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Hydrodynamical self-interference of a scattered polariton quanta

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Light(Science & Applications) 2020年第1期9卷 541-542页

作者： Jiahui Huang wei Liu chee wei Wong Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCA 90095USA

Researchers have observed the free-propagation of a single microcavity polariton directly and its self-interference when scattering upon a *** experimental observations of quantum hydrodynamics in the single polariton limit test the wave-particle duality and aid in the development of polariton-based photonic circuits in quantum information processing.

关键词： defect polar quantum

Optomechanically-induced-transparency cooling of massive mechanical resonators to the quantum ground state

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Science China(Physics,Mechanics & Astronomy) 2015年第5期58卷 46-51页

作者： LIU Yong-Chun XIAO Yun-Feng LUAN Xing-Sheng WONG chee wei State Key Laboratory for Mesoscopic Physics and School of Physics Peking University Collaborative Innovation Center of Quantum Matter Optical Nanostructures Laboratory Columbia University

Ground state cooling of massive mechanical objects remains a difficult task restricted by the unresolved mechanical sidebands. We propose an optomechanically-induced-transparency cooling scheme to achieve ground state cooling of mechanical motion without the resolved sideband condition in a pure optomechanical system with two mechanical modes coupled to the same optical cavity mode. We show that ground state cooling is achievable for sideband resolution ωm/k as low as - 0.003. This provides a new route for quantum manipulation of massive macroscopic devices and high-precision measurements.

关键词： ground state cooling resolved sideband limit optomechanics

Probing 10μK stability and residual drifts in the cross-polarized dual-mode stabilization of single-crystal ultrahigh-Q optical resonators

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Light(Science & Applications) 2019年第1期8卷 1170-1178页

作者： Jinkang Lim wei Liang Anatoliy A.Savchenkov Andrey B.Matsko Lute Maleki chee wei Wong Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCA 90095USA OEwaves Inc. 465 North Halstead StreetSuite 140PasadenaCA 91107USA

The thermal stability of monolithic optical microresonators is essential for many mesoscopic photonic applications such as ultrastable laser oscillators,photonic microwave clocks,and precision navigation and *** fundamental performance is largely bounded by thermal *** thermal monitoring can be achieved by utilizing cross-polarized dual-mode beat frequency metrology,determined by the polarization-dependent thermorefractivity of a single-crystal microresonator,wherein the heterodyne radio-frequency beat pins down the optical mode volume temperature for precision ***,we investigate the correlation between the dualmode beat frequency and the resonator temperature with time and the associated spectral noise of the dual-mode beat frequency in a single-crystal ultrahigh-Q MgF_(2) resonator to illustrate that dual-mode frequency metrology can potentially be utilized for resonator temperature stabilization reaching the fundamental thermal noise limit in a realistic *** show a resonator long-term temperature stability of 8.53μK after stabilization and unveil various sources that hinder the stability from reaching sub-μK in the current system,an important step towards compact precision navigation,sensing,and frequency reference architectures.

关键词： resonator polarization stabilization

Soliton bursts and deterministic dissipative Kerr soliton generation in auxiliary-assisted microcavities

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Light(Science & Applications) 2019年第1期8卷 739-748页

作者： Heng Zhou Yong Geng Wenwen Cui Shu-wei Huang Qiang Zhou Kun Qiu chee wei Wong Key Lab of Optical Fiber Sensing and Communication Networks University of Electronic Science and Technology of China611731 ChengduChina Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCA 90095USA Department of Electrical Computerand Energy EngineeringUniversity of ColoradoBoulderCO 80309USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China611731 ChengduChina

Dissipative Kerr solitons in resonant frequency combs offer a promising route for ultrafast mode-locking,precision spectroscopy and time-frequency *** dynamics for the dissipative soliton generation,however,are intrinsically intertwined with thermal nonlinearities,limiting the soliton generation parameter map and statistical success probabilities of the solitary ***,via use of an auxiliary laser heating approach to suppress thermal dragging dynamics in dissipative soliton comb formation,we demonstrate stable Kerr soliton singlet formation and soliton ***,we access a new soliton existence range with an inverse-sloped Kerr soliton evolution—diminishing soliton energy with increasing pump ***,we achieve deterministic transitions from Turinglike comb patterns directly into the dissipative Kerr soliton singlet pulse bypassing the chaotic *** is achieved by avoiding subcomb overlaps at lower pump power,with near-identical singlet soliton comb generation over twenty ***,with the red-detuned pump entrance route enabled,we uncover unique spontaneous soliton bursts in the direct formation of low-noise optical frequency combs from continuum background *** burst dynamics are due to the rapid entry and mutual attraction of the pump laser into the cavity mode,aided by the auxiliary laser and matching well with our numerical *** by the auxiliary-assisted frequency comb dynamics,we demonstrate an application of automatic soliton comb recovery and long-term stabilization against strong external *** findings hold potential to expand the parameter space for ultrafast nonlinear dynamics and precision optical frequency comb stabilization.

