检索结果-南通市图书馆

Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-Smith chee h.ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental health the University of MelbourneParkville 3052Australia NICM health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the ch.nge in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on ch.nge in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPh1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An Overview of the Expert Consensus on the Prevention and Treatment of Gaming Disorder in China(2019 Edition)

引用

Neuroscience Bulletin 2020年第7期36卷 825-828页

作者： Yu-Tao Xiang Yu Jin Ling Zh.ng Lu Li Gabor S.Ungvari chee h.ng Min Zhao Wei hao Unit of Psychiatry Institute of Translational MedicineFaculty of Health SciencesUniversity of MacaoMacao 999078China Center for Cognition and Brain Sciences University of MacaoMacao 999078China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital&the Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversitySchool of Mental HealthBeijing 100088China The Affiliated Brain hospital of Guangzhou Medical University(Guangzhou huiai hospital) Guangzhou 510370China 不详

Gaming disorder has gained considerable attention worldwide,including in China[1],where epidemiological surveys have found that its prevalence is as high as 17%[2].The Bureau of Disease Control and Prevention run by the National health and health Commission in China recently released an expert consensus[2]that systematically describes the definition,clinical presentation,assess-assessment,diagnosis,treatment,rehabilitation,and related areas of gaming disorder.

关键词： gained Expert diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Process,Material,and Regulatory Considerations for 3D Printed Medical Devices and Tissue Constructs

引用

Engineering 2024年第5期36卷 146-166页

作者： Wei Long ng Jia Anb chee Kai Chua Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Centre for healthcare Education Entrepreneurship and Research@SUTD(CHEERS)Singapore University of Technology and DesignSingapore 487372Singapore

Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on *** is a highly promising technique for the fabrication of personalized medical devices or even patient-specific tissue *** type of 3D printing technique has its unique advantages and limitations,and the selection of a suitable 3D printing technique is highly dependent on its intended *** this review paper,we present and highlight some of the critical processes(printing parameters,build orientation,build location,and support structures),material(batch-to-batch consistency,recycling,protein adsorption,biocompatibility,and degradation properties),and regulatory considerations(sterility and mechanical properties)for 3D printing of personalized medical *** goal of this review paper is to provide the readers with a good understanding of the various key considerations(process,material,and regulatory)in 3D printing,which are critical for the fabrication of improved patient-specific 3D printed medical devices and tissue constructs.

关键词： 3D printing Bioprinting Biofabrication Medical devices Tissue constructs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microbleeds in fronto-subcortical circuits are predictive of dementia conversion in patients with vascular cognitive impairment but no dementia

引用

Neural Regeneration Research 2018年第11期13卷 1913-1918页

作者： Yang-Kun Chen Wei-Min Xiao Wei Li Zhuo-Xin Ni Yong-Lin Liu Li Xu Jian-Feng Qu chee h.ng Yu-Tao Xiang Department of Neurology Dongguan People’s Hospital(Affiliated Dongguan HospitalSouth Medical University) Faculty of Neurology Guangdong Medical University Department of Psychiatry University of Melbourne Faculty of health Sciences University of Macao

Cerebral small vessel disease（CSVD） is a common etiology of vascular cognitive impairment with no dementia（V-CIND）. Studies have revealed that cerebral microbleeds（CMBs）, a feature of CSVD, contribute to cognitive impairment. however, the association between CMBs and dementia conversion in individuals with V-CIND is still unclear. here, we analyzed the predictive role of CMBs in the conversion from V-CIND to dementia in CSVD patients. We recruited and prospectively assessed 85 patients with CSVD and V-CIND. V-CIND was evaluated using a series of comprehensive neuropsychological scales, including the Chinese version of the Montreal Cognitive Assessment and the Clinical Dementia Rating. MRI assessments were used to quantify lacunar infarcts, white matter hyperintensities, CMBs, and medial temporal lobe atrophy. Eighty-two of the 85 patients completed the assessment for dementia conversion at a 1-year follow-up assessment. Multivariate logistic regression analyses were conducted to examine independent clinical and MRI variables associated with dementia conversion. Twenty-four patients（29.3%） had converted to dementia at the 1-year follow-up, and these individuals had significantly more CMBs in the fronto-subcortical circuits. Multivariate logistic regression analyses revealed that the patients with CMBs in the fronto-subcortical circuits（odds ratio = 4.4; 95% confidence interval： 1.602-12.081, P = 0.004） and 5 or more CMBs overall（odds ratio = 17.6, 95% confidence interval： 3.23-95.84, P = 0.001） had a significantly increased risk of dementia at the 1-year follow-up. These findings indicate that CMBs in the fronto-subcortical circuits may be predictive of dementia conversion in CSVD patients with V-CIND, and thus extend the clinical significance of CMBs.

