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The power of comments： fostering social interactions in microblog networks

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Frontiers of Computer Science 2016年第5期10卷 889-907页

作者： Tiany. WANG y.ng chen y. WANG Bolun WANG Gang WANG Xing LI Haitao ZHENG Ben y. ZHAO Department of Electronic Engineering Tsinghua University Beijing 100084 China Tsinghua National Laboratory.for Information Science and Technology Beijing 100084 China Department of Computer Science University of California Santa Barbara CA 93106-5110 USA School of Computer Science Fudan University Shanghai 201203 China Department of Mathematics Syracuse University Syracuse NY 13244-1150 USA

Today.s ubiquitous online social networks serve multiple purposes, including social communication （Face- book, Renren）, and news dissemination （Twitter）. But how does a social network＇s design define its functionality. An- swering this would need social network providers to take a proactive role in defining and guiding user behavior. In this paper, we first take a step to answer this question with a data-driven approach, through measurement and anal- y.is of the Sina Weibo microblogging service. Often com- pared to Twitter because of its format, Weibo is interesting for our analy.is because it serves as a social communication tool and a platform for news dissemination, too. While similar to Twitter in functionality. Weibo provides a distinguishing feature, comments, allowing users to form threaded con- versations around a single tweet. Our study.focuses on this feature, and how it contributes to interactions and improves social engagement. We use analy.is of comment interactions to uncover their role in social interactivity. and use comment graphs to demonstrate the structure of Weibo users interac- tions. Finally. we present a case study.that shows the impact of comments in malicious user detection, a key.application on microblogging sy.tems. That is, using properties of com- ments significantly.improves the accuracy.in both modeling and detection of malicious users.

关键词： microblogs comments social and interactiongraph user behavior

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： y.nting Liu Wei Huang Jiay. Wen Xin Xiong Ting Xu Qi Wang Xiusheng chen Xianxian Zhao Shihua Li Xiaojiang Li Weili y.ng Guangdong Key.Laboratory.of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority.of in vitro studies have demonstrated that PINK1 phosphory.ates Parkin to work together in mitophagy.to protect against neuronal ***,it remains largely.unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically.low levels of PINK1 and undetectable levels of phosphory.ated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively.expressed as a truncated form(PINK1–55)in the primate *** the present study.we used multiple antibodies,including our recently.developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably.expressed in the monkey.brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey.***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under phy.iological conditions in cultured monkey.astrocy.es,though they.did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may.have distinct roles bey.nd their well-known function in mitophagy.during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

Active elastic metamaterials for subwavelength wave propagation control

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Acta Mechanica Sinica 2015年第3期31卷 349-363页

作者： y.y.chen G.L.Huang Department of Mechanical and Aerospace Engineering University of Missouri

Recent research activities in elastic metamaterials demonstrate a significant potential for subwavelength wave propagation control owing to their interior locally.resonant mechanism. The growing technological developments in electro/magnetomechanical couplings of smart materials have introduced a controlling degree of freedom for passive elastic metamaterials. Active elastic metamaterials could allow for a fine control of material phy.ical behavior and thereby.induce new functional properties that cannot be produced by.passive approaches. In this paper, two ty.es of active elastic metamaterials with shunted piezoelectric materials and electrorheological elastomers are proposed. Theoretical analy.es and numerical validations of the active elastic metamaterials with detailed microstructures are pre- sented for designing adaptive applications in band gap structures and extraordinary.waveguides. The active elastic metamaterial could provide a new design methodology.for adaptive wave filters, high signal-to-noise sensors, and structural health monitoring applications.

关键词： Active elastic metamaterials Subwavelengthwave control Adaptive metastructures Smart materials

TDP-43 regulates cancer-associated microRNAs

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Protein & Cell 2018年第10期9卷 848-866页

