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Evidence for particle acceleration approaching PeV energies in the W51 complex

science Bulletin 2024年第18期69卷 2833-2841页

作者： Cao, Zhen Aharonian, F. Axikegu Bai, Y.X. Bao, Y.W. Bastieri, D. Bi, X.J. Bi, Y.J. Bian, W. Bukevich, A.V. Cao, Q. Cao, W.Y. Cao, Zhe Chang, J. Chang, J.F. chen, A.M. chen, E.s. chen, h.X. chen, Liang chen, Lin chen, Long chen, M.J. chen, M.L. chen, Q.h. chen, s. chen, s.h. chen, s.Z. chen, T.L. chen, Y. cheng, N. cheng, Y.D. Cui, M.Y. Cui, s.W. Cui, X.h. Cui, Y.D. Dai, B.Z. Dai, h.L. Dai, Z.G. Danzengluobu Dong, X.Q. Duan, K.K. Fan, J.h. Fan, Y.Z. Fang, J. Fang, J.h. Fang, K. Feng, C.F. Feng, h. Feng, L. Feng, s.h. Feng, X.T. Feng, Y. Feng, Y.L. Gabici, s. Gao, B. Gao, C.D. Gao, Q. Gao, W. Gao, W.K. Ge, M.M. Geng, L.s. Giacinti, G. Gong, G.h. Gou, Q.B. Gu, M.h. Guo, F.L. Guo, X.L. Guo, Y.Q. Guo, Y.Y. han, Y.A. hasan, M. he, h.h. he, h.N. he, J.Y. he, Y. hor, Y.K. hou, B.W. hou, C. hou, X. hu, h.B. hu, Q. hu, s.C. huang, D.h. huang, T.Q. huang, W.J. huang, X.T. huang, X.Y. huang, Y. Ji, X.L. Jia, h.Y. Jia, K. Jiang, K. Jiang, X.W. Jiang, Z.J. Jin, M. Kang, M.M. Karpikov, I. Kuleshov, D. Kurinov, K. Li, B.B. Li, C.M. Li, cheng Li, Cong Li, D. Li, F. Li, h.B. Li, h.C. Li, Jian Li, Jie Li, K. Li, s.D. Li, W.L. Li, X.R. Li, Xin Li, Y.Z. Li, Zhe Li, Zhuo Liang, E.W. Liang, Y.F. Lin, s.J. Liu, B. Liu, C. Liu, D. Liu, D.B. Liu, h. Liu, h.D. Liu, J. Liu, J.L. Liu, M.Y. Liu, R.Y. Liu, s.M. Liu, W. Liu, Y. Liu, Y.N. Luo, Q. Luo, Y. Lv, h.K. Ma, B.Q. Ma, L.L. Ma, X.h. Mao, J.R. Min, Z. Mitthumsiri, W. Mu, h.J. Nan, Y.C. Neronov, A. Ou, L.J. Pattarakijwanich, P. Pei, Z.Y. Qi, J.C. Qi, M.Y. Qiao, B.Q. Qin, J.J. Raza, A. Ruffolo, D. sáiz, A. saeed, M. semikoz, D. shao, L. shchegolev, O. sheng, X.D. shu, F.W. song, h.C. stenkin, Yu.V. stepanov, V. su, Y. sun, D.X. sun, Q.N. sun, X.N. sun, Z.B. Takata, J. Tam, P.h.T. Key Laboratory of Particle Astrophysics & Experimental Physics Division & Computing Center Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China University of Chinese Academy of sciences Beijing 100049 China TIANFU Cosmic Ray Research Center Chengdu China Dublin Institute for Advanced studies 31 Fitzwilliam Place 2 Dublin Ireland Max-Planck-Institut for Nuclear Physics P.O. Box 103980 Heidelberg 69029 Germany s.h.ol of Physical science and Technology & s.h.ol of Information science and Technology Southwest Jiaotong University Chengdu 610031 China s.h.ol of Astronomy and space science Nanjing University Nanjing 210023 China Center for Astrophysics Guangzhou University Guangzhou 510006 China Tsung-Dao Lee Institute & s.h.ol of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute for Nuclear Research of Russian Academy of sciences Moscow 117312 Russia hebei Normal University Shijiazhuang 050024 China University of science and Technology of China Hefei 230026 China state Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and space Astronomy & Key Laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210023 China Research Center for Astronomical Computing Zhejiang Laboratory Hangzhou 311121 China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China s.h.ol of Physics and Astronomy Yunnan University Kunming 650091 China Key Laboratory of Cosmic Rays (Tibet University) Ministry of Education Lhasa 850000 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100101 China s.h.ol of Physics and Astronomy (Zhuhai) & s.h.ol of Physics (Guangzhou) & sino-French Institute of Nuclear Engineering and Technology (Zhuhai) Sun Yat-sen University Zhuhai 519000 & Guangzhou 510275 Guangdong China Institute of Frontier and