关键词： cerebrovascular disease stroke cerebral microbleeds cognitive impairment fronto-subcortical circuits small vessel disease whitematter hyperintensities lacunar infarct magnetic resonance imaging subcortical ischemic vascular disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adjunctive melatonin for tardive dyskinesia in patients with schizophrenia： a meta-analysis

引用

上海精神医学 2017年第3期29卷 129-136页

作者：孙辰辉郑伟杨欣湖蔡东滨 chee h.ng Gabor S.UngVARI 李海燕吴玉洁宁玉萍项玉涛 Qingdao Mental health Center The Affiliated Brain hospital of Guangzhou Medical University (Guangzhou huiai hospital) Clinics of Chinese Medicine the First Clinical Medical College of Guangzhou University of Chinese Medicine Department of Psychiatry University of Melbourne The University of Notre Dame Australia/Marian Centre School of Psychiatry & Clinical Neurosciences University of Western Australia Unit of Psychiatry Faculty of Health Sciences University of Macao

背景:迟发性运动障碍(TD)的临床特征是异常不自主运动。TD具有严重的不可逆的致残性和社会功能损害。目的 :此荟萃分析基于随机对照试验(RCTs)文献系统评估褪黑素对精神分裂症患者迟发性运动障碍的临床疗效和安全性。方法 :两位独立评... 详细信息

背景:迟发性运动障碍(TD)的临床特征是异常不自主运动。TD具有严重的不可逆的致残性和社会功能损害。目的 :此荟萃分析基于随机对照试验(RCTs)文献系统评估褪黑素对精神分裂症患者迟发性运动障碍的临床疗效和安全性。方法 :两位独立评估者从以下数据库对相关的临床随机对照试验(RCT)文献进行检索(万方数据、中国知网(CNKI)、中国生物医学文摘数据库和PubM ed、PsycI NFO、Embase、Cochrane Library数据库),检索时间截止于2017年6月8日。以TD症状严重程度为主要结局指标,采用Rev Man 5.3版本进行统计分析,对RCTs的质量评估采用Cochrane风险评估偏倚和Jadad量表来评估各种偏倚的风险性。采用GRADE(Grades of Recommendation,Assessment,Development,and Evaluation)系统推荐分级方法对meta-分析结果的整体证据质量水平进行分级评价。结果 :最终筛选确定4个RCTs(n=130)。3个RCTs采用双盲法,1个RCT单盲,根据Cochrane风险评估偏倚和Jadad量表显示3个RCTs的疗效评估指标的证据质量被评定为"高质量"。与对照组相比,根据不自主运动量表(AIMS)评定褪黑素可改善TD严重程度(4个RCTs,n=130,加权平均差值(WMD):-1.52(95%CI:-3.24,0.20),p=0.08;I2=0%),但尚没有达到显著差异。根据等级方法,改善TD症状的meta分析结果的整体证据质量被评为"低",而关于不良反应和认知损害方面则数据太少。结论 :荟萃分析表明,褪黑素或可改善精神分裂症TD症状。但仍有待今后更高质量和更大样本的RCTs验证。

关键词：迟发性运动障碍抗精神病药褪黑素荟萃分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regional homogeneity and functional connectivity analysis of restingstate magnetic resonance in patients with bipolar Ⅱ disorder

Regional homogeneity and functional connectivity analysis of...

引用

2020年浙江省医学会精神病学学术大会浙江省医师协会精...

作者：徐哲 Jianbo Lai haorong Zh.ng chee h.ng Peng Zh.ng DongrongXu Shaohua hu 湖州市第三人民医院 Department of Psychiatry the First Affiliated HospitalZhejiang University School of Medicine The Key Laboratory of Mental Disorder Management in Zhejiang Province The Sh.nghai Key Laboratory of Magnetic Resonance & Institute of Cognitive Neuroscience East China Normal University Department of Psychiatry University of Melbourne Mental health Center Zhejiang Xiaoshan Hospital Molecular Imaging and Neuropathology Division and MRI Unit Department of PsychiatryColumbia University and New York State Psychiatric Institute

