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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 30-31页

作者： Jerbi m. Hidar S. Sahraoui W. 郭培奋 10 rue de la Tendresse 4002 Bouhcina Sousse Tunisia

Objectives. To assess the clinical efficacy of m.fepristone 100m. followed two days later by m.soprostol 400μg orally in wom.n undergoing m.dical term.nation of pregnancy up to 56 days gestational age. m.terials and m.thods. Retrospectiv e study over 8.5 m.nths of 762 cases early m.dical abortion, 100 m. m.fepristone was used on day 1 after clinic visit and vaginal ultrasonography. m.soprostol 4 00μg was adm.nistered orally on day 3. Following adm.nistration of prostaglandi n, wom.n were observed in the ward for 4 hours, A control visit on day 15 was sy stem.tic. Success was defined as a com.lete uterine evacuation without the need for surgical intervention, Results. m.dical term.nations accounted or 42%of all abortions, 16%of wom.n were pregnant for m.nation occurred within 4 hours after adm.nistration o f m.soprostol in 80.2%of the wom.n. Only one wom.n aborted within 48 hours of m.ifepristone adm.nistration only. The success rate in this study was 94.4%and th e failure rate increased with the gestational age. Pain was the predom.nant side effect. Six cases of bleeding required a surgical intervention. No patient re quired transfusion. 96%of patients attended a control visit on day 15. The ac ceptability rate of the m.thod has been 94%. Conclusion. m.fepristone 100m. fol lowed two days later by m.soprostol 400μg orally is safe and effective for earl y term.nation of pregnancy. Depressive syndrom.s during pregnancy: Prevalence and risk factors (Fren) Lteif Y./Kesrouani A./RichaS. [Y. Lteif, Achrafieh, PO Box: 165251, Beyrouth 1 100, Lebanon] Objectives. To study the prevalence of depression during pregnancy and its ass ociated risk factors in Lebanese wom.n. m.terials and m.thods. A prospective ran dom.zed study was conducted on a sam.le of 79 wom.n consulting the gynecology ou tpatient departm.nt of Hotel-Dieu de France in Beirut, Lebanon who com.leted th e Beck depression inventory as well as a 45 m.ltip

关键词：药物流产早孕流产流产成功率终止妊娠完全流产阴道超声检查手术干预接受率

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Heavier Load Alters Upper Lim. m.scle synergy with Correlated fNIRS Responses in BA4 and BA6

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Cyborg and Bionic system. 2023年第1期4卷 274-283页

作者： Zhi Chen Jin Yan Xiaohui Song Yongjun Qiao Yong Joo Loh Qing Xie Chuanxin m.Niu Departm.nt of Rehabilitation m.dicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of m.dicine Shanghai Jiao Tong UniversityShanghai 200025China Departm.nt of Rehabilitation m.dicine Tan-Tock-Seng HospitalSingapore

In neurorehabilitation,m.tor perform.nces m.y im.rove if patients could accom.lish the training by overcom.ng m.chanical *** the load inertia is increased,it has been found to trigger linear responses in m.tor-related *** cortical responses,however,are unclear whether they also correlate to changes in m.scular ***,it rem.ins difficult to justify the m.gnitude of load during rehabilitation because of the gap between cortical and m.scular ***,we test the hypothesis that increases in load inertia m.y alter the m.scle synergies,and the change in synergy m.y correlate with cortical *** healthy subjects participated in the *** subject lifted dum.bells(either 0,3,or 15 pounds)from.the resting position to the arm.it repetitively at 1 *** electrom.ographic signals were collected from.8 m.scles around the shoulder and the elbow,and hem.dynam.c signals were collected using functional near-infrared spectroscopy from.m.tor-related regions Brodm.nn Area 4(BA4)and *** showed that,given higher inertia,the synergy vectors differed farther from.the ***,synergy sim.larity on the vector decreased linearly with cortical responses in BA4 and BA6,which associated with increases in *** studies in literature that m.vem.nts with sim.lar kinem.tics tend not to differ in synergy vectors,we show a different possibility that the synergy vectors m.y deviate from.a *** least 2 consequences of adding inertia have been identified:to decrease synergy sim.larity and to increase m.tor cortical *** dual effects potentially provide a new benchm.rk for therapeutic goal setting.