The γ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays (CRs) accelerated by the shock of supernova remnant (sNR) W51C and the dense molecular clouds in the adjacent star-forming region, W51B. however, the maximum acceleration capability of W51C for CRs remains elusive. Based on observations conducted with the Large high Altitude Air shower Observatory (LhAAsO), we report a significant detection of γ rays emanating from the W51 complex, with energies from 2 to 200 TeV. The LhAAsO measurements, for the first time, extend the γ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of TeV. By combining the "π0-decay bump" featured data from Fermi-LAT, the broadband γ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision model. The observed spectral bending feature suggests an exponential cutoff at ∼400 TeV or a power-law break at ∼200 TeV in the CR proton spectrum, most likely providing the first evidence of sNRs serving as CR accelerators approaching the PeV regime. Additionally, two young star clusters within W51B could also be theoretically viable to produce the most energetic γ rays observed by LhAAsO. Our findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs. © 2024 science China Press

关键词： Cosmic rays

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PARAMETER IDENTIFICATION IN hEMODYNAMIC MODEL OF CEREBRAL CIRCULATION

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Journal of hydrodynamics 2001年第1期13卷 34-38页

作者： Yao, W. Ding, G.h. Liu, h. Wang, s.Z. Lu, C.Z. chen, s.h. Dep. of Mech. and Eng. sci. Fudan Univ. Shanghai 200040 China

With a hemodynamic model of the Willis circulation, we developed a mathematical method to solve the inverse problem and obtained the values of indices in the model. Compared with the clinical data from hospital, most ... 详细信息

关键词： Mathematical models

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Mixed h_(∞)/Passive Exponential synchronization for Delayed Memristive Neural Networks with switching Event-Triggered Control

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Journal of systems science & Complexity 2024年第1期37卷 294-317页

作者： WU Wenhuang GUO Lulu chen hong shanghai Research Institute for Intelligent Autonomous systems Tongji UniversityShanghai 200092China Department of Control science and Engineering Tongji UniversityShanghai 201804China

This paper is devoted to event-triggered synchronization of delayed memristive neural networks with h∞and passivity *** aim is to guarantee the exponential synchronization and mixed h∞and passivity control for memristive neural networks by using event-triggered ***,a switching system is constructed under the event-triggered control ***,by adopting a piece-wise Lyapunov functional,a sufficient condition is established for the exponential synchronization and mixed h_(∞)and passivity ***,an event-triggered controller design s.h.me is proposed using matrix decoupling ***,the effectiveness of the designed controller is exemplified by a numerical example.

关键词： Event-triggered control exponential synchronization memristive neural networks time delays.

