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2021亚太心脏病学会P2Y12受体拮抗剂应用于亚太特殊人群的共识

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中华心血管病杂志 2023年第1期51卷 19-31页

作者： Jack Wei Chieh Tan Derek P Chew Kin Lam Tsui Doreen Tan Dmitry Duplyakov Ayman Hammoudeh 张波李毅徐凯 Paul J Ong DoniFirman Habib Gamra Wael Almahmeed Jamshed Dalal Lihua Tan Gabriel Steg Quang N Nguyen Junya Ako Jassim Al Suwaidi Mark Chan Mohamed Sobhy Abdulla Shehab Wacin Buddhari 王祖禄 Alan Yean Yip Fong Bilgehan Karadag Byeong-Keuk Kim Usman Baber chee tang chin 韩雅玲新加坡国立心脏中心新加坡盛港综合医院澳大利亚弗林德斯大学医学与公共卫生学院香港特别行政区东区尤德夫人那打素医院新加坡国立大学理学院药学系俄罗斯萨马拉地区心脏病医院约旦安曼Istishari医院心脏病科大连医科大学第一附属医院心内科大连116000 北部战区总医院心内科沈阳110840 新加坡伊丽莎白诺维娜医院新加坡陈笃生医院印度尼西亚Harapan Kita国家心血管中心、印度尼西亚大学医学院心脏病学和血管医学系突尼斯Fattouma Bourguiba大学医院/莫纳斯提尔大学心脏病科阿拉伯联合酋长国阿布扎比克利夫兰诊所印度孟买Kokilaben Dhirubhai Ambani医院心脏中心香港特别行政区广华医院法国巴黎比夏医院心脏病科越南河内医科大学心脏病科日本神奈川县相模原市北里大学医学院心血管内科卡塔尔多哈哈马德医疗公司成人心脏病科新加坡国立大学心脏中心埃及亚历山大大学医学院阿拉伯联合酋长国阿联酋大学医学与健康科学学院泰国曼谷朱拉隆功国王纪念医院马来西亚砂拉越哥打三马拉汉心脏中心土耳其伊斯坦布尔大学-Cerrahpasa医学院韩国首尔延世大学医学院Severance心血管医院心脏病科美国俄克拉荷马大学健康科学中心

高龄、糖尿病(DM)和慢性肾脏疾病(CKD)不仅会增加慢性冠状动脉综合征(CCS)患者缺血事件的风险,还会增加其接受抗血小板治疗期间的出血风险。此类特殊人群可能需要调整治疗方案,尤其是亚洲的特殊人群,往往表现出与西方人群不同的临床特... 详细信息

高龄、糖尿病(DM)和慢性肾脏疾病(CKD)不仅会增加慢性冠状动脉综合征(CCS)患者缺血事件的风险,还会增加其接受抗血小板治疗期间的出血风险。此类特殊人群可能需要调整治疗方案,尤其是亚洲的特殊人群,往往表现出与西方人群不同的临床特征。关于亚洲人群CCS高风险的分类和急性冠状动脉综合征(ACS)后使用新一代强效P2Y12受体抑制剂(如替格瑞洛和普拉格雷)的国际指南已相继发表。本共识总结了在特殊人群中使用强效P2Y12受体抑制剂的相关证据,提出了在冠状动脉疾病(CAD)特殊人群中应用标准疗程双联抗血小板治疗(DAPT)、短期DAPT和单一抗血小板治疗的推荐意见。本共识的特殊人群包括从ACS过渡至CCS,老年,或患有CKD、DM、多血管CAD和治疗期间发生出血并发症等特征的患者。

关键词：血小板聚集抑制剂亚洲心肌缺血共识双联抗血小板治疗

An integrated approach for machine-learning-based system identification of dynamical systems under control:application towards the model predictive control of a highly nonlinear reactor system

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Frontiers of Chemical Science and Engineering 2022年第2期16卷 237-250页

作者： Ewan chee Wee chin Wong Xiaonan Wang Department of Chemical&Biomolecular Engineering Faculty of EngineeringNational University of SingaporeSingapore 117585Singapore Chemical Engineering&Food Technology Cluster Singapore Institute of TechnologySingapore 138683Singapore

Advanced model-based control strategies,e.g.,model predictive control,can offer superior control of key process variables for multiple-input multiple-output *** quality of the system model is critical to controller performance and should adequately describe the process dynamics across its operating range while remaining amenable to fast *** work articulates an integrated system identification procedure for deriving black-box nonlinear continuous-time multiple-input multiple-output system models for nonlinear model predictive *** showcase this approach,five candidate models for polynomial and interaction features of both output and manipulated variables were trained on simulated data and integrated into a nonlinear model predictive controller for a highly nonlinear continuous stirred tank reactor *** procedure successfully identified system models that enabled effective control in both servo and regulator problems across wider operating *** controllers also had reasonable per-iteration times of ca.0.1 *** demonstration of how such system models could be identified for nonlinear model predictive control without prior knowledge of system dynamics opens further possibilities for direct data-driven methodologies for model-based control which,in the face of process uncertainties or modelling limitations,allow rapid and stable control over wider operating ranges.