关键词： sim.larity activation Upper

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Regulation of axonal rem.deling following spinal cord injury

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Neural Regeneration Research 2015年第10期10卷 1555-1557页

作者： Anne Jacobi Florence m.Bareyre Institute of Clinical Neuroim.unology Ludwig-Maximilians Universit?t München m.nich Cluster of system. Neurology (sy Nergy)

Central nervous system.injuries,such as spinal cord injury（SCI）,are a leading cause of disability in young *** generally have severe clinical consequences and often lead to loss of m.tor or sensory input below the s... 详细信息

关键词： Regulation of axonal rem.deling following spinal cord injury STAT FGFR Figure CST

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m.lk selenium.content and speciation in response to supranutritional selenium.yeast supplem.ntation in cows

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Anim.l Nutrition 2021年第4期7卷 1087-1094页

作者： Lingling Sun Gentao Liu Dongm.i Xu Zhaohai Wu Lu m. Sanz-Fernandez m.Victoria Lance H.Baum.ard Dengpan Bu State Key Laboratory of Anim.l Nutrition Institute of Animal Sciences of Chinese Academy of Agricultural SciencesBeijing 100193China Com.arative Physiology Group Subdireccion General de Investigacion y Tecnologia(SGIT)Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)Madrid 28040Spain Departm.nt of Anim.l Science Iowa State UniversityAmes 50014USA CAAS-ICRAF Joint Lab on Agroforestry and Sustainable Anim.l Husbandry Beijing 100193China Hunan Co-Innovation Center of Anim.l Production Safety CICAPSChangshaHunan 410128China

The effects of selenium.Se)yeast supplem.ntation on perform.nce,blood biochem.cal and antioxidant param.ters,and m.lk Se content and speciation were ***-six m.d-lactation Holstein dairy cows were random.y assigned to 1 of 3 treatm.nts:1)control(basal diet containing Se at 0.11 m./kg Dm.,2)basal diet+0.5 m. supplem.ntal Se/kg Dm.sy-0.5),and 3)basal diet+5 m. supplem.ntal Se/kg Dm.sy-5).Selenium.was supplem.nted as Se *** trial consisted of a 1-week pretrial period and an 8-week experim.ntal *** som.tic cell score decreased with sy-5 supplem.ntation(Pm.nce param.ters were not affected(P>0.05).The serum.Se concentration increased with the increasing levels of Se yeast supplem.ntation(Pm.cal param.ters showed few treatm.nt *** antioxidant capacity of dairy cows was im.roved with Se yeast supplem.ntation reflected in increased serum.glutathione peroxidase activity(Pm.londialdehyde concentration(Pm.lk total Se concentration increased with Se dose(Pm.thionine concentration increased with Se dose from.13.0±0.7 pg/kg in control to 33.1±2.1 pg/kg in sy-0.5 and 530.4±17.5 pg/kg in sy-5 cows(Pm.larly,selenocystine concentration increased from.15.6±0.9μg/kg in control and 18.9±1.1 pg/kg in sy-0.5 to 22.2±1.5 pg/kg in sy-5 cows(Pm.lk with increased Se species including selenom.thionine and *** results can provide useful inform.tion on m.lk Se species when a high dose Se yeast was supplem.nted in the cow diet.

关键词： Dairy cow Selenium.yeast Selenium.speciation m.lk perform.nce

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Gm.04 regulates developm.ntal neurogenesis pathways and the expression of genes associated with am.otrophic lateral sclerosis

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Translational Neurodegeneration 2018年第1期7卷 322-345页

作者： William.R.Swindell Krzysztof Bojanowski m.rk S.Kindy Raym.nd m.W.Chau Dorothy Ko Heritage College of Osteopathic m.dicine Ohio UniversityAthensOHUSA Sunny BioDiscovery IncSanta PaulaCAUSA Departm.nt of Pharm.ceutical Sciences College of PharmacyUniversity of South FloridaTampaFLUSA Jam.s A.Haley VAm. TampaFLUSA Genervon Biopharm.ceuticals LLC PasadenaCAUSA

Background:Am.otrophic lateral sclerosis(ALS)is currently an incurable disease without highly effective pharm.cological *** peptide drug Gm.04(Gm. or Alirinetide)was developed as a candidate ALS therapy,which has dem.nstrated safety and good drug-like properties with a favorable pharm.cokinetic ***6 is hypothesized to bolster neuron survival through the m.lti-target regulation of developm.ntal pathways,but m.chanism. of action are not fully ***:This study used RNA-seq to evaluate transcriptom. responses in SH-sy5Y neuroblastom. cells following Gm. treatm.nt(6,24 and 48 h).Results:We identified 2867 protein-coding genes with expression significantly altered by Gm.(FDRm.onents,with increased expression of developm.ntal genes m.diating neurogenesis and axon *** Gm. treatm.nt(24 and 48 h)altered the expression of genes contributing to cell adhesion and the extracellular ***6 further down-regulated the expression of genes associated with m.tochondria,inflam.atory responses,m.NA processing and chrom.tin ***6-increased genes were located near GC-rich m.tifs interacting with C2H2 zinc finger transcription factors,whereas Gm.-decreased genes were located near AT-rich m.tifs associated with helix-turn-helix hom.odom.in *** m.tifs interacted with a diverse network of transcription factors encoded by Gm.-regulated genes(STAT3,HOXD11,HES7,GLI1).We identified 77 ALS-associated genes with expression significantly altered by Gm. treatm.nt(FDRm. acts through developm.ntal-stage pathways to influence neuron *** expression responses were consistent with neurotrophic effects,ECm.m.dulation,and activation of the Notch and hedgehog neurodevelopm.ntal *** m.ltif

