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Enhancing single-cell encapsulation in droplet microfluidics with fine-tunable on-chip sample enrichment

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Microsystems & Nanoengineering 2024年第1期10卷 149-160页

作者： Tao Tang Hao Zhao Shaofei shen Like Yang Chwee Teck lim Department of Biomedical Engineering National University of Singapore117583 SingaporeSingapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of Singapore119077 SingaporeSingapore Shanxi Key Lab for Modernization of TCVM College of Life ScienceShanxi Agricultural UniversityTaiguShanxi 030801China Institute for Health Innovation&Technology National University of Singapore117599 SingaporeSingapore Mechanobiology Institute National University of Singapore117411 SingaporeSingapore Institute for Digital Molecular Analytics and Science Nanyang Technological University636921 SingaporeSingapore

Single-cell encapsulation in droplet microfluidics is commonly hindered by the tradeoff between cell suspension density and on-chip focusing *** this study,we introduce a novel droplet microfluidic chip to overcome this *** chip comprises a double spiral focusing unit,a flow resistance-based sample enrichment module with fine-tunable outlets,and a crossflow droplet generation *** a low-density cell/bead suspension(2×10^(6) objects/mL),cells/beads are focused into a near-equidistant linear arrangement within the double spiral *** excess water phase is diverted while cells/beads remain focused and sequentially encapsulated in individual *** performance was assessed through numerical simulations and experiments at three flow rates(40,60,80μL/min),demonstrating successful focusing at 40 and 80μL/min for beads and cells,*** addition,both simulation and experimental results revealed that the flow resistance at the sample enrichment module is adjustable by punching different outlets,allowing over 50%of the aqueous phase to be ***8n-based droplet detection algorithms realized the counting of cells/beads in droplets,statistically demonstrating single-cell and bead encapsulation rates of 72.2%and 79.2%,*** the results indicate that this on-chip sample enrichment approach can be further developed and employed as a critical component in single-cell encapsulation in water-in-oil droplets.

关键词： beads outlet sample

Safety and efficacy of Kaffes intraductal self-expanding metal stents in the management of post-liver transplant anastomotic strictures

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World Journal of Transplantation 2024年第2期14卷 88-98页

作者： chee lim Jonathan Ng Babak Sarraf Rhys Vaughan Marios Efthymiou Leonardo Zorron Cheng Tao Pu Sujievvan Chandran Department of Gastroenterology and Hepatology Austin HealthMelbourne HeidelbergVIC 3084Australia Melbourne Medical School The University of MelbourneMelbourne ParkvilleVIC 3052Australia

BACKGROUND Endoscopic management is the first-line therapy for post-liver-transplant anas-tomotic *** the optimal duration of treatment with plastic stents has been reported to be 8-12 months,data on safety and duration for metal stents in this setting is *** to limited access to endoscopic retrograde cholan-giopancreatography(ERCP)during the coronavirus disease 2019 pandemic in our centre,there was a change in practice towards increased usage and length-of-stay of the Kaffes biliary intraductal self-expanding stent in patients with suitable *** was mainly due to the theoretical benefit of Kaffes stents allowing for longer indwelling periods compared to the traditional plastic *** Adult liver transplant recipients aged 18 years and above who underwent ERCP were retrospectively identified during a 10-year period through a database *** admissions post-Kaffes stent insertion were identified manually through electronic and scanned medical *** main outcome was the incidence of complications when stents were left indwelling for 3 months vs 6 *** efficacy was calculated via rates of stricture recurrence between patients that had stenting courses for≤120 d or>120 *** During the study period,a total of 66 ERCPs with Kaffes insertion were performed in 54 patients throughout their stenting *** 33 ERCPs,the stent was removed or exchanged on a 3-month *** pancreatitis,perfor-ations or deaths *** post-ERCP complications were similar between the 3-month(abdominal pain and intraductal migration)and 6-month(abdominal pain,septic shower and embedded stent)groups-6.1%vs 9.1%respectively,P=*** strictures resolved at the end of the stenting course,but the stenting course was variable from 3 to 22 *** recurrence rate for stenting courses lasting for up to 120 d was 71.4%and 21.4%for stenting courses of 121 d or over(P=0.03).There were 28 patients that were treated with a sin

