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Radiation-induced anaplastic astrocytoma occurring 15 years after radiation therapy for cerebellar pilocytic astrocytoma:case report

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Radiation-induced anaplastic astrocytoma occurring 15 years ...

Pilocytic astrocytoma of the cerebellum in children

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Shen-long Howng Ann-Shung Lieu Joon-Khim Loh chee-yin chai Aij-Lie Kwan Chih-Jen Wang Department of Neurosurgery PathologyKaohsiung Medical University and Hospital

＜正＞Malignant gliomas have been reported to arise in the radiation field of patients with previously radiation-treated brain *** the incidence of radiation-induced brain tumors is low at approximately 1%,it is an im...

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Pilocytic astrocytoma of the cerebellum in children

Dip2a regulates stress susceptibility in the basolateral amygdala

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Joon-Khim Loh Ann-Shung Lieu chee-yin chai Aij-Lie Kwan Chih-Jen Wang Shen-long Howng Department of Neurosurgery PathologyKaohsiung Medical University and Hospital

＜正＞Pilocytic astrocytoma is a slowly growing,relatively circumscribed neoplasia that is classified by the World Health Organization（WHO） as grade I *** most common sites of tumor occurrence are the cerebellum and...

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

A Novel Rolling Bearing Vibration Impulsive Signals Detection Approach Based on Dictionary Learning

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IEEE/CAA Journal of Automatica Sinica 2021年第6期8卷 1188-1198页

作者： Chuan Sun Hongpeng yin Yanxia Li Yi chai School of Big Data&Software Engineering Chongqing UniversityChongqing 401331China Key Laboratory of Complex System Safety and Control Ministry of EducationChongqing UniversityChongqing 400044China

The localized faults of rolling bearings can be diagnosed by its vibration impulsive ***,it is always a challenge to extract the impulsive feature under background noise and non-stationary *** paper investigates impulsive signals detection of a single-point defect rolling bearing and presents a novel data-driven detection approach based on dictionary *** overcome the effects harmonic and noise components,we propose an autoregressive-minimum entropy deconvolution model to separate harmonic and deconvolve the effect of the transmission *** address the shortcomings of conventional sparse representation under the changeable operation environment,we propose an approach that combines K-clustering with singular value decomposition(K-SVD)and split-Bregman to extract impulsive components *** experiments on synthetic signals and real run-to-failure signals,the excellent performance for different impulsive signals detection verifies the effectiveness and robustness of the proposed ***,a comparison with the state-of-the-art methods is illustrated,which shows that the proposed approach can provide more accurate detected impulsive signals.

关键词： Dictionary learning impulsive signals detection Kclustering with singular value decomposition(K-SVD) minimum entropy deconvolution rolling bearing signal processing

Effects of nitrogen and phosphorus concentrations on the bioaccumulation of polybrominated diphenyl ethers by Prorocentrum donghaiense

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Journal of Environmental Sciences 2013年第2期25卷 376-385页

作者： Chao chai Xundong yin Wei Ge Jinye Wang College of Resources and Environment Qingdao Agricultural University College of Life Sciences Qingdao Agricultural University College of Animal Science and Veterinary Qingdao Agricultural University

The growth, cellular total lipids, bioaccumulation amount, and bioaccumulation factors （BAFs） of 2,4,4 ′ -tribromodiphenyl ether （BDE28）, 2,2 ′ ,4,4 ′ -tetrabromodiphenyl ether （BDE47）, and 2,2 ′ ,4,4 ′ ,5-pentabromodiphenyl ether （BDE99） in a semi-continuous culture of Prorocentrum donghaiense were studied in relation to nitrate （0, 128, and 512 μmol/L） and phosphate （0, 8, and 32 μmol/L） concentrations. The BDE28, BDE47, and BDE99 content per cell under 0 μmol N/L were 3.77 × 10 6 , 3.95 × 10 6 , and 4.32 × 10 6 ng/cell, respectively, which were significantly higher than those under 128 and 512 μmol N/L. A nearly 5-fold increase in polybrominated diphenyl ether （PBDE） content per algal cell was found between 0 and 8 μmol P/L and between 8 and 32 μmol P/L. With increasing N and P concentrations, the PBDE content per volume of algal culture and the accumulation percentage of available PBDEs declined slightly. The BAFs for the PBDEs based on lipids showed that the logBAF lip under 0 μmol N/L was higher than those under 128 and 512 μmol N/L. The logBAF lip under 0 μmol P/L was higher than that under 8 μmol P/L but lower than that under 32 μmol P/L. Correlation analysis indicated a significant negative correlation between nutrient concentration and cellular total lipids, as well as the PBDE content per cell. The results indicate that different N and P concentrations change the total lipids content of P. donghaiense, thereby resulting in varying PBDE accumulation.

