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Astragalus membranaceus reduces free radical mediated injury to renal tubules in rabbits receiving high energy shock waves

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中华医学杂志(英文版) 2005年第1期 44-50页

作者： SHENG Bin wu, chen Xing fa, ZHAO Jun, HE Da lin and NAN Xun yi Department of Urology, First Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China (Sheng BW, chen xf, Zhao J, He DL and Nan XY)

Background Recent studies have revealed the important role of free radicals in renal damage induced by high energy shock waves (HESW) This study aimed at investigating the effects of Astragalus membranaceus , a traditional Chinese medicinal herb, on free radical mediated HESW induced damage to renal tubules in a live rabbit model Methods Forty five healthy male New Zealand white rabbits were randomly divided into three groups: control group ( n =15), sham group ( n =15), and herb treated group ( n =15) Three days prior to HESW application, the controls received verapamil (0 4 mg/kg), the shams received physiological saline (20 ml), and the herb treated animals received Astragalus membranaceus (2 4 g/kg) intravenously HESW (1500 shocks, 18kV) was applied to the right kidneys of all anesthetized rabbits We measured superoxide dismutase (SOD) and malondialdehyde (MDA) levels before and after shock treatment in blood and kidney homogenates Histopathological changes were also observed Results MDA levels increased and SOD activity decreased significantly in the sham group ( P 0 05) SOD values were significantly higher in the controls than in the shams ( P <0 05) By contrast, SOD levels recovered rapidly in the rabbits receiving Astragalus membranaceus , reaching a nadir within 24 hours, and returning to baseline more quickly than in control and sham rabbits ( P <0 05) Histopathological examinations showed that renal tubular damage in the controls was less severe than in the shams, while damage in the Astragalus membranaceus group was even more mild, with rapid recovery in comparison with the controls Conclusion This study provides preliminary evidence indicating that Astragalus membranaceus has strong protective effects on free radical mediated renal tubular dama

关键词： astragalus membranaceus · high-energy shock wave · kidney · injury

Apoptosis in rabbit embryos produced by fertilization or nuclear transfer with fibroblasts and cumulus cells

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Apoptosis in rabbit embryos produced by fertilization or nuc...

Global Phase Portraits of Uniform Isochronous Centers System of Degree Six with Polynomial Commutator

第三届细胞结构与功能的信号基础研讨会

作者： Liu SZ,Yao LJ,Jiang MX,Lei ZL,Zhang LS,Zhang YL,Sun QY,Zheng YL,Song xf,chen DY. State Key Laboratory of Reproductive Biology,Institute of Zoology,Graduate School,Chinese Academy of Sciences,Beijing 100080,China.

In this study,we investigated the development,the cell number of the blastocyst, and apoptosis in rabbit nuclear transfer(NT) embryos derived from adult fibroblasts and cumulus cells as compared with embryos derived from in vivo fertilization and in vitro *** developmental rate and the total cell number of the blastocyst were significantly lower in NT embryos than in fertilized embryos(FEs).The type of donor cells did not affect the embryonic developmental rate and the total cell number of blastocysts in NT *** present study investigated the onset and the frequency of apoptosis in NT embryos and FEs by using a terminal deoxynucleotidyl transferase-mediated dUTP nick and labeling(TUNEL) *** earliest positive TUNEL signals were detected at the eight-cell stage in NT embryos and at the morula stage in *** apoptotic index of the total blastocysts,the inner cell mass and the trophoderm was greatly higher in the NT embryos than in ***,the apoptotic index of the blastocyst from fibroblasts was significantly higher than that of the blastocyst from cumulus cells.