关键词： nonlinear model predictive control black-box modeling continuous-time system identification machine learning industrial applications of process control

High responsivity and fast response 8×8β-Ga_(2)O_(3)solar-blind ultraviolet imaging photodetector array

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Science china(Technological Sciences) 2023年第11期66卷 3259-3266页

作者： SHEN GaoHui LIU Zeng tang Kai SHA ShuLin LI Lei TAN chee-Keong GUO YuFeng tang WeiHua Innovation Center of Gallium Oxide Semiconductor(IC-GAO) College of Integrated Circuit Science and EngineeringNanjing University of Posts and TelecommunicationsNanjing 210023China National and Local Joint Engineering Laboratory for RF Integration and Micro-Assembly Technologies Nanjing University of Posts and TelecommunicationsNanjing 210023China Key Laboratory of Aerospace Information Materials and Physics(NUAA) MIITNanjing 211106China College of Physics MIIT Key Laboratory of Aerospace Information Materials and PhysicsKey Laboratory for Intelligent Nano Materials and DevicesNanjing University of Aeronautics and AstronauticsNanjing 211106China Advanced Materials Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Nansha 511458China Department of Electronic and Computer Engineering School of EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China

In this work,an 8×8 Ga_(2)O_(3)solar-blind ultraviolet photodetector array is introduced for image sensing *** 2-in wafer-scaled Ga_(2)O_(3)thin film was grown by metalorganic chemical vapor deposition technique;and the photodetector array was fabricated through ultraviolet photolithography,lift-off,and electron-beam *** addition to the high solar-blind/visible rejection ratio of 104,every photodetector cell in the array has high performance and fast response speed,such as responsivity of 49.4 A W^(-1),specific detectivity of 6.8×10^(14)Jones,external quantum efficiency of 1.9×10^(4)%,linear dynamic range of 117.8 d B,and response time of 41 ms,respectively,indicating the high photo-response performance of the ***,the photodetector array displayed uniform responsivity with a standard deviation of~6%,and presented a sensing image of low chromatic aberration,owing to the high resolution of the photodetector *** a word,this work may contribute to developing Ga_(2)O_(3)-based optoelectronic device applications.

关键词： Ga_(2)O_(3) photodetector array imaging photo-response

Hydrophobic protein in colorectal cancer in relation to tumor stages and grades

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World Journal of Gastroenterology 2010年第22期16卷 2754-2763页

作者： Lay-chin Yeoh chee-Keat Loh Boon-Hui Gooi Manjit Singh Lay-Harn Gam School of Pharmaceutical Sciences Universiti Sains Malaysia Department of Surgery Penang General Hospital

AIM: To identify differentially expressed hydrophobic proteins in colorectal cancer. METHODS: Eighteen pairs of colorectal cancerous tissues in addition to tissues from normal mucosa were analysed. Hydrophobic proteins were extracted from the tissues, separated using 2-D gel electrophoresis and analysed using Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS). Statistical analysis of the proteins was carried out in order to determine the significance of each protein to colorectal cancer (CRC) and also their relation to CRC stages, grades and patients’ gender. RESULTS: Thirteen differentially expressed proteins which were expressed abundantly in either cancerous or normal tissues were identified. A number of these proteins were found to relate strongly with a particular stage or grade of CRC. In addition, the association of these proteins with patient gender also appeared to be ***: Stomatin-like protein 2 was found to be a promising biomarker for CRC, especially in female patients. The differentially expressed proteins identified were associated with CRC and may act as drug target candidates.

