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Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2(Delta)variant of COVID-19

World Journal of Pediatrics 2022年第5期18卷 343-349页

作者： Jing Hao Xiao-chen hu Ming-Xing Fan Jun chen Qi-Rui cheng Zhuo Li Zhi-Liang hu Xu-hua Ge Pediatric Intensive Care Unit Children's Hospital of Nanjing Medical UniversityNo 72 Guangzhou RoadNanjingChina Nanjing Infectious Disease Center The Second Hospital of NanjingNanjing University of Chinese MedicineNanjingChina

Background The aim of this study was to analyze the clinical characteristics of 66 pediatric patients with B.l.617.2(Delta)variant of coronavirus disease 2019(COVID-19).Methods Sixty-six pediatric patients with B.1.617.2(Delta)variant of COVID-19 admitted to the hospital from July to August 2021 were classified into mild(n=41)and moderate groups(n=25).Clinical characteristics,laboratory data and dynamic trends in different time periods were analyzed *** There were no statistically significant differences in age,gender ratios and clinical symptoms between the mild group and the moderate *** the patients in the moderate group had clusters of onsets,and the incubation period was shorter than that of the mild *** 24 hours of admission,the levels of erythrocyte sedimentation rate,cardiac troponin I,D-dimer in the moderate group were higher than that in the mild group(P<0.05).The titers of immunoglobulin(Ig)G and IgM antibodies gradually increased after disease ***-five(53.03%)children were tested positive for antibodies in 4-12 *** increased gradually,while IgM decreased obviously in about 15 days after disease *** cycle threshold values of open reading frame lab and nucleocapsid protein gene in the severe acute respiratory syndrome coronavirus 2 genomes in creased gradually on the 3rd,6th,9th,and 12th days after disease onset,compared with those in day *** The symptoms of children with B.l.617.2(Delta)variant of COVID-19 were *** description and analysis of the clinical characteristics and laboratory data can help medical stafiF to evaluate the condition of children with COVID-19 and to accumulate more clinical experience.

关键词： B.1.617.2(Delta) Children Clinical features Coronavirus disease 2019(COVID-19)

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Effect of the mixing of s-wave and chiral p-wave pairings on electrical shot noise properties of normal metal/superconductor tunnel junctions

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Chinese Physics B 2024年第7期33卷 538-545页

作者：胡雨辰胡梁宾 Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of PhysicsSouth China Normal UniversityGuangzhou 510631China

We study theoretically the electrical shot noise properties of tunnel junctions between a normal metal and a superconductor with the mixture of singlet s-wave and chiral triplet p-wave pairing due to broken inversion symmetry. We investigate how the shot noise properties vary as the relative amplitude between the two parity components in the pairing potential is changed. It is demonstrated that some characteristics of the electrical shot noise properties of such tunnel junctions may depend sensitively on the relative amplitude between the two parity components in the pairing potential, and some significant changes may occur in the electrical shot noise properties when the relative amplitude between the two parity components is varied from the singlet s-wave pairing dominated regime to the chiral triplet p-wave pairing dominated regime. In the chiral triplet p-wave pairing dominated regime, the ratio of noise power to electric current is close to 2e both in the in-gap and in the out-gap region. In the singlet s-wave pairing dominated regime, the value of this ratio is close to 4e in the inner gap region but may reduce to about 2e in the outer gap region as the relative amplitude of the chiral triplet pairing component is increased. The variations of the differential shot noise with the bias voltage also exhibit some significantly different features in different regimes. Such different features can serve as useful diagnostic tools for the determination of the relative magnitude of the two parity components in the pairing potential.

关键词： normal metal/superconductor tunnel junctions shot noise mixing of s-wave and chiral p-wave pairing spin–orbit coupling

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Simple and Rapid Hollow Fiber Liquid Phase Microextraction Followed by High Performance Liquid Chromatography Method for Determination of Drug-protein Binding

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Chemical Research in Chinese Universities 2011年第5期27卷 764-768页

作者： XI Guo-chen hu Shuang BAI Xiao-hong Department of Pharmaceutical Analysis School of Pharmaceutical Science Shanxi Medical University Taiyuan 030001 P. R. China

A method was established using hollow fiber-liquid phase microextraction（HF-LPME） followed by high performance liquid chromatography（HPLC） to determine the concentration of the free（unbound） drug in the solution of the drug and protein. Measurements of drug-protein binding ratios and free drug concentrations were then analyzed with the Klotz equation to determine the equilibrium binding constant and number of binding sites for drug-protein interaction. The optimized method allows one to perform the efficient extraction and separation of free drug from protein-bound drug, protein, and other interfering substances. This approach was used to characterize the binding of the anticholinergic drugs atropine sulfate and scopolamine hydrobromide to proteins in human plasma and bovine serum albumin（BSA）. The results demonstrate the utility of HF-LPME method for measuring free drug concentrations in protein-drug mixtures and determining the protein binding parameters of a pharmacologically important class of drugs.