作者： Xiaowei chen Zhen Fan Warren McGee Mengmeng chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin chen Jianghong Liu Li Zhu Runsheng chen Jane y. Wu CAS Key.Laboratory.of RNA Biology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Research Network of Computational Biology RNCB Beijing 100101 China Core Facility.for Protein Research institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key.Laboratory.of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101China Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School ofMedicine Chicago IL 60611 USA Guangdong Geneway.Decoding Bio-Tech Co. Ltd Foshan 528316 China

regulation of miRNA genes contributes to pathogenesis of a wide range of human diseases, including cancer. The TAR DNA binding protein 43 （TDP- 43）, a RNAJDNA binding protein associated with neu- rodegeneration, is involved in miRNA biogenesis. Here, we sy.tematically.examined miRNAs regulated by.TDP- 43 using RNA-Seq coupled with an siRNA-mediated knockdown approach. TDP-43 knockdown affected the expression of a number of miRNAs. In addition, TDP-43 down-regulation led to alterations in the patterns of dif- ferent isoforms of miRNAs （isomiRs） and miRNA arm selection, suggesting a previously.unknown role of TDP- 43 in miRNA processing. A number of TDP-43 associ- ated miRNAs, and their candidate target genes, are associated with human cancers. Our data reveal highly.complex roles of TDP-43 in regulating different miRNAs and their target genes. Our results suggest that TDP-43 may.promote migration of lung cancer cells by.regulat- ing miR-423-3p. In contrast, TDP-43 increases miR-500a- 3p expression and binds to the mature miR-500a-3p sequence. Reduced expression of miR-500a-3p is associated with poor survival of lung cancer patients,suggesting that TDP-43 may.have a suppressive role in cancer by.regulating miR-500a-3p. Cancer-associated genes LIF and PAPPA are possible targets of miR-500a- 3p. Our work suggests that TDP-43-regulated miRNAs may.play.multifaceted roles in the pathogenesis of cancer.

关键词： TDP-43 miRNA cancer migration prognosis

Research on dual-command operation path optimization based on Fly.ng-V warehouse lay.ut

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High Technology.Letters 2023年第4期29卷 388-396页

作者：刘建胜 y.AN Bin y.NG Zan ZHONG ray y School of Advanced Manufacturing Nanchang UniversityNanchang 330031P.R.China Department of Industrial and Manufacturing Sy.tems Engineering University of Hong KongHong Kong 999077P.R.China

To enhance the efficiency.of warehouse order management,this study.investigates a dual-com-mand operation mode in the Fly.ng-V non-traditional warehouse *** dual-command opera-tion strategies are designed,and a dual-command operation path optimization model is established with the shortest path as the optimization ***,a genetic algorithm based on a dy.amic decoding strategy.is *** results demonstrate that the Fly.ng-V lay.ut warehouse management and access cooperation operation can reduce the operation time by.an average of 25%-35%compared with the single access operation path,and by.an average of 13%-23%compared with the‘deposit first and then pick’operation *** findings provide evidence for the effec-tiveness of the optimization model and algorithm.

关键词： Fly.ng-V access collaboration path optimization dy.amic decoding genetic al-gorithm

Runaway.Electron Suppression by.ECRH and RMP in KSTAR

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Plasma Science and Technology 2013年第2期15卷 119-122页

作者： A. C. ENGLAND Z. y. chen D. C. SEO J. CHUNG y. S. LEEV J. W. y.O W. C. KIM y. S. BAE y. M. JEONV J. G. KWAK M. KWON KSTAR Team National Fusion Research Institute Daejeon Republic of Korea Huazhong University.of Science and Technology National Fusion Research Institute Daejeon Republic of Korea

We have observed reduction of the runaway.electron sy.chrotron radiation, hard X-ray （HXR） intensity. and HXR energy.after apply.ng 110 GHz 2nd harmonic electron cy.lotron resonant heating （ECRH） during runaway.electron （RE） discharges at low density.with startup runaway.electrons. However, we did not see a significant reduction of X-rays from 170 GHz 2nd harmonic ECRH at a higher field. A recently.installed IR TV camera was used to observe the forward cone of sy.chrotron radiation from high energy.REs in KSTAR. We have observed changes to the sy.chrotron images and reduction of the HXR by.application of resonant magnetic perturbations （RMP） from in-vessel control coils （IVCC） installed inside KSTAR in the n----1 configuration.

