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Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea

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World Journal of Gastroenterology 2011年第37期17卷 4218-4224页

作者： Chien-Chang Chen chee-Jen Chang Tzou-Yien Lin Ming-Wei Lai Hsun-chin.Chao Man-Shan Kong Division of Gastroenterology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan 333 Taiwan China Department of Medicine Chang Gung University College of Medicine Taoyuan 333 Taiwan China Graduate Institute of Clinical Medical Sciences Clinical Informatics and Medical Statistics Research Center Chang Gung Memorial Hospital Taoyuan 333 Taiwan China

AIM:To explore the value of fecal lactoferrin in predicting and monitoring the clinical severity of infectious ***:Patients with acute infectious diarrhea ranging from 3 mo to 10 years in age were enrolled,and one to three stool samples from each subject were *** parameters,including white blood cells /differential count,C-reactive protein,fecal mucus,fecal pus cells,duration of fever,vomiting,diarrhea and severity(indicated by Clark and Vesikari scores),were recorded and *** lactoferrin was determined by enzyme-linked immunosorbent assay and compared in different pathogen and disease *** estimating equations(GEE) were also used for ***:Data included 226 evaluations for 117 individuals across three different time *** lactoferrin was higher in patients with Salmonella(11.17 μg/g ± 2.73 μg/g) or Campylobacter(10.32 μg/g ± 2.94 μg/g) infections and lower in patients with rotavirus(2.82 μg/g ± 1.27 μg/g) or norovirus(3.16 μg/g ± 1.18 μg/g) *** of fecal lactoferrin were significantly elevated in patients with severe(11.32 μg/g ± 3.29 μg/g) or moderate(3.77 μg/g ± 2.08 μg/g) disease activity compared with subjects with mild(1.51 μg/g ± 1.36 μg/g) disease activity(P < 0.05).GEE analysis suggests that this marker could be used to monitor the severity and course of gastrointestinal infections and may provide information for disease ***:Fecal lactoferrin increased during bacterial infection and with greater disease severity and may be a good marker for predicting and monitoring intestinal inflammation in children with infectious diarrhea.

关键词： Lactoferrin Diarrhea Generalized estimating equations Vesikari scores Clark scores

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国内外信息援助制度研究综述

情报科学 2018年第8期36卷 165-170,176页

作者：相丽玲焦丽叶郝雅玲山西大学经济与管理学院山西太原030006

【目的/意义】弱势群体信息援助(Vulnerable Group Information Assistan.e,IA)一直是图书馆学、情报学关注的研究课题。【方法/过程】国外IA研究始于20世纪80年代,国内则兴起于90年代末,发展至今积累了大量的研究成果。本文分析总结了... 详细信息

【目的/意义】弱势群体信息援助(Vulnerable Group Information Assistan.e,IA)一直是图书馆学、情报学关注的研究课题。【方法/过程】国外IA研究始于20世纪80年代,国内则兴起于90年代末,发展至今积累了大量的研究成果。本文分析总结了国内外围绕信息援助制度研究的相关文献,其内容主要涉及基本问题探讨、相关立法分析、实施机制与评估机制研究四个方面。【结果/结论】归纳得出,当前相关文献在研究方法、研究角度与研究内容上还有待补充。在此基础上,本文提出研究展望,致力于为信息援助制度的研究提供新的思路。

关键词：信息弱势群体信息援助制度保障公共图书馆

Csk-homologous kinase （Chk/Matk）： a molecular policeman suppressing cancer formation and progression

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Frontiers in Biology 2015年第3期10卷 195-202页

作者： Gahana Advani Anderly C. Chueh Ya chee Lim Amardeep Dhillon Heung-chin.Cheng Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute University of Melbourne 30 Flemington Road Parkville Victoria 3010 Australia A CRF Chemical Biology Division The Walter and Eliza Hall Institute for Medical Research Royal Melbourne Hospital and Department of Medical Biology University of Melbourne Parkville Victoria 3052 Australia Peter MacCallum Cancer Research Institute St. Andrews Place East Melbourne Hctoria Australia

