检索结果-南通市图书馆

维普期刊数据库

A bilateral heterogeneous graph model for interpretable job recommendation considering both reciprocity and competition

在线全文

学校读者我要写书评

暂无评论

Frontiers of Engineering Management 2024年第1期11卷 128-142页

作者： Xiaowei shi Qiang WEI Guoqing chen School of Economics and Management Tsinghua UniversityBeijing 100084China

Amidst the inefficiencies of traditional job-seeking approaches in the recruitment ecosystem, the importance of automated job recommendation systems has been magnified. However, existing models optimized to maximize user clicks for general product recommendations prove inept in addressing the unique challenges of job recommendation, namely reciprocity and competition. Moreover, sparse data on online recruitment platforms can further negatively impact the performance of existing job recommendation algorithms. To counteract these limitations, we propose a bilateral heterogeneous graph-based competition iteration model. This model comprises three integral components: 1) two bilateral heterogeneous graphs for capturing multi-source information from people and jobs and alleviating data sparsity, 2) fusion strategies for synthesizing attributes and preferences to produce mutually beneficial job matches, and 3) a competition-enhancing strategy for dispersing competition realized through a two-stage optimization algorithm. Augmented by granular attention mechanisms for enhanced interpretability, the model’s efficacy, competition dispersion, and interpretability are validated through rigorous empirical evaluations on a real-world recruitment platform.

关键词： job recommendation competition reciprocity interpretability

Cloning and Sequence Analysis of E Gene from Chicken Flavivirus Isolate CJD05

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Husbandry and Feed Science 2012年第6期4卷 245-246,249页

作者： WANG Shao chen shi-long chen Shao-ying LIN Feng-qian chenG Xiao-xia ZHU Xiao-Li JIANG Bin LI Zhao-long Institute of Animal Husbandry and Veterinary Medicine FuJian Academy of Agriculture Sciences Fujian Livestock and Poultry Diseases Control Technology Development Center

[ Objective] This experiment aimed to find out the origin and genetic evolution relationship of chicken flavivirus （CFV） CJD05 strain in Fujian Province. [Method] A pair of primers were designed and synthesized according to the sequences of E gene from Duck flavivirus （DFV） iso- late BYD-1. E gene of CFV isolate CJD05 was specially amplified and its sequences were analyzed. [Result] The target bar which was cloned from CFV isolate C, JD05 was I 503 bp. Homology analysis was conducted to compare E gene nucleotide sequence of CFV isolate CJD05 with DFV iso- late BYD-I and goose flavivirus （GFV） isolate JS804. Results indicated that isolate nuclectide homologies were 99.2% and 99.3%, and amino acid homologies were 99.0% and 98.6% respectively. [Conclusion] CFV isolate C, JD05, DFV isolate BYD-1 and GFV isolate JS804 were highly homologous. The homology of CFV isolate CJD05 with Tembusu virus （TMUV） was higher than with other arthropod-borne flaviviruses.

关键词： Chicken flavivirus (CFV) E gene Sequence analysis

Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第6期14卷 2761-2772页

作者： Zhipeng Zeng Runcheng Tan shi chen Haolin chen Zhijia Liu Lixin Liu Mingqiang Li Yongming chen Laboratory of Biomaterials and Translational Medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China School of Materials Science and Engineering Center of Functional BiomaterialsKey Laboratory of Polymeric Composite Materials and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China

Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic *** long-acting insulin analogs,such as insulin-polymer conjugates,are mainly used to improve pharmacokinetics by reducing renal ***,these conjugates are synthesized without sacrificing the bioactivity of insulin,thus retaining the narrow therapeutic index of native insulin,and exceeding the efficacious dose still leads to ***,we report a kind of di-PEGylated insulin that can simultaneously reduce renal clearance and receptor-mediated *** impairing the binding affinity to the receptor and the activation of the receptor,di-PEGylated insulin not only further prolongs the half-life of insulin compared to classical mono-PEGylated insulin but most importantly,increases its maximum tolerated dose *** target of long-term glycemic management in vivo has been achieved through improved pharmacokinetics and a high *** work represents an essential step towards long-acting insulin medication with superior safety in reducing hypoglycemic events.