关键词： Liver transplantation Cholangiopancreatography Endoscopic retrograde Constriction Pathologic Self expandable metallic stents Bile duct diseases Cholestasis

Carbon Fiber Breakage Mechanism in Aluminum(Al)/Carbon Fibers(CFs) Composite Sheet during Accumulative Roll Bonding(ARB) Process

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 167-173页

作者：胡淑芬 SUN Zhenzhong shen Fanghua DENG Jun 杨卫平杨浩坤 School of Engineering Jiangxi Agricultural UniversityNanchang 330045China School of Mechanical Engineering Dongguan University of TechnologyDongguan 510730China Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology Dongguan 510730China Smart Manufacturing Division Hong Kong Productivity Council78 Tat Chee AvenueHong Kong 5999075China

We put forward a method of fabricating Aluminum(Al)/carbon fibers(CFs) composite sheets by the accumulative roll bonding(ARB) method. The finished Al/CFs composite sheet has CFs and pure Al sheets as sandwich and surface layers. After cross-section observation of the Al/CFs composite sheet, we found that the CFs discretely distributed within the sandwich layer. Besides, the tensile test showed that the contribution of the sandwich CFs layer to tensile strength was less than 11% compared with annealed pure Al sheet. With ex-situ observation of the CFs breakage evolution with-16%,-32%, and-45% rolling reduction during the ARB process, the plastic instability of the Al layer was found to bring shear damages to the CFs. At last, the bridging strengthening mechanism introduced by CFs was sacrificed. We provide new insight into and instruction on Al/CFs composite sheet preparation method and processing parameters.

关键词： Al/CFs composite sheet accumulative roll bonding tensile strength plastic instability carbon fiber breakage

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全球日晒行为调查研究

中华皮肤科杂志 2024年第7期57卷 672-673页

作者： Thierry Passeron Henry W. lim chee Leok Goh Hee Young Kang Fatimata Ly Akimichi Morita Jorge Ocampo-Candiani Susana Puig Sergio Schalka Wei Liu Anne-Laure Demessant-Flavigny Caroline Le Floc’h Delphine Kerob Brigitte Dreno Jean Krutmann Department of Dermatology Côte d'Azur University Nice University Hospital Center Nice France INSERM U1065 C3M Côte d'Azur University Nice France Department of Dermatology Henry Ford Health Detroit Michigan USA National Skin Centre Singapore City Singapore Department of Dermatology Ajou University School of Medicine Suwon South Korea Department of Dermatology Cheikh Anta Diop Dakar University EPS Institute of Social Hygiene Dakar Senegal Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Universidad Autonoma de Nuevo León Facultad de Medicina University Hospital “Dr. Jose E. González” Monterrey Mexico Dermatology Department Hospital Clinic de Barcelona Barcelona University Barcelona Spain Medcin Skin Research Center and Biochemistry Department Chemistry Institute of Sao Paulo University Sao Paulo Brazil Department of Dermatology The General Hospital of Air Force PLA Beijing China La Roche-Posay International Levallois-Perret France Nantes University Univ Angers INSERM Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 Nantes France IUF Leibniz Research Institute for Environmental Medicine Duesseldorf Germany Medical Faculty Heinrich-Heine-University Duesseldorf Germany

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,40... 详细信息

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,400~700nm)和红外线(700nm~1mm)也是皮肤光老化和光损伤的影响因素,可见光会导致黄褐斑等色素性疾病加重。

关键词：色素性疾病皮肤光老化光变态反应慢性损伤日光照射黄褐斑机体损伤维生素D

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儒家智德思想赋能智能时代大学生道德教育

教育文化论坛 2024年第2期16卷 77-86页

作者：孙雷林志敏拉曼大学中华研究院马来西亚吉隆坡43200 海口经济学院网络学院海南海口571100

人工智能的发展影响着人类社会的各个领域,特别是ChatGPT的出现,给教育领域带来了变革。先进的人工智能技术与海量的数据信息为教育提供了更多与更好的技术支持,然而也给学校的思想道德教育带来了前所未有的挑战。教育是兴邦之本,教育... 详细信息

