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Correlation between the gut microbiome and neurodegenerative diseases:a review of metagenomics evidence

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Neural Regeneration Research 2024年第4期19卷 833-845页

作者： Xiaoyan Liu Yi Liu Junlin Liu Hantao Zhang Chaofan shan Yinglu Guo Xun Gong Mengmeng Cui Xiubin Li min Tang School of Life Sciences Jiangsu University Institute of Animal Husbandry Jiangsu Academy of Agricultural Sciences Department of Rheumatology&Immunology Affiliated Hospital of Jiangsu University Department of Neurology The Second Affiliated Hospital of Shandong First Medical University

A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain *** a contributing factor,microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral ***-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms,and for both neuroimmune and neuroendocrine ***,we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases,with an emphasis on multi-omics studies and the gut *** pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also ***,we discuss the role of diet,prebiotics,probiotics,postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases.

关键词： biomarker diet pattern gut microbiota gut-brain axis metagenomics mitochondrial dysfunction multi-omics neurodegenerative disease neuroinflammation probiotic

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家具搁板许用弯曲程度视觉感知评价

西北林学院学报 2021年第6期36卷 254-258页

作者：陈敏珊关惠元南京林业大学家居与工业设计学院江苏南京210037

为了提高家具产品的质量,提供家具搁板许用弯曲程度评判依据,通过视觉感知的实验方法,按照“无变形”“轻微变形”“严重变形”3个等级的评价指标,设定5种长度的搁板,每种长度的搁板设定12种弯曲变形条件,237名受试者对搁板进行变形情... 详细信息

为了提高家具产品的质量,提供家具搁板许用弯曲程度评判依据,通过视觉感知的实验方法,按照“无变形”“轻微变形”“严重变形”3个等级的评价指标,设定5种长度的搁板,每种长度的搁板设定12种弯曲变形条件,237名受试者对搁板进行变形情况判定,以探讨搁板弯曲程度超出受试者心理接受范围的临界点。结果表明:1)随着搁板长度的增加,感知到搁板变形的人数比例也随之增加;2)当搁板弯曲程度在3.0‰~4.0‰时,超过90%受试者认为搁板有轻微变形,而当搁板弯曲程度超过4.0‰时,受试者中认为搁板发生严重变形的比例逐渐增加;3)可将3.0‰、4.0‰分别作为搁板许用弯曲程度的一级指标和二级指标。研究结果可为相关标准的修订提供参考依据。

关键词：板式家具搁板许用弯曲程度视觉感知变形情况

Electroacupuncture activates AMPKa1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： Wei-wei Jia Hua-wei Lin min-guang Yang Ya-ling Dai Yan-yi Ding Wen-shan Xu Si-nuo Wang Ya-jun Cao Sheng-xiang Liang Zhi-fu Wang Cong chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine The Institute of Rehabilitation Industry Fujian University of Traditional Chinese Medicine National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese Medicine Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese Medicine

Objective: Studies have shown that electroacupuncture(EA) can alleviate cognitive impairments from Alzheimer's disease(AD) by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK), but the specific mechanism involved remains to be elucidated. Therefore, this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial ***: The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKa1-subunit conditional knockout(AMPKa1-cKO) were used for experiments. To evaluate the effects of EA treatment on cognitive function, the T-maze and Morris water maze were used. In addition,chemical exchange saturation transfer, thioflavin staining, transmission electron microscopy, mitochondrial membrane potential, and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 ***: Both APP/PS1 mice and AMPKa1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory impairment. Inactivation of the AMPK/peroxisome proliferatoractivated receptor-γ coactivator-1a(PGC-1a) pathway increased pathological amyloid-β(Aβ) deposition and aggravated the dysfunction in mitochondrial dynamics. In addition, EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1a pathway, specifically by reducing pathological Aβ deposition, normalizing energy metabolism, protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins, and downregulating the expression of fission proteins. However, the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by ***: The regulation of hippocampal mitochondrial dynamics and reduction in Aβ deposition via the AMPK/PGC-1a pathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics

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肝内胆管癌局部治疗及评价

中国实用外科杂志 2020年第6期40卷 684-688页

作者：陈敏山傅毅振中山大学肿瘤防治中心肝脏外科广东广州510060

肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)是一种较为少见、高度侵袭性的原发肝脏恶性肿瘤。ICC的治疗手段较为有限,手术治疗是惟一的根治性手段,局部治疗近年技术有较多大的进展,主要包括消融治疗、介入治疗和放射治疗。局部... 详细信息

肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)是一种较为少见、高度侵袭性的原发肝脏恶性肿瘤。ICC的治疗手段较为有限,手术治疗是惟一的根治性手段,局部治疗近年技术有较多大的进展,主要包括消融治疗、介入治疗和放射治疗。局部治疗可贯穿于ICC治疗的整个过程之中。对于不适合手术的早期ICC病人,局部治疗有达到治愈的可能;对于中晚期ICC病人,局部治疗可以降低肿瘤负荷、缓解症状、延长生存,甚至有机会通过局部治疗获得手术机会;而辅助介入治疗或者放射治疗也可以降低根治性术后病人复发的风险。由此可见,局部治疗是ICC多学科综合治疗的重要组成部分,可使病人获益。

关键词：肝内胆管癌局部治疗消融治疗介入治疗放射治疗

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响应面法优化复合澄清剂澄清山药醋工艺

食品工业科技 2021年第1期42卷 138-143页

作者：王美洪陈善敏许洋蒋和体西南大学食品科学学院重庆400715 食品科学与工程国家级实验教学示范中心(西南大学) 重庆400715

以明胶、果胶酶、壳聚糖、硅藻土四种澄清剂单一和复合使用的处理方法对山药醋进行澄清处理,以发酵山药醋透光率为考察指标,运用响应面法优化山药醋复合澄清工艺。结果表明:山药复合澄清响应面模型的建立具有可靠稳定性,最佳复合澄清工... 详细信息

以明胶、果胶酶、壳聚糖、硅藻土四种澄清剂单一和复合使用的处理方法对山药醋进行澄清处理,以发酵山药醋透光率为考察指标,运用响应面法优化山药醋复合澄清工艺。结果表明:山药复合澄清响应面模型的建立具有可靠稳定性,最佳复合澄清工艺条件为硅藻土与壳聚糖配比5∶2(g∶g),复合澄清剂添加量4 g/L,澄清温度36.5℃,澄清时间83 min。在此优化条件下,山药醋透光率达到95.8%,比原醋升高27%,同时对山药醋其他各项指标均无明显影响,氨基酸态氮0.27 g/100 mL,总酸5.29 g/100 mL,可溶性固形物8.74°B x,处理后的山药醋外观呈浅黄棕,透明无悬浮物质,口感柔和。

关键词：山药醋复合澄清剂澄清透光率响应面

Efficacy and safety of Yiqi Peiyuan granules for improving the short-term prognosis of patients with acute kidney injury:A multicenter,double-blind,placebo-controlled,randomized trial

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Journal of Integrative Medicine 2024年第3期22卷 279-285页

作者： Jia-jia Wu Tian-yi Zhang Ying-hui Qi min-yan Zhu Yan Fang Chao-jun Qi Li-ou Cao Ji-fang Lu Bo-han Lu Lu-min Tang Jian-xiao Shen shan Mou Department of Nephrology Molecular Cell Lab for Kidney DiseaseShanghai Peritoneal Dialysis Research CenterUremia Diagnosis and Treatment CenterRenji Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200127China Department of Nephrology Shanghai Pudong New Area Punan HospitalShanghai 200125China Department of Nephrology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