关键词： Diabetes Insulin Therapeutic index Hypoglycemia PEGylation Receptor-mediated clearance Half-life Diabetic nephropathy

Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang shi-lin Huang Nan-nan chen Department of Hematology PLA 967th Hospital

Introduction: There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL). Here, we report a case series of realgar-indigo naturalis formula(RIF) for the successful treatment of patients with relapsed and ATO-resistant *** presentation: Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR) when reinduced by ATO; the other five patients progressed to relapse during ATO-based regimens for post-remission therapy. These eight patients received RIF in three doses per day totaling 130 mg/kg(≤ 30 pills) as induction therapy and achieved HCR at a median time of46.5 days. They received 5 years of post-remission therapy, which consisted of combined chemotherapy followed by RIF. During this period, the patients did not experience renal dysfunction or QT interval prolongation. At the last follow-up, three patients survived without relapse, two patients survived with a second or third relapse and third or fourth remission, and the other three patients relapsed for a third or fourth time and died. The 5-year overall survival and event-free survival rates were 75.0%(95% confidence interval [CI]: 31.5–93.1) and 37.5%(95% CI: 5.6–71.7), ***: RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan shi Chunyan Cao Yiheng Zeng Yuanliang Ding long chen Fuze Zheng Xuejiao chen Fanggui Zhou Xiefeng Yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin chen Kang Yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

Sedimentary paleoenvironment and its control on organic matter enrichment in the Mesoproterozoic hydrocarbon source rocks in the Ordos Basin, southern margin of the North China Craton

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2257-2272页

作者： Zhi-chen Wu Ju-Ye shi Tai-Liang Fan Ming Jiang School of Energy Resources China University of Geosciences (Beijing) Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of Education China University of Geosciences (Beijing)

The black shale of the Mesoproterozoic Cuizhuang Formation in the Changcheng System in Yongji city,North China Craton, is a potential source rock. Understanding the organic matter enrichment mechanism is crucial for evaluating source rock resources and understanding oil and gas accumulation *** this study, we evaluated the sedimentary paleoenvironment and organic matter enrichment mechanisms of shale using thin section observations, mineral composition analysis, organic geochemistry, and elemental geochemistry. We found significant differences in the sedimentary paleoenvironment and organic matter enrichment mechanisms between the lower Cuizhuang Formation and the Beidajian Formation shale. The Cuizhuang Formation was deposited in a late-stage, restricted basin environment during the rift phase, and elemental and geochemical indicators showed that the Cuizhuang Formation was in a suboxic-anoxic water environment, that was influenced by a warm and humid paleoclimate and submarine hydrothermal activities, which promoted the accumulation of organic matter. However, the enrichment of organic matter in the Cuizhuang Formation was mainly controlled by redox *** formation of suboxic-anoxic water environments may be closely related to the warm and humid paleoclimate and submarine hydrothermal activities. Warm conditions promote continental weathering and increase marine productivity, thereby consuming oxygen in the bottom water. Moreover, acidic hydrothermal activity also helps to establish an anoxic environment. Our results reveal the effects controlling various coupled mechanisms dominated by redox conditions, which may explain the development of source rocks in the Cuizhuang Formation.