关键词： Liquid phase microextraction Drug-protein binding ratio Binding parameter Anticholinergic drug

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Exact Solutions to the Quantum Rabi-Stark Model Within Tunable Coherent States

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Communications in Theoretical Physics 2019年第5期71卷 623-628页

作者： You-Fei Xie Qing-hu chen Department of Physics Zhejiang UniversityHangzhou310027China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing210093China

The quantum Rabi-Stark model, where the linear dipole coupling and the nonlinear Stark-like coupling is present on an equal footing, is studied within the tunable extended coherent states. The eigenvalues and eigenstates are therefore obtained exactly. Surprisingly, the entanglement entropy in the ground-state is found to jump suddenly with the coupling strength. The first-order quantum phase transition can be detected by level crossing of the ground state and the first excited state, which is however lacking in the original linear quantum Rabi model. Performing the first-order approximation in the present theory, we can derive closed-form analytical results for the ground-state. Interestingly, it agrees well with the exact solutions up to the ultra-strong coupling regime in a wide range of model parameters. The spectral collapses when the absolute value of the nonlinear coupling strength approaches to twice the cavity frequency is observed with the help of new solutions in the limits.

关键词： extended coherent states exact eigenvalues first-order phase transitions spectral collapse

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Synthesis and characterization of nanocrystalline NaTaO_3

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Rare Metals 2006年第Z2期25卷 69-72页

作者： chen Jingfang hu Long ZHAO Jianling TANG chengchun LI Yangxian School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China School of Material Science and Engineering Hebei University of Technology Tianjin 300130 China

Tantalum pentoxide reacts actively with concentrated NaOH solution under hydrothermal conditions at 180 ℃. In the reaction between NaOH solution and Ta2O5, the structure and composition of the tantalates depend on the reaction time, and the structure evolution results in a remarkable change in light absorption. Powder X-ray diffraction (XRD), scanning electron microscopy (SEM), and ultraviolet-visible (UV-Vis) diffused reflection spectrum were used to characterize various properties of the obtained solid products. At 180 ℃, the reaction proceeds rapidly. With the increase of time, the reflection peaks of unreacted Ta2O5 in the XRD patterns becomes weaker and weaker. Pure NaTaO3 is obtained after 60 min, which is well crystallized with a uniform cubic morphology.

关键词： NaTaO3 hydrothermal characterization crystal morphology

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Development of a direct current power system for a multi-node cabled ocean observatory system

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第8期13卷 613-623页

作者： Yan-hu chen Can-jun YANG De-jun LI Bo JIN Ying chen State Key Lab of Fluid Power Transmission and Control Zhejiang UniversityHangzhou 310027China

Due to the shortage of suitable research methods for real-time and long-term observation of oceans,an innovative approach that can provide abundant power and wide bandwidth is being developed worldwide for undersea *** this paper,we develop a direct current(DC) power system which is applied to a multi-node cabled ocean observatory system named ZERO(Zhejiang University Experimental and Research Observatory).The system addresses significant issues ranging from terrestrial facility to subsea infrastructure,and focuses on using appropriate methods to deal with several key challenges,including delivery,conversion,distribution,and management of power,and heat dissipation in pressure vessels.A basic laboratory platform consisting of a shore station,a primary node in a water tank,and a secondary node in a deep-sea simulation chamber under 42 MPa pressure was built and fully *** improved secondary node was deployed in Monterey Bay in California for a deep-sea *** 11-day laboratory test and a half-year sea trial proved that the DC power system based on our proposed methods is viable for the underwater multi-node observatory system.

关键词： Cabled ocean observatory system DC power system Heat dissipation Deep sea

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A common rule for the intermediate state caused by DNA mismatch in single-molecule experiments

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Communications in Theoretical Physics 2023年第5期75卷 158-166页

作者： Xiaoya Song Chao Yang Yuyu Feng hu chen Yanhui Liu College of Physics Guizhou UniversityGuiyang 550025China Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Lab for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang 550025China Kechuang Industrial Development Company Limited Guian New AreaGuiyang 550025China

Defective structures,such as DNA mismatches,occur in DNA with a high frequency in some biological *** are difficult to identify and have recently become the focus of singlemolecule *** single-molecule experiments were successively conducted to detect the effects of DNA mismatch on the stability of DNA ***,there was no consensus regarding the results of the intermediate state caused by DNA *** on the extended ox-DNA model,DNA mismatch was introduced to the stem of DNA hairpins with different stem lengths(12-20 bps)and 4T in hairpin *** intermediate state and its dependence on the position of the DNA mismatch in the stem from the hairpin loop were systematically *** results indicated that DNA mismatch definitely reduced the critical forces of DNA *** the same time,a common rule about the dependence of the intermediate state on the position of DNA mismatch was generalized in a phase diagram constructed in a phase space of a scaled position of DNA *** segments on its diagonal line corresponded to the ranges of the scaled position of DNA mismatch[0,0.55),[0.55,0.85),and[0.85,1],*** the[0.55,0.85)range,the extension probability distribution of DNA hairpins had unfolded,intermediate,and folded *** contrast,in the other ranges[0,0.55)and[0.85,1],the extension probability distributions had unfolded and folded *** scaled positions of DNA mismatch for the DNA hairpins used in the three single-molecule experiments(0.65,0.4736,and 0.5)fell in the ranges[0.55,0.85)and[0,0.55).Obviously,the common rule generalized in the phase diagram not only clarifies the nonconsensus between the three single-molecule experiments but also highlights the design of single-molecule experiments in the future.