Objective:To explore the characteristics of local brain activity in patients with bipolar depression and its correlation with clinical ***:In accord with the DSM-Ⅳ of bipolar disorder,21 patients were enrolled while 21 healthy controls were matched with similar gender,age,level of educations.A 3.0 T GE magnetic resonance scanner was used to collect the imaging data,and a two-sample t-test was *** homogeneity(Reho)method was used to estimate regional activation patterns through indices of localized *** values were compared between ***-based correlation analysis was used to analyze functional ***:In the patients’ group,Reho(regional homogeneity) values of resting state functional magnetic resonance imaging(rsfMRI) data on the right cerebellum 4 and 5 area,cerebellar vermis 6 area,left insula were positively correlated with hAMD *** values on the left of the triangle of inferior frontal gyrus,right inferior frontal gyrus of orbital region showed negative correlation with hAMD *** value of Reho in the patients ’ group was positively correlated with the patients’ hAMA score in the right fusiform gyrus,and negative correlation was found in the left *** Reho value of the patients’ group was negatively correlated with the patients’ MADRS score in regions of the *** value of Reho in patients’ group was significantly reduced in the right central ***:The depression and anxiety severity of bipolar depression patients may be associated with the consistency activity of left insula,right cerebellum,and cerebellar vermis related area,fusiform *** addition,the Reho of the midbrain neurons activity may be associated with depression level of patients with bipolar Ⅱ disorder.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

抑郁症状快速评定量表自评版(QIDS-SR)应用于hBV相关肝脏疾病患者的心理测量学特性（英文）

引用

上海精神医学 2017年第1期29卷 15-20页

作者：刘梅王园园赵景郑素军 Gabor S.UngVARI chee h.ng 段钟平项玉涛 Artificial Liver Center Beijing YouAn HospitalCapital Medical University Unit of Psychiatry Faculty of Health SciencesUniversity of Macao The University of Notre Dame Australia/Marian Centre School of Psychiatry & Clinical Neurosciences University of Western Australia Department of Psychiatry University of Melbourne

背景:乙型肝炎病毒(hBV)感染伴发抑郁症是一种常见的现象。建立精确并且有时效的工具,用以评估hBV患者抑郁症状,对研究和临床实践是非常重要的。目的:这项研究测试了抑郁症状快速评定量表自评版(QIDS-SR)在乙型肝炎患者中使用的心理测... 详细信息

背景:乙型肝炎病毒(hBV)感染伴发抑郁症是一种常见的现象。建立精确并且有时效的工具,用以评估hBV患者抑郁症状,对研究和临床实践是非常重要的。目的:这项研究测试了抑郁症状快速评定量表自评版(QIDS-SR)在乙型肝炎患者中使用的心理测量学特性。方法:这项研究招募了245名患有乙型肝炎病毒和相关肝病的抑郁症患者。采用蒙特玛莉抑郁评定量表(MADRS)和QIDS-SR评估抑郁症状的严重程度。结果:QIDS-SR的内部一致性((Cronbachα)为0.796.其总分与MADRS总分显著相关r=0.698,p<0.001)。探索性因素分析的QIDS-SR显示一维测量性能结论:QIDS-SR(中文版)在乙型肝炎患者中有良好的心理测量学特性,并且在评估临床抑郁症方面是有用的。

关键词：抑郁症状心理测量学特性 QIDS-SR 乙型肝炎病毒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Safety and efficacy of Kaffes intraductal self-expanding metal stents in the management of post-liver transplant anastomotic strictures

引用

World Journal of Transplantation 2024年第2期14卷 88-98页

作者： chee Lim Jonathan ng Babak Sarraf Rhys Vaughan Marios Efthymiou Leonardo Zorron Ch.ng Tao Pu Sujievvan Chandran Department of Gastroenterology and hepatology Austin HealthMelbourne HeidelbergVIC 3084Australia Melbourne Medical School The University of MelbourneMelbourne ParkvilleVIC 3052Australia