关键词： nitrogen phosphorus bioaccumulation polybrominated diphenyl ethers Prorocentrum donghaiense

The Effect of Send/Receive Dual Channel Parameters on Polarization Parameters Measurement

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Chinese Journal of Electronics 2017年第2期26卷 336-344页

作者： ZHANG Wenwen yin Fulian chai Juanfang BAI Xuesong Beijing Aerospace System Engineering Institute Information Engineering School Communication University of China Shanghai Electromechanical Engineering Institute

The dual-linear polarization radar is what China will popularize gradually following the Doppler radar *** the Doppler radar technology,the dual-linear polarization radar,which has been widely applied to enhancing modem weather radar system,becomes more and more popular in *** characteristics of hydrometeors,such as differential reflectivity,specific differential phase,and zero-lag correlation coefficient,are usually provided by the *** by the angular orientation of the feed,drop canting,and backscatter depolarization,however,inevitable measurement errors exit because of the unwanted horizontal and vertical wave *** small errors in these sensitive parameters may lead to erroneous judgment,both the factors themselves and their weights of influence should be studied specifically,with the mode of simultaneous transmission and reception of horizontally and vertically polarized *** study provides theoretical basis for the design of dual polarization Doppler radar,and will be helpful in the research of cloud,precipitation physics,and weather modification.

关键词： Doppler radar Dual-polarization technology Weather modification Elliptically polarized light Send/receive

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Mechanical and thermal properties of mesogen-jacketed liquid crystalline polymer/epoxy resin composites

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Science China Chemistry 2015年第6期58卷 1021-1026页

作者： Chunpeng chai Fangfang yin Guoping Li Yunjun Luo School of Material Science and Engineering Beijing Institute of Technology

The effects of mesogen-jacketed liquid crystalline polymer poly(dipropyl vinylterephthalate)(PDPVT) on the mechanical and thermal properties of diglycidyl ether of bisphenol-A(DGEBA) epoxy resin were investigated by impact test, tensile test and thermogravimetric analysis(TGA). The mechanism underlying the enhancement of mechanical properties of epoxy resin was studied using 1D wide-angle X-ray diffraction(WAXD) and scanning electron microscope(SEM). It was found that the mechanical properties of 1 wt%–5 wt% PDPVT/DGEBA composites were significantly improved compared to neat epoxy resin. Especially, the epoxy resin with 3 wt% PDPVT had the greatest increase in mechanical properties, with the impact strength, tensile strength and elongation while breaking increased by 87%, 59% and 174%, respectively. The increased mechanical strength was due to the fact that PDPVT maintained liquid crystalline phase in cured PDPVT/DGEBA composites, which would blunt the crack tip and prevent crack propagation. Moreover, PDPVT had slight effect on the thermal stability properties of epoxy resin.

关键词： mesogen-jacketed liquid crystalline polymer epoxy resin mechanical properties thermal stability properties

Variation of Bioaccumulation Ability of 2,2',4,4'-Tetrabromodiphenyl Ether by Marine Diatom Skeletonema costatum Under Different N:P Ratios

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Journal of Ocean University of China 2014年第3期13卷 523-530页

作者： chai Chao GE Wei yin Xundong College of Resources and Environment Qingdao Agricultural University College of Life Sciences Qingdao Agricultural University

The growth, biochemical content and bioaccumulation quantity of 2,2',4,4'-tetrabromodiphenyl ether(BDE-47) in Skeletonema costatum were studied under different N:P ratios(1, 4, 16, 64 and 128). All cellular biochemical contents of S. costatum presented decreasing trend over cultivation time. At early stage of cultivation, the cellular protein, carbohydrate and lipid in S. costatum presented higher values in treatments of N:P=4 and 16. However, they were lower in these treatments at the late stage, but higher in treatments N:P=1 and 128. Similarly, BDE-47 levels per cell of S. costatum were higher in treatments of N:P=4 and 16 at early stage of cultivation, which were 3.8 and 3.7 ng(106 cells)-1, respectively. At the middle stage of cultivation, the BDE-47 level per S. costatum cell lowered; and it further reduced in the treatments of N:P=4 and 16 at the late stage with the values 0.6 and 0.5 ng(106 cells)-1, respectively. However, it rose in N:P=128, reaching up to 2.3 ng(106 cells)-1. Compared with BDE-47 per cell, BDE-47 per algal volume under different N:P ratios did not present obvious difference. The quantity BDE-47 accumulated per cell of S. costatum was positively correlated with protein, carbohydrate and lipid per cell; meanwhile, the BDE-47 per volume had a positive correlation with biochemical content per volume. The variation of bioaccumulation ability of BDE-47 in S. costatum can be explained by biochemical changes due to N:P ratios.

关键词： N:P ratio bioaccumulation polybrominated diphenyl ethers microalgae nutrient