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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-min Liu Hai-Lin Zhang Bi-Quan chen Yuan chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang Ling Cao Yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao Xiao-Yan Dong Dao-Jiong Lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-min chen Li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

在继承和借鉴中创新中国演剧--访导演艺术家徐晓钟

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中国文艺评论 2024年第2期 112-124,I0004页

作者：陈敏中央戏剧学院

一、要充分重视和发挥戏剧艺术的本性陈敏(以下简称“陈”):高峰作品难出是当代中国文艺创作的突出问题,您执导的《桑树坪纪事》被学界公认为是中国当代戏剧的高峰作品,具有里程碑意义。曹禺先生以“完美的艺术”评价您的作品,他说,“... 详细信息

一、要充分重视和发挥戏剧艺术的本性陈敏(以下简称“陈”):高峰作品难出是当代中国文艺创作的突出问题,您执导的《桑树坪纪事》被学界公认为是中国当代戏剧的高峰作品,具有里程碑意义。曹禺先生以“完美的艺术”评价您的作品,他说,“戏处理得很精彩很有趣味”,看了您的戏,他的感想是,“海是装不满的,人的路是走不尽的,花是不谢的,感情的长河是流不完的”。[1]您能否结合个人的成长历程,谈谈执导《桑树坪纪事》的感受和体会?

关键词：徐晓钟文艺创作戏剧艺术里程碑意义充分重视成长历程

Adrenaline in pulp capping treatment of reversible pulpitis

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World Journal of Clinical Cases 2024年第22期12卷 5024-5031页

作者： Si-Yun Yang Jin-Zhu Wang Hao Fan min chen Department of Stomatology Anhui Jieshou People's HospitalFuyang 236500Anhui ProvinceChina Department of Stomatology Jiangsu Yancheng Maternal and Child Health HospitalYancheng 224000Jiangsu ProvinceChina

BACKGROUND The role of epinephrine in the treatment of pulp capping in patients with reversible pulpitis is not *** To explore the role of epinephrine in the treatment of pulp capping in patients with reversible *** A total of 100 patients with reversible pulpitis who were treated in Anhui Jieshou People's Hospital from January 2020 to December 2021 were included in the *** were categorized into an observation group(n=50;treatment with adrenaline)and a control group(n=50;treatment with zinc oxide eugenol paste).The 24-h postoperative pain,regression time of gingival congestion and redness,clinical efficacy,and incidence of adverse reactions were compared between the *** were further categorized into the ineffective and effective treatment groups based on clinical *** multiple regression analysis explored factors affecting the efficacy of pulp capping *** A significant difference in 24-h postoperative pain was observed between the groups(P0.05).The proportion of adrenaline usage was lower(P<0.05)and that of anaerobic digestion by Streptococcus and Fusobacterium nucleatum was higher in the ineffective treatment group than in the effective treatment group(P<0.05).Logistic multiple regression analysis revealed adrenaline as a protective factor(P<0.05)and anaerobic digestion by Streptococcus and *** as risk factors for pulp capping in

关键词： Adrenaline Reversible pulpitis Pulp capping Efficacy Safety

Organic Integration of Traditional Chinese and Western Medicines—Future of Clinical Practice Guidelines of Integrated Traditional Chinese and Western Medicines

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Chinese Journal of Integrative Medicine 2024年第4期30卷 359-365页

作者： XIE Ying-lan HAN Fei JIN Ying-hui DING Yan-bing GUO Jing JI Dong-xiao ZHANG Teng chenXiao-min SHANG Hong-cai Department of Traditional Chinese Medicine Encephalopathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan(430074)China Department of Traditional Chinese Medicine Encephalopathy Hubei Province Traditional Chinese Medicine Research InstituteWuhan(430074)China Xuanwu Hospital of Traditional Chinese Medicine Beijing(100000)China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan(430074)China College of Acupuncture and Massage College of Health and RehabilitationNanjing University of Chinese MedicineNanjing(210023)China Department of Ophthalmology Huaihe Hospital of Henan UniversityKaifengHenan Province(475000)China ministry of Education and Beijing Key Laboratory of Internal Medicine of Traditional Chinese Medicine Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine/Ministry of Education and Beijing Key Laboratory of Internal Medicine of Traditional Chinese MedicineBeijing(100700)China

The transformation and implementation of clinical practice guidelines for integrated traditional Chinese medicine(TCM)and Western medicine(WM)is crucial to the adoption of medical science and technological findings and is an important way for TCM to be made available to the ***,clinical practice guidelines(CPGs)of TCM and WM integration in recent years was analyzed to clarify the current situation and problems in the existing guidelines according to the following four perspectives:(1)perspective of TCM and WM integration in guidelines,(2)diagnosis Using integrated TCM and WM,(3)integration of TCM and WM treatment,(4)promoting TCM and WM ***,the information and quality evaluation of CPGs for integrated Chinese and Western medicine in 2020–2022 were analyzed to explore the degree and methods of integration of Chinese and Western medicine *** last this study aimed to lay a foundation for the further establishment of Chinese characteristic,repeatable,and calculable clinical practice guidelines of TCM and WM integration.

