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Epidemiological, Clinical and Angiographic Profile of Chronic Coronary Syndromes in the Catheterization Room. Single-Centre Study Carried Out in the Cardiology Department of the Chu Aristide Le Dantec in Dakar (Senegal)

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World Journal of Cardiovascular Diseases 2023年第10期13卷 674-685页

作者： cheikh mouhamadou bamba mbacke diop Radja Juste Bissakonou Nzaya Joseph Salvador Mingou Papa Guirane Ndiaye Youssou Diouf Khadimu Rassoul diop Demba Ware Balde Ahmadou bamba Samb Malick Bodian Fatou Aw Simon Antoine Sarr mouhamadou bamba Ndiaye Abdoul Kane Maboury Diao Cardiology Department CHU Aristide Le Dantec Dakar Senegal Cardiology Department Dalal Jamm Hospital Dakar Senegal

Background: Ischaemic heart disease is the cause of 7.4 million deaths per year. Their prevention is based on the management of cardiovascular risk factors, but also on the early detection and management of chronic coronary syndromes (CCS), for which few data are available in Africa. The main objective of our study was to determine the factors related to significative coronary artery disease in patients undergoing coronarography for suspected chronic coronary syndrome (CCS). Methodology: We conducted a retrospective descriptive and analytical study over 2 years (from January, 1st, 2018 to December 31st, 2019) in the Cardiology Department of the University Hospital Aristide Le DANTEC in Dakar. All patients admitted for coronary angiography for suspected chronic coronary syndrome were included. Results: One hundred and fifty-two patients were included with a mean age of 60.79 ± 9.73 years, the most represented age group was 60 - 69 years. Advanced age was the most frequent risk factor (77.63%) followed by sedentary lifestyle (56.58%) and hypertension (41.45%). Diabetes was present in 17.1% of cases. A history of angioplasty was found in 1.97% of patients. Typical pain was found in 71.05% of cases, atypical pain in 19.74% and exertional dyspnoea in 2.63%. The pre-test probability was intermediate in 67.1% of cases, low in 25% and high in 7.9%. Significative coronary lesion was found in 52.63% of the patients, while coronary angiography was normal in the remaining cases. Tritroncular status was observed in 37.50%, it was bitroncular in 26.25% and monotroncular in 36.25% of cases. Factors associated with significative coronary artery disease were age (p = 0.0001), diabetes (p = 0.006), previous angioplasty (p = 0.023), previous myocardial infarction (p = 0.018), typical angina (p = 0.001), intermediate pretest probability (p = 0.001). Low pretest probability was significantly correlated with the absence of a coronary lesion with a p = 0.001. Conclusion: Our study shows that screening for chronic

关键词： Chronic Coronary Syndroms Coronarography Aristide Le Dantec Hospital Dakar

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Screening of Myocardial Cardiotoxicity Induced by Anticancer Chemotherapy and the Importance of Global Longitudinal Strain

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World Journal of Cardiovascular Diseases 2024年第6期14卷 381-391页

作者： Marguerite Téning Diouf Fatou Aw Hussein Khadra Sophie Ba Doudou Diouf Michel Ngonar Sarr Joseph Salvador Mingou Malick Ndiaye Simon Antoine Sarr Momar Dioum Aliou Alassane Ngaide Serigne Mor Beye Simon Manga Alain Affangla Youssou Diouf Khadimu Rassoul diop Malick Bodian Mohamed Leye mouhamadou bamba Ndiaye Alassane Mbaye Adama Kane Maboury Diao Abdoul Kane Cardiology Department of the Dalal Jamm Hospital Dakar Senegal Cardiology Department Hospital Aristide Le Dantec Dakar Senegal Cardiology Department Hospital Fann Dakar Senegal UFR2S Saint Louis Saint Louis Senegal UFR Ziguinchor Ziguinchor Senegal Training and Research in Health Sciences Unit University of Thies Thies Senegal Cardiology Department Hospital General Idrissa Pouye Dakar Senegal

