检索结果-南通市图书馆

Grain boundary engineering for enhancing intergranular damage resistance of ferritic/martensitic steel P92

Nuclear Science and Techniques 2024年第5期35卷 186-199页

作者： Lei Peng Shang-Ming chen Jing-Yi Shi Yong-Jie Sun Yi-Fei Liu Yin-Zhong Shen Hong-Ya He Hui-juan Wang Jie Tian State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China School of Materials Engineering Shanghai University of Engineering Science333 Long Teng RoadShanghai 201620China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Ferritic/martensitic(F/M)steel is widely used as a structural material in thermal and nuclear power ***,it is susceptible to intergranular damage,which is a critical issue,under service *** this study,to improve the resistance to intergranular damage of F/M steel,a thermomechanical process(TMP)was employed to achieve a grain boundary engineering(GBE)microstructure in F/M steel *** TMP,including cold-rolling thickness reduction of 6%,9%,and 12%,followed by austenitization at 1323 K for 40 min and tempering at 1053 K for 45 min,was applied to the as-received(AR)P92 *** prior austenite grain(PAG)size,prior austenite grain boundary character distribution(GBCD),and connectivity of prior austenite grain boundaries(PAGBs)were *** to the AR specimen,the PAG size did not change *** fraction of coincident site lattice boundaries(CSLBs,3≤Σ≤29)and Σ3^(n) boundaries along PAGBs decreased with increasing reduction ratio because the recrystallization fraction increased with increasing reduction *** PAGB connectivity of the 6%deformed specimen slightly deteriorated compared with that of the AR ***,potentiodynamic polarization studies revealed that the intergranular damage resistance of the studied steel could be improved by increasing the fraction of CSLBs along the PAGBs,indicating that the TMP,which involves low deformation,could enhance the intergranular damage resistance.

关键词： Grain boundary engineering Ferritic/martensitic steel Prior austenite grain boundary character distribution Grain boundary connectivity Intergranular damage resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary Lipid Intervention in the Prevention of Brain Aging

引用

Engineering 2024年第6期37卷 128-137页

作者： Wei Xiong Bing Fang Xiaoyu Wang Ming Zhang Min Du Jiazeng Sun juan chen Yixuan Li Changhao Sun Xingen Lei Xue Zhang Fazheng Ren Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China Key Laboratory of Functional Dairy Co-Constructed by the Ministry of Education and Beijing MunicipalityCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China School of Food Science and Chemical Engineering Beijing Technology and Business UniversityBeijing 100048China Department of Animal Science Washington State UniversityPullmanWA 99164USA Department of Nutrition and Food Hygiene School of Public HealthHarbin Medical UniversityHarbin 150028China Department of Animal Science Cornell UniversityIthacaNY 14853USA National Health Commission(NHC)and Chinese Academy of Medical Sciences(CAMS)Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbin 150028China

As people live longer,the burden of aging-related brain diseases,especially dementia,is *** aging increases the risk of cognitive impairment,which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid ***,supplemental dietary lipids have the potential to prevent brain *** review summarizes the important roles of dietary lipids in brain function from both structure and mechanism *** and animal studies have provided evidence of the functions of polyunsaturated fatty acids(PUFAs)in brain *** results of interventions indicate that phospholipids—including phosphatidylcholine,phosphatidylserine,and plasmalogen—are efficient in alleviating cognitive impairment during aging,with plasmalogen exhibiting higher efficacy than *** is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of *** research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

关键词： Brain aging Nutritional intervention Phospholipids Phosphatidylcholine Phosphatidylserine Plasmalogen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

