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菲律宾地热场中矿物和地球化学条件对砷迁移的制约

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地质学报 2006年第4期80卷 616-616页

作者： chelo pascua Tsutomu SATO Glenn GOLLA Graduate School of Natural Scienceand Technology Kanazawa UniversityIshikawaJapan Institute of Natureand Environmental Technology Kanazawa UniversityIshikawaJapan Unocal

Assessment of heavy metal contents in bed sediments of a mineralized catchment of the Agno River, Benguet, Philippines

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Chinese Journal Of Geochemistry 2006年第B8期25卷 41-41页

作者： Dymphna D. Nolasco-Javier chelo S. pascua Carlos Primo C. David Tsutomo Sato University of the Philippines Tsukuba University National Institute of Geological Sciences Hokkaido University

Cardiac Malformations in Congenital Hypothyroidism: A Case Report

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Open Journal of Pediatrics 2024年第2期14卷 279-284页

作者： Suzanne Sap Gaelle Ntsoli Jocelyn Tony Ritha Mbono Helene Kamo David chelo Mother and Child Center of Chantal Biya Foundation Yaounde Cameroon University of Yaounde I Yaounde Cameroon Laquintinie Hospital University of Douala Douala Cameroon General Hospital of Garoua University of Garoua Garoua Cameroon

Introduction: Congenital hypothyroidism is the most common causes of preventable mental retardation. It is associated with other births defects like cardiac malformations. Descriptions in Sub Saharan Africa are rare, justifying the present report. Case Report: We reported the cases of 3 female patients, diagnosed with hypothyroidism, presenting in addition pulmonary stenosis. The diagnosis was late in all the patients and we noticed clinical improvement under levothyroxine. Conclusion: Association congenital hypothyroidism and cardiac defect is not rare. Our patients are female with no history of consanguinity, presenting congenital hypothyroidism with a gland in situ associated with pulmonary stenosis. Systematic screening of other births defects is thus recommended in affected patients.

关键词： Congenital Hypothyroidism Cardiac Malformations Children

Exercise-induced albuminuria vs circadian variations in blood pressure in type 1 diabetes

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World Journal of Diabetes 2017年第2期8卷 74-79页

作者： Isabelle Hota Tadida Meli Aurel T Tankeu Mesmin Y Dehayem David chelo Jean Jacques N Noubiap Eugene Sobngwi Institut Supérieur des Sciences de la Santé Université des Montagnes Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences National Obesity Center Yaoundé Central Hospital Mother and Child Center of the Chantal Biya Foundation Department of Medicine Groote Schuur Hospital and University of Cape Town

AIM To investigated the relationship between exerciseinduced ambulatory blood pressure measurement(ABPM) abnormalities in type 1 diabetes mellitus(T1DM) adolescents. METHODS We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio(ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1 DM patients and 20 matched controls. T1 DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure(BP) and renal function according to the general referencepopulation. Non-diabetic controls were adolescents of general population matched for sex, age and *** Mean duration of diabetes was 4.2 ± 2.8 years. The mean 24 h systolic blood pressure(SBP) and diastolic blood pressure(DBP) were respectively 116 ± 9 mm Hg in the diabetic group vs 111 ± 8 mm Hg in the nondiabetic(P = 0.06), and 69 ± 7 mm Hg vs 66 ± 5 mm Hg(P = 0.19). There was no difference in the diurnal pattern of BP in diabetes patients and non-diabetic controls(SBP: 118 ± 10 mm Hg vs 114 ± 10 mm Hg, P = 0.11; DBP: 71 ± 7 mm Hg vs 68 ± 6 mm Hg, P = 0.22). Nighttime BP was higher in the diabetic group with respect to SBP(112 ± 11 mm Hg vs 106 ± 7 mm Hg, P = 0.06) and to the mean arterial pressure(MAP)(89 ± 9 mm Hg vs 81 ± 6 mm Hg, P = 0.06). ACR at rest was similar in both groups(5.5 mg/g vs 5.5 mg/g, P = 0.74), but significantly higher in diabetes patients after exercise(10.5 mg/g vs 5.5 mg/g, P = 0.03). SBP was higher in patients having exercise-induced albuminuria(116 ± 10 mm Hg vs 108 ± 10 mm Hg, P = 0.09). CONCLUSION Exercise-induced albuminuria could be useful for early diagnosis of kidney damage in adolescents with T1 DM.

