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Journal of Geriatric Cardiology 2006年第1期3卷 29-34页

作者： Sze Piaw CHIN Tiong Kiam ONG chee khoon liew M.Tobias Seyfarth Fong Yean Yip ALAN Houng Bang liew Kui Hian SIM Dept of Cardiology Sarawak General Hospital Siemens Cardiac Solutions Erlangen Germany

Background and objectives The recent joint ACCF/AHA clinical competence statement on cardiac imaging with multi-detector computed tomography recommended a minimum of 6 months training and 300 contrast examinations, of which the candidate must be directly involved in at least 100 studies. Whether this is adequate to become proficient in interpretation of coronary computed tomogsignificant coronary stenosis in a center with 1 year's experience using a 64-row scanner. Methods A total of 778 patients underwent contrast-enhanced CTA between January and December 2005. Out of these patients, 301 patients also underwent contrast-enhanced conventional coronary angiography (CCA). These patients were divided into 4 groups according to the time the examination was underwent. Group Q1: first quarter of the year (n=20), Group Q2: second quarter (n=128), Group Q3: third quarter (n=134), and Group Results The sensitivity, specificity, positive, and negative predictive values were Q1 - 64%, 89%, 49% and 94%, respectively; Q2 -79%, 96%, 74% and 97%, respectively; Q3 - 78%, 96%, 74%, 97%, respectively, and Q4 - 100% for all. Conclusions In a center with formal training and high caseload, our accuracy in CTA analysis reached a plateau after 6 months experience. Test-bolus protocols produce better image quality and can improve accuracy. New centers embarking on CTA will need to overcome an initial 6-month learning curve depending upon the caseload during which time they should consider correlation with CCA.

关键词： computed tomography training angiography coronary artery disease

Assessment of left ventricular ejection fraction: comparison of two dimensional echocardiography, cardiac magnetic resonance imaging and 64-row multi-detector computed tomography

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Journal of Geriatric Cardiology 2006年第1期3卷 2-8页

作者： chee khoon liew Rapaee ANNUAR Tiong Kiam ONG Sze Piaw CHIN Tobias Seyfarth Yean Yip FONG Choon Kiat ANG Houng Bang liew Kui Hian SIM Department of Cardiology Sarawak General Hospital Sarawak Malaysia University Malaysia Sarawak Siemens Cardiac Solutions Erlangen Germany Department of Cardiology Sarawak General Hospital SarawakMalaysia

Objectives To compare left ventricular ejection fraction (LVEF) determined from 64-row multi-detector computed tomography (64-row MDCT) with those determined from two dimensional echocardiography (2D echo) and cardiac magnetic resonance imaging (CMR). Methods Thirty-two patients with coronary artery disease underwent trans-thoracic 2D echo, CMR and contrast-enhanced 64-row MDCT for assessment of LVEF within 48 hours of each other. 64-row MDCT LVEF was derived using the Syngo Circulation software; CMR LVEF was by Area Length Ejection Fraction (ALEF) and Simpson method and 2D echo LVEF by Simpson *** The LVEF was 49.13 ± 15.91% by 2D echo, 50.72 ± 16.55% (ALEF method) and 47.65 ± 16.58%(Simpson method) by CMR and 50.00 ± 15.93% by 64-row MDCT. LVEF measurements by 64-row MDCT correlated well with LVEF measured with CMR using either the ALEF method (Pearson correlation r = 0.94, P ＜0.01) or Simpson method (r = 0.92, P＜0.01). It also correlated well with LVEF measured using 2D echo (r = 0.80, P ＜ 0.01). Conclusion LVEF measurements by 64-row MDCT correlated well with LVEF measured by CMR and 2D echo. The correlation between 64-row MDCT and CMR was better than the correlation between 2D echo with CMR. Standard data set from a 64-row MDCT coronary study can be reliably used to calculate the LVEF.

关键词： ejection fraction echocardiography magnetic resonance imaging computed tomography

Feasibility and accuracy of coronary imaging in elderly patients using the 64-row multi-detector computed tomography: a correlation study with conventional coronary angiography

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Journal of Geriatric Cardiology 2006年第1期3卷 9-14页

作者： chee khoon liew Sze Piaw CHIN Tiong Kiam ONG Seyfarth Tobias Yean Yip FONG Choon Kiat ANG Houng Bang liew Rapaee ANNUAR Kui Hian SIM Deptartment of Cardiology Sarawak General Hospital SarawakMalaysia Siemens Cardiac Solutions Erlangen Germany Universitv Malaysia Sarawak Malaysia

Background Elderly patients generally have higher occurrence of coronary calcification, increased heart rate and difficulty with prolonged breath-holding. The aim of our study was to investigate the feasibility and accuracy of using 64-row multi-detector computed tomography (MDCT) in the assessment of coronary artery stenoses in elderly patients. Methods One hundred and fifty two patients with suspected or known coronary artery disease were divided into 4 groups according to their age (Group A: 40-49 years,n=34; Group B: 50-59 years, n=57; Group C: 60-69 years, n=48; Group D: 70 years and above; n=13). Coronary CT angiography (CTA) using a 64-row MDCT was performed and the findings were compared with that of conventional coronary angiography (CCA).Using axial images, multi-planar reconstructions (MPR) and maximum intensity projections (MIP), coronary segments of lumen diameter = 1.5mm were analyzed for the presence of significant stenosis (= 50% ). Results Percentages of poor image quality from coronary CTA preventing reliable correlations with CCA were 21%, 14%, 19% and 62% in Groups A to D respectively. Patients in Group D had significantly higher calcium scores compared with the other groups (P＜0.001). In patients where CTA images were of acceptable quality, percentages of accurate correlations with CCA were 89.8%, 93.4%, 86.6% and 78.0% for Groups A to D *** were no significant difference in serum creatinine, heart rate and contrast volume between the 4 groups. Conclusions The 64-row MDCT coronary angiography was less accurate and feasible for patients aged 70 years or above due to heavy coronary calcification and inability to perform a satisfactory breath-hold. However, a high diagnostic accuracy with the MDCT is possible in patients aged less than 70 years.

关键词： computed tomography angiography coronary artery disease elderly

High-resolution computed tomography in patients with atypical 'cardiac' chest pain: a study investigating patients at 10-year cardiovascular risks defined by the Framingham and PROCAM scores

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Journal of Geriatric Cardiology 2006年第1期3卷 17-21页

作者： Choon Kiat ANG Alan Yean Yip FONG Sze Piaw CHIN Tiong Kiam ONG Seyfarth M Tobias chee khoon liew Rapaee ANNUAR Houng Bang liew Kui Hian SIM Deptartment of Cardiology Sarawak General Hospital Sarawak Malaysia Siemens Medical Solutions Germany Deptartment of Cardiology Sarawak General Hospital SarawakMalaysia University Malaysia Sarawak Malaysia

Background and objective Atypical 'cardiac' chest pain (ACCP) is not usually caused by myocardial ischaemia. Current noninvasive investigations for these symptoms are not yet as accurate as invasive coronary angiography. The latest 64-row multi-detector computed tomography (MDCT) technology is non-invasive, has high specificity and negative predictive values for the detection of significant coronary disease. Our aim was to investigate if this modality can provide more information in the assessment of outpatients with ACCP in addition to established cardiovascular risk scores. Methods Seventy consecutive patients presenting to the outpatient clinic with ACCP underwent 64-row MDCT scan of the coronary arteries. They were categorized into low, medium or high risk groups based upon the Framingham and PROCAM scores. We defined a clinically abnormal MDCT scan as coronary stenosis =50% or calcium score ＞400 Agatston. Results Fifty-three (75.7%) patients did not have clinically abnormal scans. Framingham score classified 43 patients as low-risk while PROCAM classified 59 patients as low-risk. MDCT scans were abnormal for 18.6% and 22.0% of the respective low-risk group of patients. For patients with medium-to-high risk, 33.3% and 36.4% of Framingham and PROCAM patient groups respectively had abnormal MDCT scans. Conclusion MDCT adds valuable information in the assessment of patients with ACCP by identifying a significant proportion of patients categorized as low-risk to have underlying significant coronary stenosis and coronary calcification by established cardiovascular risk scores.