引用

Signal Transduction and Targeted Therapy 2024年第7期9卷 3063-3076页

作者： Wenjing Zai Min Yang Kuan Jiang juan Guan Huijing Wang Kongying Hu Chao Huang Jieliang chen Wei Fu Changyou Zhan Zhenghong Yuan Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Research Unit of Cure of Chronic Hepatitis B Virus Infection(CAMS)Shanghai Frontiers Science Center of Pathogenic Microbes and InfectionSchool of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghaiP.R.China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghaiP.R.China Shanghai Engineering Research Center for Synthetic Immunology Fudan UniversityShanghaiP.R.China Eye Institute and Department of Ophthamology Eye and ENT HospitalFudan UniversityShanghaiP.R.China Pharmacy Department of Huashan Hospital Fudan UniversityShanghaiP.R.China Institute of Pediatric Translational Medicine Shanghai Institute for Pediatric Congenital Heart DiseaseShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Institute of Infectious Disease and Biosecurity ShanghaiP.R.China

This study aimed to develop a pan-genotypic and multifunctional small interfering RNA(siRNA)against hepatitis B virus(HBV)with an efficient delivery system for treating chronic hepatitis B(CHB),and explore combined RNA interference(RNAi)and immune modulatory modalities for better viral *** synthetic siRNAs targeting consensus motifs distributed across the whole HBV genome were designed and *** lipid nanoparticle(LNP)formulation was optimized by adopting HO-PEG_(2000)-DMG lipid and modifying the molar ratio of traditional polyethylene glycol(PEG)lipid in LNP *** efficacy and safety of this formulation in delivering siHBV(tLNP/siHBV)along with the mouse IL-2(mIL-2)mRNA(tLNP/siHBVIL2)were evaluated in the rAAVHBV1.3 mouse model.A siRNA combination(terms“siHBV”)with a genotypic coverage of 98.55%was selected,chemically modified,and encapsulated within an optimized LNP(tLNP)of high efficacy and security to fabricate a therapeutic formulation for *** results revealed that tLNP/siHBV significantly reduced the expression of viral antigens and DNA(up to 3log_(10)reduction;vs PBS)in dose-and time-dependent manners at single-dose or multi-dose frequencies,with satisfactory safety *** studies showed that tLNP/siHBVIL2 enables additive antigenic and immune control of the virus,via introducing potent HBsAg clearance through RNAi and triggering strong HBV-specific CD4^(+)and CD8^(+)T cell responses by expressed mIL-2 *** adopting tLNP as nucleic acid nanocarriers,the co-delivery of siHBV and mIL-2 mRNA enables synergistic antigenic and immune control of HBV,thus offering a promising translational therapeutic strategy for treating CHB.

关键词： formulation enable offering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

引用

Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG Xin ZHANG Zhao-xin LI Li-fei HE Feng chen Ming-long LIU Ying-ze HUANG Jian-mei MO Kong-lan LUO juan-juan XIAO Feng ZHU Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung ***,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is *** study aimed to evaluate the radiosensitization of TOPK knockdown in CRC *** The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western ***-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC ***,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after *** damage was detected by the comet *** in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow *** The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade *** irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated ***,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

联合添加木质素多酚与铜锌交联物质对断奶仔猪生长性能、免疫力及铜锌沉积的影响

引用

饲料研究 2023年第8期46卷 24-29页

作者：张伟贾曾浩韩帅娟郭豪民陈赛娟陈宝江河北农业大学动物科技学院河北保定071001 河北农业大学山区研究所河北保定071001 上海梵蓝国际贸易有限公司上海201101 河北省山区农业技术创新中心河北保定071001

试验旨在研究日粮中联合添加木质素多酚和铜锌交联物质对断奶仔猪生长性能、免疫力和铜锌沉积的影响。选择体重相近、健康状况良好的“杜×长×大”三元杂交断奶仔猪96头,随机分成3组,每组4个重复,每个重复8头猪。对照组仔猪饲喂基础日... 详细信息