Introduction: The improvement of survival in patients with cancer and the expansion of therapeutic options have led to the emergence of a new profile of cardiotoxicity, specifically associated with antimitotic agents. Our study aimed to assess the incidence of chemotherapy-induced myocardial toxicity in patients with cancer. Patients and Methods: We conducted a looking-forward longitudinal cohort study including all patients admitted to the Cardiology departments of Aristide le Dantec Hospital and Dalal Jamm National Hospital Centre for apre-chemotherapy check-up. The included patients did not undergo any pre-existing cardiopathy. Results: Over a period of two years ranging from January 2019 to December 2021, a total of 37 patients were included in the study. Notably, there was a female predominance (92%) with an average age of 49.7 years ± 13.69. Breast cancer accounted for 70% of the neoplasms. Laboratory findings revealed moderate anemia in 19 patients (51%). At inclusion, the left ventricle (LV) was of normal size (LV diastole at 44.46 ± 4.97 mm). The systolic function of the left ventricle was normal in all patients, with an average ejection fraction (EF) of 63.1% ± 5.80 and a mean global longitudinal strain (GLS) of −20.4% ± 2.58. The most commonly used agents were anthracyclines. During follow-up, 3 patients (8.1%) developed clinical symptoms of left heart failure, and LV dysfunction on echocardiography was observed in 5 (13.5%) patients, with a significant decrease in EF Conclusion: The incidence of cardiac toxicity is not negligible, hence the importance of early screening. Strain imaging is an essential tool that should be performed as part of the assessment before chemotherapy and re-evaluated during treatment.

关键词： Cancer Chemotherapy Global Longitudinal Strain Cardiotoxicity

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Epidemiological Aspect of ST-Segment Elevation Myocardial Infarction (STEMI) in Saint-Louis of Senegal

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World Journal of Cardiovascular Diseases 2022年第12期12卷 544-555页

作者： Khadimu Rassoul diop Joseph Salvador Mingou Serigne Mor Beye Awa Niasse Youssou Diouf Papa Guirane Ndiaye cheikh mouhamadou bamba diop cheikh Ahmadou bamba Samb Fatou Aw Simon Antoine Sarr Malick Bodian mouhamadou bamba Ndiaye Adama Kane Maboury Diao Abdoul Kane Cardiology Department CHU Aristide Le Dantec Dakar Senegal Cardiology Department Saint Louis Regional Hospital Saint Louis Senegal Cardiology Department Dalal Jamm Hospital Dakar Senegal

Background: Cardiovascular Disease (CVD) has become the largest and most common cause of Non-Communicable Diseases (NCD) related deaths worldwide, accounting for more than 50%. In Senegal, a few studies done on the topic showed a low prevalence of acute coronary syndrome in hospital settings. In the city of Saint-Louis in Northern Senegal, there is little epidemiological data on Acute Coronary Syndrome (ACS) and no study specifically concerned with ST-segment Elevation Myocardial Infarction (STEMI) has been carried out to date. With this in mind, we conducted a study that focused on the analysis of STEMI patients hospitalized in the Cardiology Department of the Regional Hospital of Saint-Louis. The aim of our study was to collect and analyze the epidemiological aspect of STEMI. Results: There were 39 cases of STEMI, (i.e. 82.29% of ACS), giving a hospital prevalence of 8.21%. There was a slight male predominance with a male to female ratio of 1.05. The average age of our patients was 62.93 years ranging from 38 to 90 years. The average time between the onset of pain and arrival at the hospital was 50 hours, ranging from 1 hour to 720 hours. Patients received within the first 12 hours made up 66% (n = 26) of our population, among them, 80.76% (n = 21) (i.e. 53.84% of STEMIs) were able to benefit from thrombolysis. All thrombolysis was performed with Streptokinase. The mean time to thrombolysis was 6 hours ranging from 1 hour and 45 minutes to 11 hours. Arterial hypertension was the most frequent cardiovascular risk factor in our popular with a 43.6% prevalence, followed by diabetes (33.33%), then active smoking (23%). Chest pain was the most frequent symptom, reported in 34 patients (87.17%). The lesions on the Electrocardiogram (EKG) were located in the anterior territory in 64% of the cases (n = 25), in the inferior territory in 28% of the cases (n = 11), in the circumferential territory in 5% of the cases (n = 2), and lateral territory in 5% of the cases (n = 2). Twenty-five patients had a transthoracic echocar