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homeostatic regulation of NAD(h)and NADP(h)in cells

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Genes & Diseases 2024年第5期11卷 285-299页

作者： Luojun chen Xiaoke Xing Pingfeng Zhang Lulu chen huadong Pei Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430062China Department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA

Nicotinamide adenine dinucleotide(NAD^(+))/reduced NAD^(+)(NADh)and nicotinamide adenine dinucleotide phos.h.te(NADP^(+))/reduced NADP^(+)(NADPh)are essential metabolites involved in multiple metabolic pathways and cellular ***^(+)and NADh redox couple plays a vital role in catabolic redox reactions,while NADPh is crucial for cellular anabolism and antioxidant *** NAD(h)and NADP(h)homeostasis is crucial for normal physiological activity and is tightly regulated through various mechanisms,such as biosynthesis,consumption,recycling,and conversion between NAD(h)and NADP(h).The conversions between NAD(h)and NADP(h)are controlled by NAD kinases(NADKs)and NADP(h)phos.h.tases[specifically,metazoan spoT homolog-1(MEsh1)and nocturnin(NOCT)].NADKs facilitate the synthesis of NADP^(+)from NAD^(+),while MEsh1 and NOCT convert NADP(h)into NAD(h).In this review,we summarize the physiological roles of NAD(h)and NADP(h)and discuss the regulatory mechanisms governing NAD(h)and NADP(h)homeostasis in three key aspects:the transcriptional and posttranslational regulation of NADKs,the role of MEsh1 and NOCT in maintaining NAD(h)and NADP(h)homeostasis,and the influence of the circadian clock on NAD(h)and NADP(h)*** conclusion,NADKs,MEsh1,and NOCT are integral to various cellular processes,regulating NAD(h)and NADP(h)*** of these enzymes results in various.h.man diseases,such as cancers and metabolic ***,strategies aiming to restore NAD(h)and NADP(h)homeostasis.h.ld promise as novel therapeutic approaches for these diseases.

关键词： MEsh1 NAD(h) NADK NADP(h) Nocturnin

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Regulation of PM_(2.5)on mitochondrial damage in h9c2 cells through miR-421/sIRT3 pathway and protective effect of miR-421 inhibitor and resveratrol

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Journal of Environmental sciences 2024年第4期138卷 288-300页

作者： shanshan chen Wenqi chen Zhiping Li Jianwei Yue Ken Kin Lam Yung Ruijin Li Institute of Environmental science Shanxi UniversityTaiyuan 030006China Institute of Judicial Identification Techniques for Environmental Damage Shanxi University and Shanxi Unisdom Testing Technology Co.Ltd.Taiyuan 030006China Department of Biology Hong Kong Baptist UniversityHong KongChina shanxi Yellow River Laboratory Taiyuan 030006China

Fine particulate matter(PM_(2.5))exposure is associated with cardiovascular disease(CVD)morbidity and *** are sensitive targets of PM_(2.5),and mitochondrial dysfunction is closely related to the occurrence of *** epigenetic mechanism of PM_(2.5)-triggered mitochondrial injury of cardiomyocytes is *** study focused on the mi R-421/sIRT3 signaling pathway to investigate the regulatory mechanism in cardiac mitochondrial dynamics imbalance in rat h9c2 cells induced by PM_(2.5).Results illustrated that PM_(2.5)impaired mitochondrial function and caused dynamics.h.meostasis ***,PM_(2.5)up-regulated mi R-421 and down-regulated sIRT3 gene expression,along with decreasing p-FOXO3a(sIRT3 downstream target gene)and p-Parkin expression and triggering abnormal expression of fusion gene OPA1 and fission gene ***,mi R-421 inhibitor(mi R-421i)and resveratrol significantly elevated the sIRT3 levels in h9c2 cells after PM_(2.5)exposure and mediated the expression of sOD2,OPA1 and Drp1,restoring the mitochondrial morphology and *** suggests that mi R-421/sIRT3 pathway plays an epigenetic regulatory role in mitochondrial damage induced by PM_(2.5)and that mi R-421i and resveratrol exert protective effects against PM_(2.5)-incurred cardiotoxicity.