Aberrant activation of Src-family tyrosine kinases （SFKs） directs initiation of metastasis and development of drug resistan.e in multiple solid tumors and hematological cancers. Since oncogenic mutations of SFKs are rare events, aberrant activation of SFKs in cancer is likely due to dysregulation of the two major upstream inhibitors： C-terminal Src kinase （Csk） and its homolog Csk-homologous kinase （Chk/Matk）. Csk and Chk/Matk inhibit SFKs by selectively phosphorylating the inhibitory tyrosine residue at their C-terminal tail. Additionally, Chk/Matk can also employ a non- catalytic inhibitory mechanism to inhibit multiple active forms of SFKs, suggesting that Chk/Matk is a versatile inhibitor capable of constraining the activity of multiple active forms of SFKs. Mounting evidence suggests that Chk/ Mark is a potential tumor suppressor downregulated by epigenetic silencing and/or missense mutations in several cancers such as colorectal and lung carcinoma. In spite of the potential significance of Chk/Matk in cancer, little is known about its structure and regulation. This review focuses on the mechanisms by which Chk/Matk expression and activity is downregulated in cancers. Specifically, we assessed the evidence demonstrating downregulation of Chk/Matk by epigenetic silencing and missense mutations in cancers. The other focus is the tumor suppressive mechanism of Chk/ Matk. The final focus of the review is on the clinical applications of the investigations into the mechanism of epigenetic silencing of Chk/Matk expression and the tumor suppressive mechanism of Chk/Matk; specifically we discussed how they can benefit the development of biomarkers for early diagnosis of cancers and specific SFK inhibitors for use as cancer therapeutics.

关键词： tumour suppressor protein tyrosine kinase Src-family kinases CSK CHK/Matk colon cancer

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茶树CsNCED2基因的克隆和表达分析

西北植物学报 2018年第6期38卷 994-1002页

作者：王赞陈丹岳川曹红利郭雅玲福建农林大学园艺学院茶学福建省高校重点实验室福州350002

该研究以铁观音茶树品种叶片为材料,通过RT-PCR技术,克隆了茶树脱落酸(ABA)合成途径关键限速酶——9-顺式环氧类胡萝卜素裂解双加氧酶(9-cis-epoxycarotenoid dioxygenase,NCED)基因的全长cDNA序列。该基因cDNA全长1 931bp,包含1 821bp... 详细信息

该研究以铁观音茶树品种叶片为材料,通过RT-PCR技术,克隆了茶树脱落酸(ABA)合成途径关键限速酶——9-顺式环氧类胡萝卜素裂解双加氧酶(9-cis-epoxycarotenoid dioxygenase,NCED)基因的全长cDNA序列。该基因cDNA全长1 931bp,包含1 821bp完整开放阅读框,共编码606个氨基酸残基。NCBI同源分析结果表明,与葡萄VvNCED2相似性最高(78%),命名为CsNCED2(NCBI登录号:MF765770)。氨基酸序列分析显示,其具有NCED家族的FLNO2258保守结构域,以及MIAHPKxDP和HDFAITE保守结构域序列;在保守区存在4个Fe2+活性组氨酸结合位点,N-端含有叶绿体转运肽。实时荧光定量PCR分析表明,CsNCED2基因在铁观音叶、茎和花中表达量较高;白茶萎凋和乌龙茶做青均可以诱导CsNCED2基因显著上调表达;除干旱胁迫抑制CsNCED2表达外,ABA和低温胁迫均能够诱导CsNCED2基因显著上调表达。表明CsNCED2基因在茶树ABA合成代谢以及胁迫响应中发挥重要作用。

关键词：茶树基因克隆 NCED基因脱落酸表达模式

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媒体新生态下的铜陵铜文化传播策略研究

铜陵学院学报 2017年第1期16卷 95-98页

作者：谢雅玲铜陵学院安徽铜陵244000

作为以铜立市的代表性工业城市,安徽铜陵一直以发达的铜工业驰名中外。近年来,铜陵市积极响应国家推动产业转型和文化产业建设的号召,开发建设铜陵特色铜文化,目前,已经建立起了包括文化品牌宣传和产业链建设等多方面立体化的的文化产... 详细信息

作为以铜立市的代表性工业城市,安徽铜陵一直以发达的铜工业驰名中外。近年来,铜陵市积极响应国家推动产业转型和文化产业建设的号召,开发建设铜陵特色铜文化,目前,已经建立起了包括文化品牌宣传和产业链建设等多方面立体化的的文化产业系统,与此相悖的是,铜陵的铜文化知名度低,宣传策略落后,尤其是随着传媒业态的不断变化,新媒体不断涌现,传统的铜文化传播策略的局限性日益凸显,研究如何利用新兴媒体和新型传播手段推动铜文化的传播和产业发展具有了现实意义。

关键词：媒体新生态铜文化传播

传统“三高”行业在现代循环经济工业产业园区中的表现形式

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中国氯碱 2018年第7期 1-4页

作者：王雅玲新疆中泰化学股份有限公司新疆乌鲁木齐830009

用定义法的论证方法,学习理解当前政策、法规,以新疆拟规划建设的一个产业链耦合项目为案例,从循环经济发展角度,通过具体逻辑分析、统计消耗排放数据、连通产业相互耦合、对比物流运输等多维度,用实际运行数据与高排放、高污染、高能(... 详细信息

用定义法的论证方法,学习理解当前政策、法规,以新疆拟规划建设的一个产业链耦合项目为案例,从循环经济发展角度,通过具体逻辑分析、统计消耗排放数据、连通产业相互耦合、对比物流运输等多维度,用实际运行数据与高排放、高污染、高能(水)耗进行逐一对比,论证该项目不是传统的"三高"项目,即是循环经济项目,并对"三高"项目的界定提出了建议。

