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Bilateral proficiency over time leads to reduced donor morbidity in living donor hepatectomy

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 459-469页

作者： Viola Huang Chao-Long Chen Yu-Hung lin Tsan-Shiun lin Chih-Che lin Shih-Ho Wang chee-Chien Yong Chih-Yi Chen Yu-Fan Cheng Liver Transplantation Center and Department of Surgery Kaohsiung Chang Gung Memorial HospitalKaohsiungTaiwan Department of General Surgery Dartmouth Hitchcock Medical CenterLebanonNew HampshireUSA Liver Transplantation Center and Department of Diagnostic Radiology Kaohsiung Chang Gung Memorial HospitalKaohsiungTaiwan

Background:Although left-lobe donation is considered safer,right-sided donor hepatectomy predominatesin adult living donor liver transplantation(LDLT).We hypothesized that bilateral proficiency with donorhepatectomy reduces overall donor ***:A retrospective review of 834 adult LDLT donors(221 left lobes)from January 2004 toDecember 2014 was performed,dividing cases into two eras based on left-graft *** within 6 months were investigated,focusing on graft side and surgical ***:The overall complication rate was 17.6%,and was higher in right-lobe *** Era 2,duringwhich left-lobe donation rates were three times higher,total complications decreased(14.7%vs.20.9%,P=0.02).A significant reduction in postoperative ascites accounted for the lower overall complication *** proportion of major biliary complications(BCs)was halved from 62.5%to 25.0%.Right-lobe donorcomplications also decreased significantly(15.8%vs.22.9%,P=0.032),demonstrating that it was not onlyincreased left-lobe donations leading to lowered complication rates,but also greater experience with donorhepatectomy in ***:Accumulating experience with bilateral donor hepatectomy leads to decreased donormorbidity and comparable outcomes for right and left lobes,further enhancing the goal of donor safety whilebalancing recipient needs.

关键词： Living donor liver transplantation(LDLT) donor safety biliary complications(BCs)

A single center analysis of long-term outcomes and survival related risk factors in liver retransplantation

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 425-443,I0011页

作者： Zhihao Li Yi Ping Sng Chao-Long Chen Chih-Che lin Shih-Ho Wang chee-Chien Yong Liver Transplantation Center and Department of Surgery Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung

Background:Liver retransplant is the only option to save a patient with liver graft ***,it is controversial due to its poor survival outcome compared to primary *** deceased organ donation in Taiwan leads to high waitlist ***,living-donor grafts offer a valuable alternative for *** study aims to analyze the single center’s outcome in living donor liver retransplantation(re-LDLT)and deceased donor liver retransplantation(re-DDLT)as well as the survival related confounding risk ***:This is a single center retrospective study including 32 adults who underwent liver retransplantation(re-LT)from June 2002 to April *** cohort was divided into a re-LDLT and a re-DDLT group and survival outcomes were *** outcomes over different periods,the effect of timing on survival,and multivariate analysis for risk factors were also demonstrated Results:Of the 32 retransplantations,the re-LDLT group(n=11)received grafts from younger donors(31.3 vs.43.75 years,P=0.016),with lower graft weights(688 vs.1,457.2 g,P<0.001)and shorter cold ischemia time(CIT)(45 vs.313 min,P<0.001).The 5-year survival was significantly better in the re-LDLT group than in the re-DDLT group(100%vs.70.8%,P=0.02).This difference was adjusted when only retransplantation after 2010 was *** analysis showed that the timing of retransplantation(early ***)did not affect patient *** analysis revealed that prolonged warm ischemia time(WIT)and intraoperative blood transfusion were related to poor long-term ***:Retransplantation with living donor graft demonstrated good long-term outcomes with acceptable complications to both recipient and *** may serve as a choice in areas lacking deceased *** timing of retransplantation did not affect the long-term *** effort should be made to reduce WIT and massive blood transfusion as they contributed to poor survi

关键词： Retransplantation living donor liver retransplantation(re-LDLT) deceased donor liver retransplantation(re-DDLT) timing of retransplantation long-term outcome

A nonparametric estimation of the infection curve

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Science China Mathematics 2011年第9期54卷 1815-1828页

作者： lin HuaZhen YIP paul S. F HUGGINS Richard M School of Statistics Southwestern University of Finance and Economics Chengdu 611130 China Social Work and Social Administration University of Hong Kong Hong Kong China Department of Mathematics and Statistics The University of Melbourne Melbourne Australia

Predicting the future course of an epidemic depends on being able to estimate the current numbers of infected ***,while back-projection techniques allow reliable estimation of the numbers of infected individuals in the more distant past,they are less reliable in the recent *** propose two new nonparametric methods to estimate the unobserved numbers of infected individuals in the recent past in an *** proposed methods are noniterative,easily computed and asymptotically normal with simple variance *** show that the proposed methods are much more robust and accurate than the existing back projection method,especially for the recent past,which is our primary *** apply the proposed methods to the 2003 Severe Acute Respiratory Syndorme(SARS) epidemic in Hong Kong.