关键词： Biomarker Colorectal cancer Liquid chromatography tandem mass spectrometry Proteomic approach 2D-polyacrylamide gel electrophoresis

VR and AR in human performance research―An NUS experience

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Virtual Reality & Intelligent Hardware 2020年第5期2卷 381-393页

作者： Jun-Hao YIN chin-Boon CHNG Pooi-Mun WONG Nicholas HO Matthew CHUA chee-Kong CHUI Department of Mechanical Engineering National University of Singapore119077Singapore Institute of Systems Science National University of Singapore119077Singapore

With the mindset of constant improvement in efficiency and safety in the workspace and training in Singapore,there is a need to explore varying technologies and their capabilities to fulfil this *** ability of Virtual Reality(VR)and Augmented Reality(AR)to create an immersive experience of tying the virtual and physical environments coupled with information filtering capabilities brings a possibility of introducing this technology into the training process and *** paper surveys current research trends,findings and limitation of VR and AR in its effect on human performance,specifically in Singapore,and our experience in the National University of Singapore(NUS).

关键词： Human computer interaction Virtual environment Human performance

Csk-homologous kinase （Chk/Matk）： a molecular policeman suppressing cancer formation and progression

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Frontiers in Biology 2015年第3期10卷 195-202页

作者： Gahana Advani Anderly C. Chueh Ya chee Lim Amardeep Dhillon Heung-chin Cheng Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute University of Melbourne 30 Flemington Road Parkville Victoria 3010 Australia A CRF Chemical Biology Division The Walter and Eliza Hall Institute for Medical Research Royal Melbourne Hospital and Department of Medical Biology University of Melbourne Parkville Victoria 3052 Australia Peter MacCallum Cancer Research Institute St. Andrews Place East Melbourne Hctoria Australia

Aberrant activation of Src-family tyrosine kinases （SFKs） directs initiation of metastasis and development of drug resistance in multiple solid tumors and hematological cancers. Since oncogenic mutations of SFKs are rare events, aberrant activation of SFKs in cancer is likely due to dysregulation of the two major upstream inhibitors： C-terminal Src kinase （Csk） and its homolog Csk-homologous kinase （Chk/Matk）. Csk and Chk/Matk inhibit SFKs by selectively phosphorylating the inhibitory tyrosine residue at their C-terminal tail. Additionally, Chk/Matk can also employ a non- catalytic inhibitory mechanism to inhibit multiple active forms of SFKs, suggesting that Chk/Matk is a versatile inhibitor capable of constraining the activity of multiple active forms of SFKs. Mounting evidence suggests that Chk/ Mark is a potential tumor suppressor downregulated by epigenetic silencing and/or missense mutations in several cancers such as colorectal and lung carcinoma. In spite of the potential significance of Chk/Matk in cancer, little is known about its structure and regulation. This review focuses on the mechanisms by which Chk/Matk expression and activity is downregulated in cancers. Specifically, we assessed the evidence demonstrating downregulation of Chk/Matk by epigenetic silencing and missense mutations in cancers. The other focus is the tumor suppressive mechanism of Chk/ Matk. The final focus of the review is on the clinical applications of the investigations into the mechanism of epigenetic silencing of Chk/Matk expression and the tumor suppressive mechanism of Chk/Matk; specifically we discussed how they can benefit the development of biomarkers for early diagnosis of cancers and specific SFK inhibitors for use as cancer therapeutics.

关键词： tumour suppressor protein tyrosine kinase Src-family kinases CSK CHK/Matk colon cancer

Application of hydrochemistry and strontium isotope for understanding the hydrochemical characteristics and genesis of strontium-rich groundwater in karst area,Gongcheng County,Southwest china

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Journal of Groundwater Science and Engineering 2024年第3期12卷 264-280页

作者： Mi tang Jun Lv Shi Yu Yan Liu Shao-hong You Ping-ping Jiang College of Environmental Science and Engineering Guilin University of TechnologyGuilin 541004GuangxiChina Guangxi Zhuang Autonomous Region Hydrographic Centre Nanning 530023China Technical Innovation Center of Mine Geological Environmental Restoration Engineering in Southern Karst Area Ministry of Natural ResourcesNanning 530028China Key Laboratory of Karst Dynamics Ministry of Natural Resources&Guangxi Zhuang Autonomous RegionInstitute of Karst GeologyChinese Academy of Geological SciencesGuilin 541004GuangxiChina International Research Centre on Karst under the Auspices of UNESCO/National Center for International Research on Karst Dynamic System and Global Change Guilin 541004GuangxiChina Guilin Research Institute of Environmental Protection Sciences Guilin 541004GuangxiChina Guangxi Key Laboratory of Green Preparation and Application of Inorganic Materiais Laibin 546199GuangxiChina College of Earth Sciences Guilin University of TechnologyGuilin 541004GuangxiChin