Background:Yiqi Peiyuan(YQPY)prescription,a composite prescription of traditional Chinese medicine,has been used to prevent or delay the continued deterioration of renal function after acute kidney injury(AKI)in some institutions and has shown considerable ***:This is the first randomized controlled trial to assess efficacy and safety of YQPY for improving short-term prognosis in adult patients with ***,setting,participants and interventions:This is a prospective,double-blind,multicenter,randomized,and placebo-controlled clinical trial.A total of 144 enrolled participants were randomly allocated to two groups according to a randomization ***,caregivers and investigators assessing the outcomes were blinded to group *** in the YQPY group received 36 g YQPY granules twice a day for 28 *** in the placebo group received a placebo in the same dose as the YQPY *** outcome measures:The primary outcome was the change in the estimated glomerular filtration rate(eGFR)between baseline and after 4 and 24 weeks of *** secondary outcomes were the change of serum creatinine(Scr)level between baseline and after treatment,and the incidence of endpoint events,defined as eGFR increasing by more than 25%above baseline,eGFR>75 mL/min per1.73 m2or the composite endpoint,which was defined as the sum of patients meeting either of the above ***:Data from a total of 114 patients(59 in the YQPY group and 55 in the control group)were *** mean changes in eGFR and Scr in weeks 4 and 24 had no difference between the two *** further subgroup analysis(22 in the YQPY group and 31 in the control group),the mean change in eGFR after treatment for 4 weeks was 27.39 mL/min per 1.73 m2in the YQPY group and 5.78 mL/min per1.73 m2in the placebo group,and the mean difference between groups was 21.61 mL/min per 1.73 m2(P<0.001).Thirteen(59.1%)patients in the YQPY group and 5(16.1%)in the placebo g

关键词： Chinese herbal medicine Randomized controlled trial Acute kidney injury Renal function

Radical innovation breakthroughs of biodegradation of plastics by insects:history,present and future perspectives

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 127-165页

作者： shan-shan Yang Wei-min Wu Federica Bertocchini Mark Eric Benbow Suja P.Devipriya Hyung Joon Cha Bo-Yu Peng Meng-Qi Ding Lei He Mei-Xi Li chen-Hao Cui Shao-Nan Shi Han-Jun Sun Ji-Wei Pang Defu He Yalei Zhang Jun Yang Deyi Hou De-Feng Xing Nan-Qi Ren Jie Ding Craig S.Criddle State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Department of Civil and Environmental Engineering William&Cloy Codiga Resource Recovery CenterStanford UniversityStanfordCA 94305USA Plasticentropy rue Thiers 28Reims 51100France Department of Entomology and Department of Osteopathic Medical Specialties Michigan State UniversityEast LansingMI 48824USA School of Environmental Studies Cochin University of Science and TechnologyKochi 682022India Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Environmental Science and Engineering Tongji UniversityShanghai 200092China China Energy Conservation and Environmental Protection Group CECEP Talroad Technology Co.Ltd.Beijing 100096China School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China Research Institute for Frontier Science Beihang UniversityBeijing 100191China School of Environment Tsinghua UniversityBeijing 100084China

Insects damaging and penetrating plastic packaged materials has been reported since the *** innovation breakthroughs of plastic biodegradation have been initiated since the discovery of biodegradation of plastics by Tenebrio molitor larvae in 2015 followed by Galleria mellonella in *** we review updated studies on the insect-mediated biodegradation of *** biodegradation by insect larvae,mainly by some species of darkling beetles(Tenebrionidae)and pyralid moths(Pyralidae)is currently a highly active and potentially transformative area of *** the past eight years,publications have increased explosively,including discoveries of the ability of different insect species to biodegrade plastics,biodegradation performance,and the contribution of host and microbiomes,impacts of polymer types and their physic-chemical properties,and responsible enzymes secreted by the host and gut *** date,almost all major plastics including polyethylene(PE),polypropylene(PP),polyvinyl chloride(PVC),polyethylene terephthalate(PET),polyurethane(PUR),and polystyrene(PS)can be biodegraded by *** and ten other insect species representing the Tenebrionidae and Pyralidae *** biodegradation processes are symbiotic reactions or performed by synergistic efforts of both host and gut-microbes to rapidly depolymerize and biodegrade plastics with hourly *** digestive ezymens and bioreagents screted by the insects play an essential role in plasatic biodegradation in certain species of Tenebrionidae and Pyralidae *** research on the insect itself,gut microbiomes,transcriptomes,proteomes and metabolomes has evaluated the mechanisms of plastic biodegradation in *** conclude this review by discussing future research perspectives on insect-mediated biodegradation of plastics.