关键词： soliton auxiliary dissipative

Effects of illness perception on negative emotions and fatigue in chronic rheumatic diseases:Rumination as a possible mediator

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World Journal of Clinical Cases 2022年第34期10卷 12515-12531页

作者： Yanxia Lu Xia Jin Li-wei Feng CSK Tang Michelle neo Roger C Ho Department of Medical Psychology and Ethics School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina The Third Hospital of Jinan Jinan 250132Shandong ProvinceChina College of Education for the Future Beijing Normal UniversityZhuhai 519087Guangdong ProvinceChina Department of Obstetrics and Gynecology National University of SingaporeThe Chinese University of Hong KongSingapore 117570Singapore Department of Psychological Medicine National University of SingaporeSingapore 119228Singapore

BACKGROUND Illness perception has long been hypothesized to be linked to psychological well-b eing in patients with rheumatic diseases,although substantial evidence is lacking,and the contribution of ruminative coping style to this relationship is *** To investigate the roles of illness perception and rumination in predicting fatigue and negative emotions in patients with chronic rheumatic *** Illness perception,rumination,fatigue and negative emotions(***,anxiety and stress)were assessed by the Illness Perception Questionnaire-Revised,Stress Reactive Rumination Scale,Multidimensional Assessment of Fatigue,and the Depression,Anxiety and Stress Scale *** regression analysis,the Sobel test,and the bootstrap were used to identify the mediating effect of *** All five subscales of illness perception,including perceived illness identity,chronicity,cyclical nature,consequences and coherence of illness,were significantly associated with fatigue and negative *** mediational analysis,rumination was found to mediate three components of illness perception(the identity,cyclical nature and consequences of illness)and negative emotions/*** Perceived identity,cyclical nature,and consequences of illness are significantly associated with fatigue and negative emotions in patients with chronic rheumatic diseases and these associations are mediated by *** findings suggest that psychological intervention should target rumination to improve physical and emotional well-being of patients with chronic rheumatic diseases.

关键词： Fatigue Illness perception Negative emotions Rheumatoid arthritis Rumination Systemic lupus erythematosus

Phytoplankton diversity in a tropical bay,North Borneo,Malaysia as revealed by light microscopy and Next-Generation Sequencing

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Acta Oceanologica Sinica 2022年第12期41卷 142-151页

作者： Brian wei Khong Chong Sandric chee Yew Leong Victor SKuwahara Teruaki Yoshida Unit for Harmful Algal Bloom Studies Borneo Marine Research InstituteUniversiti Malaysia SabahKota Kinabalu 88400Malaysia St.John’s Island National Marine Laboratory Tropical Marine Science InstituteNational University of SingaporeSingapore 119227Singapore Faculty of Education&Graduate School of Science and Engineering Soka UniversityHachiojiTokyo 192-8577Japan

Assessments of phytoplankton diversity in Sabah waters,North Borneo,have primarily relied on morphology-based identification,which has inherent biases and can be ***-Generation Sequencing(NGS)technology has been shown to be capable of overcoming several limitations of morphology-based *** were collected from the Sepanggar Bay over the course of the year 2018 in different monsoon ***-based identification and NGS sequencing of the V8–V9 region of the 18S LSU rDNA were used to investigate the diversity of the phytoplankton *** and NGS showed complementary results with more diatom taxa detected by microscopy whereas NGS detected smaller and rarer *** harmful algal genera in the study site comprised of Skeletonema,Margalefidinium,Pyrodinium,Takayama,and Alexandrium as detected by *** study showed that that an integrative approach of both morphological and molecular techniques could provide more comprehensive information about the phytoplankton community as the approach captured quantitative variability as well as the diversity of phytoplankton species.