关键词： epidemic back-projection nonparametric method infection curve

Expert insights on Malaysia’s residential solar-energy policies:shortcomings and recommendations

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Clean Energy 2022年第4期6卷 619-631页

作者： lin-Sea Lau Yuen-Onn Choong Suet-ling Ching Chooi-Yi Wei Abdelhak Senadjki chee-Keong Choong Ai-Na Seow Faculty of Business and Finance Universiti Tunku Abdul RahmanMalaysia

Malaysia has a long way before achieving the 20%renewable-energy penetration by ***,merely 2%of the country’s electricity is generated by renewable energy sources including solar *** the abundant literature about solar energy,qualitative studies that focus on experts’opinions on the weaknesses of residential solar-energy policies have received less attention,particularly in the context of *** the flaws in the existing policies would lead to creating a better policy framework for solar-energy ***,this study aims to identify the shortcomings of the current government initiatives and policies that deter solar photovoltaic adoption among households from experts’*** also provide recommendations for better future policy design and *** study employs a qualitative research approach(via semi-structured interviews)in collecting experts’*** concerns emerging from the interviews include insufficient financial support,lack of awareness programmes and subsidized electricity ***,interviewed experts suggest sufficient financial incentives,increased public awareness programmes and comprehensive legislation aimed at safeguarding consumer interests as a means to raising solar-energy adoption in the *** underlines the need for policymakers to create public awareness,provide financial support and develop regulatory measures aimed at managing solar companies for the sake of solar development in Malaysia.

关键词： qualitative study interview expert insights solar energy households policy shortcomings policy recommendations

On-treatment isolated superior ophthalmic vein thrombosis complicated with carotid cavernous fistula: a case report

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1726-1728页

作者： Yee lin Lo Kah Wei Ong Teck chee Cheng Wan Haslina Wan Abdul Halim Meng Hsien Yong Department of Ophthalmology Faculty of MedicineUniversiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia

Dear Editor, We are writing this letter to present a case of ontreatment isolated superior ophthalmic vein thrombosis(SOVT) that progressed to cavernous sinus thrombosis(CST) and further complicated with carotid cavernous fistula(CCF). SOVT is a rare but potentially lethal illness. It is normally presented with orbital congestion syndrome with proptosis, ophthalmoplegia, diplopia, and high intraocular pressure(IOP)[1]. Late detection of this disease can lead to devastating complications such as optic nerve compression。

关键词： such letter complicated

Is the time right for systematically serotyping SARS-related coronaviruses?

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hLife 2024年第1期2卷 4-5页

作者： chee Wah Tan lin-Fa Wang Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore CitySingapore Duke-NUS Medical School Singapore CitySingapore

IS THERE A NEED FOR SEROTYPING?The emergence and rapid selection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)immune escape variants have exerted significant challenges in many different ways,from public health response to vaccine boosting strategy and monitoring of herd immunity against future variants or related severe acute respiratory syndrome(SARS)related coronaviruses(SARSr-CoVs).The Omicron sub-variants,which differ substantially from the pre-Omicron variants,are circulating worldwide and continuing to evolve extensively through mutations and/or recombination predominantly in the spike protein,mainly due to immune-selective *** their phylogenetically close relationship to ancestral SARS-CoV-2,antigenically,Omicron variants are very different from the original *** is therefore very natural to raise the question whether we need a better way to classify and differentiate those CoVs which are genetically very similar,but antigenically quite *** of viruses is a common practice for many known virus groups,most notably for human papillomavirus(HPV)and dengue virus(DENV)[1,2].The concept of CoV serotypes was not new and has been applied to study the antigenicity of feline CoVs[3].The possibility of establishing distinctive serotypes for the SARS-CoV-2 virus was first raised by Simon-Loriere and Schwartz in 2022[4].Serotyping SARS-CoV-2 is expected to help more scientifically define the differences between variants and facilitate more targeted diagnostics,therapeutics,and vaccine development.