关键词： multi-detector computed tomography atypical 'cardiac' chest pain coronary artery disease risk stratification

Unique and conserved features of floral evocation in legumes

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Journal of Integrative Plant Biology 2014年第8期56卷 714-728页

作者： Lim chee liew Mohan B. Singh Prem L. Bhalla Plant Molecular Biology and Biotechnology Laboratory Melbourne School of Land and Environment University of Melbourne

Legumes, with their unique ability to fix atmo- spheric nitrogen, play a vital role in ensuring future food security and mitigating the effects of climate change because they use less fossil energy and produce less greenhouse gases compared with N-fertilized systems. Grain legumes are second only to cereal crops as a source of human and animal food, and they contribute approximately one third of the protein consumed by the human population. The productivityof seed crops, such as grain legumes, is dependent on flowering. Despite the genetic variation and importance of flowering in legume production, studies of the molecular pathways that control flowering in legumes are limited. Recent advances in genomics have revealed that legume flowering pathways are divergent from those of such model species as Arabidopsis thaliana. Here, we discuss the current understanding of flowering time regulation in legumes and highlight the unique and conserved features of floral evocation in legumes.

关键词： Flowering legume soybean

Need for surveillance of concomitant peripheral artery disease in patients with coronary disease: results of the AGATHA survey in Malaysia

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Journal of Geriatric Cardiology 2007年第4期4卷 195-199页

作者： Kui Hian Sim Kok Han chee Inderjit Singh Choon Kiat Ang HoungBang liew Kim Heung Tan Omar Ismail Department of Cardiology Sarawak General Hospital Sarawak Malaysia Department of Cardiology Universiti Malaya Medical Centre Petaling Jaya Malaysia Department of Cardiology Penang General Hospital Penang Malaysia

Background For patients with cardiovascular disease (CVD), co-existence of peripheral artery disease (PAD) predicts increased mortality, and such patients are also more likely to benefit from aggressive therapy. Surveillance of PAD is often neglected at health clinics. Our aim is to highlight the importance and ease of surveillance of PAD in patients with CVD. Objective To determine the prevalence of symptomatic and asymptomatic PAD in a Malaysian patient population with documented CVD. Methods and Results A total of 393 subjects with established CVD were recruited from three centres (85 women and 308 men), as part of a larger international (AGATHA) survey. PAD, determined by presence of claudicant symptoms on interview and/or abnormal ankle-brachial index (ABI) score of less than 0.9, was present in 21.4% of patients-of whom 64% were asymptomatic. Abnormal ABI is associated with higher systolic blood pressure and number of arterial beds affected. Conclusions Concomitant PAD is prevalent among CVD patients in Malaysia. ABI screening is simple and yields a high proportion of patients with extensive atherosclerosis who may require more aggressive atherosclerotic risk management.(J Geriatr Cardiol 2007;4:195-199.)

关键词： arteriosclerosis atherothrombosis Malaysia cardiovascular diseases epidemiologic factors anklebrachial index peripheral arterial disease

Convalescent plasma: A potential therapeutic option for COVID-19 patients

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Asian Pacific Journal of Tropical Medicine 2020年第11期13卷 477-486页

作者： Swee Li Ng Tsuey Ning Soon Wei Hsum Yap Kai Bin liew Ya chee Lim Long Chiau Ming Yin-Quan Tang Bey Hing Goh Biofunctional Molecule Exploratory Research Group(BMEX) School of PharmacyMonash University MalaysiaBandar SunwayMalaysia School of Biosciences Faculty of Medical and Health SciencesTaylor’s UniversitySubang JayaSelangorMalaysia Faculty of Pharmacy University of CyberjayaCyberjayaSelangorMalaysia PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences Universiti Brunei DarussalamGadongBrunei Darussalam College of Pharmaceutical Sciences Zhejiang UniversityHangzhouP.R.China

The new coronavirus disease(COVID-19)outbreak has challenged us to take unprecedented steps to bring this pandemic under *** view of the urgency of this situation,convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current *** is mainly due to the fact that convalescent plasma has been studied in a few case series with promising *** addition,on-going large clinical trials aimed to further evaluate the effectiveness,safety,and optimal dosage,duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising ***,this article aims to provide an overview of possible mechanisms of actions of convalescent plasma,its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.

关键词： Coronavirus Convalescent plasma COVID-19 SARS-COV-2 Neutralizing antibody Immunomodulation Convalescent plasma transfusion

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过渡中的日本卫生体系

医学与哲学（A） 2007年第8期28卷 9-11,23页

作者： Chan chee khoon 姚振军张斌马来西亚科学大学东北财经大学国际商务外语学院大连医科大学

主要探讨日本过渡中的医疗卫生体系。近十年间,由于日本经济持续迟滞和通货紧缩,共产资本主义下的社会平等已受到挑战,新自由主义改革已经波及到医疗保健领域,改革已势在必行。通过借鉴池上和坎贝尔的研究成果基础上,回顾了日本医疗卫... 详细信息

主要探讨日本过渡中的医疗卫生体系。近十年间,由于日本经济持续迟滞和通货紧缩,共产资本主义下的社会平等已受到挑战,新自由主义改革已经波及到医疗保健领域,改革已势在必行。通过借鉴池上和坎贝尔的研究成果基础上,回顾了日本医疗卫生体系的特征,试图为日本医疗卫生体系改革提供选择性的方案。

关键词：日本医疗卫生体系池上坎贝尔改革

Utilization of microwave steam pyrolysis to produce biochar for thermal energy storage

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Waste Disposal and Sustainable Energy 2022年第4期4卷 335-341页

作者： Wahap bin Abu Bakar Peter Nai Yuh Yek Kah Yein Cheong Augustine Chioma Affam chee Chung Wong Rock Keey liew Yie Hua Tan Su Shiung Lam Centre for Research of Innovation and Sustainable Development University of Technology SarawakNo.1Jalan University96000SibuMalaysia Centre on Technological Readiness and Innovation in Business Technopreneurship(CONTRIBUTE) University of Technology Sarawak96000SibuSarawakMalaysia NV Western PLT No.208BSecond FloorMacalister Road10400GeorgetownPenangMalaysia Department of Chemical and Energy Engineering Faculty of Engineering and ScienceCurtin University MalaysiaCDT 25098009MiriSarawakMalaysia Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia

Microwave steam pyrolysis(MSP)is an innovative thermochemical approach to converting biomass into high-quality biochar using steam to improve the dielectric heating of microwave *** shows high fixed carbon and carbon contents at a maximum temperature of 550℃in 10 *** MSP achieved a heating rate of 112℃/min from 200℃to 400℃to produce biochar ***,the thermal properties of biochar in microwave heating were investigated in this study to explore its potential as a microwave heat-absorbent *** is able to perform volumetric and controllable heating to the ***,biochar shows good microwave heat absorbency,storing and transferring heat *** temperature profile of three different sizes of biochar was investigated to examine the efficiency of biochar in heat absorption from microwave *** was found that the powder form of biochar showed a higher heat transfer rate of 40℃/min and a low cooling rate of 7.5℃/*** presented results are useful for evaluating the application of biochar as a promising medium for heat storage systems.

关键词： Microwave Steam Pyrolysis Biochar Thermal Storage

30泰铢治疗所有疾病——泰国医疗保健制度的一种尝试

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医学与哲学（A） 2007年第10期28卷 7-8,13页

作者： Chan chee khoon 杨阳（翻译）赵明杰（审阅）马来西亚科技大学马来西亚槟城不详

随着20世纪90年代民主政府的建立并实施一系列社会、经济和制度的变革以来,泰国的医疗体制也相继发生了变化,特别是30泰铢的普及医疗计划,提高了医疗服务的可及性,但是由于医疗资源配置方式的不健全,仍存在公立部门医务人员短缺、私人... 详细信息

随着20世纪90年代民主政府的建立并实施一系列社会、经济和制度的变革以来,泰国的医疗体制也相继发生了变化,特别是30泰铢的普及医疗计划,提高了医疗服务的可及性,但是由于医疗资源配置方式的不健全,仍存在公立部门医务人员短缺、私人医疗机构不断膨胀的问题,为此必须要合理规范医疗市场,避免医疗服务的两极分化。

关键词：医疗改革普及医疗计划私立机构泰国