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光热-跨临界压缩二氧化碳储能循环动态特性研究

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化工学报 2024年第5期75卷 2047-2059页

作者：王迪陈伟倩孙灵芳周云龙东北电力大学自动化工程学院吉林吉林132012

为了改善新能源发电波动对电网的影响,提出了一种光热-跨临界压缩二氧化碳储能(transcritical compressed carbon dioxide energy storage,TC-CCES)循环集成热力系统,采用模块化机理建模方法,基于能质平衡关系分别建立TC-CCES系统与光... 详细信息

为了改善新能源发电波动对电网的影响,提出了一种光热-跨临界压缩二氧化碳储能(transcritical compressed carbon dioxide energy storage,TC-CCES)循环集成热力系统,采用模块化机理建模方法,基于能质平衡关系分别建立TC-CCES系统与光热系统的动态数学模型,获取TC-CCES系统在储释能阶段关键参数的动态响应曲线。研究结果表明,系统的储能密度达到28.43 kW/m3,储能效率与循环效率分别为58.01%和60.85%,动态数学模型的最大误差均小于5%。此外,太阳直射辐射变化促使系统热源温度变化,而系统负荷对热源温度变化非常敏感,热源温度升高2.29%,换热器负荷升高3.36%,而且在某地区四季典型日冬季比秋季机组负荷低了23.9%。提出的动态数学模型可用于分析太阳能发电的动态特性,可为控制系统的设计提供理论参考。

关键词：光热 T-CO_(2)储能循环模型动态特性建模仿真

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Fe-Al金属间化合物的第一性原理研究综述

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材料保护 2024年第7期57卷 142-153页

作者：陈维铅喇培清李亚明许世鹏兰州理工大学省部共建有色金属先进加工与再利用重点实验室甘肃兰州730050 酒泉职业技术学院甘肃省太阳能发电系统重点实验室甘肃酒泉735000

Fe-Al金属间化合物具有密度低、比强度高、抗高温氧化和耐腐蚀性良好等优点,且成本低廉,成为镍基高温合金潜在的替代结构材料。综述了利用第一性原理计算研究元素掺杂/微合金化对Fe-Al金属间化合物及涂层的室温脆性、高温强度、界面结... 详细信息

Fe-Al金属间化合物具有密度低、比强度高、抗高温氧化和耐腐蚀性良好等优点,且成本低廉,成为镍基高温合金潜在的替代结构材料。综述了利用第一性原理计算研究元素掺杂/微合金化对Fe-Al金属间化合物及涂层的室温脆性、高温强度、界面结合、抗高温氧化及耐腐蚀性能影响的研究进展,设计了第一性原理研究B2型Fe-Al合金耐氯化盐腐蚀机理的理论计算方案,展望了第一性原理计算应用于Fe-Al合金及涂层材料研究的发展方向。

关键词：第一性原理 Fe-Al金属间化合物力学性能耐腐蚀性界面强度

Biomarkers for Primary Sjgren's Syndrome

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Genomics, Proteomics & Bioinformatics 2015年第4期13卷 219-223页

作者： weiqian chen Heng Cao Jin Lin Nancy Olsen Song Guo Zheng Division of Rheumatology The First Affiliated Hospital College of Medicine Zhejiang University Division of Rheumatology Penn State University Hershey College of Medicine

Primary Sjogren＇s syndrome （pSS） is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and sensitive biomarker candidates in pSS is significant. This review aims to summarize recent advances in the identification of biomarkers of Sjogren syndrome, trying to identify reliable, sensitive, and specific biomarkers that can be used to guide treatment decisions.

关键词： Biomarkcr Fins-like tyrosine kinase 3 ligand Myxovirus-rcsistance protein A Non-coding RNAs Saliva Sjogren syndrome

同伴互助学习策略在风湿免疫科住院医师临床研究培训中的应用

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中国毕业后医学教育 2024年第3期8卷 174-177,190页

作者：梁钧昱柯旖旎曹恒陈伟钱林进浙江大学医学院附属第一医院风湿免疫科浙江杭州310000

目的评估同伴互助学习(peer-assisted learning,PAL)策略对于内科住院医师的临床科研能力培养的作用与意义。方法以在风湿免疫科轮转的62名住院医师为研究对象,分为对照组(32人)与观察组(30人),两组住院医师分别接受传统授课模式和PAL... 详细信息