试验旨在研究日粮中联合添加木质素多酚和铜锌交联物质对断奶仔猪生长性能、免疫力和铜锌沉积的影响。选择体重相近、健康状况良好的“杜×长×大”三元杂交断奶仔猪96头,随机分成3组,每组4个重复,每个重复8头猪。对照组仔猪饲喂基础日粮+2 kg/t氧化锌+100 g/t金霉素+40 g/t黏杆菌素,T1组仔猪饲喂基础日粮+1 kg/t木质素多酚+700 g/t铜锌交联物质,T2组仔猪饲喂基础日粮+2 kg/t木质素多酚+700 g/t铜锌交联物质。预试期7 d,正式试验期28 d。结果显示,与对照组相比,T2组仔猪平均日采食量和平均日增重均略有提高(P>0.05),T1组仔猪平均日采食量显著降低(P0.05)。与对照组相比,T1组仔猪血清中干扰素-γ (IFN-γ)含量显著降低(P<0.05)。与对照组和T1组相比,T2组仔猪血清的补体C4含量升高,且显著高于T1组(P<0.05);T2组仔猪血清的D-乳酸(DLA)含量降低,且显著低于T1组(P<0.05)。与对照组相比,T1组和T2组仔猪的血清和粪便中锌含量均显著降低(P<0.05)。研究表明,在断奶仔猪日粮中联合添加2 kg/t木质素多酚和700 g/t铜锌交联物质替代高锌与抗生素组合,能够保持断奶仔猪正常的生长性能,提高免疫力,显著降低粪便中锌的排泄量。

关键词：断奶仔猪木质素多酚铜锌交联物质生长性能免疫力铜锌沉积

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy

引用

Asian Journal of Andrology 2024年第4期26卷 409-414页

作者： Di Jin Xiao-Qi Kong Ya-juan Zhu Zong-Xin chen Xi-Ming Wang Cai-Hua Xu Jin-Xian Pu Jian-Quan Hou Yu-Hua Huang Fu-Hai Ji chen Huang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China.

This study aims to conduct a cost-effectiveness analysis of three different anesthesia strategies,namely chatting while under local anesthesia(Chat-LA),total intravenous anesthesia(TIVA),and general anesthesia with laryngeal mask airway(GA-LMA),employed in transperineal magnetic resonance imaging(MRI)/ultrasound(US)fusion prostate biopsy(TP-MUF-PB).A retrospective study was conducted involving 1202 patients who underwent TP-MUF-PB from June 2016 to April 2023 at The First Affiliated Hospital of Soochow University(Suzhou,China).Clinical data and outcomes,including total costs,complications,and quality-adjusted life years(QALYs),were *** sensitivity and subgroup analyses were also ***-LA was found to be the most cost-effective option,outperforming both TIVA and ***,subgroup analyses revealed that in younger patients(under 65 years old)and those with smaller prostate volumes(<40 ml),TIVA emerged as a more cost-effective *** Chat-LA may generally be the most cost-effective and safer anesthesia method for TP-MUF-PB,personalization of anesthesia strategies is crucial,considering specific patient demographics such as age and prostate volume.

关键词： anesthesia strategy cost-effectiveness analysis economic evaluation prostate biopsy prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microbial interactions within Chinese traditional medicinal plants

引用

Chinese Herbal Medicines 2024年第2期16卷 169-171页

作者： juan chen Luping Qin Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China

Plants harbor diverse microbes(including bacteria,fungi,archaea,protists,and viruses)both inside and outside their tissues,so called the plant-associated *** of research have demonstrated the importance of plant microbiome in promoting the productivity and health of the plant in natural environment because of their essential functions in improving plant nutrition and plant resistance to biotic and abiotic stresses(Trivedi,Leach,Tringe,Sa,&Singh,2020).Thus,a plant can be regarded as a holobiont comprising the host plant and the associated microbiota(Hassani,Durán,&Hacquard,2018).Within the plant microbiota,mutualistic fungal and bacterial symbionts(*** fungi and Rhizobia)are striking examples of microorganisms playing crucial roles in nutrient acquisition(Martin&van der Heijden,2024)and non-symbitic plant growth-promoting rhizobacteria or fungi(PGPR or PGPF)also have drawn interest due to their ability to improve soil properties and confer stress tolerance in plants(Upadhyay et al.,2023).