关键词： immunity SARS establishing

An unusual COVID-19 case with over four months of viral shedding in the presence of low neutralizing antibodies: a case report

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The Journal of Biomedical Research 2020年第6期34卷 470-474页

作者： Wei Chen Zhiliang Hu Changhua Yi Yun Chi Qingfang Xiong chee Wah Tan Yongxiang Yi lin-Fa Wang Clinical Research Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Nanjing infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore 169857Singapore

The ongoing coronavirus disease 2019(COVID-19)pandemic is a global public health crisis,causing social and economic disasters in many *** China,two-consecutive negative results of nucleic acid tests for SARS-CoV-2 from the respiratory samples are required to end the quarantine of COVID-19 ***,clinicians face a dilemma in case of patients with long-term viral *** report described an unusual COVID-19 case who had persistent viral RNA positivity for more than 4 months after initial illness in the presence of low neutralizing antibodies,but without prolonged clinical *** anti-viral drug treatments had no impact and there was no evidence of *** the patient was self-quarantined at home,no infection occurred to the three family members living with her for 15 to 19 *** viral culture in BSL-3 laboratory on the 102nd day after symptom onset was *** the 129th day on,8 continuous nucleic acid tests of sputum samples showed negative *** patient was discharged on 137th days since symptom *** conclusion,viral RNA shedding in the sputum of the COVID-19 patient may last over 4 *** no evidence shows the existence of infectious virus,two-consecutive negative nucleic acid tests may not be the prerequisite for ending quarantine of COVID-19 patients with prolonged viral shedding.

关键词： COVID-19 SARS-CoV-2 viral shedding neutralizing antibodies quarantine

Microwave heating as a universal method to transform confined molecules into armchair graphene nanoribbons

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Nano Research 2023年第7期16卷 10644-10651页

作者： Haoyuan Zhang Yingzhi Chen Kunpeng Tang Ziheng lin Xuan Li Hongwei Zhang Yifan Zhang Chi Ho Wong Chi Wah Leung chee Leung Mak Yuan Hu Weili Cui Kecheng Cao Lei Shi State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterGuangdong Province Key Lab of Display Material and TechnologySchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Huzhou Key Laboratory of Environmental Functional Materials and Pollution Control School of EngineeringHuzhou UniversityHuzhou 313000China Department of Industrial and Systems Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong 999077China Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai 201210China

Armchair graphene nanoribbons(AGNRs)with sub-nanometer width are potential materials for the fabrication of novel nanodevices thanks to their moderate direct band *** are usually synthesized by polymerizing precursor molecules on substrate ***,it is time-consuming and not suitable for large-scale *** can also be grown by transforming precursor molecules inside single-walled carbon nanotubes(SWCNTs)via furnace annealing,but the obtained AGNRs are normally *** this work,microwave heating is applied for transforming precursor molecules into *** fast heating process allows synthesizing the AGNRs in *** different molecules were successfully transformed into AGNRs,suggesting that it is a universal *** importantly,as demonstrated by Raman spectroscopy,aberrationcorrected high-resolution transmission electron microscopy and theoretical calculations,less twisted AGNRs are synthesized by the microwave heating than the furnace *** results reveal a route for rapid production of AGNRs in large scale,which would benefit future applications in novel AGNRs-based semiconductor devices.

关键词： armchair graphene nanoribbons(AGNRs) microwave heating single-walled carbon nanotubes(SWCNTs) Raman spectroscopy

Complete portal vein occlusion after cyanoacrylate sclerotherapy in biliary atresia treated by living donor liver transplantation with intraoperative portal vein stenting via segment 4 portal vein stump

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 313-316页

作者： Chao-Long Chen Yu-Fan Cheng Hsin-You Ou chee-Chien Yong Tsan-Shiun lin Shih-Ho Wang Chih-Che lin Allan M.Concejero Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiungTaiwan Liver Transplantation Center Department of Diagnostic RadiologyKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiungTaiwan Department of Surgery University of the Philippines College of MedicineManilaPhilippines

IntroductionLiving donor liver transplantation(LDLT)is a durable treatment for end-stage liver disease due to biliary atresia(BA)with excellent graft and patient survivals as shown in our previous study(1).Vascular complications are a major cause of graft failure in LDLT,particularly in children,where size disparity between donor and recipient vessels is often unavoidable.

关键词： liver donor biliary