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来源： cnki会议评论

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 577-599页

作者： Li-na GUO Ai-yong chen Shuai-feng ZHAO School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang 471023China Department of Mathematics Hunan First Normal UniversityChangsha 410205China School of Mechatronics Engineering Henan University of Science and TechnologyLuoyang 471023China

This paper studies the global phase portraits of uniform isochronous centers system of degree six with polynomial *** systems have the form x=-y+xf(x,y),y=x+yf(x,y),where f(x,y)=a_(1)x+a_(2)xy+a_(3)xy^(2)+a_(4)xy^(3)+a_(5)xy^(4)=xσ(y),and any zero of 1+a_(1)y+a_(2)y^(2)+a_(3)y^(3)+a_(4)y^(4)+a_(5)y^(5),y=y is an invariant straight *** last,all global phase portraits are drawn on the Poincare disk.

关键词： global phase portraits uniform isochronous center polynomial commutator invariant straight lines

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丘脑卒中患者认知功能损害及其临床判别

中国组织工程研究与临床康复 2007年第13期11卷 2498-2502页

作者：韩振鹏孙月吉刘启贵姜长斌陈晓芳曲芳吕静周宇大连市第二人民医院神经内科辽宁省大连市116011 大连医科大学神经精神教研室辽宁省大连市116027 大连海港医院神经内科辽宁省大连市116001

目的:探讨丘脑卒中后认知损害的特点,尝试应用回归函数方程推测和判别这种损害程度。方法:①选择2004-04/12大连市第二人民医院和大连市海港医院收治,并经CT确诊的丘脑卒中患者21例为丘脑卒中组;按1∶3匹配原则,将63例年龄与性别与丘脑... 详细信息

目的:探讨丘脑卒中后认知损害的特点,尝试应用回归函数方程推测和判别这种损害程度。方法:①选择2004-04/12大连市第二人民医院和大连市海港医院收治,并经CT确诊的丘脑卒中患者21例为丘脑卒中组;按1∶3匹配原则,将63例年龄与性别与丘脑卒中组匹配的非脑部疾病者入选为对照组。②丘脑卒中组住院后进行影像学和生理、生化学指标检查,对所有入组人员进行神经心理学测查其认知功能,内容包括4个纬度(智能纬度、执行功能纬度、注意机能纬度和记忆纬度)13个认知因子,以韦氏成人智力量表、韦氏记忆量表和威斯康星卡片分类实验等为测查工具。③将对照组每项认知因子均数根据其在认知中的作用不同,加或减1.64标准差为界值,以判断丘脑卒中组认知损害程度,并建立回归方程和认知损害程度表达式。结果:84例均进入结果分析。①丘脑卒中组在13个认知指标中有9个指标与对照组相比差异显著(P8.15时可考虑为重度认知损害。结论:①丘脑卒中可引起广泛的认知损害。②临床可以根据影响因素建立回归方程,计算出Y值,以Y值推测F0值。

关键词：丘脑卒中认知损害临床判别

低血糖指数膳食改善超重老年糖尿病患者氧化应激水平

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中国组织工程研究与临床康复 2007年第47期11卷 9499-9502页

作者：孙建琴张鑫毅宗敏陈艳秋张密陈霞飞潘逸茹杨柯君吴玉苗王敬丽陈茂芳陈爱芳复旦大学附属华东医院临床营养中心上海市200040 上海市石门二路社区卫生服务中心上海市200041 上海市曹家渡社区卫生服务中心上海市200042

目的:观察低血糖指数的膳食对2型糖尿病患者氧化应激状态的影响。方法:2004-10/11在上海市静安区二个社区卫生服务中心招募受试者,经医生明确诊断为2型糖尿病、病程超过6个月,体质量指数≥24kg/m2的老年糖尿病志愿者43名,受试者对试验... 详细信息