关键词： Fine particulate matter Rat h9c2 cells Mitochondrial damage MiR-421 sIRT3 Resveratrol

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Preparation of PVA/GO/h-BN Janus Film with high Thermal Conductivity and Excellent Flexibility via a Density Deposition self-assembly Method

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Chinese Journal of Polymer science 2024年第8期42卷 1217-1226页

作者： Fang-hua Luo Zhi-Tao Dong Guo-hua chen chen Ma huai-Yuan Wang College of Chemistry and Chemical Engineering Northeast Petroleum UniversityDaqing 163318China College of Materials science and Engineering Huaqiao UniversityXiamen 361000China s.h.ol of Chemical Engineering and Technology and state Key Laboratory for Chemical Engineering Tianjin UniversityTianjin 300350China

Janus films with asymmetric physical/chemical properties.h.ve attracted con siderable attention due to their promising applications in personal thermal management,electronic skin s,sensors,actuators,***,traditional methods for fabricating Janus films conventionally need the assistance of an interface or auxiliary equipment,which are usually complex and ***,flexible poly(vinyl alcohol)(PVA)/graphene oxide(GO)/h-BN(recorded as PVA/GO/h-BN)Janus films with thermally,optically,and electrically anisotropic properties are fabricated by a simple density deposition self-assem bly method,which just utilizes the density difference between GO and h-BN during water *** results show that the two sides of the acquired Janus films.h.ve obvious asymmetric *** the original state of the PVA/GO/h-BN Janus films,the thermal conductivity of the GO side(10.06 W·m^(-1)·K^(-1))is generally lower than that of the h-BN side(10.48W·m^(-1)·K^(-1)).But after GO is reduced,the thermal conductivity of the rGO side reaches 12.17 W·m^(-1)·K^(-1),surpassing that of the h-BN *** addition,the relative reflectance of the h-BN side of Janus film is also significantly higher than that of the rGO side,and the su rface resistance difference between the two sides is about 4 orders of *** prepared PVA/GO/h-BN Janus films show great application potential in human thermal management,light conversion switches,and electronic *** study provides a simple and versatile strategy for fabricating Janus films with multifunctional(such as thermal,optical,and electrical)anisotropies.

关键词： Janus films PVA/GO/h-BN Density deposition self-assembly method

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Estimating Critical Clearing Time of Grid Faults Using DA of state-Reduction Model of Power systems

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CsEE Journal of Power and Energy systems 2024年第2期10卷 807-820页

作者： Yang Liu Zhongyang chen huanjin Yao Lin Yi Q.h.Wu s.h.ol of Electric Power Engineering South China University of TechnologyGuangzhou 510640China China southern Power Grid Research Institute Guangzhou 510663China

This paper proposes a critical clearing time (CCT) estimation method by the domain of attraction (DA) of a state-reduction model of power systems using sum of squares (sOs) programming. By exploiting the property of the Jacobian matrix and the structure of the boundary of the DA, it is found the DA of the state-reduction model and that of the full model of a power system are topological isomorphism. There are one-to-one correspondence relationships between the number of equilibrium points, the type of equilibrium points, and solutions of the two system models. Based on these findings, an expanding interior algorithm is proposed with sOs programming to estimate the DA of the state-reduction model. state trajectories of the full model can be transformed to those of the state-reduction model by orthogonal or equiradius projection. In this way, CCT of a grid fault is estimated with the DA of the state-reduction model. The calculational burden of sOs programming in the DA estimation using the state-reduction model is rather small compared with using the full model. simulation results show the proposed expanding interior algorithm is able to provide a tight estimation of DA of power systems with higher accuracy and lower time costs.

关键词： Critical clearing time domain of attraction expanding interior algorithm state-reduction model sOs programming

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[h_(2)dab][GaB_(5)O_(10)]:an Acentric Galloborate with a 4-Connected Uninodal Framework

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Chemical Research in Chinese Universities 2024年第4期40卷 747-752页

作者： LIU Wenfang chen Chongan YANG Guoyu s.h.ol of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing102488P.R.China

A new acentric galloborate(GBO)[h_(2)dab][GaB_(5)O_(10)](1,1,4-dab:1,4-diaminobutane)has been synthesized under solvothermal *** alternation of 4,4-connected GaO4 and B5O10 cluster build up the 3D[GaB_(5)O_(10)]_(n)^(2n-)uninodal framework,which contains three pairs of helical channels with 8-member ring(MR)and 7-MR apertures,*** 1 exhibits a moderate second harmonic generation(shG)response of 1.8 times that of Kh_(2)PO_(4)(KDP),indicating its potential application in UV *** acentric uninodal framework in compound 1 represents a new type of zeolitic framework in the GBOs’family.