关键词： DNA mismatch intermediate state DNA hairpin Bell’s Model extended Ox-DNA model single-molecule experiment

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Effectiveness and safety of splenectomy for gastric carcinoma:A meta-analysis

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World Journal of Gastroenterology 2009年第42期15卷 5352-5359页

作者： Kun Yang Xin-Zu chen Jian-Kun hu Bo Zhang Zhi-Xin chen Jia-Ping chen Department of Gastrointestinal Surgery West China Hospital Sichuan University No. 37 Guo Xue Xiang Chengdu 610041 Sichuan Province China

AIM： To evaluate the impact of splenectomy on longterm survival, postoperative morbidity and mortality of patients with gastric cancer by performing a metaanalysis METHODS： A search of electronic databases to identify randomized controlled trials in The Cochrane Library trials register, Mediine, CBMdisc （Chinese Biomedical Database） and J-STAGE, etc was performed. Data was extracted from the studies by 2 independent reviewers. Outcome measures were survival, postoperative morbidity and mortality and operation-related events. The meta-analyses were performed by RevMan 4.3. RESULTS： Three studies comprising 466 patients were available for analysis, with 231 patients treated by gastrectomy plus splenectomy. Splenectomy could not increase the 5-year overall survival rate [RR = 1.17, 95% confidence interval （CI） 0.97-1.41]. The postoperative morbidity （RR = 1.76, 95% CI 0.82-3.80） or mortality （RR = 1.58, 95% CI 0.45-5.50） did not suggest any significant differences between the 2 groups. No significant differences were noted in terms of number of harvested lymph nodes, operation time, length of hospital stay and reoperation rate. Subgroup analyses showed splenectomy did not increase the survival rate for proximal and whole gastric cancer. No obvious differences were observed between the 2 groups when stratified by stage. Sensitivity analyses indicated no significant differences regarding the survival rates （P 〉 0.05）. CONCLUSION： Splenectomy did not show a beneficial effect on survival rates compared to splenic preservation. Routinely performing splenectomy should not be recommended.

关键词： Gastric cancer Splenectomy Survival rate Morbidity Operative surgical procedure Postoperative period Treatment outcome

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An architecture decomposition method of pneumatic catapult system based on OPM and DSM

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Chinese Journal of Aeronautics 2023年第8期36卷 168-181页

作者： Lu GAN Gang YANG Xianhui LI Enze Zhu hu chen Xiaohui WEI State Key Laboratory of Mechanics and Control of Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of General Aviation and Flight Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The architecture strategy of the Unmanned Aerial Vehicle(UAV)pneumatic launch system should continue to evolve to adapt to complex and variable operating *** representation,decomposition perspective,and cluster analysis play a vital role in the early phase of system architecture *** order for the system to emerge anticipated and desirable intrinsic functional properties,an architecture decomposition method based on the ObjectProcess Methodology(OPM)and Design Structure Matrix(DSM)is put forward in this *** OPM is proposed to model the UAV launch process formally,and the matrix representation of the architecture of the pneumatic launch system is *** the extension of the definition and operations of DSM,with the Idicula-Gutierrez-Thebeau Algorithm plus(IGTA+)clustering algorithm,the transformation of the pneumatic launch system architecture from process decomposition to function decomposition is demonstrated in this *** analysis shows that the architecture decomposition of the pneumatic launch system meets the functional requirements of stakeholders.

关键词： Architecture decomposition Cluster analysis Design structure matrix Object-process methodology Pneumatic catapult system

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A Solution to a Single Molecular Experiment Problem

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Communications in Computational Physics 2009年第8期6卷 577-585页

作者： Yanhui Liu hu chen Lin hu Zhong-Can Ou-Yang Jie Yan Guizhou Provincial Key Lab for Photoelectron Technology and Application Guizhou UniversityGuiyang550025China National University of Singapore Department of Physics2 Science Drive 3117542Singapore Institute of Theoretical Physics Chinese Academy of SciencesBeijing100080China

Recently Hari Shroff and his collaborators[Nano Letters 5(2005)]developed a nanoscopic force sensor,but the force which they measured in their single molecular experiment was much lower than the theoretical critical *** order to fix this problem,we investigate the micromechanics of dsDNA based on the worm-like chain model and flexible hinge model by using Monte Carlo *** simulation results not only address Hari Shroff’s experiment difficulty reasonably,but also provide strong support for flexible hinge mechanism put forward recently by Yan and Marko[***.93(2004)].

关键词： Monte Carlo algorithm worm-like chain(WLC)model flexible hinge model single molecular experiment micromechanics of double-stranded DNA(dsDNA)

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