人工智能的发展影响着人类社会的各个领域,特别是ChatGPT的出现,给教育领域带来了变革。先进的人工智能技术与海量的数据信息为教育提供了更多与更好的技术支持,然而也给学校的思想道德教育带来了前所未有的挑战。教育是兴邦之本,教育承担着人才培养、文化传承与社会服务等历史使命,德育是教育的重中之重。通过分析智能时代大学生的道德教育面临新的挑战,提出以儒家“智德”思想赋能“智能”时代大学生道德教育,从儒家“智德”思想中总结出五重价值:明辨是非,知耻明辱;仁者爱人,以智辅仁;学而知之,崇智明德;仁智并重,从善利他;敬德修业,知行并进。

关键词：智能时代儒家智德大学生道德教育

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A hierarchical salt-rejection strategy for sustainable and high-efficiency solar-driven desalination

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Nano Materials Science 2024年第1期6卷 38-43页

作者： Zhengyi Mao Xuliang Chen Yingxian Chen Junda shen Jianpan Huang Yuhan Chen Xiaoguang Duan Yicheng Han Kannie Wai Yan Chan Jian LU CityU-shenzhen Futian Research Institute Shenzhen518045China Department of Mechanical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Department of Material Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Department of Biomedical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideAustralia Hong Kong Branch of National Precious Metals Material Engineering Research Centre City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhen518057China

Solar steam generation(SSG)is widely regarded as one of the most sustainable technologies for seawater ***,salt fouling severely compromises the evaporation performance and lifetime of evaporators,limiting their practical ***,we propose a hierarchical salt-rejection(HSR)strategy to prevent salt precipitation during long-term evaporation while maintaining a rapid evaporation rate,even in high-salinity *** salt diffusion process is segmented into three steps—insulation,branching diffusion,and arterial transport—that significantly enhance the salt-resistance properties of the ***,the HSR strategy overcomes the tradeoff between salt resistance and evaporation ***,a high evaporation rate of 2.84 kg m^(-2) h^(-1),stable evaporation for 7 days cyclic tests in 20 wt%NaCl solution,and continuous operation for 170 h in natural seawater under 1 sun illumination were *** with control evaporators,the HSR evaporator exhibited a>54%enhancement in total water evaporation mass during 24 h continuous evaporation in 20 wt%salt ***,a water collection device equipped with the HSR evaporator realized a high water purification rate(1.1 kg m^(-2) h^(-1)),highlighting its potential for agricultural applications.

关键词： Solar water evaporation 3D printing Salt-rejection Hierarchical structures High efficiency

Facile electrochemical surface-alloying and etching of Au wires to enable high-performance substrates for surface enhanced Raman scattering

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Nano Materials Science 2024年第3期6卷 305-311页

作者： Yawen Zhan Guobin Zhang Junda shen Binbin Zhou Chenghao Zhao Junmei Guo Ming Wen Zhilong Tan Lirong Zheng Jian Lu Yang Yang Li Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina Kunming Institute of Precious Metals Sino-platinum Metals Co.Ltd.KunmingYunan ProvinceChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research Institute8 Yuexing 1st RoadShenzhen Hi-Tech Industrial ParkNanshan DistrictShenzhenChina shenzhen Key Laboratory on Power Battery Safety Research and shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Institute of High Energy Physics Beijing100049China

Surface-enhanced Raman Spectroscopy(SERS)is a nondestructive technique for rapid detection of analytes even at the single-molecule ***,highly sensitive and reliable SERS substrates are mostly fabricated with complex nanofabrication techniques,greatly restricting their practical applications.A convenient electrochemical method for transforming the surface of commercial gold wires/foils into silver-alloyed nanostructures is demonstrated in this *** substrates are treated with repetitive anodic and cathodic bias in an electrolyte of thiourea,in a one-pot one-step manner.X-rays absorption fine structure(XAFS)spectroscopy confirms that the AuAg alloy is induced at the *** unique AuAg alloyed surface nanostructures are particularly advantageous when served as SERS substrates,enabling a remarkably sensitive detection of Rhodamine B(a detection limit of 10^(-14)M,and uniform strong response throughout the substrates at 10^(-12)M).