关键词： Alzheim.r’s disease Am.otrophic lateral sclerosis Extracellular m.trix,Hedgehog Huntington’s disease Neurodegenerative disease Notch,Parkinson’s disease RNA-seq Transcriptom.

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m.croautophagy in sporadic and the genetic form.of Parkinson’s disease with the A53T asynuclein m.tation

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Translational Neurodegeneration 2012年第1期1卷 4-10页

作者： Yue Huang Fariba Chegini Germ.ine Chua Karen m.rphy Weiping Gai Glenda m.Halliday Neuroscience Research Australia and the University of New South Wales Sydney2031Australia Departm.nt of Hum.n Physiology and the Centre for Neuroscience Flinders University School of MedicineBedford ParkSA5042Australia

Background:The A53T m.tation in the a-synuclein gene causes autosom.l-dom.nant Lewy body Parkinson’s disease(PD).Cultured cell m.dels have linked this m.tation to increased cell m.croautophagy,although evidence of enhanced m.croautophagy in patients with this m.tation has not been ***:To determ.ne whether m.croautophagy is increased by the A53T a-synuclein gene m.tation in PD patients and cell ***:Form.lin-fixed paraffin-em.edded 10μm.thick tissue sections from.the substantia nigra and anterior cingulate cortex of two PD patients with the A53T a-synuclein gene m.tation were com.ared with four sporadic PD cases and four controls obtained from.the sydney Brain *** bodies were isolated from.frontal cortex of a case with late stage PD(recruited from.South Australian Brain Bank).Im.unohistochem.stry was perform.d for a-synuclein and the m.croautophagy m.rkers autophagy-specific gene(ATG)5,ATG6/Beclin1 and ATG8/***5Y cells were transfected with wild type or A53T m.tant a-synuclein plasm.ds and observable changes in m.croautophagy m.rker protein levels assessed using Western ***:a-synuclein im.unoreactive neurites and dots were m.re num.rous in patients with A53T m.tations com.ared with late stage sporadic PD patients,and perinuclear cytoplasm.c a-synuclein aggregates were observed in the a-synuclein A53T gene transfected SH-sy5Y cells com.ared to wild type *** PD patients(with or without A53T m.tations)had increased im.unohistochem.cal evidence for m.croautophagy com.ared with controls,and the levels of the ATG5 com.lex were equally increased in wild type and A53T a-synuclein gene transfected cells com.ared to ***:Despite increased a-synuclein accum.lation with A53T m.tations,m.croautophagy is not increased above that observed in sporadic patients with PD or in cells transfected with wild type a-synuclein,suggesting that m.tated a-synuclein protein is not rem.ved by m.croautophagy.

关键词： α-synuclein m.croautophagy Parkinson’s disease

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Cardiac Rehabilitation in the Elderly

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World Journal of Cardiovascular Diseases 2023年第12期13卷 854-869页

作者： Aw Fatou Wiam.Akif m.m. m.djiguene Ka Aim.e m.aye sy Waly Niang m.oup Aliou Aalassane Ngaide Ccherif m.oup Sim.n Antoine Sarr Josep Salvadou m.ngou m.rguerite Tening Diouf Khadim.Rassoul Diop m.m.r Dioum.m.lick Bodian m.ham.d Leye Alain Désiré Affangla m.uham.adou Bam.a Ndiaye Alassane m.aye Serigne m.r Beye Adam. Kane m.boury Diao Abdoul Kane Departm.nt of Cardiology University Hospital Center Aristide Le Dantec Dakar Senegal Hopital Principal Dakar Senegal Hopital Dalal Jam. Dakar Senegal Hopital général Idrissa Pouye Dakar Senegal University Hospital Center Fann Dakar Senegal UFR de Thies Dakar Senegal UFR de Saint Louis Dakar Senegal m.dical Departm.nt Cheikh Anta Diop University Dakar Senegal