关键词： Galloborate solvothermal synthesis Nonlinear optics Zeolitic framework

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Dual Additives for stabilizing Li Deposition and sEI Formation in Anode-Free Li-Metal Batteries

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Energy & Environmental Materials 2024年第3期7卷 84-92页

作者： Baolin Wu Chunguang chen Dmitri L.Danilov Zhiqiang chen Ming Jiang Rüdiger-A.Eichel Peter h.L.Notten Fors.h.ngszentrum Jülich(IEK-9) D-52425Jülich Germany RWTh Aachen University D-52074Aachen Germany LNM Institute of MechanicsChinese Academy of SciencesBeijing 100190China s.h.ol of Engineering sciences University of Chinese Academy of SciencesBeijing 100049China Eindhoven University of Technology P.O.Box 5135600 MBEindhoven The Netherlands s.h.ol of Electronics and Information Institute of Carbon Neutrality and New EnergyHangzhou Dianzi UniversityHangzhou 310018China University of Technology sydney BroadwaySydney NSW 2007Australia

Anode-free Li-metal batteries are of significant interest to energy storage industries due to their intrinsically high ***,the accumulative Li dendrites and dead Li continuously consume active Li during *** results in a short lifetime and low Coulombic efficiency of anode-free Li-metal *** effective electrolyte additives can improve the Li deposition homogeneity and solid electrolyte interphase(sEI)stability for anode-free Li-metal ***,we reveal that introducing dual additives,composed of LiAsF6 and fluoroethylene carbonate,into a low-cost commercial carbonate electrolyte will boost the cycle life and average Coulombic efficiency of NMC‖Cu anode-free Li-metal *** NMC‖Cu anode-free Li-metal batteries with the dual additives exhibit a capacity retention of about 75%after 50 cycles,much higher than those with bare electrolytes(35%).The average Coulombic efficiency of the NMC‖Cu anode-free Li-metal batteries with additives can maintain 98.3%over 100 *** contrast,the average Coulombic efficiency without additives rapidly decline to 97%after only 50 *** situ Raman measurements reveal that the prepared dual additives facilitate denser and smoother Li morphology during Li *** dual additives significantly suppress the Li dendrite growth,enabling stable sEI formation on anode and cathode *** results provide a broad view of developing low-cost and high-effective functional electrolytes for high-energy and long-life anode-free Li-metal batteries.

关键词： anode-free lithium metal battery dual additives in situ Raman Li growth sEI formation

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A near-infrared fluorescent probe for visualizing transformation pathway of Cys.h.y and h2s and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： Yudi cheng Xiao Wang Jiao chen Zihan Zhang Jiadong Ou Mengyao she Fulin chen Jianli Li Key Laboratory of synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

sulfydryl-contained(-sh)substances including hydrogen sulfide(h_(2)s),cysteine(Cys),homocysteine(hcy)and glutathione(Gsh)play crucial roles in living systems,and their variations are closely associated with various ***,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys.h.y and h_(2)s with different fluorescent signals(green-red for Cys.h.y,red for h_(2)s),large stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to Gsh.Y-NBD was successfully applied to image exogenous/endogenous Cys.h.y and h_(2)s in various living cancer cells.h.La,A549,and hepG2)and in *** not only visualized the transformation pathway of several thiols in hepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver *** work provides a promising tool for imaging Cys.h.y and h_(2)s in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared hydrogen sulfide Cysteine/homocysteine Large stokes shift Dicyanoisophorone Drug-induced liver injury

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