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Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse

Asian Journal of Andrology 2008年第2期10卷 219-226页

作者： Yibing Han Xue-Xiong Song Huai-Liang Feng che-kwok cheung Po-Mui Lam Chi-Chiu Wang Christophe John Haines Department of Obstetrics and Gynaecology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China Department of Animal Sciences Laiyang Agricultural College Qingdao Shandong 266109 China Center for Human Reproduction North Shore University Hospital NYU School of Medicine Manhasset NY 11030 USA Li Ka Shing Institute of Health Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

Aim： To determine the possible roles of the t-complex testis expressed gene 5 （Tctex5） on sperm functions, the fulllength sequence of mRNA was studied and compared in the testis between the normal wild-type and the sterile t-haplotype mutant mice. Methods： We applied rapid amplification of cDNA ends, Northern blot and reverse transcription polymerase chain reaction to analyze the full length of Tctex5 mRNAs isolated from testes of the wild-type and the t-haplotype mice. Reverse transcription polymerase chain reaction was used to semi-quantitatively compare expression of Tctex5 transcripts in the 16 tissues and 9.5 day stage embryos in the wild-type mice. E-translation was applied to estimate the amino acid sequences. Results： One long and one short transcript of Tctex5 mRNA were discovered in mouse testis of wild-type （Tctex5^long-＋ and Tctex5^short-＋） and t-haplotype （Tctex5^long-＋ and Tctex5^short-＋） mice, respectively. Being enhanced only in the testis, Tctex5^long-＋ had 17 point mutations and one 15-bp-deletion in the exon 1 region, comparing with the Tctex5^long-＋, whereas the Tctex5^short-＋ was similar to the Tctex5^short-＋. The short isoforms of Tctex5 mRNAs in the two models encoded exactly the same peptides, but the long isoforms did not. The estimated peptide encoded by Tctex5^long-＋ had significant mutations on putative sites of phosphorylation and PP1 binding. Conclusion： We established that mutations that occur in the Tctex5 long transcript of the t-haplotype mice are important for normal sperm function, whereas the short transcript of Tctex5 might have a conserved function among different tissues. （Asian J Androl 2008 Mar; 10： 219-226）

关键词： t-complex testis expressed gene 5 transcripts testis mice

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Discrete Choice Analysis of Temporal Factors on Social Network Growth

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Intelligent Information Management 2024年第1期16卷 21-34页

作者： kwok-Wai cheung Yuk Tai Siu School of Communication The Hang Seng University of Hong Kong Hong Kong China

Social networks like Facebook, X (Twitter), and LinkedIn provide an interaction and communication environment for users to generate and share content, allowing for the observation of social behaviours in the digital world. These networks can be viewed as a collection of nodes and edges, where users and their interactions are represented as nodes and the connections between them as edges. Understanding the factors that contribute to the formation of these edges is important for studying network structure and processes. This knowledge can be applied to various areas such as identifying communities, recommending friends, and targeting online advertisements. Several factors, including node popularity and friends-of-friends relationships, influence edge formation and network growth. This research focuses on the temporal activity of nodes and its impact on edge formation. Specifically, the study examines how the minimum age of friends-of-friends edges and the average age of all edges connected to potential target nodes influence the formation of network edges. Discrete choice analysis is used to analyse the combined effect of these temporal factors and other well-known attributes like node degree (i.e., the number of connections a node has) and network distance between nodes. The findings reveal that temporal properties have a similar impact as network proximity in predicting the creation of links. By incorporating temporal features into the models, the accuracy of link prediction can be further improved.

关键词： Discrete Choice Models Temporal Factors Social Network Link Prediction Network Growth

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Options and survival benefits of conversion therapy for unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第18期30卷 2479-2481页

作者： Wong Hoi She Tan To cheung Department of Surgery The University of Hong KongHong Kong 999077China

In the study by Wu et al,patients with unresectable hepatocellular carcinoma were subjected to transarterial chemoembolization(TACE)as a conversion therapy in order to render their tumors suitable for resection.A nomogram was devised and shown to be effective in predicting the survival of these *** of the results,however,is questionable since the study subjects consisted of patients who had resection after TACE while excluding patients with the same disease but not suitable for *** can be considered to be an option for conversion ***,markers for determining responses to a conversion therapy and for guiding the decision between TACE and sequential immunotherapy have been *** question of whether effective conversion therapy can truly enhance overall survival remains unanswered.