目的评估同伴互助学习(peer-assisted learning,PAL)策略对于内科住院医师的临床科研能力培养的作用与意义。方法以在风湿免疫科轮转的62名住院医师为研究对象,分为对照组(32人)与观察组(30人),两组住院医师分别接受传统授课模式和PAL策略的临床科研培训,比较培训前后总体认知情况、研究思维及统计分析方面的差异,统计不同组学员的合格率及学习满意度。结果两组住院医师培训前在总体认知、研究思维和统计分析方面差异无统计学意义(均P>0.05)。分别接受不同方法培训后,观察组住院医师在总体认知、研究思维与统计分析等评估中较对照组差异均有统计学意义,且评估合格人数较对照组亦显著增多,差异均有统计学意义(均P<0.05)。而在学习满意度调查方面,观察组较对照组的满意度更高,差异有统计学意义(P<0.05)。结论PAL策略对于内科住院医师的临床科研能力培养具有重要意义及显著有效性。

关键词：住院医师规范化培训同伴互助学习临床研究科研能力

Timing of transplantation of autologous bone marrow derived mesenchymal stem cells for treating myocardial infarction

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Science China(Life Sciences) 2014年第2期57卷 195-200页

作者： chen YiHuan TENG XiaoMei chen weiqian YANG JunJie YANG ZiYing YU YunSheng SHEN ZhenYa Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science of Soochow University

It is still unclear whether the timing of intracoronary stem cell therapy affects the therapeutic response in patients with myocardial *** natural course of healing the infarction and the presence of putative homing signals within the damaged myocardium appear to favor cell engraftment during the transendothelial passage in the early days after ***,the adverse inflammatory environment,with its high oxidative stress,might be deleterious if cells are administered too early after *** we highlight several aspects of the timing of intracoronary stem cell *** results showed that transplantation of bone marrow mesenchymal stem cells at 2 4 weeks after myocardial infarction is more favorable for reduction of the scar area,inhibition of left ventricular remodeling,and recovery of heart *** injection of autologous bone marrow mesenchymal stem cells at 2 4 weeks after acute myocardial infarction is safe and does not increase the incidence of complications.

关键词： bone marrow mesenchymal stem cells(BMSCs) cell transplantation myocardial infarction

Deformation Mechanism of Bimodal Structured 2205 Duplex Stainless Steel in Two Yield Stages

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 184-191页

作者：盛捷 DU Mingchen LI Yufeng MA Guocai chen weiqian ZHENG Yuehong ZHAN Faqi REN Junqiang G I Raab 喇培清 State Key Laboratory of Gansu Advanced Non-Ferrous Metal Materials Lanzhou University of TechnologyLanzhou 730050China Jiuquan Iron and Steel(Group)Co. Ltd.Jiayuguan 735100China Key Laboratory of Solar Power System Engineering Jiuquan Vocational and Technical CollegeJiuquan 735000China Institute of Physics of Advanced Materials Ufa State Aviation Technical University12 K.Marx StreetUfa 450008Russia

A kind of micro/nanostructured 2205 duplex stainless steel(DSS)with uniform distribution of nanocrystals was prepared via aluminothermic reaction *** analysis of stress-strain curve showed that the fracture strength and elongation of the specimen were 946 MPa and 24.7%,*** present,the research on microstructure of bimodal 2205 DSS at room temperature(RT)mainly depended on scanning electron microscope(SEM)observation after loading *** test result indicates that there are two different yield stages in stress-strain curve of specimen during tensile *** microstructure of duplex bimodal structured stainless steel consists of two pairs of soft hard regions and *** studying deformation mechanism of bimodal structured stainless steel,the interaction between soft phase and hard phase are *** principle of composition design and microstructure control of typical duplex stainless steel is obtained,which provides an important research basis for designing of advanced duplex stainless steel.