关键词： Myocardial Infarction STEMI Saint-Louis Senegal

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Indications and Results of Lower Gastrointestinal Endoscopy in a Regional Hospital Center in Senegal

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Open Journal of Gastroenterology 2023年第1期13卷 43-48页

作者： Marième Polèle Fall Marie Louise Basséne Salamata Diallo Mamadou Ngoné Gueye cheikh Ahamadou bamba Cissé Madoky Magatte diop Daouda Dia mouhamadou Mbengue Department of Gastroenterology and Hepatology Aristide Le Dantec Hospital Dakar Senegal Department of Gastroenterology and Hepatology General Hospital Idrrisa Pouye Dakar Senegal Department of Internal Medecine Regional Hospital Center of Thiès Thiès Senegal

Introduction: Gastrointestinal endoscopy plays a crucial role in the management of gastrointestinal diseases. The aim of this study was to report the indications and results of lower digestive endoscopy in a hospital center in Senegal. Patients and Methods: We conducted a descriptive retrospective study from September 1st, 2017, to September 30, 2018 at the gastrointestinal endoscopy unit of the regional hospital center of Thiès. All patients received for lower gastrointestinal endoscopy and whose reports were usable, were included. In the reports, we collected and analyzed sociodemographic data, indication and results of the endoscopic examination. Results: We included 250 patients. There were 140 men (sex ratio 1.27). The average age was 42 years [range 1 - 92 years]. There were 37 colonoscopies (14.8%), 51 rectosigmoidoscopies (20.4%) and 162 anorectoscopies (64.8%). The patients were from the region of Thiès in 82% of cases. In most cases, they were most often referred by general practitioners (22.8%) and surgeons (20.8%). The main indications were rectal bleeding (36.8%), hemorrhoidal disease (23.2%) and proctalgia (11.6%). Hemorrhoidal disease (63.6%), anal fistula (14%) and tumors (8.8%) were the most common pathologies. Conclusion: Admitted patients at the gastrointestinal endoscopy unit of the regional hospital center of Thiès have many indications as well as pathologies. Anal pathology is dominated by hemorrhoidal disease.

关键词： Lower Gastrointestinal Endoscopy Rectal Bleeding Hemorrhoidal Disease

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St-Segment Elevation Myocardial Infarction with Multiple Complications: A Case Report

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World Journal of Cardiovascular Diseases 2023年第3期13卷 124-129页

作者： Khadimu Rassoul diop Mame Awa Sene Serigne Mor Beye Joseph Salvador Mingou Aliou Alassane Ngaïdé Youssou Diouf Papa Guirane Ndiaye cheikh mouhamadou bamba diop Marguerite Tening Diouf Adama Kane Maboury Diao Abdoul Kane Department of Cardiology CHU Aristide Le Dantec Dakar Senegal Department of Cardiology Dalal Jamm Hospital Dakar Senegal Department of Cardiology Saint Louis Regional Hospital Saint Louis Senegal Department of Cardiology Idrissa Pouye General Hospital Dakar Senegal

Introduction: ST-Segment Elevation Myocardial Infarction (STEMI) usually involves complete thrombotic occlusion of a coronary artery and require urgent reperfusion;it is one of the leading cause of global mortality and morbidity worldwide. A variety of mechanical, rhythmic, conductive, embolic or hemodynamic complications can occur following STEMI, especially when the treatment is delayed or inadequate. Clinical presentation: A 58-year-old patient with hypertension was admitted to our department for a circumferential STEMI complicated by an ischemic stroke;received 24 hours after the onset of pain. His blood pressure was 100/60 mmHg, heart rate was 55 beats/min. The examination revealed right central facial paralysis and a slight motor deficit of the right upper limb (muscle strength 4/5). The first electrocardiogram (ECG) showed a significant circumferential ST-segment elevation with Q waves in the same territory, as well as a Luchiani Wenckebach atrio-ven- tricular block. The first echocardiography performed showed apical akinesia along with the presence of an apical thrombus. Coronarography was not performed because it was not available and the patient was given curative low molecular weight heparin combined with dual antiplatelet therapy, an angiotensin converting enzyme inhibitor and high dose statins. Seventy-two hours later, the ECG showed a complete atrioventricular block with narrow QRS and the average ventricular rate was 51 beats/min. The patient was asymptomatic. Another echocardiography was performed to assess new complications and showed a rupture of the left ventricular wall and a moderate amount of circumferential pericardial effusion, without any sign of cavity compression. No particular therapeutic attitude was adopted apart from close monitoring with daily ECG and echocardiography. Ten days later, spontaneous regression of the AV Bloc was noted. Conclusion: ST-Segment Elevation Myocardial Infarction is a major cause of morbidity and mortality worldwide. A variety of complications can occur afte