关键词： clinical practice guidelines integrated traditional Chinese and Western medicine organic integration

Granulomatosis with polyangiitis presented as multiple cutaneous abscesses after hysterectomy

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Chinese Medical Journal 2024年第6期137卷 755-756页

作者： Xiaoting Song Mengrui Li Yinggai Song Ping Tu Hang Li Yang Wang Rong Xu min chen Xiaojuan Yu Suxia Wang Fude Zhou minghui Zhao Ruoyu Li Xiaoyu Jia Xiaowen Wang Department of Dermatology and Venereology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing 100034China National Clinical Research Center for Skin and Immune Diseases Beijing 100034China Renal Division Department of MedicinePeking University First HospitalBeijing 100034China Institute of Nephrology Peking UniversityBeijing 100034China Key Laboratory of Renal Disease Ministry of Health of ChinaBeijing 100034China Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China

To the Editor:A 62-year-old woman presented to the dermatology department with a 5-month history of multiple painless cutaneous abscesses and ulcers[Figure 1A],occurring 1 month after a transvaginal hysterectomy due to uterine *** general condition was good before and after the surgery,with no abnormal physical signs apart from *** reported no fever,night sweat,cough,or abdominal pain,but 10 kg *** has no history of diabetes,autoimmune diseases,or chronic infectious *** was no similar illness in her family.

关键词： hysterectomy pain surgery

A multicenter uroflowmetry study of healthy women in China

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Chinese Medical Journal 2024年第10期137卷 1225-1227页

作者： Xiaodong Liu Lingfeng Meng Jiawen Wang Tianming Ma Benkang Shi Hai Huang Qingwei Wang min chen Limin Liao Hong Shen Zhongqing Wei Yuansong Xiao Tiejun Pan Jian Ren Peng Zhang Xiaojun Tian Yaoguang Zhang Department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China Department of Urology Qilu HospitalShandong UniversityJinanShandong 250013China Department of Urology SUN YAT-SEN Memorial HospitalGuangzhouGuangdong 510235China Department of Urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450003China Department of Urology Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430030China Department of Urology China Rehabilitation Research CenterBeijing 100068China Department of Urology West China HospitalChengduSichuan 610041China Department of Urology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China Department of Urology General Hospital of Southern Theatre CommandGuangzhouGuangdong 510010China Department of Urology General Hospital of Central Theatre CommandWuhanHubei 430071China Department of Urology China-Japan Friendship HospitalBeijing 100029China Department of Urology Beijing Chao-Yang HospitalBeijing 100027China Department of Urology Peking University Third HospitalBeijing 100191China

Uroflowmetry is an uroflow measurement technique used to record the voided volume(VV)and flow rate,which can help clinicians objectively evaluate lower urinary tract ***,few uroflowmetry studies have focused on the female population,[1]especially on the uroflow curve standard ***,we sought to establish dependable uroflow reference values and nomograms for Chinese women and to evaluate the relationship between uroflow patterns and demographic data.

关键词： function. flowmetry analysis.

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肾脏病领域近十年进展

中华内科杂志 2024年第4期63卷 328-332页

作者：陈旻赵明辉北京大学第一医院肾内科北京100034

近十年来, 肾脏病领域有了多方面的重大进展。在慢性肾脏病方面, 我国的病因谱发生了显著的变迁。钠-葡萄糖协同转运蛋白2(SGLT-2)抑制剂和新一代高选择性非甾体类盐皮质激素受体拮抗剂(MRA)可改善慢性肾脏病患者的预后。肾小球疾病和... 详细信息

近十年来, 肾脏病领域有了多方面的重大进展。在慢性肾脏病方面, 我国的病因谱发生了显著的变迁。钠-葡萄糖协同转运蛋白2(SGLT-2)抑制剂和新一代高选择性非甾体类盐皮质激素受体拮抗剂(MRA)可改善慢性肾脏病患者的预后。肾小球疾病和遗传性肾脏病的病因与诊疗研究亦有了突破性进展。异种器官移植术显示了基因和生物工程学进展对肾脏病领域产生的深远影响。急性肾损伤流行病学和肾脏替代治疗时机的研究, 为急性肾损伤标准化诊疗增添了新的证据。

