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Isolated varices over hepatic flexure colon indicating superior mesenteric venous thrombosis caused by uncinate pancreatic head cancer - a case report

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World Journal of Gastroenterology 2005年第12期11卷 1886-1889页

作者： Yu-Pin Ho Chun-Jung lin Jeng-Hwei Tseng cheng-Tang chiu Department of Gastroenterology

Very rare cases of varices involving right side colon were reported. Most of them were due to cirrhotic portal hypertension or other primary causes. No report case contributed to pancreatic cancer. Here, we reported a case of uncinate pancreatic cancer with the initial finding of isolated hepatic flexure colon varices. Following studies confirmed isolated varices involving hepatic flexure colon due to pancreatic cancer with occlusion of superior mesenteric vein. From this report, superior mesenteric vein occlusion caused by uncinate pancreatic head cancer should be considered as a differential diagnosis of colon varices.

关键词： Colon varices Pancreatic cancer Superior mesenteric vein occlusion

Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse

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Asian Journal of Andrology 2008年第2期10卷 219-226页

作者： Yibing Han Xue-Xiong Song Huai-Liang Feng che-Kwok cheung Po-Mui Lam Chi-chiu Wang Christophe John Haines Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China Department of Animal Sciences Laiyang Agricultural College Qingdao Shandong 266109 China Center for Human Reproduction North Shore University Hospital NYU School of Medicine Manhasset NY 11030 USA Li Ka Shing Institute of Health Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

Aim： To determine the possible roles of the t-complex testis expressed gene 5 （Tctex5） on sperm functions, the fulllength sequence of mRNA was studied and compared in the testis between the normal wild-type and the sterile t-haplotype mutant mice. Methods： We applied rapid amplification of cDNA ends, Northern blot and reverse transcription polymerase chain reaction to analyze the full length of Tctex5 mRNAs isolated from testes of the wild-type and the t-haplotype mice. Reverse transcription polymerase chain reaction was used to semi-quantitatively compare expression of Tctex5 transcripts in the 16 tissues and 9.5 day stage embryos in the wild-type mice. E-translation was applied to estimate the amino acid sequences. Results： One long and one short transcript of Tctex5 mRNA were discovered in mouse testis of wild-type （Tctex5^long-＋ and Tctex5^short-＋） and t-haplotype （Tctex5^long-＋ and Tctex5^short-＋） mice, respectively. Being enhanced only in the testis, Tctex5^long-＋ had 17 point mutations and one 15-bp-deletion in the exon 1 region, comparing with the Tctex5^long-＋, whereas the Tctex5^short-＋ was similar to the Tctex5^short-＋. The short isoforms of Tctex5 mRNAs in the two models encoded exactly the same peptides, but the long isoforms did not. The estimated peptide encoded by Tctex5^long-＋ had significant mutations on putative sites of phosphorylation and PP1 binding. Conclusion： We established that mutations that occur in the Tctex5 long transcript of the t-haplotype mice are important for normal sperm function, whereas the short transcript of Tctex5 might have a conserved function among different tissues. （Asian J Androl 2008 Mar; 10： 219-226）

关键词： t-complex testis expressed gene 5 transcripts testis mice

Learning of medical pharmacology via innovation:a personal experience at McMaster and in Asia

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Acta Pharmacologica Sinica 2004年第9期25卷 84-92页

作者： chiu-yin KWAN Canada Department of Medicine HSC-4N40 Faculty of Health Sciences Hamilton L8N 3Z5 McMaster University Ontario

Pharmacology in the traditional medical curriculum has been treated as a discrete "preclinical" discipline identifying itself distinctly different from the other preclinical sciences or clinical subjects in knowledge base as well as learning/teaching instructions. It is usually run in series with other pre-clinical courses (eg, anatomy, biochemistry, physiology etc), but in parallel with other paraclinical courses such as pathology, microbiology and community medicine. Clinical pharmacology was only introduced relatively recently designed to overcome the perceived deficiency in "preclinical" pharmacology regarding its therapeutic relevance and application to medicine. In many universities, both preclinical and clinical pharmacology courses co-exist, usually independently offered by two separate, sometimes non-interacting Departments of Pharmacology and Clinical Pharmacology. In this model, pharmacology is generally taught in a teacher-centered, discipline-oriented, and knowledge-based curriculum. Further

关键词： problem-based learning pharmacology medical education self-directed learning small group tutorial

Dextrose in the banked blood products does not seem to affect the blood glucose levels in patients undergoing liver transplantation

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World Journal of Gastroenterology 2005年第18期11卷 2789-2791页