关键词： Myocardial Infarction Delayed Reperfusion Complication

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Profile of Prosthetic Care Consumers at the Institute of Odontology and Stomatology Clinic of Dakar

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Open Journal of Stomatology 2022年第10期12卷 281-293页

作者： Mbathio diop Amadou Dieng Serigne Ndame Dieng Morel Aguiar Aida Kanouté Massamaba Diouf Daouda Faye cheikh mouhamadou Mbacké Lô Public Health Service Institute of Dentistry and Stomatology Faculty of Medicine Pharmacy and Odonto-Stomatology Cheikh Anta Diop University of Dakar Dakar Senegel

The high frequency of dental extractions creates a high demand for prosthetic rehabilitation. Therefore, this study aimed to describe the profile of consumers of prosthetic care at the Institute of Odontology and Stomatology in Dakar. It was a descriptive and retrospective study of patients who had been consulted at the prosthetic clinic of the Institute of Odontology and Stomatology of Dakar. Data were collected from medical records from 09 November 2019 to 09 June 2020. The tools used to collect and process the information were the Sphinx software and the Excel spreadsheet. Out of the 101 patient records, 51% were male and 48% belonged to the age group of 18 to 39 years. Nearly 38.61% of the patients lived less than 5 km from the health care facility and 70.3% of the respondents had a monthly income of fewer than 100,000 FCFA. Clinically, 96% of patients came for functional reasons, 78.2% for aesthetic reasons, and partial edentulism was the most frequent diagnosis (96%). Chi-square tests were performed to find a dependency or non-dependency relationship between diagnosis and age, but also between income and treatment cost. In sum, age and diagnosis were independent of each other, just as patient income was not related to treatment cost. Proximity to health facilities, income, and cost of treatment are factors that influence accessibility to oral health care. It is important to integrate the profile of the consumer of care into global management.

关键词： Prosthetic Care Consumers Profile Prosthetic Clinic Senegal

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Bat 26 Microsatellite Instability in Oral Cavity Cancers in Senegal

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Journal of Cancer Therapy 2023年第1期14卷 25-37页

作者： Mame Diarra Samb Fatimata Mbaye mouhamadou Makhtar Ndiaye Silly Toure mbacke Sembene Genomics Laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal Department of Maxillofacial Surgery and Stomatology Faculty of Medicine Pharmacy and Stomatology Cheikh Anta Diop University Dakar Senegal

Oral cavity cancers are part of head and neck cancers. They have become frequent in the world in general and Senegal in particular. This study evaluates microsatellite instability tumors in oral cavity cancers in Senegal. Forty cancerous tissues, 20 healthy tissues, and 12 blood tissues were included in this study. These tissues were collected from each patient during the biopsy after obtaining consent. DNA extraction, Polymerase Chain Reaction (PCR) and sequencing were carried out to obtain sequences. Mutation surveyor, Bioedit and Dnasp software were used to perform our analyses. High instability was found in 57.5% of patients with cancer. Moreover, 90% of the patients had the same motif on healthy and cancerous tissue. Furthermore, 26.12%, 20.72%, and 11.71% polymorphic sites were found in cancerous, healthy and blood tissue respectively. Thus, a similarity between cancerous and healthy tissues seems to exist. This implies that instability of the Bat 26 microsatellite could occur early in the occurrence of oral cavity cancers.