关键词： Cuizhuang formation Paleoproterozoic source rocks Marine productivity Paleoenvironments Submarine hydrothermal activity Organic matter enrichment

Distribution, bioaccumulation, trophic transfer and risk assessment of trace elements in fish from a typical shallow outflow lake basin, China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第7期18卷 141-156页

作者： Miao He Guijian Liu Xiaodan shi Lei Wu Qiang chen CAS Key Laboratory of Crust-Mantle Materials and Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Anhui Academy of Environmental Sciences Hefei 230022China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Fish are important food sources for humans,and the availability of appropriate amount of trace elements(TEs)plays a crucial role in fish ***,due to large volumes of sewage discharge,high levels of certain elements are present in aquatic environments,and these elements accumulate in fish and potentially affect human *** this study,the distribution and bioaccumulation capacity of trace elements in six dominant fish species from Chaohu Lake(China)were *** results showed that the bioaccumulation capacity of fish for Zn was greater than other *** the source of the TEs in the fish were explored along with the concentration of the TEs in the aquatic environment,which indicated that TEs in fish were mainly obtained through ingestion and indirectly affected by the industrial activities in the ***,stable carbon and nitrogen isotopes were used to classify the trophic levels and explore the biological magnification of TEs of the *** was found that Sb and Sr showed biomagnification with the increase of trophic level of *** on the above analyses,the environmental biogeochemical cycle model of TEs in the lake was distinguished and established,which can offer valuable insights for sustainable fishery management in the downstream Yangtze River Delta ecosystem.

关键词： Trophic level Bioaccumulation Risk assessment Trace elements

A 26.5–29.5-GHz Doherty PA with enhanced linearity and efficiency based on adaptive bias circuit for 5G MIMO arrays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第7期67卷 341-342页

作者： long WANG Jixin chen Debin HOU Xiaojie XU Wei HONG State Key Laboratory of Millimeter Waves Southeast University Misic Microelectronics Co. Ltd.

Power amplifiers (PAs) play a crucial role in achieving key performance metrics such as efficiency, power, and ***, in the millimeter-wave frequency range, the performance of active devices rapidly deteriorates with increasing frequency. The typical Doherty architecture, through load modulation techniques, can achieve high back-off efficiency [1]. To enhance the linearity of the PA, adaptive bias circuits (ADBs) have been widely adopted [2, 3].

关键词： POWER-AMPLIFIER

Winter Wheat Yield Estimation Based on Sparrow Search Algorithm Combined with Random Forest:A Case Study in Henan Province,China

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical Science 2024年第2期34卷 342-356页

作者： shi Xiaoliang chen Jiajun DING Hao YANG Yuanqi ZHANG Yan College of Geomatics Xi’an University of Science and TechnologyXi’an 710054China

Precise and timely prediction of crop yields is crucial for food security and the development of agricultural ***,crop yield is influenced by multiple factors within complex growth *** research has paid relatively little attention to the interference of environmental factors and drought on the growth of winter ***,there is an urgent need for more effective methods to explore the inherent relationship between these factors and crop yield,making precise yield prediction increasingly *** study was based on four type of indicators including meteorological,crop growth status,environmental,and drought index,from October 2003 to June 2019 in Henan Province as the basic data for predicting winter wheat *** the sparrow search al-gorithm combined with random forest(SSA-RF)under different input indicators,accuracy of winter wheat yield estimation was *** estimation accuracy of SSA-RF was compared with partial least squares regression(PLSR),extreme gradient boosting(XG-Boost),and random forest(RF)***,the determined optimal yield estimation method was used to predict winter wheat yield in three typical *** are the findings:1)the SSA-RF demonstrates superior performance in estimating winter wheat yield compared to other *** best yield estimation method is achieved by four types indicators’composition with SSA-RF)(R^(2)=0.805,RRMSE=9.9%.2)Crops growth status and environmental indicators play significant roles in wheat yield estimation,accounting for 46%and 22%of the yield importance among all indicators,respectively.3)Selecting indicators from October to April of the follow-ing year yielded the highest accuracy in winter wheat yield estimation,with an R^(2)of 0.826 and an RMSE of 9.0%.Yield estimates can be completed two months before the winter wheat harvest in June.4)The predicted performance will be slightly affected by severe *** with severe drought year(201

关键词： winter wheat yield estimation sparrow search algorithm combined with random forest(SSA-RF) machine learning multi-source indicator optimal lead time Henan Province,China

维普期刊数据库