作者： Kwok-Wai cheng Chia-Chih Tseng Chih-Hsien Wang Yaw-Sen chen Chih-Chi Wang Tung-Liang Huang Hock-Liew Eng King-Wah chiu Shih-Hor Wang Chih-che lin Tsan-Shiun lin Yueh-Wei Liu Bruno Jawan Department of Anesthesiology and Liver Transplantation Program Chang Gung Memorial Hospital Kaohsiung Medical Center Taiwan China Chang Gung University Ta-pei Taiwan China

AIM: Hyperglycemia commonly seen in liver transplantation (LT) has often been attributed to the dextrose in the storage solution of blood transfusion products. The purpose of the study is to compare the changes of the blood glucose levels in transfused and non-transfused patients during LT. METHODS: A retrospective study on 60 biliary pediatric patients and 16 adult patients undergoing LT was carried out. Transfused pediatric patients were included in Group Ⅰ (GⅠ), those not transfused in Group Ⅱ (GⅡ). Twelve adult patients were not given transfusion and assigned to Group Ⅲ(GⅢ); whereas, four adult patients who received massive transfusion were assigned to Group Ⅳ (GⅣ). The blood glucose levels, volume of blood transfused, and the volume of crystalloid infused were recorded, compared and analyzed. RESULTS: Results showed that the changes in blood glucose levels during LT for both non-transfused and minimally transfused pediatric groups and non-transfused and massively-transfused adult groups were almost the same. CONCLUSION: We conclude that blood transfusion does not cause significant changes in the blood glucose levels in this study.

关键词： Organ Liver surgery Transplantation Anesthesia General monitoring Blood glucose transfusion Bank blood component Infusion 5% dextrose in 1/4 saline

Nonlinear dynamical characteristics of bed load motion

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Science China(Technological Sciences) 2006年第3期49卷 365-384页

作者： chiu-On Ng Department of Mechanical Engineering the University of Hong Kong Hong Kong China

Bed forms of various kinds that evolve naturally on the bottom of sandy coasts and rivers are a result of the kinematics of bed load transport. Based on the group motion of particles in the bed load within the bottom layer, a study on the nonlinear dy- namics of bed load transport is presented in this paper. It is found that some development stages, such as the initiation, the equilibrium sediment transport, and the transition from a smooth bed to sand dunes, can be accounted for by different states in the nonlinear sys- tem of the bed load transport. It is verified by comparison with experimental data reported by Laboratoire Nationae D’Hydraulique, Chatou, France, that the evolution from a smooth bed to sand dunes is determined by mutation in the bed load transport. This paper pre- sents results that may offer theoretical explanations to the experimental observations. It is also an attempt to apply the state-of-the-art nonlinear science to the classical sediment transport mechanics.

关键词： bed load, bed form, nonlinear dynamics.

Interaction of oblique waves with an array of long horizontal circular cylinders

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Science China(Technological Sciences) 2007年第4期50卷 490-509页

作者： NG chiu-On Department of Mechanical Engineering the University of Hong Kong Pokfulam Road Hong Kong China

The scattering and radiations of linear oblique waves by multiple long horizontal circular cylinders submerged in water of finite depth are investigated using the multipole expansion method. Analytical expressions for the diffracted and radiated potentials are given as a linear combination of infinite multipoles. The unknown coefficients in the expressions are determined by using the addition theorem of the Bessel function and the cylinder boundary conditions. Also analytical expressions for wave forces, hydrodynamic coefficients and reflection and transmission coeffi-cients are derived. The present analytical solution is verified through the boundary element method and applied to investigate three different cases of the interaction of oblique waves with multiple submerged horizontal circular cylinders. The results show that the number of cylinders, the arrangement and spacing between cylinders play an important role in wave forces, hydrodynamic coefficients and reflection and transmission coefficients. Some interesting and important phenomena are ob-served in numerical experiments.

关键词： scattering and radiation water waves analytical technique hydrodynamic characteristics

Green's Function for Periodic Solutions in Alternately Advanced and Delayed Differential Systems

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Acta Mathematicae Applicatae Sinica 2020年第4期36卷 936-951页

作者： Kuo-Shou chiu Departamento de Matematica Facultad de Ciencias BasicasUniversidad Metropolitana de Ciencias de la EducacionSantiagoChile

In this paper we investigate the existence of the periodic solutions of a nonlinear differential equation with a general piecewise constant argument,in short DEPCAG,that is,the argument is a general step *** consider the critical case,when associated linear homogeneous system admits nontrivial periodic *** of existence of periodic solutions of such equations are *** the process we use the Green?s function for periodic solntions and convert the given DEPCAG into an equivalent integral *** we construct appropriate mappings and employ Krasnoselskii's fixed point theorem to show the existence of a periodic solution of this type of nonlinear differential *** also use the contraction mapping principle to show the existence of a unique periodic *** examples are given to show the feasibility of our results.