BACKGROUND Endoscopic management is the first-line therapy for post-liver-transplant anas-tomotic *** the optimal duration of treatment with plastic stents has been reported to be 8-12 months,data on safety and duration for metal stents in this setting is *** to limited access to endoscopic retrograde cholan-giopancreatography(ERCP)during the coronavirus disease 2019 pandemic in our centre,there was a ch.nge in practice towards increased usage and length-of-stay of the Kaffes biliary intraductal self-expanding stent in patients with suitable *** was mainly due to the theoretical benefit of Kaffes stents allowing for longer indwelling periods compared to the traditional plastic *** Adult liver transplant recipients aged 18 years and above who underwent ERCP were retrospectively identified during a 10-year period through a database *** admissions post-Kaffes stent insertion were identified manually through electronic and scanned medical *** main outcome was the incidence of complications when stents were left indwelling for 3 months vs 6 *** efficacy was calculated via rates of stricture recurrence between patients that had stenting courses for≤120 d or>120 *** During the study period,a total of 66 ERCPs with Kaffes insertion were performed in 54 patients throughout their stenting *** 33 ERCPs,the stent was removed or exch.nged on a 3-month *** pancreatitis,perfor-ations or deaths *** post-ERCP complications were similar between the 3-month(abdominal pain and intraductal migration)and 6-month(abdominal pain,septic shower and embedded stent)groups-6.1%vs 9.1%respectively,P=*** strictures resolved at the end of the stenting course,but the stenting course was variable from 3 to 22 *** recurrence rate for stenting courses lasting for up to 120 d was 71.4%and 21.4%for stenting courses of 121 d or over(P=0.03).There were 28 patients that were treated with a sin

关键词： Liver transplantation Cholangiopancreatography Endoscopic retrograde Constriction Pathologic Self expandable metallic stents Bile duct diseases Cholestasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of laser parameters on the microstructures and surface properties in laser surface modification of biomedical magnesium alloys

引用

Journal of Magnesium and Alloys 2024年第1期12卷 72-97页

作者： chee Ying Tan Cuie Wen hua Qian Ang School of Engineering RMIT UniversityMelbourneVictoria 3001Australia

Biodegradable implants from magnesium(Mg)alloys have emerged in the biomedical field especially in the orthopedic and cardiovascular stent applications owing to their low density,high specific strength,excellent machinability,good biocompatibility,and *** primary shortcoming of Mg-based implants is their low corrosion resistance in the physiological environment,which results in premature mechanical integrity loss before adequate healing and the production of excessive hydrogen gas,which is harmful to the body tissues and negatively affects the biocompatibility of the *** surface modification has recently received attention because it can improve the surface properties such as surface chemistry,roughness,topography,corrosion resistance,wear resistance,hydrophilicity,and thus cell response to the surface of the *** composition and microstructures including textures and phases of laser-treated surfaces depend largely on the laser processing parameters(input laser power,laser scan velocity,frequency,pulse duration,pressure,gas circulation,working time,spot size,beam focal position,and laser track overlap)and the thermophysical properties of the substrate(solubility,melting point,and boiling point).This review investigates the impacts of various laser surface modification techniques including laser surface melting,laser surface alloying,laser cladding,laser surface texturing,and laser shock peening,and highlights their significance in improving the surface properties of biodegradable Mg alloys for implant ***,we explore how different laser process parameters affect its composition,microstructure,and surface properties in each laser surface modification technique.

关键词： Biocompatibility Biodegradability Corrosion Implant applications Laser surface modification Magnesium alloys

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gut microbiota in bipolar disorder:where are we now?

Gut microbiota in bipolar disorder:where are we now?

引用

2020年浙江省医学会精神病学学术大会浙江省医师协会精...

作者： Peifen Zh.ng Jiajun Jiang Lingling Wu Caixi Xi Xingle Gao Danhua Zh.ng Jianbo Lai chee h.ng Shaohua hu

Bipolar disorder(BD) is characterized by recurrent episodes of depression and hypomania or *** to lack of definite pathogenesis and specific markers,the diagnosis of BD is challenging as it can easily be misdiagnosed as other mental diseases such as major depressive disorder(MDD) or schizophrenia(SZ).Further,the efficacy of standard treatments for BD is limited and recovery rates are *** evidences indicate that in addition to genetics,environmental factors contribute to the pathophysiology of *** terms of environmental factors involved in the occurrence and development of BD,recent studies have found that ch.nges in the diversities and compositions of gut microbiota in patients with BD are evident and can further moderate mood,cognition and behaviors mainly through the pathway known as the ’gut-brain axis’(GBA).Therefore,this review focuses on the mechanisms of GBA and explores its relationship with the pathogenesis of *** overview of previous studies concerning gut microbiota with BD,MDD and SZ is provided to discriminate the *** that many factors such as dietary habits,probiotics or prebiotics,fecal bacteria transplantation or exercising as well as some antipsychotic drugs influencing the state of the gut microbiota,we also discuss these factors with the aim of exploring the potential adjuvant treatments for BD.

关键词： bipolar disorder gut microbiota gut-brain axis treatment

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：