关键词： Plastics Biodegradation Insects Gut microbiomes Enzymes

石油钻井噪声与振动对鲤鱼(Cyprinus carpio)能量收支的影响

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生态学报 2008年第8期28卷 3527-3534页

作者：孙耀陈民山陈聚法赵俊宋云利农业部海洋渔业资源可持续利用重点开放实验室中国水产科学研究院黄海水产研究所青岛266071

应用现场模拟实验方法测定了石油钻井噪声与振动对鲤鱼能量收支的影响。结果表明,该污染对鲤鱼摄食、生长、代谢和排泄等各能量收支组分均有显著影响,但其影响程度和趋势却不尽相同。鲤鱼摄食、生长和生长转换效率均随噪声与振动强度增... 详细信息

应用现场模拟实验方法测定了石油钻井噪声与振动对鲤鱼能量收支的影响。结果表明,该污染对鲤鱼摄食、生长、代谢和排泄等各能量收支组分均有显著影响,但其影响程度和趋势却不尽相同。鲤鱼摄食、生长和生长转换效率均随噪声与振动强度增大呈减小趋势;其中摄食较为敏感,但生长的受影响程度却显著大于摄食。与摄食和生长的变化趋势不同,在受到显著影响范围内,排泄能和代谢能随噪声与振动强度增大呈U型变化趋势;其敏感程度与摄食相同,受影响程度也显著低于生长。钻井噪声与振动对鲤鱼影响可分两个阶段;第一阶段为,鲤鱼能量摄入量降低导致各能量支出水平不同程度的下降;第二阶段为,噪声与振动进一步增强,除使摄食量继续减小外,同时造成体内代谢量和排泄量的增大,这两种影响的协同作用使鲤鱼生长大幅度降低。通过所建立的不同钻井噪声与振动强度下鲤鱼的能量收支模型,可以看出,鲤鱼生长大幅度降低总是与代谢量和排泄量增大相对应。

关键词：能量收支鲤鱼噪声与振动石油钻井

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肝癌术后复发的多学科综合治疗

中国实用外科杂志 2019年第10期39卷 1042-1044页

作者：张耀军陈敏山中山大学肿瘤防治中心肝脏外科广东广州510060

复发性肝癌的治疗手段主要包括再次手术切除、肝移植、局部消融治疗、介入治疗、靶向治疗以及全身化疗等,但由于复发性肝癌病情复杂,单一治疗效果并不满意,多学科综合治疗是其必然选择,目前比较常用的联合治疗方式主要有经皮肝动脉化疗... 详细信息

复发性肝癌的治疗手段主要包括再次手术切除、肝移植、局部消融治疗、介入治疗、靶向治疗以及全身化疗等,但由于复发性肝癌病情复杂,单一治疗效果并不满意,多学科综合治疗是其必然选择,目前比较常用的联合治疗方式主要有经皮肝动脉化疗栓塞(TACE)+外科治疗、TACE+局部治疗、TACE+全身治疗等。临床上应以延长生存和保证生存质量为目的,针对不同病人的肝脏情况、全身状况以及肿瘤复发情况选择不同的多学科联合治疗方案,可显著延长病人的生存时间。

关键词：经导管动脉化疗栓塞肝切除术肝移植射频消融化疗