关键词： Albuminuria Blood pressure Ambulatory blood pressure measurement Exercise Type 1 diabetes

Assessment of Knowledge, Attitudes and Practices (KAP) on Rheumatic Heart Disease among Senior Medical Students in Cameroon

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World Journal of Cardiovascular Diseases 2020年第6期10卷 363-378页

作者： David chelo Leslie Mbapah Tasha Anastase Dzudie Tamdja Clovis Nkoke Denis Georges Tewafeu Nelson Njedock Samuel Kingue Mother and Child Center Chantal BIYA Foundation Yaoundé Cameroon Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Department of Internal Medicine University of Buea Buea Cameroon Department of Internal Medicine Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroun

Background: Rheumatic heart disease (RHD) is the commonest cause of valvular heart disease in low and middle-income countries (LMICs). The low cardiologist to patient ratio leaves a big challenge of RHD prevention and management to general practitioners in Cameroon. This makes it important to assess the aptitude of senior medical students who are doctors-to-be on RHD. This could thus give a base on which to increase awareness and decrease the burden of the disease. Therefore, we sort to evaluate the knowledge, attitudes, and practices (KAP) of senior medical students on rheumatic heart disease. General objective: To determine the level of knowledge, attitudes on rheumatic heart disease, and assess practices towards RHD and its prevention. Methodology: A cross-sectional study was conducted in four medical schools in Cameroon for a period of 3 months (from January 1st to April 1st, 2019). The senior medical students were recruited using a structured self-administered questionnaire and electronic forms. Data were entered into an excel spreadsheet and analysed with IBM SPSS version 25.0 for windows. The knowledge level was divided into tertiles (poor, moderate and good) while the attitudes and practices were divided into poor

关键词： Senior Medical Students Rheumatic Heart Disease Cameroon Attitude Knowledge and Practice General Practitioners

Exercise-induced albuminuria and circadian blood pressure abnormalities in type 2 diabetes

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World Journal of Nephrology 2017年第4期6卷 209-216页

作者： Aurel T Tankeu Fran,ois Folefack Kaze Jean Jacques Noubiap David chelo Mesmin Yefou Dehayem Eugene Sobngwi Fran ois Folefack KazeMesmin Yefou DehayemEugene SobngwiDepartment of Internal Medicine and SpecialtiesFaculty of Medicine and Biomedical SciencesYaoundé1364Cameroon National Obesity Center YaoundéCentral HospitalYaoundé1364Cameroon Division of Nephrology University Teaching HospitalYaoundé1364Cameroon Department of Medicine Groote Schuur Hospital and University of Cape TownCape Town 7925South Africa Mother and Child Center of the Chantal Biya Foundation Yaoundé1364Cameroon

AIMTo investigate the relationship between circadian vari-ations in blood pressure （BP） and albuminuria at rest, and during exercise in non-hypertensive type 2 diabetes （T2D） *** conducted a cross-sectional study in well controlled T2D patients, non-hypertensive, without clinical pro-teinuria and normal creatinine clearance. In each parti-cipant, we recorded the BP using ambulatory bloodTankeu AT et al . Exercise-induced albuminuria and BP in T2DMpressure monitoring （ABPM） for 24-h, and albuminuria at rest and after a standardized treadmill *** enrolled 27 type 2 patients with a median age of 52; and a mean duration of diabetes and HbA1c of 3.6 ± 0.8 years and 6.3% ± 0.5% respectively. Using a 24-h ABPM, we recorded a mean diurnal systolic blood pressure （SBP） of 128 ± 17 mmHg vs nocturnal of 123 ± 19 mmHg （ P = 0.004）, and mean diurnal diastolic blood pressure （DBP） of 83 ± 11 mmHg vs nocturnal 78 ± 14 mmHg （ P = 0.002）. There was a signifcant difference between albuminuria at rest [median = 23 mg, interquartile range （IQR） = 10-51] and after exercise （median = 35 mg, IQR = 23-80, P 〈 0.001）. Patients with exercise induced albuminuria had an increase in nocturnal BP values on all three components （128 mmHg vs 110 mmHg, P = 0.03 for SBP; 83 mmHg vs 66 mmHg, P = 0.04; 106 vs 83, P = 0.02 for mean arterial pressure）, as well as albuminuric patients at rest. Moreover, exercise induced albuminuria detect a less increase in nocturnal DBP （83 vs 86, P = 0.03） than resting *** induced albuminuria is associated with anincrease in nocturnal BP values in T2D patients.

关键词： Albuminuria Ambulatory measurement of blood pressure Exercise Type 2 diabetes mellitus

State of Play of the Use of Children’s Health Booklets in Cameroon according to Child Health Professionals

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Open Journal of Pediatrics 2022年第4期12卷 688-710页

作者： Collins Tchakoute Félicitée Nguefack Anicet Romaric Mpangop David chelo Yolande Djike Puepi Fokam Georges Nguefack-Tsague Centre Médical la Cathédrale Yaoundé Cameroon Centre Médical la Cathédrale Yaoundé Cameroon Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon AfricanGenesic Health Medical and Surgical Centre Yaoundé Cameroon Centre Mèreet Enfant of the Chantal Biya Foundation Yaoundé Cameroon Faculty of Health Sciences University of Buea Buea Cameroon