关键词： Cancer Oral Cavity Microsatellite Instability Bat 26 Senegal

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Compressive Pericardial Teratoma about a Case at Regional Hospital of Saint Louis/Senegal

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Journal of Biosciences and Medicines 2022年第6期10卷 1-7页

作者： Serigne Mor Beye cheikh Ahmadou bamba Samb Aicha Ndichout Ndeye Rokhaya diop Khadimu Rassoul diop Ansoumana Condé Joseph Salvador Mingou Jean Baptiste Mathieu Sy Adama Kane Departement of Cardiology Regional Hospital of Saint Louis City Senegal Departement of Radiology Regional Hospital of Saint Louis City Senegal

Introduction: Cardiac tumors in children are rare. Most are discovered in children under one year of age. Echocardiography is the basic examination for the screening, it allows their detection from the fetal stage. Observation: She was a 14-year-old patient with no known history of pathology. She was admitted to our department for the exploration of dyspnea and chest pain. At her admission, she had stable hemodynamics. At cardiac auscultation, heart sounds were muffled. The EKG recorded a sinus rhythm, and negative T-waves from V1 to V4. The chest X-ray showed cardiomegaly and a dense, rounded, heterogeneous left hilar opacity, well limited. Echocardiography objected to a great intrapericardial mass in front of the left cardiac cavities compressing part of the left atrium and left ventricle associated with an important pericardial effusion. The CT scan found a heterogeneous pericardial suspected myxoma mass. The pathological examination confirmed pericardial teratoma. The patient had an excision of the pericardial mass. The evolution after surgery was favorable. Conclusion: Intra-pericardial teratomas are benign tumor. Complete removal of the tumor is curative and without recurrence.

关键词： Teratoma Pericardium Saint-Louis

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Electrical Modeling of a Silicon Photovoltaic Solar Cell: Comparative Study of Models Characterizing the Photovoltaic Solar Cell

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应用科学(英文) 2023年第10期13卷 1787-1795页

作者： Mamadou bamba Sene Almoustapha Samoura Saliou Diouf Amadou Diao cheikh Mbow Solid State Physics and Materials Sciences Laboratory Faculty of Sciences and Techniques University of Cheikh Anta Diop Dakar Senegal Laboratory for the Use of Rays X (LUX) Dakar Senegal Fluid Mechanics and Applied Dynamics System Laboratory Faculty of Sciences and Techniques University of Cheikh Anta Diop Dakar Senegal

In this article we make a detailed study and a presentation of the different models of circuit’s equivalent to silicon-based photovoltaic solar cells. Starting from a real solar cell and real phenomena from the manufacture of the cell to the production of current by the cell. A comparison of the models with a real experimental method is carried out. The comparison is based on an overlay of the results. The study allowed us to choose the most suitable model. We are interested in the losses by leaks and the losses due to the development of the cell. In fact, we studied the influence of the shunt resistance on the current-voltage characteristic and the electrical power.

关键词： Current Characteristic-Voltage Photon Current Electric model Photocurrent Photo Voltage Electric Power Semiconductor

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Effects of the Nature of Boundaries Conditions and Their Truncation Errors on the Distribution of Minority Carriers in Silicon Solar Cell

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Journal of Modern Physics 2022年第3期13卷 315-322页

作者： Mamadou bamba Sene Mountaga Boiro Alioune Faye Amadou Diao cheikh Mbow Solid State Physics and Materials Sciences Laboratory Faculty of Sciences and Techniques University of Cheikh Anta Diop Dakar Senegal Fluid Mechanics and Applied Dynamics System Laboratory Faculty of Sciences and Techniques University of Cheikh Anta Diop Dakar Senegal

In this work, the effects of boundaries conditions and truncation errors in the distribution of minority carriers in the semiconductor are studied. It is a one-dimensional digital study of a polycrystalline silicon solar cell under polychromatic illumination in a dynamic state. Starting from the Boltzmann equation of semiconductors, the author establishes the general equation of particle transport. Assumptions made on the latter allow it to give the equation of distribution of minority carriers in a general way in its case to be studied. This dimensioned distribution equation reveals the parameters of influences on the distribution of carriers. It obtains a partial derivative equation for the carrier distribution function. The boundary conditions are then discretized to order one and then to order two. By considering boundary conditions and the nature of the carriers, the author numerically resolves the discretized general equation by assessing the influence of the nature of the boundary conditions and truncation errors and the influence of the discretization step on the density of the charge carriers by setting certain parameters and varying others. The work ends with a conclusion and logical follow-up to this work.

关键词： Transport Equation Load Carrier Densities Implicit Scheme Semiconductor Discretization

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