关键词： 2205 duplex stainless steel bimodal structure in-situ tensile test deformation mechanism two different yield stages

“双高计划”背景下工科类人才培养创新研究——以画法几何及机械制图课程改革为例

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中阿科技论坛（中英文） 2024年第7期 137-141页

作者：马超李玉宏许世鹏闫旺陈维铅甘肃省太阳能发电系统重点实验室甘肃酒泉735000 酒泉职业技术学院甘肃酒泉735000

《关于实施中国特色高水平高职学校和专业建设计划的意见》(以下简称“双高计划”)对新时代高职教育发展提出了要求、指明了方向、明确了任务。“双高计划”以立德树人为根本、以提升质量为核心、以内涵式发展为主线、以世界水平的高职... 详细信息

《关于实施中国特色高水平高职学校和专业建设计划的意见》(以下简称“双高计划”)对新时代高职教育发展提出了要求、指明了方向、明确了任务。“双高计划”以立德树人为根本、以提升质量为核心、以内涵式发展为主线、以世界水平的高职学校和专业群建设为抓手,从产教融合、师资建设、服务水平等多维度提升高职教育发展质量,有针对性地破解高职教育在发展中的瓶颈问题,以形成中国特色职业教育的发展模式,打造中国职业教育的国际品牌。文章以画法几何及机械制图课程为例,探讨“双高计划”背景下课程改革思路和实践教学方法,提出通过调整课程内容、创新教学手段、拓展实践环节等措施,来提高学生的实践能力和职业素养,提升画法几何及机械制图课程改革成效。

关键词： “双高计划” 画法几何及机械制图高职教育

Overexpressing dominant negative MyD88 induces cardiac dysfunction in transgenic mice

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Chinese Science Bulletin 2010年第31期55卷 3569-3575页

作者： chen weiqian LI ChuanFu JIANG Xuan RUAN HaiBin QI Xin LIU Li ZHAO QingShun GAO Xiang Key Laboratory of Model Animal for Disease Study of Ministry of Education Model Animal Research Center Nanjing University Nanjing 210061 China Department of Surgery East Tennessee State University Johnson City TN 37614 USA Departments of Gerontology and Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Myeloid differentiation protein-88(MyD88) is a crucial adaptor protein in the innate immune response.A protective role for MyD88 in normal cardiac function has been proposed in a surgical hypertrophic *** assess the in vivo role of MyD88 in cardiac remodeling,we generated transgenic mice with cardiac-restricted expression of a dominant negative mutant of MyD88(dnMyD88).Surprisingly,dnMyD88 transgenic mice displayed characteristic features of heart failure;including heart weight increase,cardiomyocytes enlargement,interstitial fibrosis,and re-expression of "fetal" *** examination of dnMyD88 hearts revealed dilated chamber volume and reduced cardiac ***88 mice died from heart failure before they were 7 months old,as shown by Kaplan-Meier ***,the heart failure phenotype of dnMyD88 mice was associated with abnormal activation of the Akt/GSK-3β signaling *** data provide the first evidence that normal MyD88 signaling is crucial for maintaining the physiological function of the adult heart.

关键词：转基因小鼠心脏功能功能障碍过量表达显性信号转导通路诱导心肌收缩力

Release of VEGF and BMP9 from injectable alginate based composite hydrogel for treatment of myocardial infarction

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Bioactive Materials 2021年第2期6卷 520-528页

作者： Yong Wu Tianqi Chang weiqian chen Xiaoyu Wang Jingjing Li Yueqiu chen You Yu Zhenya Shen Qian Yu Yanxia Zhang Institute for Cardiovascular Science&Department of Cardiovascular Surgery of the First Affiliated Hospital Medical CollegeSoochow UniversitySuzhou215000PR China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123PR China

Myocardial infarction(MI)is one of cardiovascular diseases that pose a serious threat to human *** pathophysiology of MI is complex and contains several sequential phases including blockage of a coronary artery,necrosis of myocardial cells,inflammation,and myocardial *** at the treatment of different stages of MI,in this work,an injectable alginate based composite hydrogel is developed to load vascular endothelial active factor(VEGF)and silk fibroin(SF)microspheres containing bone morphogenetic protein 9(BMP9)for releasing VEGF and BMP9 to realize their respective *** results of in vitro experiments indicate a rapid initial release of VEGF during the first few days and a relatively slow and sustained release of BMP9 for days,facilitating the formation of blood vessels in the early stage and inhibiting myocardial fibrosis in the long-term stage,*** injection of such composite hydrogel into the infarct border zone of mice MI model via multiple points promotes angiogenesis and reduces the infarction *** together,these results indicate that the dual-release of VEGF and BMP9 from the composite hydrogel results in a collaborative effect on the treatment of MI and improvement of heart function,showing a promising potential for cardiac clinical application.

关键词： Myocardial infarction Injectable hydrogel Silk fibroin microspheres Angiogenesis Myocardial fibrosis