关键词： Conversion therapy Immunotherapy Liver resection Survival Transarterial chemoembolization Unresectable hepatocellular carcinoma

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Significant annealing-induced hardening effect in nanolaminate d-nanotwinne d(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8)me dium-entropy alloy by severe cold rolling

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Journal of Materials Science & Technology 2024年第3期170卷 156-166页

作者： Shuqing Yuan Hui Fu Lei Qian Chi Fai cheung Xu-Sheng Yang State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518060China

Due to the easy coarsening caused by poor thermal stability,the verified annealing-induced hardening in nanograined metals can only maintain at a relatively low-temperature *** this study,a nanolam-inated(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8)medium-entropy alloy with an average lamellae thickness of∼20 nm embedded by thinner nanotwins was fabricated by severe cold rolling to achieve superior thermal *** with the conventional nanotwinned CrCoNi with nanotwins inside ultra-fined grains,the hier-archical nanolaminated-nanotwinned(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8) exhibits a significant annealing-induced hard-ening effect,i.e.,hardness increasing from∼250 HV in the original specimen to∼500 HV in the cold-rolled status and finally∼630 HV after annealing at 600℃for 1 *** microstructure characterizations reveal that the reduced dislocation density and formation of L1_(2)ordered domain are mainly responsible for such hardening effect,which is facilitated by the effectively suppressed coarsening with annealing temperature,i.e.,slow detwinning process and well-retained low-angle nanolamellar *** coarsening mechanisms from the cold-rolled nanolamellae to the fully recrystallized micro-equiaxed structures under the annealing temperatures ranging from 400 to 800℃ were also elucidated by atomic observations.

关键词： Annealing-induced hardening Thermal stability Nanolaminated-nanotwinned structure CrCoNi Detwinning Grain boundary migration

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Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho Hung cheung Wong Hoi She Siu Lun Ho Albert Chi Yan Chan Chung Mau Lo Tan To cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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Science China(Life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao Li Kenneth C.P.cheung Xiaojiao Zheng School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune *** the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing *** allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune *** review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and *** BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

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Novel Batch Polishing Method of Ceramic Cutting Inserts for Reducing Tool Wear

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 74-83页

作者： Rui Gao Chunjin Wang Yee Man Loh Xiaoliang Liang chen Jiang Chi Fai cheung State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Ceramic cutting inserts are a type of cutting tool commonly used in high-speed metal cutting ***,the wear of these inserts caused by friction between the workpiece and cutting inserts limits their overall *** order to improve the tool life and reduce wear,this study introduces an emerging method called magnetic field-assisted batch polishing(MABP)for simultaneously polishing multiple ceramic cutting *** polishing experiments were conducted under different conditions,and the wear characteristics were clarified by cutting S136H *** results showed that after 15 min of polishing,the surface roughness at the flank face,edge,and nose of the inserts was reduced to below 2.5 nm,6.25 nm,and 45.8 nm,***,the nose radii of the inserts did not change significantly,and there were no significant changes in the weight percentage of elements before and after ***,the tool life of the batch polished inserts was found to be up to 1.75 times longer than that of unpolished *** findings suggest that the MABP method is an effective way to mass polish ceramic cutting inserts,resulting in significantly reduced tool ***,this novel method offers new possibilities for polishing other tools.

关键词： Polishing Finishing Magnetic field-assisted Tool wear Ultra-precision machining

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Post-fontan circulation hepatocellular carcinoma:Open and laparoscopic hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 90-93页

作者： Karin KY Ho Wong Hoi She Simon HY Tsang Kevin S Lo Tan To cheung Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Anaesthesiology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic *** hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.

关键词： hepatocellular hepatectomy surgery

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Repeatability,interocular correlation and agreement of optic nerve head vessel density in healthy eyes:a sweptsource optical coherence tomographic angiography study

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 896-903页

作者： Dan-Qi Fang Da-Wei Yang Xiao-Ting Mai Carol Y cheung Hao-Yu chen Joint Shantou International Eye Center Shantou University&the Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology and Visual Sciences Chinese University of Hong KongHong Kong 999077China

AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy ***:Thir ty-three healthy subjects were *** ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning *** of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were *** repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman ***:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel ***:OCTA ONH parameters demonstrate good repeatability in healthy *** interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.

关键词： interocular correlation repeatability optic nerve head optical coherence tomography angiography vessel density

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Quantum Realities and Observer-Dependent Universes: An Advanced Observer Model

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Journal of Quantum Information Science 2024年第3期14卷 69-121页

作者： Joseph Hon cheung Wong Department of Computing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China

This paper presents a novel observer model that integrates quantum mechanics, relativity, idealism, and the simulation hypothesis to explain the quantum nature of the universe. The model posits a central server transmitting multi-media frames to create observer-dependent realities. Key aspects include deriving frame rates, defining quantum reality, and establishing hierarchical observer structures. The model’s impact on quantum information theory and philosophical interpretations of reality are examined, with detailed discussions on information loss and recursive frame transmission in the appendices.

关键词： Quantum Mechanics Observer Model Frame Rates Quantum Reality Hierarchical Observers Information Theory Simulation Hypothesis Recursive Frame Transmission Information Loss

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