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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua Li weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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人不是物:社会认知的稽古维新

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心理学报 2025年第1期57卷 173-189页

作者：董达陈巍绍兴文理学院心理学系大脑、心智与教育研究中心浙江绍兴312000 中国人民大学哲学与认知科学交叉平台北京100080

当代社会认知的理论版图可分为经典概念工具箱与正在与之对抗的新概念工具两部分。经考证,理论论和模拟论等经典概念工具集中诞生于1980年代的美国认知科学界,可以被视为1956认知革命蔓延至社会心理学领域的产物,而新概念工具可以被视... 详细信息

当代社会认知的理论版图可分为经典概念工具箱与正在与之对抗的新概念工具两部分。经考证,理论论和模拟论等经典概念工具集中诞生于1980年代的美国认知科学界,可以被视为1956认知革命蔓延至社会心理学领域的产物,而新概念工具可以被视为与第二代认知革命相适合的替代理论。历史上,社会心理学接受了认知主义的“物”的抽象认知原理,也全盘接受了它带来的理论负荷,即对“人”的感知被还原为对“物”的感知,并且隶属于后者。然而,基于“物”的抽象认知原理始终无法与社会认知的以“人”为本的实践经验相结合,也未能实现该领域的自治。事实上,这一理论困难并非一直存在于“社会认知”的历史路径中,至少在以Heider为标志性人物的1950年代早期社会认知中便不是这样。Heider“人不是物”理论体系在个体层面上包括知觉实在论、事件归因和生命性−非生命性范畴区分三个部分,但是第三个理论部件彼时囿于作者主题侧重、证据不足、技术匮乏等多种原因未能完成。结合当代来自演化和比较的、行为和发展的以及神经通路假设的新证据,通过重新发掘并最终完整构建了“人不是物”论题,尝试为当代社会认知理论困难提供一个建设性意见。

关键词：社会认知人的感知认知革命生命性主体间性

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou wei chen Aidong Wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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凡纳滨对虾肌质钙结合蛋白纯化鉴定、理化特性及抗原表位分析

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食品科学 2025年第2期46卷 30-37页

作者：陈伟周军君陈雅纯贾英民马爱进北京工商大学食品与健康学院北京100048

以凡纳滨对虾(Penaeus vannamei)为原料,分离纯化和鉴定过敏原肌质钙结合蛋白(sarcoplasmiccalcium-binding protein,SCP),对其理化性质(免疫活性、热稳定性、pH值稳定性及消化稳定性)、二级结构和抗原表位进行研究。结果表明:采用蛋白... 详细信息

以凡纳滨对虾(Penaeus vannamei)为原料,分离纯化和鉴定过敏原肌质钙结合蛋白(sarcoplasmiccalcium-binding protein,SCP),对其理化性质(免疫活性、热稳定性、pH值稳定性及消化稳定性)、二级结构和抗原表位进行研究。结果表明:采用蛋白粗提、硫酸铵分级沉淀、阴离子交换层析等步骤纯化得到的蛋白分子质量为21.6 kDa,经鉴定,该蛋白为凡纳滨对虾SCP,肽段覆盖率达93.26%。凡纳滨对虾SCP具有较强的免疫活性,在热处理温度≥65℃和强酸强碱条件下免疫活性减弱;SCP对肠液消化具有较强的稳定性,而对胃液消化稳定性较差。凡纳滨对虾SCP的二级结构中α-螺旋、β-折叠、β-转角和无规卷曲的相对含量分别为26%、16.9%、17.5%、39.6%。利用生物信息学工具结合免疫学技术最终预测识别出8条凡纳滨对虾SCP抗原表位。

关键词：凡纳滨对虾肌质钙结合蛋白稳定性抗原表位

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河口海岸的“颜值”评价:环境亲民指标研究

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生态经济 2025年第1期41卷 52-59页

作者：张懿璇张宇轩陈唯中国环境科学研究院北京100012

当前是美丽中国建设的关键时期。美丽中国要坚持以人民为中心,如何突出人民至上、让工作成效体现在人民群众直观感受上,将人民群众直观感受纳入相关考核与评价指标,是美丽中国建设的新任务和新挑战。论文从设计制定水环境的“亲民指标... 详细信息

当前是美丽中国建设的关键时期。美丽中国要坚持以人民为中心,如何突出人民至上、让工作成效体现在人民群众直观感受上,将人民群众直观感受纳入相关考核与评价指标,是美丽中国建设的新任务和新挑战。论文从设计制定水环境的“亲民指标”入手,以亲水空间具备的感性工学特征为基础,采用感性工学方法设计亲民指标,能够直观地体现水环境的用户满意度,有助于确定水环境治理和亲水空间的社会资源价值,进一步丰富和改善水环境的社会功能。同时,感性工学方法也能够应用在环保设施公众开放等公众参与并获取情感体验的设施和项目中,有助于全面把握公众体验、提高公众满意度,形成公众与生态环境部门积极互动的良性循环,共同促进生态环境治理体系建设。

关键词：感性工学亲水空间 Kano模型亲民指标河口海岸美丽中国建设

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An amorphous carbon-graphite composite cathode for long cycle life rechargeable aluminum ion batteries

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Journal of Materials Science & Technology 2018年第6期34卷 983-989页

作者： Jiang wei wei chen Demin chen Ke Yang University of Chinese Academy of Sciences Beijing 100049 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Natural graphite is investigated as the cathode for aluminum ion batteries in recent years. However, some drawbacks of the natural graphite such as severe volume swelling shorten its lifetime, In this work, we prepared a composite material by depositing an amorphous carbon on the graphite paper, The composite was used as a cathode to study the electrochemical performance in aluminum ion batteries. The charge/discharge results showed that the composite could exhibit a longer cycle life than the graphite paper, Electrochemical analyses demonstrated that the interface between the amorphous carbon and the graphite paper made a major contribution to the improvement of the cycling stability.