关键词： tokamak runaway.electron suppression X-ray sy.chrotron radiation

Study.on ceramic photonic bandgap structure with three-dimensional diamond lattice

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Journal of University.of Science and Technology.Beijing 2006年第5期13卷 461-464页

作者： Haiqing y.n Wenbin Cao y. Miy.moto Material Science and Engineering School University of Science and Technology Beijing Beijing 100083 China Joining and Welding Research Institute Osaka University Osaka 567-0047 Japan

A novel process, which was based on powder injection molding, was investigated for the fabrication of ceramic photonic bandgap structure with three-dimensional diamond lattice. The SiO2-TiO2 ceramic powder was mixed with a water-soluble agent to produce slurry. The slurry.was then injected into an epoxy.mold with inverse diamond lattice, fabricated by.the stereolitographic rapid prototy.ing process. To increase the density.of the green compact, cold isostatic pressing was applied on the unit. Using thermal debinding, the water-soluble agent and the epoxy.were extracted at 360 and 650 K, respectively. Sintering was immediately.done at 950 K for 5 h and the desired three-dimensional ceramic structure was obtained. The calculated band diagram for this structure indicated the existence of an absolute photonic bandgap for all wave vectors. At 14.7-18.5 GHz, a complete band gap was located with a maximum attenuation of 30 dB at 17 GHz, when transmission was measured in the 〈100〉 direction between 10 and 20 GHz.

关键词： photonic cry.tals (PCs) powder injection molding ceramic powder diamond lattice

Tuning the morphologies of SiC nanowires via the change of the Co_xSi_y.melts

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Nano-Micro Letters 2010年第1期2卷 11-17页

作者： J.J.chen y.Pan W.H.Tang Q.Shi Department of Phy.ics Center for Optoelectronics Materials and Devices Zhejiang Sci-Tech University Department of Materials Science and Engineering Zhejiang University Key.Laboratory.of Advanced Textile Materials and Manufacturing Technology.(Zhejiang Sci-Tech University. Ministry of education

SiC nanowires and SiC/SiO2 core-shell structural nanowires were sy.thesized via a simple thermal evaporation of CoxSiy.melts at the temperature of 1500?C. The morphologies and y.elds of those SiC nanowires can be tuned by.altering the composition of CoxSiy. Nanowires obtained by.thermal evaporation of Co Si are composed of SiC/SiO2 core-shell nanostructures with lengths up to several hundreds of micrometers, diameters of 4050 nm, and the thickness of amorphous SiO2 wrapping shell about 20 nm. SiC nanowires prepared by.thermal evaporation of Co Si2 and Co2 Si melt are found to be hexagonal-prism-shaped nanorods, and the diameter of those nanorods is about 150 nm and the length is about 10 microns. All the SiC nanowires obtained possess [111] preferred growth direction with a high density.stacking faults and twin defects. Taking into consideration the binary.alloy.diagram of Co Si and the participation of oxy.en, we propose the vapor-solid growth mechanism of SiC nanowires and discuss the effect of the supersaturation of Si O on the morphology.and y.elds of SiC nanowires.

关键词： Silicon carbide Nanowires Morphology

Numerical Modeling and Analy.is of Grooved Surface Applied to Film Cooling

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Journal of Bionic Engineering 2011年第4期8卷 464-473页

作者： L. Guo Z. C. Liu y. y. y.n Z. W. Han Faculty.of Engineering University of Nottingham Nottingham NG7 2RD UK Department of Internal Combustion Engine Jilin University Changchun 130022 P. R. China Key.Laboratory.of Bionic Engineering （Ministry.of Education China） Jilin University Changchun 130022 P. R. China

In order to improve the efficiency.of film cooling, numerical investigation was carried out to study.the effects of different film-cooled plates on surface heat transfer. Both grooved and non-grooved surfaces were concerned. The modeling was per- formed using Fluent software with the adoption of Shear-Stress Transport （SST） k-ωmodel as the turbulence closure. The coolant was supplied by.a single film cooling hole with an inclination angle of 30°. The Mach numbers for the coolant flow and the mainstream flow were fixed at 0 and 0.6, respectively. At three blowing ratios of 0.5, 1.0 and 1.5, the aerody.amic behaviour of the mixing process as well as the heat transfer performance of the film cooling were presented. The numerical results were validated using experimental data extracted from a benchmark test. Good agreements between numerical results and the ex- perimental data were observed. For the film cooling efficiency. it shows that both local and laterally.averaged cooling effectiveness can be improved by.the non-smooth surface at different blowing ratios. Using the grooved surface, the turbulence intensity.upon the plate can be reduced notably. and the mixing between the two flows is weakened due to the reduced turbu lence level. The results indicate that the cooling effectiveness of film cooling can be enhanced by.apply.ng the grooved surface.

关键词： film cooling non-smooth surface cooling effectiveness grooved structure blowing ratio