关键词： Electrodeposition Dealloying Surface-alloyed Noble metals Surface enhanced Raman spectroscopy substrates

Relevant Visual Semantic Context-Aware Attention-Based Dialog

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Computers, Materials & Continua 2023年第8期76卷 2337-2354页

作者： Eugene Tan Boon Hong Yung-Wey Chong Tat-chee Wan Kok-lim Alvin Yau National Advanced IPv6 Centre Universiti Sains MalaysiaPenangMalaysia Lee Kong Chian Faculty of Engineering and Science(LKCFES) Universiti Tunku Abdul RahmanSungai LongSelangorMalaysia

The existing dataset for visual dialog comprises multiple rounds of questions and a diverse range of image ***,it faces challenges in overcoming visual semantic limitations,particularly in obtaining sufficient context from visual and textual aspects of *** paper proposes a new visual dialog dataset called Diverse History-Dialog(DS-Dialog)to address the visual semantic limitations faced by the existing ***-Dialog groups relevant histories based on their respective Microsoft Common Objects in Context(MSCOCO)image categories and consolidates them for each ***,each MSCOCO image category consists of top relevant histories extracted based on their semantic relationships between the original image caption and historical *** relevant histories are consolidated for each image,and DS-Dialog enhances the current dataset by adding new context-aware relevant history to provide more visual semantic context for each *** new dataset is generated through several stages,including image semantic feature extraction,keyphrase extraction,relevant question extraction,and relevant history dialog *** DS-Dialog dataset contains about 2.6 million question-answer pairs,where 1.3 million pairs correspond to existing VisDial’s question-answer pairs,and the remaining 1.3 million pairs include a maximum of 5 image features for each VisDial image,with each image comprising 10-round relevant question-answer ***,a novel adaptive relevant history selection is proposed to resolve missing visual semantic information for each ***-Dialog is used to benchmark the performance of previous visual dialog models and achieves better performance than previous ***,the proposed DSDialog model achieves an 8% higher mean reciprocal rank(MRR),11% higher R@1%,6% higher R@5%,5% higher R@10%,and 8% higher normalized discounted cumulative gain(NDCG)compared to ***-Dialog also achieves approximately 1 point improvement o

关键词： Visual dialog context-aware relevant history computer vision natural language processing

Measurement of sub-fm/Hz^(1/2) displacement spectral densities in ultrahigh-Q single-crystal microcavities with hertz-level lasers

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Photonics Research 2022年第5期10卷 1202-1209页

作者： YOON-SOO JANG JINKANG lim WENTING WANG SEUNG-WOO KIM ANATOLIY SAVCHENKOV ANDREY BMATSKO chee WEI WONG Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCalifornia 90095USA Division of Physical Metrology Korea Research Institute of Standards and Science(KRISS)Daejeon 34113Republic of Korea CACI-LGS Labs Florham ParkNew Jersey 07932USA Department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea OEwaves Inc. PasadenaCalifornia 91107USA Jet Propulsion Laboratory California Institute of TechnologyPasadenaCalifornia 91109USA

Tracing a resonance frequency of a high quality factor(Q)optical cavity facilitates subpicometer displacement measurements of the optical cavity via Pound-Drever-Hall(PDH)locking scheme,tightly synchronizing a laser frequency to the optical *** we present observations of subfemtometer displacements on a ultrahigh-Q single-crystal MgF_(2)whispering-gallery-mode microcavity by frequency synchronization between a 1 Hz cavity-stabilized laser and a resonance of the MgF_(2) cavity using PDH laser-cavity *** characterize not only the displacement spectral density of the microcavity with a sensitivity of 1.5×10^(-16) m/Hz^(1/2) over the Fourier offset frequency ranging from 15 mHz to 100 kHz but also a 1.77 nm displacement fluctuation of the microcavity over 4500 *** measurement capability not only supports the analysis of integrated thermodynamical and technical cavity noise but allows for minute displacement measurements using laser-cavity locking for ultraprecise positioning,metrology,and sensing.

关键词： synchronization displacement cavity