar effect Potassium-ion batteries

Role of magnetic fields on the outer crust in a magnetar

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Chinese Physics C 2024年第7期48卷 160-167页

作者：蒋威陈晏军 Department of Physics and Electronic Science Changsha University of Science and TechnologyChangsha 410114China Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering Changsha 410114China

We explore the properties of 4110 nuclides from Z=5 to Z=82 with the Sky3D code and the composition of the outer crust in magnetars under extreme magnetic *** effects of the variation in nuclear masses due to magnetic fields on the outer crust are comprehensively *** neutron-drip transition pressure,equation of state,and neutron fraction in the outer crust are also discussed.

关键词： outer crust in a magnetar magnetic fields nuclear masses Sky3D code

Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2024年第3期19卷 619-628页

作者： jun Chang Yujiao Li Xiaoqian Shan Xi chen Xuhe yan Jianwei Liu Lan Zhao First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina Tianjin University of Traditional Chinese Medicine TianjinChina

Recent studies have demonstrated that neuroplasticity,such as synaptic plasticity and neurogenesis,exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer’s ***,promoting neuroplasticity may represent an effective strategy with which Alzheimer’s disease can be *** to their significant ability to self-renew,differentiate,and migrate,neural stem cells play an essential role in reversing synaptic and neuronal damage,reducing the pathology of Alzheimer’s disease,including amyloid-β,tau protein,and neuroinflammation,and secreting neurotrophic factors and growth factors that are related to *** events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the mammalian ***,neural stem cells are considered to represent a potential regenerative therapy with which to improve Alzheimer’s disease and other neurodegenerative *** this review,we discuss how neural stem cells regulate neuroplasticity and optimize their effects to enhance their potential for treating Alzheimer’s disease in the clinic.

关键词： Alzheimer’s disease amyloid-β cell therapy extracellular vesicle neural stem cell synaptic plasticity tau

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开门角度决定单开门椎板成形术的扩容效果

解剖学研究 2024年第5期46卷 489-493,501页

作者：钟煜花崔皓桢陈予幸刘彧婷陶敏懿陈焱君欧阳钧钱蕾南方医科大学第一临床医学院广东广州510515 南方医科大学第三附属医院广东广州510515 南方医科大学基础医学院广东广州510515

目的本研究旨在确定多节段脊髓型颈椎病(CSM)患者进行颈椎后路单开门椎板成形术(PCOL)时的最佳开门角度(OA)。研究方法利用颈椎三维模型模拟PCOL,计算不同OA下的椎管扩大容积和比例,以及扩容比增幅;同时在传统二维平面测量PCOL后椎管矢... 详细信息

目的本研究旨在确定多节段脊髓型颈椎病(CSM)患者进行颈椎后路单开门椎板成形术(PCOL)时的最佳开门角度(OA)。研究方法利用颈椎三维模型模拟PCOL,计算不同OA下的椎管扩大容积和比例,以及扩容比增幅;同时在传统二维平面测量PCOL后椎管矢状径。结果随着OA的增加,椎管扩大容积和扩容比显著增加,其中0A为30°时通过三维测量得出的扩容效果最佳,而0A为60°时通过二维测量得出的扩容效果最佳。此外,0A为30°和60°时扩容比增幅和扩径比增幅最大,且差异有统计学意义(P<0.05)。结论开门角度与颈椎管扩大容积存在密切关系,通过三维测量方法计算出0A为30°时扩容效果最佳,而通过二维测量方法计算出OA为60°时扩容效果最佳。

关键词：脊髓型颈椎病,多节段颈后路单开门椎板成形术开门角度扩容效果

Strengthening Organizational Support Is Essential for the High-Quality Development of Disease Prevention and Control Initiatives

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China CDC weekly 2024年第38期6卷 982-985页

作者： Ying Cui Qingfeng chen Hao chen Kaixuan Liu Yuan Wang chengyu Lai Zhi Zeng jun yan Office of Policy and Planning Research Chinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina

Organizational security in public health encompasses structural and supportive measures designed to ensure public health security and effectively prevent and control disease *** measures include organizational leadership,investment mechanisms,information technology support,scientific research,and international exchange and *** prevention and control is often described as an“invisible war”,emphasizing the need for preparedness and proactive measures(1).As the adage states,“Before soldiers and horses move,food and grass go first,”highlighting the critical role of a robust organizational security foundation for successful disease prevention and control *** foundation is essential for promoting high-quality development within the *** its 14th Five-Year Plan period,the Chinese government has implemented policies to bolster organizational *** this commitment,on December 25,2023,the State Council issued the“Guiding Opinions on Promoting the High-Quality Development of Disease Prevention and Control.”

关键词： prevention measures foundation

Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao Ru Wu yan‑yan Gao yang Zhou jun‑Jie Zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors