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Process,Material,and Regulatory Considerations for 3D Printed Medical Devices and Tissue Constructs

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Engineering 2024年第5期36卷 146-166页

作者： Wei Long Ng Jia An chee kai chua Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Centre for Healthcare Education Entrepreneurship and Research@SUTD(CHEERS)Singapore University of Technology and DesignSingapore 487372Singapore

Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on *** is a highly promising technique for the fabrication of personalized medical devices or even patient-specific tissue *** type of 3D printing technique has its unique advantages and limitations,and the selection of a suitable 3D printing technique is highly dependent on its intended *** this review paper,we present and highlight some of the critical processes(printing parameters,build orientation,build location,and support structures),material(batch-to-batch consistency,recycling,protein adsorption,biocompatibility,and degradation properties),and regulatory considerations(sterility and mechanical properties)for 3D printing of personalized medical *** goal of this review paper is to provide the readers with a good understanding of the various key considerations(process,material,and regulatory)in 3D printing,which are critical for the fabrication of improved patient-specific 3D printed medical devices and tissue constructs.

关键词： 3D printing Bioprinting Biofabrication Medical devices Tissue constructs

Two-Way 4D Printing： A Review on the Reversibility of 3D-Printed Shape Memory Materials

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Engineering 2017年第5期3卷 663-674页

作者： Amelia Yilin Lee Jia An chee kai chua Singapore Centre for 3D Pr/nt/ng School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore 639798 Singapore

The rapid development of additive manufacturing and advances in shape memory materials have fueled the progress of four-dimensional （4D） printing. With the right external stimulus, the need for human interaction, sensors, and batteries will be eliminated, and by using additive manufacturing, more complex devices and parts can be produced. With the current understanding of shape memory mechanisms and with improved design for additive manufacturing, reversibility in 4D printing has recently been proven to be feasible. Conventional one-way 4D printing requires human interaction in the programming （or shapesetting） phase, but reversible 4D printing, or two-way 4D printing, will fully eliminate the need for human interference, as the programming stage is replaced with another stimulus. This allows reversible 4D printed parts to be fully dependent on external stimuli; parts can also be potentially reused after every recovery, or even used in continuous cycles-an aspect that carries industrial appeal. This paper presents a review on the mechanisms of shape memory materials that have led to 4D printing, current findings regarding 4D printing in alloys and polymers, and their respective limitations. The reversibility of shape memory materials and their feasibility to be fabricated using three-dimensional （3D） printing are summarized and critically analyzed. For reversible 4D printing, the methods of 3D printing, mechanisms used for actuation, and strategies to achieve reversibility are also highlighted. Finally, prospective future research directions in reversible 4D printing are suggested.

关键词： 4D printing Additive manufacturing Shape memory material Smart materials Shape memory alloy Shape memory polymer

Preliminary Investigation of the Reversible 4D Printing of a Dual-Layer Component

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Engineering 2019年第6期5卷 1159-1170页

作者： Amelia Yilin Lee Jia An chee kai chua Yi Zhang Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore

The rapid development of additive manufacturing and advances in shape memory materials have fueled the progress of four-dimensional (4D) printing. With increasing improvements in design, reversible 4D printing or two-way 4D printing has been proven to be feasible. This technology will fully eliminate the need for human interference, as the programming is completely driven by external stimuli, which allows 4D-printed parts to be actuated in multiple cycles. This study proposes a new reversible 4D print- ing actuation method. The swelling of an elastomer and heat are used in the programming stage, and heat is used in the recovery stage. The main focus of this study is on the self-actuated programming step. To attain control over the bending, a simple predictive model has been developed to study the degree of cur- vature. The parameters, temperature, and elastomer thickness have also been studied in order to gain a better understanding of how well the model predicts the curvature. This understanding of the curvature will provide a great degree of control over the reversible 4D-printed structure.