关键词： piecewise constant arguments Green's function periodic solutions hybrid equations fixed point theorems

Effect of autologous blood donation on the central venous pressure, blood loss and blood transfusion during living donor left hepatectomy

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World Journal of Gastroenterology 2005年第27期11卷 4233-4236页

作者： Bruno Jawan Yu-Fan cheng Chia-Chi Tseng Yaw-Sen chen Chih-Chi Wang Tung-Liang Huang Hock-Liew Eng Po-Ping Liu King-Wah chiu Shih-Hor Wang Chih-che lin Tsan-Shiun lin Yueh-Wei Liu Chao-Long chen Department of Anesthesiology Chang Gung Memorial Hospital Kaohsiung Medical Center TaiwanChina Liver Transplantation Program Chang Gung Memorial Hospital Kaohsiung Medical Center Taiwan China

AIM： Autologous blood donation （ABD） is mainly used to reduce the use of banked blood. In fact, ABD can be regarded as acute blood loss. Would ABD 2-3 d before operation affect the CVP level and subsequently result in less blood loss during liver resection was to be ***： Eighty-four patients undergoing living donor left hepatectomy were retrospectively divided as group Ⅰ （GⅠ） and group Ⅱ （GⅡ） according to have donated 250-300 mL blood 2-3 d before living donor hepatectomy or not. The changes of the intraoperative CVP, surgical blood loss,blood products used and the changes of perioperative hemoglobin （Hb） between groups were analyzed and compared by using Mann-Whitney ***： The results show that the intraoperative CVP changes between GⅠ （n = 35） and GⅡ （n = 49） up to graft procurement were the same, subsequently the blood loss,but ABD resulted in significantly lower perioperative Hb levels in ***： Since none of the patients required any blood products perioperatively, all the predonated bloods were discarded after the patients were discharged from the hospital. It indicates that ABD in current series had no any beneficial effects, in term of cost, lowering the CVP, blood loss and reduce the use of banked blood products, but resulted in significant lower Hb in perioperative period.

关键词： Blood Transfusion, Autologous Central Venous Pressure Hepatectomy Liver Transplantation Living Donors Adult Blood Loss, Surgical control Female Humans Intraoperative Care Male Retrospective Studies

MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding

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World Journal of Gastroenterology 2011年第16期17卷 2120-2125页

作者： Chun-Yen lin I-Shyan Sheen Tsung-Nan lin Chun-Jung lin Wen-Juei Jeng Chien-Hao Huang Yu-Pin Ho cheng-Tang chiu Department of Hepato-Gastroenterology Linkou Medical CenterChang Gung Memorial Hospital and Chang Gung University College of Medicine

AIM:To investigate the outcomes,as well as risk factors for 6-wk mortality,in patients with early rebleeding after endoscopic variceal band ligation (EVL) for esophageal variceal hemorrhage (EVH).METHODS:Among 817 EVL procedures performed for EVH between January 2007 and December 2008,128 patients with early rebleeding,defined as rebleeding within 6 wk after EVL,were enrolled for ***:The rate of early rebleeding after EVL for acute EVH was 15.6% (128/817).The 5-d,6-wk,3-mo,and 6-mo mortality rates were 7.8%,38.3%,55.5%,and 58.6%,respectively,in these early rebleeding *** use of beta-blockers,occurrence of hypovolemic shock,and higher model for end-stage liver disease (MELD) score at the time of rebleeding were independent predictors for 6-wk mortality.A cut-off value of 21.5 for the MELD score was found with an area under ROC curve of 0.862 (P < 0.001).The sensitivity,specificity,positive predictive value,and negative predictive value were 77.6%,81%,71.7%,and 85.3%,*** for the 6-mo survival rate,patients with a MELD score ≥ 21.5 had a significantly lower survival rate than patients with a MELD score < 21.5 (P < 0.001).CONCLUSION:This study demonstrated that the MELD score is an easy and powerful predictor for 6-wk mortality and outcomes of patients with early rebleeding after EVL for EVH.

关键词： Model for end-stage liver disease score Esophageal variceal hemorrhage Rebleeding Cirrhosis Mortality