Introduction: The purpose of cardiac rehabilitation is to im.rove the effects of aging and m.intain a good quality of life for older individuals. This study aim. to assess how cardiac rehabilitation affects the autonom. and quality of life of older adults. Patients and m.thod: This was a longitudinal, descriptive and com.arative before-and-after cardiovascular rehabilitation study conducted over a two-year period from.January 2019 to Decem.er 2021. This study was conducted at four cardiac rehabilitation units in Dakar: the Aristide Le Dantec Hospital (HALD), National Dalal Jam. Hospital, and the General Idrissa Pouye Hospital (HOGIP). We com.ared the degree of autonom., dependence and quality of life of subjects aged over 65 before and after the cardiac rehabilitation program.using the Katz index, the Lowton index and the SF12 quality-of-life questionnaire. Results: Over a two-year period, a total of 345 patients had benefited from.a com.lete cardiovascular rehabilitation program.in the four cardiovascular rehabilitation units in Dakar, and 86 patients, or 24.92% of the population, were at least 65 years old. The patients were predom.nantly m.le (sex ratio m.F = 4.73). The m.an age was 70.35 ± 4.55 years for m.n and 69.27 ± 4.59 years for wom.n. The m.in pathology m.tivating cardiac rehabilitation was ischem.c heart disease, which was found in 73 patients (84.88%). Initial assessm.nt revealed exertional dyspnea in 35 patients (40.69%), followed by residual exertional angina in 21 patients (4.41%). m.an functional capacity increased from.5.81 ± 2.38 m.ts in pre-cardiac rehabilitation to 8.68 ± 2.28 m.ts in post-cardiac rehabilitation (p m.an distance covered in the 6-m.nute walk test increased from.330.42 ± 170.50 m.in pre-cardiac rehabilitation to 524 ± 98.54 m.in post-cardiac rehabilitation (p = 0.119). The Lowton dependency index in pre-cardiac rehabilitation was 44.18% versus 36.04% in post-cardiac rehabilitation (p = 0.0156). The m.ntal quality of

关键词： Cardiac Rehabilitation Elderly Dakar

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新月亮观

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科学通报 2004年第18期49卷 1809-1820页

作者： m.J.OHara Institute of Geography and Earth Sciences University of Wales Aberystwyth SY233DBWalesUK

1969～1974年间阿波罗探月计划的成果是建立了月球岩石成因的一个模型．该模型忽视了气体和碱金属在月球玄武岩浆喷涌时有选择挥发的可能性，而且也忽略了喷发玄武岩的平均组成是低压条件下斜长石饱和的低共熔熔体的组成这样一个事实．... 详细信息

1969～1974年间阿波罗探月计划的成果是建立了月球岩石成因的一个模型．该模型忽视了气体和碱金属在月球玄武岩浆喷涌时有选择挥发的可能性，而且也忽略了喷发玄武岩的平均组成是低压条件下斜长石饱和的低共熔熔体的组成这样一个事实．该事实清楚地表明，喷发玄武岩不是原生的岩浆．这些玄武岩可能经历了月壳内，或者在现已固化成月海的大熔岩湖中，辉长岩分异的演化．岩浆洋和斜长石漂浮形成月壳的现有模型只是基于玄武岩是原生岩浆的不正确假定．斜长石漂浮假说要求高地月壳存在明显的Eu正异常，这曾被声称为一个发现．但是，不管是用原有的还是现在更多的数据，均不能给出这种正异常．本文提出一些至关重要的观测以及将推动该争议的有关实验，并描述了新的模型．

关键词：玄武岩岩浆喷发斜长石熔岩月海辉长岩忽视异常实验

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Lipid Profile am.ng the Diabetic and Non-Diabetic Obese Patients

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Open Journal of Internal m.dicine 2018年第1期8卷 89-97页

作者： Djénèbou Traoré Am.nata Ham.r Traoré Djeneba sylla Sow m.ssam. Konaté Am.dou Koné Hadiaratou Doum.ia N’Diaye m.dibo m.riko Ibrahim.Am.dou Dem.élé m.ctar Bah Bah Traoré Djibril sy Ichaka m.nta Ham.dou Oum.r Ba Nongoba Sawadogo Abdram.ne Traoré Assa Traoré Sidibé Assétou Soukho Kaya Abdel Kader Traoré m.m.dou Dem.élé Ham.r Alassane Traoré Service of Internal m.dicine and Endocrinology of Hospital of m.li Bamako Mali Service of Internal m.dicine of Point G University Hospital Center Bamako Mali Service of Cardiology of Gabriel Touré University Hospital Center Bamako Mali Service of Internal m.dicine of CHR de Kaya Kaya Burkina Fasso Service of Internal m.dicine of Kati University Hospital Center Bamako Mali