关键词： phytoplankton community Next-Generation Sequencing(NGS) Sabah South China Sea

Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases

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World Journal of Gastroenterology 2022年第18期28卷 1934-1945页

作者： Wynne Sim wei-Meng Lim Ling-wei Hii chee-Onn Leong Chun-Wai Mai School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia School of Pharmacy International Medical UniversityKuala Lumpur 57000Malaysia Center for Cancer and Stem Cell Research Institute for ResearchDevelopmentand InnovationInternational Medical UniversityKuala Lumpur 57000Malaysia AGTC Genomics Kuala Lumpur 57000Malaysia State Key Laboratory of Oncogenes and Related Genes Renji-Med X Clinical Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Pharmaceutical Chemistry Faculty of Pharmaceutical SciencesUCSI UniversityKuala Lumpur 56000Malaysia

The immune system plays a vital role in maintaining the delicate balance between immune recognition and tumor ***,it is not uncommon that cancerous cells can intelligently acquire abilities to bypass the antitumor immune responses,thus allowing continuous tumor growth and *** evasion has emerged as a significant factor contributing to the progression and immune resistance of pancreatic *** with other cancers,pancreatic cancer has a tumor microenvironment that can resist most treatment modalities,including emerging ***,the use of immunotherapy has yet to bring significant clinical breakthrough among pancreatic cancer patients,suggesting that pancreatic cancer has successfully evaded *** this review,we summarize the impact of genetic alteration and epigenetic modification(especially histone deacetylases,HDAC)on immune evasion in pancreatic *** overexpression significantly suppresses tumor suppressor genes,contributing to tumor growth and *** review the evidence on HDAC inhibitors in tumor eradication,improving T cells activation,restoring tumor immunogenicity,and modulating programmed death 1 *** provide our perspective in targeting HDAC as a strategy to reverse immune evasion in pancreatic cancer.

关键词： Histone acetylation Histone deacetylases inhibitors Immune evasion Pancreatic cancers Pancreatic ductal adenocarcinoma

Robust Fingerprint Construction Based on Multiple Path Loss Model (M-PLM) for Indoor Localization

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Computers, Materials & Continua 2023年第1期74卷 1801-1818页

作者： Yun Fen Yong chee Keong Tan Ian Kim Teck Tan Su wei Tan School of Information Technology Monash University MalaysiaSubang JayaSelangorMalaysia School of Mathematical and Computer Sciences Heriot-Watt University MalaysiaWilayah Persekutuan PutrajayaMalaysia

A robust radio map is essential in implementing a fingerprint-based indoor positioning system(IPS).However,the offline site survey to manually construct the radio map is time-consuming and *** interpolation techniques have been proposed to infer the virtual fingerprints to reduce the time and effort required for offline site *** paper presents a novel fingerprint interpolator using a multi-path loss model(MPLM)to create the virtual fingerprints from the collected sample data based on different signal paths from different access points(APs).Based on the historical signal data,the poor signal paths are identified using their standard *** proposed method reduces the positioning errors by smoothing out the wireless signal fluctuations and stabilizing the signals for those poor signal *** consideringmultipath signal propagations from different APs,the inherent noise from these signal paths can be ***,locations of the signal data with standard deviations higher than the threshold are *** new fingerprints are then generated at these locations based on the proposed M-PLM interpolation function to replace the old *** proposed technique interpolates virtual fingerprints based on good signal paths with more stable signals to improve the positioning *** results show that the proposed scheme enhances the positioning accuracy by up to 44%compared to the conventional interpolation techniques such as the Inverse Distanceweighting,Kriging,and single Path *** a result,we can overcome the site survey problems for IPS by building an accurate radio map with more reliable signals to improve indoor positioning performance.

关键词： Path loss model radio map indoor positioning system interpolation fingerprinting

A new strain-based pentagonal membrane finite element for solid mechanics problems

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 211-216页

作者： wei Hao Koh Logah Perumal cheeKuang Kok Faculty of Engineering and Technology Multimedia UniversityMelaka 75450Malaysia

Polygonal finite elements remain an attractive option in finite element analysis due to their flexibility in modelingarbitrary shapes compared to *** this study,a pentagonal membrane element was developed with thestrain approach for the first *** element possesses invariance,and the equilibrium constraint was appliedto the assumed strain field using corrective *** by the advancing front technique,a pentagonalmesh was generated,and the mesh quality was enhanced with Laplacian *** performance of thedeveloped pentagonal element was assessed in a few numerical tests,and the results revealed its suitability inmodeling the bending of ***,the numerical results are enhanced when pentagonal elements are usedin mesh transitions along boundaries to smoothen curved edges and capture distributed loads.

关键词： Strain-based pentagonal element Corrective coefficients EquilibriumLaplacian smoothing Pentagonal mesh Mesh transition