关键词：肾脏病慢性肾脏病肾小球疾病遗传性肾脏病肾移植急性肾损伤

随机激励下带滞变阻尼的调谐质量阻尼器减振性能研究

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工程力学 2024年第1期41卷 171-181页

作者：向越谭平贺辉陈倩敏广州大学土木工程学院广州510006 广州大学工程抗震减震与结构安全教育部重点实验室广州510006 湖南工学院土木与建筑工程学院衡阳421002

近年来,阻尼力与位移呈线性关系的新型调谐质量阻尼器(Tuned mass damper, TMD)相继出现,其参数分析优化原理大部分属于动力数值分析缺乏理论参数优化指导。该文对白噪声作用下具有上述特性的TMD,即滞变阻尼调谐质量阻尼器(Hysteretic d... 详细信息

近年来,阻尼力与位移呈线性关系的新型调谐质量阻尼器(Tuned mass damper, TMD)相继出现,其参数分析优化原理大部分属于动力数值分析缺乏理论参数优化指导。该文对白噪声作用下具有上述特性的TMD,即滞变阻尼调谐质量阻尼器(Hysteretic damping tuned mass damper, HD-TMD)进行减振优化研究。总结了HD-TMD的力学机理并推导出相应的结构-HD-TMD系统运动方程;提出适用于HD-TMD的H_(2)优化和性能平衡设计,并通过数值拟合技术得到了最优参数公式和基于容忍度的性能平衡设计流程;以真实可用的变摩擦摆式调谐质量阻尼器(VFP-TMD)为HD-TMD的实际算例,检验所提出的优化方法对风振激励的减振性能影响。结果表明:H_(2)优化和性能平衡设计下的HD-TMD可以提供略优于传统黏滞阻尼TMD的控制效果。H_(2)优化的最优参数能使HD-TMD发挥最大的潜能从而实现最好的减振率,但面临VFP-TMD行程过大导致的摆动非线性问题。性能平衡设计下的最优参数可以控制VFP-TMD行程在线性范围内,同时发挥出良好且稳定的减振控制效果实现双赢。与最优参数公式结果相比,性能平衡设计的峰值减振率和均方差峰值减振率仅损失3.19%和0.74%。

关键词：结构减振控制调谐质量阻尼器滞变阻尼 H_(2)优化性能平衡设计

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面向虚拟地理环境构建的地理分析模型集成应用方法进展

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遥感学报 2024年第5期28卷 1262-1280页

作者：乐松山闾国年温永宁陈旻南京师范大学地理科学学院南京210023 虚拟地理环境教育部重点实验室(南京师范大学) 南京210023 江苏省地理信息资源开发与利用协同创新中心南京210023

地理分析模型作为求解地理问题、模拟地理环境、支撑决策分析的重要资源,在虚拟地理环境(或数字孪生地理环境)的构建中发挥着重要作用。集成多领域具备不同模拟能力的地理分析模型,能够更加全面的表达现实地理环境,支撑构建可视、可用... 详细信息

地理分析模型作为求解地理问题、模拟地理环境、支撑决策分析的重要资源,在虚拟地理环境(或数字孪生地理环境)的构建中发挥着重要作用。集成多领域具备不同模拟能力的地理分析模型,能够更加全面的表达现实地理环境,支撑构建可视、可用、可分析、可交互的虚拟地理环境。针对地理分析模型的集成应用方法,本文系统性梳理了当前的研究进展,从地理分析模型的演进特征、支撑虚拟地理环境构建的途径、多模型的集成方法和地理信息服务的相关支撑技术等方面进行了综述。总结发现,通过多模型集成来解决复杂地理问题已经成为广泛认可的研究途径,自然—人文相结合、融合大数据与深度学习的集成建模也越来越受到关注。然而,现有模型集成方法仍然面临个案化的局限,在处理异构模型的兼容性方面难以形成持续可复用的集成成果,导致模型集成容易陷入到重复的技术改造工作中。借鉴信息服务领域的容器化理念,本文提出了“地理分析模型容器”的思路并进行了方法实现。通过设计柔性装配结构的信息交互通道和事件响应机制的功能计算通道,构建了能够持续积累和提升模型集成复用能力的容器,并基于此种模型容器来进行配置式的模型集成应用。

关键词：遥感地理分析模型虚拟地理环境数字孪生地理环境模型集成地理分析模型容器