目的:观察低血糖指数的膳食对2型糖尿病患者氧化应激状态的影响。方法:2004-10/11在上海市静安区二个社区卫生服务中心招募受试者,经医生明确诊断为2型糖尿病、病程超过6个月,体质量指数≥24kg/m2的老年糖尿病志愿者43名,受试者对试验知情同意。采用随机交叉试验随机分配至低血糖指数饮食组和高血糖指数饮食组,每种膳食分别连续使用4周,间隔洗脱期4周,比较试验前后患者超氧化物歧化酶、脂质过氧化产物丙二醛和谷胱甘肽过氧化物酶含量的变化。结果:受试者依从性好,除1人因试验期间发现肿瘤而退出试验,42名志愿者按设计要求完成试验。膳食干预后低血糖指数饮食组和高血糖指数饮食组的超氧化物歧化酶活力分别升高了15.68%和21.33%,丙二醛水平分别下降23.94%和21.55%,谷胱甘肽过氧化物酶活力分别升高了15.74%和17.09%;干预后低血糖指数饮食组丙二醛下降水平与高血糖指数饮食组比较差异有显著性意义(P0.05)。结论:在控制总能量的基础上给予平衡膳食能够改善其氧化应激水平,采用低血糖指数食物有助于氧化应激水平的改善。

关键词：血糖指数 2型糖尿病氧化应激

Effect of Austenite Ageing on Martensitic Transformation

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Journal of Materials Science & Technology 1997年第6期13卷 508-514页

作者： chen, QZ Wu, xf Wei, LY Ke, J Univ Sci & Technol Beijing Dept Mat Phys Beijing 100083 Peoples R China

The effect of austenite ageing on martensite transformation in an iron and nickel alloy was studied. Attention was paid to the variation of dislocation configurations in austenite before martensite transformation, The clusters or precipitates produced during austenite ageing and the alteration of dislocation configurations affect together the consequent martensite transformation. Dispersed fine clusters and precipitates cripple nucleus role of special dislocation configurations and drop M-s. Coarse precipitates make M-g rise again. Densely piled up dislocations in nuclei lead to rise of M-s. All the changes in austenite are of benefit to small martensite plates.

关键词： Iron alloys

EFFECTS OF MICROSTRUCTURE ON THE MACROSCOPIC ELASTO-PLASTIC PROPERTIES OF METAL MATRIX COMPOSITES

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Acta Mechanica Solida Sinica 1996年第1期9卷 52-58页

作者： chen, HR Su, xf Tang, LM DALIAN UNIV TECHNOL RES INST ENGN MECHDALIAN 116023PEOPLES R CHINA

The generalized self-consistent finite-element iterative averaging method was adopted to analyze the elasto-plastic tensile properties of SiC whiskers reinforced aluminum matrix composites. The effects of varying fiber's aspect ratio and volume fraction on the macroscopic elasto-plastic deformation of the composites were studied. By the analysis of microscopic stress fields, the relation between the propagation of the elasto-plastic region in the matrix and the macroscopic elasto-plastic deformation of composites was discussed. It was found that the propagation of the plastic region in the matrix between the fiber's ends would affect prominently the elasto-plastic tensile behaviour of the composites. It was shown that the characterization of the stress-strain response in terms of the 0.2% offset yield strength is incomplete.

关键词： metal-matrix composites microstructure macroscopic elasto-plastic behaviour microscopic plastic region generalized self-consistent finite-element iterative averaging method

SYNTHESIS OF 7-DEOXY-1,2, 10,20-TETRAHYDROTAXAMAIRIN B

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Chinese Chemical Letters 1995年第7期6卷 559-560页

作者： Wang, XC Cui, YX Pan, xf chen, YZ Lanzhou Univ Dept Chem Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

A ten-step synthesis of 7-deoxy-1,2,10,20-tetrahydrataxamairin B(5). a key precursor for taxamairin A(1), B(2), has been achieved. A Friedel-Crafts annunation is the key step.

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The lipase monolayer film self-assembly on the negatively charged poly(ethylene terephthalate) substrate

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Chinese Chemical Letters 2000年第3期11卷 267-270页

作者： Lin, xf He, L Xu, LH Lu, DS chen, ZC Zhejiang Univ Ctr Anal & Measurement Hangzhou 310027 Peoples R China

The PET-CO2- film was prepared and the lipase was assembled on the surface of the PET-CO2- substrate The structure at the surface and activity of lipase/PET monolayer were studied by ATR-FTIR and AFM, and other methods.

关键词： self-assembled monolayer lipase PET-CO2 substrate