关键词： 4D printing Additive manufacturing Shape memory polymer Reversible 4D printing Two-way 4D printing Elastomer swelling

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3D打印与添加型制造原理与应用，第4版

国外科技新书评介 2015年第6期 18-19页

作者： chee kai chua 宁圃奇不详中国科学院电工研究所

3D打印和添加型制造正在改变着传统原型样品制作、小批量生产的模式和实施过程。采用最近出现的添加型制造方法后，那些曾经约束设计师和工程师们思维的各项限制逐渐得以突破。添加型制造和3D打印正在向多方向快速发展，越来越受到研究... 详细信息

3D打印和添加型制造正在改变着传统原型样品制作、小批量生产的模式和实施过程。采用最近出现的添加型制造方法后，那些曾经约束设计师和工程师们思维的各项限制逐渐得以突破。添加型制造和3D打印正在向多方向快速发展，越来越受到研究者、投资者、公司管理部门和政府机构青睐。人们相信添加型制造是引领下一代跨越式发展的先进技术，各类组织都在积极规划以发挥它们的巨大作用。

关键词：制造方法添加型打印 3D 应用原理小批量生产跨越式发展

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支架与组织的设计及3D打印

Engineering 2015年第2期 200-215页

作者：安佳 Joanne Ee Mei Teoh Ratima Suntornnond chee kai chua Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University

目前,组织工程学中应用3D打印工艺的情况越来越多。本文介绍3D打印技术在组织工程学应用领域的最前沿研究,尤其侧重于计算机辅助支架设计系统的开发、功能梯度支架的直接3D打印、选择性激光烧结(SLS)和熔融沉积成型(FDM)工艺建模、利用... 详细信息

目前,组织工程学中应用3D打印工艺的情况越来越多。本文介绍3D打印技术在组织工程学应用领域的最前沿研究,尤其侧重于计算机辅助支架设计系统的开发、功能梯度支架的直接3D打印、选择性激光烧结(SLS)和熔融沉积成型(FDM)工艺建模、利用微观和宏观特征进行支架间接增材制造、生物反应器的开发,以及3D/4D生物打印。本文还讨论3D打印的技术限制,进而突出新3D打印方法在组织工程学领域得到进一步改善的可能性。

关键词：快速原型制造 3D打印增材制造组织工程生物打印

Mg-based bulk metallic glasses:A review of recent developments

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Journal of Magnesium and Alloys 2022年第4期10卷 899-914页

作者： Shi Jie Bryan Bin kai Soon Fong Beng Wah chua Manoj Gupta Department of Mechanical Engineering National University of SingaporeSingapore 117576Singapore Singapore Institute of Manufacturing Technology 73 Nanyang DriveSingapore 637662Singapore

Metallic biomaterials have been widely used in the field of medical implants for replacement purposes and/or for regeneration of *** such as stainless steel(316 L),cobalt-chromium alloys and titanium alloys(Ti-6Al-4 V)are widely used as metallic implants ***,they often exhibit unsatisfactory results such as stress shielding,the release of toxic ions and are often permanent and invasive–where a second surgery is required to remove the implant once the bone is fully *** as a biomaterial have attracted much attention recently due to its excellent biocompatibility,similar mechanical properties to bone and *** other metals and bio ceramics,the ability for magnesium alloys to undergo biodegradation eliminates the requirement for a second surgery to remove the ***,the degradation of magnesium releases Mg2+ions,which stimulates metabolism as they are a cofactor in numerous numbers of *** the advantages of magnesium alloys,the rapid degradation of magnesium proved to be challenging as the implant is unable to retain its structural integrity sufficiently enough to act as an *** improve the corrosion resistance of magnesium alloys,researchers have been working on the synthesis and characterization of Mg-based bulk metallic glasses,which can significantly improve the corrosion resistance of Mg-based *** paper is a comprehensive review that compiles,analyzes and critically discusses the recent literature on the latest understanding of the processing,mechanical and biological characteristics of Mg-based bulk metallic glasses.