关键词： Amorphous carbon Graphite paper Aluminum ion batteries Cathode Ionic liquid Interface Phase equilibrium

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Anomalous Andreev reflection on a torus-shaped Fermi surface

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Science China(Physics,Mechanics & Astronomy) 2021年第6期64卷 2-7页

作者： wei Luo wei chen Dingyu Xing National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210093China School of Science Jiangxi University o f Science and TechnologyGanzhou 341000China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Andreev reflection(AR)refers to the electron-hole conversion at the normal metal-superconductor *** a threedimensional metal with a spherical Fermi surface,retro(specular)AR can occur with the sign reversal of all three(a single)components of particle ***,we predict a novel type of AR with the inversion of two velocity components,dubbed"anomalous Andreev reflection"(AAR),which can be realized in a class of materials with a torus-shaped Fermi surface,such as doped nodal line *** its toroidal circle perpendicular to the interface,the Fermi torus doubles the AR channels and generates multiple AR *** particular,the AAR and retro AR are found to dominate electron transport in the light and heavy doping regimes,*** show that the AAR visibly manifests itself as a ridge structure in the spatially resolved nonlocal conductance,in contrast to the peak structure for the retro *** work opens a new avenue for the AR spectroscopy and offers a clear transport signature of the torus-shaped Fermi surface.

关键词： nodal line semimetal Andreev reflection Fermi surface

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Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第1期 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan Zheng Hongqiang Li wei chen Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

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Sliding-Mode-Based Attitude Tracking Control of Spacecraft Under Reaction Wheel Uncertainties

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IEEE/CAA Journal of Automatica Sinica 2023年第6期10卷 1475-1487页

作者： wei chen Qinglei Hu the School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China. The Beihang Hangzhou Innovation Institute Yuhang Hangzhou 310023China

The attitude tracking operations of an on-orbit spacecraft with degraded performance exhibited by potential actuator uncertainties(including failures and misalignments) can be extraordinarily challenging. Thus, the control law development for the attitude tracking task of spacecraft subject to actuator(namely reaction wheel) uncertainties is addressed in this paper. More specially, the attitude dynamics model of the spacecraft is firstly established under actuator failures and misalignment(without a small angle approximation operation). Then, a new non-singular sliding manifold with fixed time convergence and anti-unwinding properties is proposed, and an adaptive sliding mode control(SMC) strategy is introduced to handle actuator uncertainties, model uncertainties and external disturbances simultaneously. Among this, an explicit misalignment angles range that could be treated herein is offered. Lyapunov-based stability analyses are employed to verify that the reaching phase of the sliding manifold is completed in finite time, and the attitude tracking errors are ensured to converge to a small region of the closest equilibrium point in fixed time once the sliding manifold enters the reaching phase. Finally, the beneficial features of the designed controller are manifested via detailed numerical simulation tests.

关键词： Actuator failures actuator misalignment angles finite time sliding mode control(SMC) spacecraft attitude tracking

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Experimental Study on Jet Impingement Boiling Heat Transfer in Brass Beads Packed Porous Layer

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Journal of Thermal Science 2020年第3期29卷 718-729页

作者： ZHANG Yunsong chen wei Merchant Marine College Shanghai Maritime UniversityShanghai 201306China

Jet impingement boiling has been widely used in industrial facilities as its higher heat transfer coefficient(HTC)and critical heat flux(CHF)can be achieved in comparison with the pool *** covering beads packed porous layer on the heated wall surface,the enlarged heat transfer area and rise of nucleation sites for boiling occur,thus,the heat transfer performance of boiling can be *** the jet impingement boiling with brass bead packed porous layers,the heat transfer performance is crucially influenced by the characteristics of porous layer and working fluid flow,so the experiments were conducted to investigate the effects of the jet flow rate,fluid inlet subcooling,number of porous layer and brass bead diameter of porous *** study shows that impingement boiling promotes the HTC and CHF as 1.5 times and 2.5 times respectively as pool boiling at similar *** heat transfer performance can be obtained in the cases of a higher jet flow rate and a higher fluid inlet subcooling,and there exist the optimal layer number and bead diameter for heat ***,a double-layer porous layer results in an increase of 39%in heat flux at superheat of 30 K compared with a single-layer case;a single porous layer at d=8 mm brings an increase of 23%in heat flux at superheat of 30 K compared with that of bare plain ***,the actual scene of jet impingement boiling was recorded with a camera to investigate the behavior evolution of vapor bubbles which is highly correlated to the heat transfer process.

关键词： jet impingement nucleate boiling beads packed porous layer heat transfer coefficient critical heat flux

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