关键词： mutual striking outside

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

彩色獭兔agouti位点基因突变及蛋白结构改变对其毛色的影响

引用

浙江农业学报 2015年第12期27卷 2071-2077页

作者：杨翠军葛剑陈赛娟刘亚娟陈宝江谷子林河北农业大学动物科技学院河北保定071001 河北北方学院生命科学研究中心河北张家口075000 河北北方学院动物科技学院河北张家口075131 河北省山区农业工程技术研究中心河北保定071001

彩色獭兔是世界上重要的特种经济动物,其毛色种类繁多,因此有必要对其毛色基因开展深入研究。以不同颜色的獭兔为试验对象,首先检测彩色獭兔的agouti基因多态性,预测蛋白质的结构,构建进化树。结果发现,彩色獭兔agouti位点共发现3个等... 详细信息

彩色獭兔是世界上重要的特种经济动物,其毛色种类繁多,因此有必要对其毛色基因开展深入研究。以不同颜色的獭兔为试验对象,首先检测彩色獭兔的agouti基因多态性,预测蛋白质的结构,构建进化树。结果发现,彩色獭兔agouti位点共发现3个等位基因,海狸色和青紫蓝色为野生型agouti,即A,紫貂色为tanagouti,即a^t;黑色、黄色和蓝色为non-agouti,即a。3种基因序列与其他兔类的同源性和进化树分析结果显示,与欧洲野兔亲缘关系最近,野生型的刺豚鼠信号蛋白(ASIP)和tan ASIP蛋白的基因均编码133个氨基酸序列,其空间结构具有24个氨基酸残基的分泌信号肽,具有富含赖氨酸的区域,C末端具有富含半胱氨酸的疏水区域,具有重要的生物学活性,而2种蛋白在序列上的差别,尤其是保守区的差别造成真黑素和棕黑素的沉积发生改变,由此造成被毛颜色的不同,non-agouti基因编码的蛋白为21个氨基酸序列,很不稳定,ASIP不能产生,导致黑色素产生和积累。

关键词：彩色獭兔 agouti ASIP 多态性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

引用

Neural Regeneration Research 2024年第3期19卷 485-486页

作者： juan JoséPérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSP)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSP,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(Parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSP.

关键词： reticulum endoplasmic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prediction of Pediatric Sepsis Using a Deep Encoding Network with Cross Features

引用

Journal of Shanghai Jiaotong university(Science) 2024年第1期29卷 131-140页

作者：陈潇张瑞汤心溢钱娟 University of Chinese Academy of Sciences Beijing 100084China Shanghai Institute of Technical Physics of the Chinese Academy of Sciences Key Laboratory of Infrared Detection and Imaging TechnologyShanghai 200083China Shanghai Children's Medical Center Shanghai Jiao Tong University School of MedicineShanghai 200127China

Sepsis poses a serious threat to health of children in pediatric intensive care *** mortality from pediatric sepsis can be effectively reduced through in-time diagnosis and therapeutic *** bacilliculture detection method is too time-consuming to receive timely *** this research,we propose a new framework:a deep encoding network with cross features(CF-DEN)that enables accurate early detection of *** features are automatically constructed via the gradient boosting decision tree and distilled into the deep encoding network(DEN)we *** DEN is aimed at learning sufficiently effective representation from clinical test *** layer of the DEN fltrates the features involved in computation at current layer via attention mechanism and outputs the current prediction which is additive layer by layer to obtain the embedding feature at last *** framework takes the advantage of tree-based method and neural network method to extract effective representation from small clinical dataset and obtain accurate prediction in order to prompt patient to get timely *** evaluate the performance of the framework on the dataset collected from Shanghai Children's Medical *** with common machine learning methods,our method achieves the increase on F1-score by 16.06%on the test set.

关键词： pediatric sepsis gradient boosting decision tree cross feature neural network deep encoding network with cross features(CF-DEN)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：