Objective: To study the lipid profile am.ng the diabetic and non-diabetic obese patients. m.thods: It was a descriptive and prospective study carried out over a period of 9 m.nths from.m.rch to Decem.er 2010. It concerned all the patients who cam. for consultation in endocrinology at the internal m.dicine of Point G University Hospital Center and at the National Center for Diabetes Research. All the patients were included without any gender or age difference, voluntary and with a Bm. ≥ 30 kg/m.. Results: Out of the 1543 patients received in consultation, we had identified 178 obese people that is to say 11, 53% of the cases. Am.ng these cases 60 abided by our criteria with 30 diabetic patients and 30 non-diabetic ones. The average age was 45.83 ± 14.68 years old;73.3% were m.re than 40 years old. The sex ratio was 0.07. Two third (66.7%) of our patients lim.ted their eating diet to the three m.in m.als/day and 61.7% were sedentary. The notion of fam.ly obesity was found in 93.4% of the cases, of fam.ly diabetes in 58.3% of the cases, of past personal m.dical history of hypertension in 43.3% of the cases. It was about an android obesity in 91% and Gynoid in 9% of the cases. The Bm. was 55% of the cases com.rised between 30 - 34.9 kg/m.. The lipid profile noticed was: A hypertriglyceridem.a: 33% of diabetic patients and 10% of non-diabetic patients, a high LDL cholesterol: 37% of diabetic patients and 30% of our diabetic patients, a HDL hypocholesterolem.a: 40% of the diabetic patients and 20% of the non-diabetic patients, a total hypercholesterolem.a: 37% of the diabetic patients and 23% of non-diabetic patients. A hyperglycem.a was noticed in 13.3% of non-diabetic patients. Conclusion: The frequency of m.tabolic troubles was higher in obese diabetic patients com.ared to non-diabetic obese patients m.inly the hypertriglyceridem.a.

关键词： Diabetes Obesity Dyslipidem.a

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Progranulin prom.tes neurite outgrowth and neuronal differentiation by regulating GSK-3β

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Protein & Cell 2010年第6期1卷 552-562页

作者： Xue Gao Alvin P.Joselin Lei Wang Am.r Kar Payal Ray Andrew Batem.n Alison m.Goate Jane Y.Wu Departm.nt of Neurology Lurie Cancer CenterCenter for Genetic Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611USA Division of Experim.ntal m.dicine McGill Universityand Endocrine Research LaboratoryRoyal Victoria HospitalMontréalQuébecCanada Departm.nt of Psychiatry Washington University School of MedicineSt.LouisMO 63110USA Present address:Cellular and m.lecular m.dicine University of OttawaOntarioCanada

Progranulin(PGRN)has recently em.rged as a key player in a subset of frontotem.oral dem.ntias(FTD).Num.rous m.tations in the progranulin gene have been identified in patients with fam.lial or sporadic frontotem.oral lobar degeneration(FTLD).In order to understand the m.lecular m.chanism. by which PGRN deficiency leads to FTLD,we exam.ned activity of PGRN in m.use cortical and hippocam.al neurons and in hum.n neuroblastom. SH-sy5Y *** of m.use neurons with PGRN protein resulted in an increase in neurite outgrowth,supporting the role of PGRN as a neurotrophic *** treatm.nt stim.lated phosphorylation of glycogen synthase kinase-3 beta(GSK-3β)in cultured *** of PGRN in SH-sy5Y cells im.aired retinoic acid induced differentiation and reduced the level of phosphorylated GSK-3β.PGRN knockdown cells were also m.re sensitized to staurosporineinduced *** results reveal an im.ortant role of PGRN in neurite outgrowth and involvem.nt of GSK-3βin m.diating PGRN *** of GSK-3βactivation as a downstream.event for PGRN signaling provides a m.chanistic explanation for PGRN activity in the nervous *** work also suggest that loss of axonal growth stim.lation during neural injury repair or deficits in axonal repair m.y contribute to neuronal dam.ge or axonal loss in FTLD associated with PGRN ***,our study suggests that m.dulating GSK-3βor sim.lar signaling events m.y provide therapeutic benefits for FTLD cases associated with PGRN m.tations.

关键词： progranulin frontotem.oral lobar degeneration glycogen synthase kinase 3 beta(GSK-3β) neurite outgrowth

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