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An Adaptive Bandwidth Allocation for Energy Efficient Wireless Communication Systems

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Journal of Electronic Science and Technology 2015年第1期13卷 27-32页

作者： Yung-Fa Huang che-Hao Li Chuan-Bi Lin chia-Chi chang Department of Information and Communication Engineering Chaoyang University of Technology

In this paper, an energy efficient bandwidth allocation scheme is proposed for wireless communication systems. An optimal bandwidth expansion（OBE） scheme is proposed to assign the available system bandwidth for users. When the system bandwidth does not reach the full load, the remaining bandwidth can be energy-efficiently assigned to the other users. Simulation results show that the energy efficiency of the proposed OBE scheme outperforms the traditional same bandwidth expansion（SBE） scheme. Thus, the proposed OBE can effectively assign the system bandwidth and improve energy efficiency.

关键词： Bandwidth resource allocation energy efficiency optimal bandwidth expansion same bandwidth expansion

Influence of Sox protein SUMOylation on neural development and regeneration

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Neural Regeneration Research 2022年第3期17卷 477-481页

作者： Kun-che chang Department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of MedicinePittsburghPAUSA

SRY-related HMG-box(Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological ***-translational modification of Sox proteins is known to alter their functions in the central nervous *** the different types of post-translational modification,small ubiquitin-like modifier(SUMO) modification of Sox proteins has been shown to modify their transcriptional ***,we review the mechanisms of three Sox proteins in neuronal development and disease,along with their transcriptional changes under *** three species,lysine is the conserved residue for *** Drosophila,SUMOylation of Sox N plays a repressive role in transcriptional activity,which impairs central nervous system ***,de SUMOylation of Sox E and Sox11 plays neuroprotective roles,which promote neural crest precursor formation in Xenopus and retinal ganglion cell differentiation as well as axon regeneration in the *** further discuss a potential translational therapy by SUMO site modification using AAV gene transduction and Clustered regularly interspaced short palindromic repeats-Cas9 *** the underlying mechanisms of Sox SUMOylation,especially in the rodent system,may provide a therapeutic strategy to address issues associated with neuronal development and neurodegeneration.

关键词： axon regeneration neural development neurological disorder neuroprotection post-translational modification small ubiquitin-like modifier Sox transcription factor SUMOylation

The fabrication and application of Ni-DNA nanowire-based nanoelectronic devices

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Nano Research 2019年第6期12卷 1293-1300页

作者： Pang-chia chang chia-Yu chang Wen-Bin Jian Chiun-Jye Yuan Yu-chang chen chia-Ching chang Department of Electrophysics "National Chiao Tung University"Hsinchu 30010TaiwanChina Department of Biological Science and Technology "National Chiao Tung University"Hsinchu 30068TaiwanChina Center for Intelligent Drug Systems and Smart Bio-devices(IDS^2B) "National Chiao Tung University"Hsinchu 30068TaiwanChina Institute of Physics "Academia Sinica"Taipei 11529TaiwanChina

DNA is a self-assembled,double stranded natural molecule that can chelate and align nickel ions between its base *** fabrication of a DNA-guided nickel ion chain (Ni-DNA) device was successful,as indicated by the conducting currents exhibiting a Ni ion redox reaction-driven negative differential resistance effect,a property unique to mem-elements (1).The redox state of nickel ions in the Ni-DNA device is programmable by applying an external bias with different polarities and writing times (2).The multiple states of Ni-DNA-based memristive and memcapacitive systems were characterized (3).As such,the development of Ni-DNA nanowire device-based circuits in the near future is proposed.

关键词： DNA-guided nickel ion chain (Ni-DNA) negative differential resistance (NDR) memristive systemmem capacitive system nanowire

Cell replacement with stem cell-derived retinal ganglion cells from different protocols

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Neural Regeneration Research 2024年第4期19卷 807-810页

作者： Ziming Luo Kun-che chang Spencer Center for Vision Research Byers Eye InstituteStanford University School of Medicine Department of Ophthalmology Louis J.Fox Center for Vision RestorationUniversity of Pittsburgh School of Medicine Department of Neurobiology Center of NeuroscienceUniversity of Pittsburgh School of Medicine

Glaucoma,characterized by a degenerative loss of retinal ganglion cells,is the second leading cause of blindness *** is currently no cure for vision loss in glaucoma because retinal ganglion cells do not regenerate and are not replaced after *** stem cell-derived retinal ganglion cell transplant is a potential therapeutic strategy for retinal ganglion cell degenerative *** this review,we first discuss a 2D protocol for retinal ganglion cell differentiation from human stem cell culture,including a rapid protocol that can generate retinal ganglion cells in less than two weeks and focus on their transplantation ***,we discuss using 3D retinal organoids for retinal ganglion cell transplantation,comparing cell suspensions and *** review provides insight into current knowledge on human stem cell-derived retinal ganglion cell differentiation and transplantation,with an impact on the field of regenerative medicine and especially retinal ganglion cell degenerative diseases such as glaucoma and other optic neuropathies.