Understanding the hydrochemical characteristics and genesis mechanisms of strontium-rich groundwater is pivotal for supporting the exploitation and utilization of natural strontium-rich *** this research,27 groundwater samples were *** analyzing major ion chemistry and strontium isotope data,and considering the hydrogeological context,various analytical approaches,including multivariate statistics,ion ratios,and isotopes,were used to reveal the characteristics and genesis mechanisms of strontium-rich groundwater in the study *** findings indicate that the predominant hydrochemical type of groundwater is HCO_(3)-Ca,with Ca^(2+)and HCO_(3)^(-)as the primary cations and *** hydrochemistry of the strontium-rich groundwater is predominantly influenced by rock weathering processes.A combination of factors,including ion exchange,and anthropogenic activities,shapes the compositional characteristics of the groundwater in the *** dissolution of calcite due to weathering emerges as the principal source of strontium in the *** ion exchange processes are not conducive to strontium enrichment in groundwater,their effect is relatively *** impact of human activities on the groundwater is minor.

关键词： Hydrochemistry analysis Strontium ^(87)Sr/^(86)Sr Groundwater Karst

Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice

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Food Science and Human Wellness 2022年第1期11卷 177-188页

作者： Wanxiu Cao Fang Liu Robert WLi Yaoxian chin Yuming Wang Changhu Xue Qingjuan tang College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China United States Department of Agriculture Agriculture Research Service(USDA-ARS)Animal Genomics and Improvement LaboratoryBeltsvilleMD 20705USA Hainan Tropical Ocean University Sanya 572022China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao 266003China

It is unclear how docosahexaenoic acid(DHA)improves insulin resistance via modulating gut microbiome in obese *** used diet-induced obesity(DIO)mice as a model to study the effects of DHA-rich fish oil(DHA-FO)on host metabolic disorders and colonic ***-FO reduced fat deposition,regulated lipid profiles and alleviated insulin resistance in DIO *** because DHA-FO prevented the permeation of lipopolysaccharide across intestinal epithelial barrier,and promoted peptide YY(PYY)secretion via the mediation of short chain fatty acids receptor(FFAR2)in ***,DHA-FO might regulate PYY expression by reversing microbial dysbiosis,including increasing the abundance ofAkkermansia muciniphila and Lactobacillus,and suppressing the growth of ***-FO also altered gut microbial function(e.g."linoleic acid metabolism")associated with PYY expression(r>0.80,P<0.05).Herein,DHA-FO enhanced insulin action on glucose metabolism by altering gut microbiome and facilitating colonic PYY expression in DIO mice.

关键词： Docosahexaenoic acid Diet-induced obesity Insulin resistance Peptide YY Gut microbiome

Are herbal medicinal products less teratogenic than Western pharmaceutical products?

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Acta Pharmacologica Sinica 2002年第12期23卷 116-119页

作者： LEUNG Kwok-Yin,LEE Yuk-Ping,CHAN Ho-Yee,LEE chin-Peng,Mary tang Hoi-Yin Department of Obstetrics & Gynaecology the University of Hong Kong Queen Mary Hospital Pokfulam Road Hong Kong SAR china Department of Prenatal Diagnosis and Counselling Tsan Yuk Hospital The University of Hong Kong Hong Kong SAR china Department of Prenatal Diagnosis and Counselling Tsan Yuk Hospital The University of Hong Kong Hong Kong SAR china Department of Prenatal Diagnosis and Counselling Tsan Yuk Hospital The University of Hong Kong Hong Kong SAR china Department of Prenatal Diagnosis and Counselling Tsan Yuk Hospital The University of Hong Kong Hong Kong SAR china

AIM: To determine the use and teratogenicity of herbal medicinal products (HMP). METHODS: A retrospective study was conducted in a University hospital to compare the difference in the pattern of use and fetal outcomes between pregnant women who took HMP and Western pharmaceutical products (WPP). RESULTS: From 1995 Jan to 2001 Dec, 61 and 372 women took HMP and WPP one month before or during their current pregnancies respectively. There was an increase in the prevalence of pregnant women who took HMP from 0 % in 1995 to 0.8 % in 2001. Among HMP users, 51.6 %, 82.8 % and 58.6 % of them had low monthly family income (<15 000), low education level (secondary education or below) and were unemployed respectively. In comparison to WPP, pregnant women used smaller number of HMP (1.4 vs 3.0, P<0.01) at a later gestation (4.8 weeks vs 3.1 weeks, P <0.01) and within a shorter duration (11.1 d vs 47.9 d, P<0.01). The prevalence of congenital fetal abnormalities in the group of women who took HMP (3.3 %) was not sig

关键词： herbal medicine pregnancy teratogenicity