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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi Min Li Jiazhi chen Zhuyong Wang Huantao Wen ming Zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

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剪切波速和含水率双指标评价黄土震陷

地震工程学报 2017年第2期39卷 329-335页

作者：张晴毅李明永王峻苏永奇陈永明马紫娟中国地震局兰州地震研究所甘肃兰州730000 中国地震黄土地震工程重点实验室甘肃兰州730000

为了研究地震荷载作用下黄土场地的震陷预测问题,以兰州黄土为研究对象来分析剪切波速和含水率与震陷系数的关系,并分别得出拟合函数关系。通过分析剪切波速和含水率在震陷过程中的内在联系,建立剪切波速和含水率双指标预测黄土震陷系... 详细信息

为了研究地震荷载作用下黄土场地的震陷预测问题,以兰州黄土为研究对象来分析剪切波速和含水率与震陷系数的关系,并分别得出拟合函数关系。通过分析剪切波速和含水率在震陷过程中的内在联系,建立剪切波速和含水率双指标预测黄土震陷系数的方法,并依据该方法预测永登地震区黄土场地震陷量。研究结果表明:在一定的剪切波速区间内,震陷系数随着含水率的增加而增大;在一定的含水率区间内,震陷系数随着剪切波速的增加而减小。同时提出剪切波速可以反映黄土不因外部条件而变化的潜在震陷能力为绝对震陷能力的概念,相应的震陷系数称为绝对震陷系数,含水率影响潜在震陷能力的释放。通过震害实例计算验证剪切波速和含水率双指标预测方法的可行性。

关键词：黄土震陷剪切波速含水率绝对震陷系数

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阶梯溢流坝水流数值模拟及消能分析

灌溉排水学报 2006年第2期25卷 68-71页

作者：陈永明吉庆丰扬州大学水利科学与工程学院江苏扬州225009

利用k-ε紊流模型模拟了带有曲线自由表面的阶梯溢流坝和非阶梯溢流坝的紊流流场,采用流体体积分数法(VOF法)来确定自由表面。通过数值模拟,得到了2种溢流坝水流的较为合理的速度场,比较了二者的消能效果。模拟结果表明,阶梯溢流坝消能... 详细信息

利用k-ε紊流模型模拟了带有曲线自由表面的阶梯溢流坝和非阶梯溢流坝的紊流流场,采用流体体积分数法(VOF法)来确定自由表面。通过数值模拟,得到了2种溢流坝水流的较为合理的速度场,比较了二者的消能效果。模拟结果表明,阶梯溢流坝消能效果更好,阶梯溢流坝的消能率比非阶梯溢流坝的消能率高约17%。

关键词： k-ε模型阶梯溢流坝自由表面消能效果

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li Xing cheng Peiqiang Su yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Merging polymers of intrinsic microporosity and porous carbon-based zinc oxide composites in novel mixed matrix membranes for efficient gas separation

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Green Energy & Environment 2025年第1期10卷 203-213页

作者： Muning chen Jiemei Zhou Jing Ma Weigang Zheng Guanying Dong Xin Li Zhihong Tian Yatao Zhang Jing Wang yong Wang School of Chemical Engineering Zhengzhou UniversityZhengzhou450001HenanChina State Key Laboratory of Materials-Oriented Chemical Engineering and College of Chemical Engineering Nanjing Tech UniversityNanjing211816JiangsuChina Singapore Membrane Technology Centre Nanyang Environment and Water Research InstituteNanyang Technological UniversitySingapore637141Singapore Engineering Research Center for Nanomaterials Henan UniversityKaifeng475004HenanChina State Key Laboratory of Coking Coal Resources Green Exploitation Zhengzhou UniversityZhengzhou 450001China School of Energy and Environment Southeast UniversityNanjing210096JiangsuChina

Mixed matrix membranes(MMMs)have demonstrated significant promise in energy-intensive gas separations by amalgamating the unique properties of fillers with the facile processability of ***,achieving a simultaneous enhancement of permeability and selectivity remains a formidable challenge,due to the difficulty of achieving an optimal match between polymers and *** this study,we incorporate a porous carbon-based zinc oxide composite(C@ZnO)into high-permeability polymers of intrinsic microporosity(PIMs)to fabricate *** dipole–dipole interaction between C@ZnO and PIMs ensures their exceptional compatibility,mitigating the formation of non-selective voids in the resulting ***,C@ZnO with abundant interconnected pores can provide additional low-resistance pathways for gas transport in *** a result,the CO_(2) permeability of the optimized C@ZnO/PIM-1 MMMs is elevated to 13,215 barrer,while the CO_(2)/N_(2) and CO_(2)/CH4 selectivity reached 21.5 and 14.4,respectively,substantially surpassing the 2008 Robeson upper ***,molecular simulation results further corroborate that the augmented membrane gas selectivity is attributed to the superior CO_(2) affinity of C@*** summary,we believe that this work not only expands the application of MMMs for gas separation but also heralds a paradigm shift in the application of porous carbon materials.