关键词： Magnesium Bulk metallic glass Amorphous Biomedical applications

VR and AR in human performance research―An NUS experience

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Virtual Reality & Intelligent Hardware 2020年第5期2卷 381-393页

作者： Jun-Hao YIN Chin-Boon CHNG Pooi-Mun WONG Nicholas HO Matthew chua chee-Kong CHUI Department of Mechanical Engineering National University of Singapore119077Singapore Institute of Systems Science National University of Singapore119077Singapore

With the mindset of constant improvement in efficiency and safety in the workspace and training in Singapore,there is a need to explore varying technologies and their capabilities to fulfil this *** ability of Virtual Reality(VR)and Augmented Reality(AR)to create an immersive experience of tying the virtual and physical environments coupled with information filtering capabilities brings a possibility of introducing this technology into the training process and *** paper surveys current research trends,findings and limitation of VR and AR in its effect on human performance,specifically in Singapore,and our experience in the National University of Singapore(NUS).

关键词： Human computer interaction Virtual environment Human performance

Keeping My Mandarin Alive: Lee Kuan Yew's Language Learning Experience (With Resource Materials And Dvd-rom) (English Version)

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High responsivity and fast response 8×8β-Ga_(2)O_(3)solar-blind ultraviolet imaging photodetector array

2005年

作者： chee Lay chua

ISBN: (数字)9789812701008

ISBN: (纸本)9789812564023

Learn Mandarin while you brush your teeth or shave? Read how Singapore's Minister Mentor Lee Kuan Yew does it!A Prime Minister as an interpreter? Find out when and why MM Lee had to do *** the first time, this towering figure of the island-state's politics gives a first-hand account of How he has learnt Mandarin over the last 50 years and kept it alive. He also tells When and Why he decided to learn the language, Where he got hold of the learning materials from, Whom he practises his Mandarin with and What spurs him *** Lee goes beyond these 5Ws and 1H in Keeping My Mandarin Alive, to share the agony of a mature Chinese language student and how he has overcome the difficulties — he strove to learn Mandarin only at age 32 (from 1955) and Hokkien at age 38 (from 1961).The comprehensive package also details how the English-educated MM Lee has been relating Mandarin to his master language in an effort to grasp the former and unravels how the latest technology has helped him in his *** by Dr chua chee Lay, one of MM Lee's Chinese tutors, Keeping My Mandarin Alive comprises:

关键词： Chinese language

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Science China(Technological Sciences) 2023年第11期66卷 3259-3266页

作者： SHEN GaoHui LIU Zeng TANG kai SHA ShuLin LI Lei TAN chee-Keong GUO YuFeng TANG WeiHua Innovation Center of Gallium Oxide Semiconductor(IC-GAO) College of Integrated Circuit Science and EngineeringNanjing University of Posts and TelecommunicationsNanjing 210023China National and Local Joint Engineering Laboratory for RF Integration and Micro-Assembly Technologies Nanjing University of Posts and TelecommunicationsNanjing 210023China Key Laboratory of Aerospace Information Materials and Physics(NUAA) MIITNanjing 211106China College of Physics MIIT Key Laboratory of Aerospace Information Materials and PhysicsKey Laboratory for Intelligent Nano Materials and DevicesNanjing University of Aeronautics and AstronauticsNanjing 211106China Advanced Materials Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Nansha 511458China Department of Electronic and Computer Engineering School of EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China

In this work,an 8×8 Ga_(2)O_(3)solar-blind ultraviolet photodetector array is introduced for image sensing *** 2-in wafer-scaled Ga_(2)O_(3)thin film was grown by metalorganic chemical vapor deposition technique;and the photodetector array was fabricated through ultraviolet photolithography,lift-off,and electron-beam *** addition to the high solar-blind/visible rejection ratio of 104,every photodetector cell in the array has high performance and fast response speed,such as responsivity of 49.4 A W^(-1),specific detectivity of 6.8×10^(14)Jones,external quantum efficiency of 1.9×10^(4)%,linear dynamic range of 117.8 d B,and response time of 41 ms,respectively,indicating the high photo-response performance of the ***,the photodetector array displayed uniform responsivity with a standard deviation of~6%,and presented a sensing image of low chromatic aberration,owing to the high resolution of the photodetector *** a word,this work may contribute to developing Ga_(2)O_(3)-based optoelectronic device applications.

关键词： Ga_(2)O_(3) photodetector array imaging photo-response