关键词： cell clumps cell suspension cell transplantation differentiation direct-induced protocol glaucoma optic neuropathy regenerative medicine retinal ganglion cell retinal organoids stem cells

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

SoxC transcription factors in retinal development and regeneration

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Neural Regeneration Research 2017年第7期12卷 1048-1051页

作者： Kun-che chang Jonathan Hertz Department of Ophthalmology School of Medicine Stanford University Palo Alto CA USA

Glaucoma and other optic neuropathies result in optic nerve degeneration and the loss of retinal ganglion cells（RGCs）through complex signaling *** the mechanisms that regulate RGC development remain unclear,uncovering novel developmental pathways may support new strategies to regenerate the optic nerve or replace *** we review recent studies that provide strong evidence that the Sry-related high-mobility-group C（SoxC）subfamily of transcription factors（TFs）are necessary and sufficient for axon guidance and RGC fate *** findings also uncover novel SoxC-dependent mechanisms that serve as master regulators during important steps of RGC *** example,we review work showing that SoxC TFs regulate RGC axon guidance and direction through the optic chiasm towards their appropriate targets in the *** also review work demonstrating that Sox11 subcellular localization is,in part,controlled through small ubiquitin-like post-translational modifier（SUMO）and suggest compensatory cross-talk between Sox4 and ***,Sox4 overexpression is shown to positively drive RGC differentiation in human induced pluripotent stem cells（hi PSCs）.Finally,we discuss how these findings may contribute to the advancement of regenerative and cell-based therapies to treat glaucoma and other optic nerve neuropathies.

关键词： Sox4 Soxl 1 retinal ganglion cell optic nerve regeneration SUMOylation cell transplantation stern cell

The effect of thermal loading waveform on the failure mechanism of atmospheric-plasma-sprayed thermal barrier coating system

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Science China(Technological Sciences) 2018年第11期61卷 1679-1687页

作者： LI ShaoLin YANG XiaoGuang QI HongYu che chang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Collaborative Innovation Center of Advanced Aero-Engine Beijing 100191China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

The hot-end components of gas turbine engines in the serviced condition usually suffer from the thermal cycle loading *** barrier coating(TBCs) have been used as a protective coating to prevent degradation during practical applications. In the current work, the influence of a loading waveform on the failure mechanism of an atmospheric plasma-sprayed TBCs is investigated at an elevated temperature. The samples under the trapezoidal loading condition present a lower thermal cycling fatigue lifetime than that under the triangular loading condition. Moreover, cracks in the TBCs samples under the triangular loading condition are initiated from the defects on the top coat formed during preparation, and cracks under the trapezoidal loading condition preferentially occur at the thermally grown oxide-top coat interface due to higher stress at the interface. Our results demonstrate that the thermal loading waveform should be carefully designed to characterize the in-service condition of hot-end components.

关键词： coating loading waveform thermal-fatigue air-plasma-sprayed

Multifunctional silver film with superhydrophobic and antibacterial properties

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Nano Research 2016年第2期9卷 442-450页

作者： Ping che Wei Liu Xiaoxue chang Anhe Wang Yongsheng Han School of chemistry and Biological Engineering University of Science & Technology Beijing Beijing 100083 China State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190China State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Science Beijing 100190 China Key Laboratory of Colloid and Interface Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Material properties are strongly dependent on material structure. The large diversity and complexity of material structures provide significant opportunities to improve the properties of the materials, expanding their applications. Here, we discuss the fabrication of a multifunctional silver film prepared by controlling the nucleation and growth of silver particles. Silver films with high hydrophobicity and antibacterial activity were fabricated by adopting an electrochemical approach. The dependence of the hydrophobic and antibacterial properties on the size and shape of the silver particles was first investigated. Small-sized silver particles exhibited a high antibacterial rate, while a porous silver film composed of dendritic particles showed a significant hydrophobic activity. By regulating the reaction time, current density, and silver salt concentration, a silver film with a contact angle of 150.9° and an antibacterial rate of 54.7% was synthesized. This study demonstrates that finding a compromise between different material structures is a suitable wav to fabricate multifunctional devices.

关键词： hydrophobicity antibacterial silver film electrodeposition

Effect of bond-coat surface roughness on failure mechanism and lifetime of air plasma spraying thermal barrier coatings

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Science China(Technological Sciences) 2019年第6期62卷 989-995页

作者： LI ShaoLin QI HongYu SONG JiaNan YANG XiaoGuang che chang School of Energy and Power Engineering Beihang University Beijing 100191 China Collaborative Innovation Center of Advanced Aero-Engine Beijing 100191 China School of Materials Science and Engineering Beihang University Beijing 100191 China

This work investigates the failure mechanism of an air plasma spraying(APS) thermal barrier coatings(TBCs) with various bond coat(BC) surface toughness under constant temperature loading condition. Results show that the increased BC surface roughness decreased the lifetime. Moreover, the relationship between the TGO depth and the lifetime can be well described by linear *** failure mechanism of the TBCs samples was studied by cross-sectional morphologies observation and using the finite element method(FEM). Cracks in the TBCs samples with higher BC surface roughness are initiated from the defects on the BC caused by Al depletion in the BC layer. However, cracks in the samples of TBCs with lower BC surface roughness condition preferentially occur at the TC-TGO interface. This finding could be attributed to the high mismatch stresses in the TC-TGO interface.

关键词： thermal barrier coatings roughness failure mechanism air plasma spraying