Introduction: The Child health booklet has been shown to be an essential tool for monitoring the implementation of interventions with a high impact on reducing infant and child mortality. Objective: To describe the opinion of child health providers about child health records. Methodology: Cross-sectional survey of health professionals on content, ease of use and recommendations for a health record of the ideal child. Results: About 3/4 (75%) of participants considered medical follow-up useful and 91.5% wanted it to be conducted at all levels of health care. According to 93% of them, all health care providers should be involved. However, almost two-thirds (65.5%) had never been trained to use the child’s health record. About half (54.2%) of them had already seen the national manual and only 43.7% had ever filled it out, 82.2% of whom found it very difficult. With regards to the assessment of the content, 44.4% to 57.7% of respondents were dissatisfied with 12 of the 16 subheadings of the handbook. As for an ideal child health record, the majority recommended that it should contain indicators related to: childbirth, growth, monitoring of preventive activities and advice to parents. Conclusion: Child health booklets available in health facilities in Cameroon are not optimally used to reduce infant and child morbidity and mortality. It is important to review the content of the child’s health booklets in order to adapt it to the Cameroonian context.

关键词： Booklets Health Child Use Opinion Providers

Growth and Associated Factors in Children and Adolescents Living with HIV/AIDS Followed at the Mother and Child Centre of the Chantal Biya Foundation, Yaoundé-Cameroon: A Case Control Study

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Open Journal of Pediatrics 2020年第1期10卷 194-205页

作者： David chelo Eulalie Landrine Moguon Fondjo Pierre Fotsing Kwetche Séraphin Nguefack Félicitée Nguefack Suzanne Ngo Um Georges Nguefack Tsague Mother and Child Centre Chantal BIYA Foundation Yaoundé Cameroon Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon Faculty of Health Sciences Banganté Cameroon Gyneco-Obstetric and Pediatric Hospital Yaoundé Cameroon Department of Public Health Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon

Background: HIV/AIDS has a negative impact on child growth. Assessing the growth of infected children is an important part of the overall care of these children which in turn improves the monitoring and prognosis of the disease. The purpose of the study was to describe and compare the growth of children living with HIV with those not infected and to identify the associated factors. Method: This was an analytical case control study conducted in a pediatric hospital, Yaoundé from January 25th to June 20th 2019. Our study population consisted of 164 children with an age range from 06 weeks to 19 years old of which we had 41 HIV-infected cases and 123 uninfected controls matched by sex and age plus or minus 02 months. Anthropometric parameters were measured according to the standards described by the WHO. The data was entered and analyzed using Epi info 3.5.4, WHO Anthro and WHO Anthropoplus softwares. The chi-square and the Fisher’s exact tests were used to compare qualitative variables, with a significance threshold set at P less than 5%. Results: Of the 41 cases, 15 (36.6%) had at least one anthropometric index (weight for age, height for age, weight for height) -2 Z score versus 05 for controls (4.1%). 36.6% of cases had growth retardation (Height for age -2 Z score) compared to 4.1% in controls with a significant difference (p = 0.000). In 18.2% of cases, underweight was found (Weight for age -2 Z score) with a significant difference compared to controls (p = 0.000). Wasting was present in 10% of infected children (P = 0.240). We found 7.3% obesity/overweight in cases and 25.2% in controls (P = 0.003). We did not find any associated factor with growth disorders in our study. Conclusion: Infected children are smaller in weight and size. After multivariate analysis, there remained a significant difference between cases and controls regarding stunting, obesity and overweight. No factors studied were associated with the growth disorders detected, which suggests that gr

关键词： Growth HIV/AIDS Child Adolescent Yaoundé

Pediatric COVID-19 in Sub-Saharan Africa: A Series of Cases Report in Cameroon

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Open Journal of Pediatrics 2020年第2期10卷 363-368页

作者： Mekone Nkwele Isabelle chelo David Eloundou Odi Eugene Sap Ngo Um Suzanne Meli Josephine Hadja Hamsatou Balla Nkonda Alain Minka Basilice Djientcheu Vincent de Paul Faculty of Medicine and Biomedical Sciences Department of Pediatrics University of Yaoundé I Yaoundé Cameroon Yaoundé General Hospital Yaoundé Cameroon Jordan Medical Service Yaoundé Cameroon

Background: Infection with the new Coronavirus 2019 SARS-CoV-2, COVID-19, is a global pandemic that does not spare children. Pediatric forms of COVID-19 are increasingly described in the literature with less severe clinical forms and lower mortality as compared to adults. We do not have data on the epidemiologic characteristics of SARS-CoV-2 infection in children in sub-Saharan Africa where the pandemic is less severe. Aim: We present four cases of pediatric COVID-19 in Cameroun. Case Presentation: These cases of COVID-19 concern children aged 12 weeks to 13 years. We discuss the diagnostic difficulties and the issues of effective management in the context of a resource-constrained country. Conclusion: COVID-19 affects children in sub-Saharan Africa. There are different clinical presentations with favorable outcomes, but there is a need for greater vigilance in the pediatric population.

关键词： COVID-19 Children Cameroon Sub-Saharan Africa