关键词： Mixed matrix membranes Polymers of intrinsic microporosity CO_(2)separation Porous carbon materials

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中国西北黄土地区地震滑坡基本特征

地震研究 2006年第3期29卷 276-280页

作者：陈永明石玉成中国地震局地震预测研究所兰州创新基地中国地震局兰州地震研究所兰州730000

针对西北黄土地区地震滑坡灾害严重的现象,对1654年天水南8.0级、1718年通渭7.5级、1920年海原8.5级和1927年古浪8.0级地震诱发的147个典型黄土地震滑坡进行了研究,分析了黄土地震滑坡的主要类型和基本特征,为黄土地区地震滑坡灾害的预... 详细信息

针对西北黄土地区地震滑坡灾害严重的现象,对1654年天水南8.0级、1718年通渭7.5级、1920年海原8.5级和1927年古浪8.0级地震诱发的147个典型黄土地震滑坡进行了研究,分析了黄土地震滑坡的主要类型和基本特征,为黄土地区地震滑坡灾害的预防提供了科学依据。

关键词：黄土地震滑坡滑坡类型发育特征

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兰州地区现代应力场的构造解析

西北地震学报 2007年第1期29卷 84-87,93页

作者：陈永明石玉成中国地震局兰州地震研究所

在对兰州地区兴隆山北缘断裂、白杨树沟断裂和西湾-雷庄断裂等的活动性研究的基础上,根据断裂擦痕斜角资料,结合区域其他构造应力场资料,应用构造应力解析方法计算了兰州的构造应力场。研究结果表明:①兰州地区区域构造应力场主压应力... 详细信息

在对兰州地区兴隆山北缘断裂、白杨树沟断裂和西湾-雷庄断裂等的活动性研究的基础上,根据断裂擦痕斜角资料,结合区域其他构造应力场资料,应用构造应力解析方法计算了兰州的构造应力场。研究结果表明:①兰州地区区域构造应力场主压应力方向总体在NE到近EW向的范围内;②现今构造应力场继承了更新世以来的构造应力场;③深部和表层构造应力场基本一致;④区域构造运动是以水平构造应力为主导的。

关键词：兰州地区应力场构造解析擦痕

29-VI(T)1780型空气预热器离合器翻板原因分析及其起动回路改造

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热力发电 2005年第5期34卷 59-60页

作者：周宏亮陈永明妈湾发电总厂广东深圳518054

分析了妈湾发电总厂1～4号锅炉空气预热器减速机超越离合器多次出现翻板的原因,提出了修改空气预热器起动程序和改动起动方式的措施。实施后,空气预热器运行完全正常,再未发生过减速机翻板的事故,为其它电厂同型空气预热器的技术改造提... 详细信息

分析了妈湾发电总厂1～4号锅炉空气预热器减速机超越离合器多次出现翻板的原因,提出了修改空气预热器起动程序和改动起动方式的措施。实施后,空气预热器运行完全正常,再未发生过减速机翻板的事故,为其它电厂同型空气预热器的技术改造提供了先例及借鉴。

关键词：空气预热器减速机离合器翻板技术改造

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词语境中汉语歧义词多个意义的加工过程

湖北大学学报（哲学社会科学版） 2006年第6期33卷 801-805页

作者：周治金陈永明华中科技大学教育科学研究院湖北武汉430074 中国科学院心理研究所北京100122

两个实验利用词语境,分别探讨汉语同形歧义词(homographs)和同音歧义词(homophones)多个意义的加工过程。实验采用词汇判断任务,被试为128名中国农业大学和北京科技大学的大学生。实验结果表明:(1)语境词可以提高汉语同形歧义词与语境... 详细信息

两个实验利用词语境,分别探讨汉语同形歧义词(homographs)和同音歧义词(homophones)多个意义的加工过程。实验采用词汇判断任务,被试为128名中国农业大学和北京科技大学的大学生。实验结果表明:(1)语境词可以提高汉语同形歧义词与语境一致的次要意义的激活水平。(2)在汉语同音歧义词多个意义的加工过程中,语境词既可以抑制同音歧义词的不适当意义,即阻止其激活;也可以促进同音歧义词适当意义的激活。(3)歧义词相对意义频率对汉语同形歧义词和同音歧义词多个意义的加工过程有影响。

关键词：同形歧义词同音歧义词激活抑制