关键词：产业耦合循环经济绿色发展排放污染能耗

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改扩建工程新旧桥梁基础差异沉降分析及控制

工程建设与设计 2018年第10期 68-69页

作者：吴雅玲上海同丰工程咨询有限公司上海200444

在改扩建工程中,新旧桥梁基础会产生差异沉降。论文介绍改扩建工程的整体方法流程,分析改扩建工程新旧桥梁基础的差异沉降及其控制措施,提出控制差异沉降的几点注意事项,给相关工程提供参考。

关键词：改扩建工程新旧桥梁基础差异沉降分析及控制

经颅磁刺激结合阿戈美拉汀治疗难治性抑郁67例临床研究

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社区医学杂志 2016年第22期14卷 22-23页

作者：王雅玲宝鸡市绛帐社会福利院精神科陕西721300

目的探讨经颅磁刺激结合阿戈美拉汀治疗难治性抑郁的临床效果。方法选取2013年10月—2015年10月诊治的127例难治性抑郁症患者,分为观察组67例和对照组60例,观察组经颅磁刺激结合阿戈美拉汀治疗,对照组只经颅磁刺激治疗,比较两组疗效,采... 详细信息

目的探讨经颅磁刺激结合阿戈美拉汀治疗难治性抑郁的临床效果。方法选取2013年10月—2015年10月诊治的127例难治性抑郁症患者,分为观察组67例和对照组60例,观察组经颅磁刺激结合阿戈美拉汀治疗,对照组只经颅磁刺激治疗,比较两组疗效,采用SPSS20.0进行统计学处理。结果治疗后观察组汉密尔顿抑郁量表(the hamilton depression scale,HAMD)评分低于对照组(t=5.871,P<0.05),血浆去甲肾上腺素NE含量高于对照组(t=4.071,P<0.05),平均巴氏指数高于对照组(t=12.890,P<0.05),总有效率高于对照组(χ2=10.209,P<0.05)。结论经颅磁刺激结合阿戈美拉汀能明显改善抑郁症患者症状,疗效优于单用经颅磁刺激治疗。

关键词：经颅磁刺激阿戈美拉汀难治性抑郁

A Novel Apprehension of the Primary Lung Meridian, Sinew Channel, Divergent Channel, Luo-Connecting Channel Acting as a Single Unit System to Serve Respiration Function Based on Modern Neurophysiology and Kinesiology

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chin.se Medicine 2020年第2期11卷 31-95页

作者： Peter chin.Wan Fung Regina Kit chee Kong Division of Medical Physics Department of Medicine University of Hong Kong Hong Kong China School of chin.se Medicine Southern Medical University Guangzhou China

The TCM philosophy of a meridian and associated channels pertains to the specific function of one or more organs. We define the Lung Primary Meridian (LUM) together with the Lung Sinew (LUSC), Divergent (LUDC), Luo-connecting (LULCC) Channels as a system of routes plus some parts of the body (such as muscles) to fulfil respiration, as a main function under different situations. There is very limited information about the Lung associated channels in classical literature of TCM. With a clear focus on the function of respiration, we have carried out a detailed analysis of the biomedical consequence of stimulating the LUM, analysed the roles played by LUSC, LUDC, and LULCC. The updated LUM and LUDC include acupoints of other meridians, serving the same purpose of performing satisfactory respiration starting from checking the quality of the inflow through the nose. The LUSC includes the respiratory muscles (plus the associated connective tissues) extending to various parts of the body. The muscles of the limb (as part of the LUSC) embrace the nerves that provide routes for somatosensory reflexes and play the role of locomotion, providing voluntary respiration via the pectoralis muscles. The muscles of LUSC are bounded by stiff connective tissue layers, forming compartments, and are part of the pulley system for various body locomotions. Within a compartment, the interstitial fluid, blood, lymph flows must be potent to protect the associated nerves related to LUM;the healthy state of the LUSC also provides freedom of various types of locomotion. The LULCC exists because the vagus nerve has a part of it passing through the spinal cords all the way down to the sacrum domain, with exiting nerve innervating two-third of the large intestine. The crucial steps of our deductions are supported by experimental evidence based on modern neurophysiology and kinesiolo

关键词： Lung Meridian Sinew Divergent Luo-Connecting Channels Mechanical Advantage of Muscles Sympathetic Nerves Parasympathetic Nerves Muscles of the Tongue Pharynx Larynx Intercostal Muscles Inspiration and Expiration Muscles Swallowing Somatosensory and Segmental Reflexes Acupoints of the Lung Urinary Bladder Kidney Governing (DU) Conception (REN) Me-ridians Pulmonary Diseases Lung → Large-Intestine Connection Acupuncture Bian Stone Therapy